LOCUS       NM_008706               1552 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus NAD(P)H dehydrogenase, quinone 1 (Nqo1), mRNA.
ACCESSION   NM_008706
VERSION     NM_008706.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Wakabayashi,N., Yagishita,Y., Joshi,T. and Kensler,T.W.
  TITLE     Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid
            Accumulation in a Lipodystrophy Mouse Model
  JOURNAL   Int J Mol Sci 24 (17), 13345 (2023)
   PUBMED   37686150
  REMARK    GeneRIF: Forced Hepatic Expression of NRF2 or NQO1 Impedes
            Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Cao,C. and Fleming,M.D.
  TITLE     Loss of the placental iron exporter ferroportin 1 causes embryonic
            demise in late-gestation mouse pregnancy
  JOURNAL   Development 149 (23) (2022)
   PUBMED   36398730
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Habeos,G.I., Filippopoulou,F., Habeos,E.E., Kalaitzopoulou,E.,
            Skipitari,M., Papadea,P., Lagoumintzis,G., Niarchos,A.,
            Georgiou,C.D. and Chartoumpekis,D.V.
  TITLE     Maternal Calorie Restriction Induces a Transcriptional
            Cytoprotective Response in Embryonic Liver Partially Dependent on
            Nrf2
  JOURNAL   Antioxidants (Basel) 11 (11), 2274 (2022)
   PUBMED   36421460
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Wang,T.X., Duan,K.L., Huang,Z.X., Xue,Z.A., Liang,J.Y., Dang,Y.,
            Zhang,A., Xiong,Y., Ding,C., Guan,K.L. and Yuan,H.X.
  TITLE     Tanshinone functions as a coenzyme that confers gain of function of
            NQO1 to suppress ferroptosis
  JOURNAL   Life Sci Alliance 6 (1), e202201667 (2022)
   PUBMED   36319062
  REMARK    GeneRIF: Tanshinone functions as a coenzyme that confers gain of
            function of NQO1 to suppress ferroptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1552)
  AUTHORS   Ruppert,S., Kelsey,G., Schedl,A., Schmid,E., Thies,E. and Schutz,G.
  TITLE     Deficiency of an enzyme of tyrosine metabolism underlies altered
            gene expression in newborn liver of lethal albino mice
  JOURNAL   Genes Dev 6 (8), 1430-1443 (1992)
   PUBMED   1644288
REFERENCE   7  (bases 1 to 1552)
  AUTHORS   Puga,A., Raychaudhuri,B. and Nebert,D.W.
  TITLE     Transcriptional derepression of the murine Cyp1a-1 gene by
            mevinolin
  JOURNAL   FASEB J 6 (2), 777-785 (1992)
   PUBMED   1311272
REFERENCE   8  (bases 1 to 1552)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   9  (bases 1 to 1552)
  AUTHORS   Petersen,D.D., Gonzalez,F.J., Rapic,V., Kozak,C.A., Lee,J.Y.,
            Jones,J.E. and Nebert,D.W.
  TITLE     Marked increases in hepatic NAD(P)H:oxidoreductase gene
            transcription and mRNA levels correlated with a mouse chromosome 7
            deletion
  JOURNAL   Proc Natl Acad Sci U S A 86 (17), 6699-6703 (1989)
   PUBMED   2505256
REFERENCE   10 (bases 1 to 1552)
  AUTHORS   Kumaki,K., Jensen,N.M., Shire,J.G. and Nebert,D.W.
  TITLE     Genetic differences in induction of cytosol
            reduced-NAD(P):menadione oxidoreductase and microsomal aryl
            hydrocarbon hydroxylase in the mouse
  JOURNAL   J Biol Chem 252 (1), 157-165 (1977)
   PUBMED   833115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075568.1 and AA982077.1.
            
            On Dec 4, 2007 this sequence version replaced NM_008706.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075568.1, U12961.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1089              AK075568.1         2-1090
            1090-1092           AA982077.1         123-125
            1093-1552           AK075568.1         1091-1550
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 54.08 cM"
     gene            1..1552
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /note="NAD(P)H dehydrogenase, quinone 1"
                     /db_xref="GeneID:18104"
                     /db_xref="MGI:MGI:103187"
     exon            1..140
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..958
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /EC_number="1.6.5.2"
                     /note="quinone reductase 1; DT-diaphorase; azoreductase;
                     phylloquinone reductase; menadione reductase;
                     NAD(P)H:quinone oxidoreductase 1; diaphorase 4
                     (NADH/NADPH); NAD(P)H menadione oxidoreductase 1, dioxin
                     inducible; NAD(P)H dehydrogenase (quinone)"
                     /codon_start=1
                     /product="NAD(P)H dehydrogenase [quinone] 1"
                     /protein_id="NP_032732.3"
                     /db_xref="CCDS:CCDS40465.1"
                     /db_xref="GeneID:18104"
                     /db_xref="MGI:MGI:103187"
                     /translation="MAARRALIVLAHSEKTSFNYAMKEAAVEALKKRGWEVLESDLYA
                     MNFNPIISRNDITGELKDSKNFQYPSESSLAYKEGRLSPDIVAEHKKLEAADLVIFQF
                     PLQWFGVPAILKGWFERVLVAGFAYTYAAMYDNGPFQNKKTLLSITTGGSGSMYSLQG
                     VHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARMQILEGWKKRLETVWEE
                     TPLYFAPSSLFDLNFQAGFLMKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK"
     exon            141..305
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..436
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..550
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..652
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..1552
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1530..1535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /note="putative"
     polyA_site      1552
                     /gene="Nqo1"
                     /gene_synonym="Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1;
                     Qr1"
                     /note="putative"
ORIGIN      
        1 aggctcagct cttactagcc tagcctgtag ccagccctaa ggatctctcc gaagagcttt
       61 agggtcgtct tggcaaccag ctgctcagcc aatcagcgtt cggtattacg atcctccctc
      121 aacatctgga gccatggcgg cgagaagagc cctgattgta ctggcccatt cagagaagac
      181 atcattcaac tacgccatga aggaggctgc tgtagaggct ctgaagaaga gaggatggga
      241 ggtactcgaa tctgacctct atgctatgaa cttcaacccc atcatttcca gaaatgacat
      301 cacaggtgag ctgaaggact cgaagaactt tcagtatcct tccgagtcat ctctagcata
      361 taaggaagga cgcctgagcc cagatattgt ggccgaacac aagaagctgg aagctgcaga
      421 cctggtgata tttcagttcc cattgcagtg gtttggggtg ccagccattc tgaaaggctg
      481 gtttgagaga gtgctcgtag caggatttgc ctacacatat gctgccatgt acgacaacgg
      541 tcctttccag aataagaaga ccttgctttc tatcaccact gggggtagcg gctccatgta
      601 ctctcttcag ggtgtccacg gggacatgaa cgtcattctc tggccgattc agagtggcat
      661 cctgcgtttc tgtggcttcc aggtcttaga acctcaactg gtttacagca ttggccacac
      721 tccaccagat gcccgcatgc agatcctgga aggatggaag aaacgtctgg aaaccgtctg
      781 ggaggagacc ccactctatt ttgctccaag cagcctgttt gacctaaact ttcaggcagg
      841 attcttaatg aaaaaggaag ttcaagagga gcagaagaag aacaagtttg gcctctctgt
      901 gggccatcac ctgggcaagt ccattccagc tgacaaccag atcaaagcta gaaaataagg
      961 atttttttcc taacatatag ttagacgcag ctttcttttt ccccagcttg tctgacttgc
     1021 tttcattttt ttcctttgct ccacgaggat gggaaaagga gtaagtttgc ttcatgcttt
     1081 tttttttttt ttgatagttc tgccataaca acaaaatgaa tgaagtcaga ttaggagcct
     1141 cagggcaagg tgcagaagcg agctggaaat actcttctag gtcatttatg caatattcgc
     1201 cattttcttc gggctagtcc cagttagatg gcatccagtc ctccatcaag attcgttgtc
     1261 tataattacc tctctgtggt ttagggcaga agggaattgc tcaaagtaaa caatggccga
     1321 gggactaact tgtttagcag ttagcagtta gctaaagcct gtttatgata catcctggtt
     1381 tcaattactg tgcagtgact gacatggcgc ccagggggtt ggctctccag ctcttttctg
     1441 tcttgtacac agcacaccca ggtcctggga aaggaatttt aaaacagatc tccgtctcat
     1501 tctttctatt tctttttttt tttaatcgaa ataaatgaat acatcacaca tc
//
