LOCUS       NM_020282               3974 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus N-ribosyldihydronicotinamide quinone reductase 2
            (Nqo2), transcript variant 1, mRNA.
ACCESSION   NM_020282
VERSION     NM_020282.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3974)
  AUTHORS   Gould NL, Sharma V, Hleihil M, Kolatt Chandran S, David O, Edry E
            and Rosenblum K.
  TITLE     Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons
            Enhances Novel Memory Formation
  JOURNAL   J Neurosci 40 (45), 8698-8714 (2020)
   PUBMED   33046554
  REMARK    GeneRIF: Dopamine-Dependent QR2 Pathway Activation in CA1
            Interneurons Enhances Novel Memory Formation.
REFERENCE   2  (bases 1 to 3974)
  AUTHORS   Cassagnes LE, Chhour M, Perio P, Sudor J, Gayon R, Ferry G, Boutin
            JA, Nepveu F and Reybier K.
  TITLE     Oxidative stress and neurodegeneration: The possible contribution
            of quinone reductase 2
  JOURNAL   Free Radic Biol Med 120, 56-61 (2018)
   PUBMED   29526807
  REMARK    GeneRIF: these data suggest that the overexpression of QR2 in brain
            cells in the presence of catechol quinones might lead to reactive
            oxygen species-induced cell death via the rapid conversion of
            superoxide radicals into hydrogen peroxide and then into highly
            reactive hydroxyl radicals
REFERENCE   3  (bases 1 to 3974)
  AUTHORS   Xu J, Patrick BA and Jaiswal AK.
  TITLE     NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S
            proteasome to stabilize transcription factor CCAAT enhancer-binding
            protein alpha (C/EBPalpha), leading to protection against gamma
            radiation-induced myeloproliferative disease
  JOURNAL   J Biol Chem 288 (48), 34799-34808 (2013)
   PUBMED   24142791
  REMARK    GeneRIF: NQO2 stabilization of C/EBPalpha was independent of NQO1,
            even though both interacted with the same C/EBPa domain.
REFERENCE   4  (bases 1 to 3974)
  AUTHORS   Adamczyk-Sowa M, Sowa P, Zwirska-Korczala K, Pierzchala K, Bartosz
            G and Sadowska-Bartosz I.
  TITLE     Role of melatonin receptor MT(2) and quinone reductase II in the
            regulation of the redox status of 3T3-L1 preadipocytes in vitro
  JOURNAL   Cell Biol Int 37 (8), 835-842 (2013)
   PUBMED   23554006
  REMARK    GeneRIF: Melatonin, acting at least partially via MT2 receptors,
            can regulate the redox status of quinone reductase II inhibited
            preadipocytes.
REFERENCE   5  (bases 1 to 3974)
  AUTHORS   Benoit CE, Bastianetto S, Brouillette J, Tse Y, Boutin JA,
            Delagrange P, Wong T, Sarret P and Quirion R.
  TITLE     Loss of quinone reductase 2 function selectively facilitates
            learning behaviors
  JOURNAL   J Neurosci 30 (38), 12690-12700 (2010)
   PUBMED   20861374
REFERENCE   6  (bases 1 to 3974)
  AUTHORS   Long DJ 2nd, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R,
            Barrios R and Jaiswal AK.
  TITLE     Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2
            (NQO2) leads to myeloid hyperplasia of bone marrow and decreased
            sensitivity to menadione toxicity
  JOURNAL   J Biol Chem 277 (48), 46131-46139 (2002)
   PUBMED   12351651
  REMARK    GeneRIF: role for NQO2 in protection against myelogenous
            hyperplasia and in metabolic activation of menadione, leading to
            hepatic toxicity
REFERENCE   7  (bases 1 to 3974)
  AUTHORS   Kaiserman D, Knaggs S, Scarff KL, Gillard A, Mirza G, Cadman M,
            McKeone R, Denny P, Cooley J, Benarafa C, Remold-O'Donnell E,
            Ragoussis J and Bird PI.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   8  (bases 1 to 3974)
  AUTHORS   Long DJ 2nd and Jaiswal AK.
  TITLE     Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene-
            and tissue-specific expression
  JOURNAL   Gene 252 (1-2), 107-117 (2000)
   PUBMED   10903442
REFERENCE   9  (bases 1 to 3974)
  AUTHORS   Petersen DD, Gonzalez FJ, Rapic V, Kozak CA, Lee JY, Jones JE and
            Nebert DW.
  TITLE     Marked increases in hepatic NAD(P)H:oxidoreductase gene
            transcription and mRNA levels correlated with a mouse chromosome 7
            deletion
  JOURNAL   Proc Natl Acad Sci U S A 86 (17), 6699-6703 (1989)
   PUBMED   2505256
REFERENCE   10 (bases 1 to 3974)
  AUTHORS   Kumaki,K., Jensen,N.M., Shire,J.G. and Nebert,D.W.
  TITLE     Genetic differences in induction of cytosol
            reduced-NAD(P):menadione oxidoreductase and microsomal aryl
            hydrocarbon hydroxylase in the mouse
  JOURNAL   J Biol Chem 252 (1), 157-165 (1977)
   PUBMED   833115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161461.5 and BC027629.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by NM_020282.4.
            
            On Jul 14, 2009 this sequence version replaced NM_020282.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2 and 3
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.221293.1, BC027629.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC161461.5         34130-34221         c
            93-1156             BC027629.1         1-1064
            1157-3974           AC161461.5         10415-13232         c
FEATURES             Location/Qualifiers
     source          1..3974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.01 cM"
     gene            1..3974
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /note="N-ribosyldihydronicotinamide quinone reductase 2"
                     /db_xref="GeneID:18105"
                     /db_xref="MGI:MGI:104513"
     exon            1..142
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            143..224
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            225..312
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1001
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /EC_number="1.10.5.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribosyldihydronicotinamide dehydrogenase; QR2; quinone
                     reductase 2; NRH:quinone oxidoreductase 2; NRH
                     dehydrogenase [quinone] 2; NAD(P)H menadione
                     oxidoreductase 2, dioxin inducible; NRH: quinone
                     oxidoreductase; NAD(P)H dehydrogenase, quinone 2"
                     /codon_start=1
                     /product="ribosyldihydronicotinamide dehydrogenase
                     [quinone] isoform 1"
                     /protein_id="NP_064678.1"
                     /db_xref="CCDS:CCDS26442.1"
                     /db_xref="GeneID:18105"
                     /db_xref="MGI:MGI:104513"
                     /translation="MAGKKVLIVYAHQEPKSFNGSLKKVAVEELSKQGCTVTVSDLYS
                     MNFEPRATRNDITGAPSNPDVFSYGIETHEAYKKKALTSDIFEEQRKVQEADLVIFQF
                     PLYWFSVPAILKGWMDRVLCRGFAFDIPGFYDSGFLKGKLALLSLTTGGTAEMYTKDG
                     VSGDFRYFLWPLQHGTLHFCGFKVLAPQISFGLDVSSEEERKVMLASWAQRLKSIWKE
                     EPIHCTPPWYFQE"
     exon            313..477
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..608
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..722
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..824
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..3974
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagaggtc agtgtgaggg cggggccggg tggggaaaac ggccctgggc gcagcggcaa
       61 agcgtgcagg caagctctag gcattctggc cctagacact ggctgtgtca cattgtgcgt
      121 gtgttccctc caggaggcag aggtccctgg ctgcatcacc agccactcac ttcaaaccag
      181 agcccagcta aataaccttt cttgctgttt cttgaactct ccagagtgct acaataacca
      241 aggagagtaa cagtacctga aacttttggc tgttatacca aatcagagaa tctatctcct
      301 ccaacatggc aggtaagaaa gtgctcatcg tctatgcaca ccaagaaccc aagtccttca
      361 atgggtccct gaagaaagtg gctgttgaag aactgagcaa gcagggatgc acagtcactg
      421 tgtctgattt atatagcatg aactttgagc caagggccac aagaaatgat atcactggtg
      481 ccccctctaa tcctgacgtc ttcagttatg ggatagaaac ccatgaagcc tacaagaaga
      541 aagctctgac cagtgatata tttgaagaac agagaaaggt gcaagaagct gatcttgtga
      601 tatttcagtt tccactatac tggttcagcg ttccagcaat cctaaaaggt tggatggata
      661 gggtgctgtg ccgagggttt gcctttgata tcccaggctt ttatgactct ggttttctca
      721 agggtaaatt agctctcctt tccttaacca cgggaggtac agcggagatg tacacaaaag
      781 atggggtcag tggagatttc cggtacttcc tgtggccact tcagcatggt acactgcact
      841 tctgtggatt taaagtcctt gccccccaga tcagttttgg tcttgatgtt tcatcagaag
      901 aagaaaggaa agtgatgctg gcatcatggg cccagcggct gaagagcatc tggaaggaag
      961 aacccatcca ctgcacaccc ccttggtact tccaagagta acattttgtg ctctgagtac
     1021 agctgacaag caacacagtg agagacctac agcatgtgca aagagaaggt ggtgttgtat
     1081 cctgagatgt atttaacagt gcccaccaat gagtgtcttc agtttaatac aactagttca
     1141 gatatttcaa aagtcagctt gttgcactgt attagttcta cctggtcatt cattcatttt
     1201 tcagttcttt aatgtttctc taaaatttct acttttgtag catagttttc tatattataa
     1261 accagggcag tgggaattgc ttctctacaa agagaaggaa atggcctcac ccatggttat
     1321 gttattaggc accattccct taggaacaca gggccttagt gaccttgcaa aatccttgtc
     1381 tctgtggaat tcagttcctt gagccactct gagcagaggt gagtaacaaa gaaggaagca
     1441 ttgttaatgt cagaaagtag ggggagtgtg gtagaaaatc ctagcagctc cagtctccaa
     1501 agtacagaga tgctggcaaa agtctctaag tggagaacac aagccccaga agatggtgaa
     1561 acacagggat taggaattag gtggtttgtg agcaattcca tgatggaggt ggtatagcat
     1621 ccttggagaa acccatcttg ttacatgaga ccttcccact gatgagtgtg ctaggccaac
     1681 agtcttgccc ttcaagtatt actccacttg gattacacca gagcctcttt atctagtaca
     1741 gtagtaattg gtccagcacc actgagacca tctggcaaga aaaccaaagg ctttagtcta
     1801 caaaaataca aagaaagtga aagtattttg gaaattaact gctgtttgag ttttgttatt
     1861 tgtttgttag cagtactagt tataatggta aggaaaaagt atctaacaca tacacacaca
     1921 cacacacaca cacacacaca cacacactga atgaatattt aacatgccag aaactgctaa
     1981 cactttttag ttatatggta gctcattgaa ttcttttaat agccttgtaa gcaagaaaag
     2041 ttgtctcatt ttataggcac agacactgag gcagaattaa gactatttct tgctcaaggg
     2101 tcacagctat aaagaggcag atgtaggatt agagctgaga catggccctc cactaagctg
     2161 gtatgtggca ctgttcacac tcagcttctc ttgcacatct tcctggtctt tctggtggcg
     2221 acactgattt ccctttgggt attgtgtcct tatgctgaga tatgttgttt tcacagtggt
     2281 ggtccctcct ttgtacccac gtgtggcatc agacagacct gactaatcca tgttctgtgg
     2341 cccagaaata acccaagcca gaaaggaaat taaattcagg gactgatcag acctgagaaa
     2401 taaagccctt tcttgctgga gttgtggcat tgtaaatcag aaagcataca tagagatgtc
     2461 agcctgcaac caaaatcatg ctgaggaaaa gattatctac gctatagaaa gatacttctg
     2521 ctggcatctg ttgaacacag gtacctatgc ttatctgcaa aagttagtca tcagcattcc
     2581 agttatgagg caatgaactg ccctttggag cttaagtggg ggttaagttt gtatcaatta
     2641 caatggaaac aaatttgggt aatcaacaga tatgattata caaaaactag caaaacttaa
     2701 agccatacaa gttatcaaaa tccttttctc ccgagatgag ttcagtgtgt agtagcatct
     2761 aataagaaaa ggagaagaga aaaagattaa gtatctgtca ctgtggcaaa ctggtggagt
     2821 aggcagaggc ttaatacatc atctagtccc agtatgactg agtggcctta agcattccag
     2881 ccagcctttg gggtaccagt cttcccattt gtgatgtaaa agggtctggt cttccattat
     2941 tataccacct aacaagctag aagacagtgt gtctgcagtt ctggcatatg taactgtgct
     3001 aggtagcttg attggatgaa cagtgcttaa gagactagtg gagcagatct ctgatgtgtc
     3061 tgagagcatt tctaatgaca actggatcag gaggctgtcc ctaaccaata gattagcctt
     3121 ttaatagatt tgtatgacac cattattggg aagtgttgaa agttaggatg tgaggcctag
     3181 ctggaagaag caggacacaa gcacgtccgt gggaactata tcttgcccta acctcttcag
     3241 gaattccctt ttcttcctct ccaagatgat atgaatagct ctcaatgggc tgaaactgtg
     3301 agctaaaata aacttttcac ctctaagttt tttctcttag atattttggt ctcagcaatg
     3361 taaagctaat aaactagctt cttgagcctc agaaacagct tgaaaacagc ttgggatccc
     3421 aaagtcctgg tacagacctg gggtgtgtgt gaaagtttct tctaagcatg tgctaacagt
     3481 cttcaggaag gttttatgat tatcttcatt ttacaggtgg gtaactgaga cagaggtaaa
     3541 gtgacttttt tagggtcaca tcacgatacc cttttctgga gctcttctct gggctgctca
     3601 gaaaccctga acaaacacat ttcagaagct cacaacaaga aaaaaaaact ccctgctcag
     3661 taatagcctg atgctttgtg agtcagagat tcttttgcta gttgtcttag tagatttcta
     3721 ttgctgtgaa gacaccatga ccacagcaat tccttttctt tttcttaata atttattttt
     3781 atgtacattg gtgtcttgat tgcatgtgtg agggtgtcag atctccctag aacaggaatt
     3841 acagacagtt gtgagctgac gggtgggtac tgggaattga acccaagtcc tctggaattg
     3901 cagccagtgc tctcttcttt attattgtta ttaaaatttt atttttatta aatcattcct
     3961 ctcatttata tctc
//
