LOCUS       NM_001163239            3804 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus N-ribosyldihydronicotinamide quinone reductase 2
            (Nqo2), transcript variant 4, mRNA.
ACCESSION   NM_001163239
VERSION     NM_001163239.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3804)
  AUTHORS   Janda,E., Parafati,M., Martino,C., Crupi,F., George William,J.N.,
            Reybier,K., Arbitrio,M., Mollace,V. and Boutin,J.A.
  TITLE     Autophagy and neuroprotection in astrocytes exposed to
            6-hydroxydopamine is negatively regulated by NQO2: relevance to
            Parkinson's disease
  JOURNAL   Sci Rep 13 (1), 21624 (2023)
   PUBMED   38062122
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3804)
  AUTHORS   Gould,N.L., Sharma,V., Hleihil,M., Kolatt Chandran,S., David,O.,
            Edry,E. and Rosenblum,K.
  TITLE     Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons
            Enhances Novel Memory Formation
  JOURNAL   J Neurosci 40 (45), 8698-8714 (2020)
   PUBMED   33046554
  REMARK    GeneRIF: Dopamine-Dependent QR2 Pathway Activation in CA1
            Interneurons Enhances Novel Memory Formation.
REFERENCE   3  (bases 1 to 3804)
  AUTHORS   Cassagnes,L.E., Chhour,M., Perio,P., Sudor,J., Gayon,R., Ferry,G.,
            Boutin,J.A., Nepveu,F. and Reybier,K.
  TITLE     Oxidative stress and neurodegeneration: The possible contribution
            of quinone reductase 2
  JOURNAL   Free Radic Biol Med 120, 56-61 (2018)
   PUBMED   29526807
  REMARK    GeneRIF: these data suggest that the overexpression of QR2 in brain
            cells in the presence of catechol quinones might lead to reactive
            oxygen species-induced cell death via the rapid conversion of
            superoxide radicals into hydrogen peroxide and then into highly
            reactive hydroxyl radicals
REFERENCE   4  (bases 1 to 3804)
  AUTHORS   Xu,J., Patrick,B.A. and Jaiswal,A.K.
  TITLE     NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S
            proteasome to stabilize transcription factor CCAAT enhancer-binding
            protein alpha (C/EBPalpha), leading to protection against gamma
            radiation-induced myeloproliferative disease
  JOURNAL   J Biol Chem 288 (48), 34799-34808 (2013)
   PUBMED   24142791
  REMARK    GeneRIF: NQO2 stabilization of C/EBPalpha was independent of NQO1,
            even though both interacted with the same C/EBPa domain.
REFERENCE   5  (bases 1 to 3804)
  AUTHORS   Adamczyk-Sowa,M., Sowa,P., Zwirska-Korczala,K., Pierzchala,K.,
            Bartosz,G. and Sadowska-Bartosz,I.
  TITLE     Role of melatonin receptor MT(2) and quinone reductase II in the
            regulation of the redox status of 3T3-L1 preadipocytes in vitro
  JOURNAL   Cell Biol Int 37 (8), 835-842 (2013)
   PUBMED   23554006
  REMARK    GeneRIF: Melatonin, acting at least partially via MT2 receptors,
            can regulate the redox status of quinone reductase II inhibited
            preadipocytes.
REFERENCE   6  (bases 1 to 3804)
  AUTHORS   Long,D.J. 2nd, Iskander,K., Gaikwad,A., Arin,M., Roop,D.R.,
            Knox,R., Barrios,R. and Jaiswal,A.K.
  TITLE     Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2
            (NQO2) leads to myeloid hyperplasia of bone marrow and decreased
            sensitivity to menadione toxicity
  JOURNAL   J Biol Chem 277 (48), 46131-46139 (2002)
   PUBMED   12351651
  REMARK    GeneRIF: role for NQO2 in protection against myelogenous
            hyperplasia and in metabolic activation of menadione, leading to
            hepatic toxicity
REFERENCE   7  (bases 1 to 3804)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   8  (bases 1 to 3804)
  AUTHORS   Long,D.J. 2nd and Jaiswal,A.K.
  TITLE     Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene-
            and tissue-specific expression
  JOURNAL   Gene 252 (1-2), 107-117 (2000)
   PUBMED   10903442
REFERENCE   9  (bases 1 to 3804)
  AUTHORS   Petersen,D.D., Gonzalez,F.J., Rapic,V., Kozak,C.A., Lee,J.Y.,
            Jones,J.E. and Nebert,D.W.
  TITLE     Marked increases in hepatic NAD(P)H:oxidoreductase gene
            transcription and mRNA levels correlated with a mouse chromosome 7
            deletion
  JOURNAL   Proc Natl Acad Sci U S A 86 (17), 6699-6703 (1989)
   PUBMED   2505256
REFERENCE   10 (bases 1 to 3804)
  AUTHORS   Kumaki,K., Jensen,N.M., Shire,J.G. and Nebert,D.W.
  TITLE     Genetic differences in induction of cytosol
            reduced-NAD(P):menadione oxidoreductase and microsomal aryl
            hydrocarbon hydroxylase in the mouse
  JOURNAL   J Biol Chem 252 (1), 157-165 (1977)
   PUBMED   833115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161461.5 and AK008465.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008465.1, AK008138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC161461.5         34194-34221         c
            29-985              AK008465.1         4-960
            986-3804            AC161461.5         10415-13233         c
FEATURES             Location/Qualifiers
     source          1..3804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.01 cM"
     gene            1..3804
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /note="N-ribosyldihydronicotinamide quinone reductase 2"
                     /db_xref="GeneID:18105"
                     /db_xref="MGI:MGI:104513"
     exon            1..142
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            143..307
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..438
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..552
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            553..654
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..3804
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      956..961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /note="hexamer: AATACA"
     polyA_site      986
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /note="major polyA site"
     regulatory      3137..3142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /note="hexamer: AATAAA"
     polyA_site      3156
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
                     /note="hexamer: ATTAAA"
     polyA_site      3782
                     /gene="Nqo2"
                     /gene_synonym="NMO2; Nmor2; Ox2"
ORIGIN      
        1 gctagaggtc agtgtgaggg cggggccggg tggggaaaac ggccctgggc gcagcggcaa
       61 agcgtgcagg caagctctag gcattctggc cctagacact ggctgtgtca cattgtgcgt
      121 gtgttccctc caggaggcag aggtaagaaa gtgctcatcg tctatgcaca ccaagaaccc
      181 aagtccttca atgggtccct gaagaaagtg gctgttgaag aactgagcaa gcagggatgc
      241 acagtcactg tgtctgattt atatagcatg aactttgagc caagggccac aagaaatgat
      301 atcactggtg ccccctctaa tcctgacgtc ttcagttatg ggatagaaac ccatgaagcc
      361 tacaagaaga aagctctgac cagtgatata tttgaagaac agagaaaggt gcaagaagct
      421 gatcttgtga tatttcagtt tccactatac tggttcagcg ttccagcaat cctaaaaggt
      481 tggatggata gggtgctgtg ccgagggttt gcctttgata tcccaggctt ttatgactct
      541 ggttttctca agggtaaatt agctctcctt tccttaacca cgggaggtac agcggagatg
      601 tacacaaaag atggggtcag tggagatttc cggtacttcc tgtggccact tcagcatggt
      661 acactgcact tctgtggatt taaagtcctt gccccccaga tcagttttgg tcttgatgtt
      721 tcatcagaag aagaaaggaa agtgatgctg gcatcatggg cccagcggct gaagagcatc
      781 tggaaggaag aacccatcca ctgcacaccc ccttggtact tccaagagta acattttgtg
      841 ctctgagtac agctgacaag caacacagtg agagacctac agcatgtgca aagagaaggt
      901 ggtgttgtat cctgagatgt atttaacagt gcccaccaat gagtgtcttc agtttaatac
      961 aactagttca gatatttcaa aagtcagctt gttgcactgt attagttcta cctggtcatt
     1021 cattcatttt tcagttcttt aatgtttctc taaaatttct acttttgtag catagttttc
     1081 tatattataa accagggcag tgggaattgc ttctctacaa agagaaggaa atggcctcac
     1141 ccatggttat gttattaggc accattccct taggaacaca gggccttagt gaccttgcaa
     1201 aatccttgtc tctgtggaat tcagttcctt gagccactct gagcagaggt gagtaacaaa
     1261 gaaggaagca ttgttaatgt cagaaagtag ggggagtgtg gtagaaaatc ctagcagctc
     1321 cagtctccaa agtacagaga tgctggcaaa agtctctaag tggagaacac aagccccaga
     1381 agatggtgaa acacagggat taggaattag gtggtttgtg agcaattcca tgatggaggt
     1441 ggtatagcat ccttggagaa acccatcttg ttacatgaga ccttcccact gatgagtgtg
     1501 ctaggccaac agtcttgccc ttcaagtatt actccacttg gattacacca gagcctcttt
     1561 atctagtaca gtagtaattg gtccagcacc actgagacca tctggcaaga aaaccaaagg
     1621 ctttagtcta caaaaataca aagaaagtga aagtattttg gaaattaact gctgtttgag
     1681 ttttgttatt tgtttgttag cagtactagt tataatggta aggaaaaagt atctaacaca
     1741 tacacacaca cacacacaca cacacacaca cacacactga atgaatattt aacatgccag
     1801 aaactgctaa cactttttag ttatatggta gctcattgaa ttcttttaat agccttgtaa
     1861 gcaagaaaag ttgtctcatt ttataggcac agacactgag gcagaattaa gactatttct
     1921 tgctcaaggg tcacagctat aaagaggcag atgtaggatt agagctgaga catggccctc
     1981 cactaagctg gtatgtggca ctgttcacac tcagcttctc ttgcacatct tcctggtctt
     2041 tctggtggcg acactgattt ccctttgggt attgtgtcct tatgctgaga tatgttgttt
     2101 tcacagtggt ggtccctcct ttgtacccac gtgtggcatc agacagacct gactaatcca
     2161 tgttctgtgg cccagaaata acccaagcca gaaaggaaat taaattcagg gactgatcag
     2221 acctgagaaa taaagccctt tcttgctgga gttgtggcat tgtaaatcag aaagcataca
     2281 tagagatgtc agcctgcaac caaaatcatg ctgaggaaaa gattatctac gctatagaaa
     2341 gatacttctg ctggcatctg ttgaacacag gtacctatgc ttatctgcaa aagttagtca
     2401 tcagcattcc agttatgagg caatgaactg ccctttggag cttaagtggg ggttaagttt
     2461 gtatcaatta caatggaaac aaatttgggt aatcaacaga tatgattata caaaaactag
     2521 caaaacttaa agccatacaa gttatcaaaa tccttttctc ccgagatgag ttcagtgtgt
     2581 agtagcatct aataagaaaa ggagaagaga aaaagattaa gtatctgtca ctgtggcaaa
     2641 ctggtggagt aggcagaggc ttaatacatc atctagtccc agtatgactg agtggcctta
     2701 agcattccag ccagcctttg gggtaccagt cttcccattt gtgatgtaaa agggtctggt
     2761 cttccattat tataccacct aacaagctag aagacagtgt gtctgcagtt ctggcatatg
     2821 taactgtgct aggtagcttg attggatgaa cagtgcttaa gagactagtg gagcagatct
     2881 ctgatgtgtc tgagagcatt tctaatgaca actggatcag gaggctgtcc ctaaccaata
     2941 gattagcctt ttaatagatt tgtatgacac cattattggg aagtgttgaa agttaggatg
     3001 tgaggcctag ctggaagaag caggacacaa gcacgtccgt gggaactata tcttgcccta
     3061 acctcttcag gaattccctt ttcttcctct ccaagatgat atgaatagct ctcaatgggc
     3121 tgaaactgtg agctaaaata aacttttcac ctctaagttt tttctcttag atattttggt
     3181 ctcagcaatg taaagctaat aaactagctt cttgagcctc agaaacagct tgaaaacagc
     3241 ttgggatccc aaagtcctgg tacagacctg gggtgtgtgt gaaagtttct tctaagcatg
     3301 tgctaacagt cttcaggaag gttttatgat tatcttcatt ttacaggtgg gtaactgaga
     3361 cagaggtaaa gtgacttttt tagggtcaca tcacgatacc cttttctgga gctcttctct
     3421 gggctgctca gaaaccctga acaaacacat ttcagaagct cacaacaaga aaaaaaaact
     3481 ccctgctcag taatagcctg atgctttgtg agtcagagat tcttttgcta gttgtcttag
     3541 tagatttcta ttgctgtgaa gacaccatga ccacagcaat tccttttctt tttcttaata
     3601 atttattttt atgtacattg gtgtcttgat tgcatgtgtg agggtgtcag atctccctag
     3661 aacaggaatt acagacagtt gtgagctgac gggtgggtac tgggaattga acccaagtcc
     3721 tctggaattg cagccagtgc tctcttcttt attattgtta ttaaaatttt atttttatta
     3781 aatcattcct ctcatttata tctc
//
