LOCUS       NM_010935               2586 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus neuropeptide Y receptor Y6 (Npy6r), mRNA.
ACCESSION   NM_010935
VERSION     NM_010935.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Khor,E.C., Yulyaningsih,E., Driessler,F., Kovacic,N., Wee,N.K.Y.,
            Kulkarni,R.N., Lee,N.J., Enriquez,R.F., Xu,J., Zhang,L., Herzog,H.
            and Baldock,P.A.
  TITLE     The y6 receptor suppresses bone resorption and stimulates bone
            formation in mice via a suprachiasmatic nucleus relay
  JOURNAL   Bone 84, 139-147 (2016)
   PUBMED   26721736
  REMARK    GeneRIF: y6R signalling is required for maintenance of bone mass,
            with loss of y6R uncoupling bone remodelling and resulting in a
            negative bone balance.
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Yulyaningsih,E., Loh,K., Lin,S., Lau,J., Zhang,L., Shi,Y.,
            Berning,B.A., Enriquez,R., Driessler,F., Macia,L., Khor,E.C.,
            Qi,Y., Baldock,P., Sainsbury,A. and Herzog,H.
  TITLE     Pancreatic polypeptide controls energy homeostasis via Npy6r
            signaling in the suprachiasmatic nucleus in mice
  JOURNAL   Cell Metab 19 (1), 58-72 (2014)
   PUBMED   24411939
  REMARK    GeneRIF: PP-initiated signaling through Npy6r in vasoactive
            intestinal peptide neurons regulates the growth hormone axis and
            body composition.
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Starback,P., Wraith,A., Eriksson,H. and Larhammar,D.
  TITLE     Neuropeptide Y receptor gene y6: multiple deaths or resurrections?
  JOURNAL   Biochem Biophys Res Commun 277 (1), 264-269 (2000)
   PUBMED   11027673
REFERENCE   4  (bases 1 to 2586)
  AUTHORS   Wraith,A., Tornsten,A., Chardon,P., Harbitz,I., Chowdhary,B.P.,
            Andersson,L., Lundin,L.G. and Larhammar,D.
  TITLE     Evolution of the neuropeptide Y receptor family: gene and
            chromosome duplications deduced from the cloning and mapping of the
            five receptor subtype genes in pig
  JOURNAL   Genome Res 10 (3), 302-310 (2000)
   PUBMED   10720571
REFERENCE   5  (bases 1 to 2586)
  AUTHORS   Kanatani,A., Mashiko,S., Murai,N., Sugimoto,N., Ito,J.,
            Fukuroda,T., Fukami,T., Morin,N., MacNeil,D.J., Van der Ploeg,L.H.,
            Saga,Y., Nishimura,S. and Ihara,M.
  TITLE     Role of the Y1 receptor in the regulation of neuropeptide
            Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient,
            and Y5 receptor-deficient mice
  JOURNAL   Endocrinology 141 (3), 1011-1016 (2000)
   PUBMED   10698177
REFERENCE   6  (bases 1 to 2586)
  AUTHORS   Naveilhan,P., Neveu,I., Arenas,E. and Ernfors,P.
  TITLE     Complementary and overlapping expression of Y1, Y2 and Y5 receptors
            in the developing and adult mouse nervous system
  JOURNAL   Neuroscience 87 (1), 289-302 (1998)
   PUBMED   9722158
REFERENCE   7  (bases 1 to 2586)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   8  (bases 1 to 2586)
  AUTHORS   Nakamura,M., Yokoyama,M., Watanabe,H. and Matsumoto,T.
  TITLE     Molecular cloning, organization and localization of the gene for
            the mouse neuropeptide Y-Y5 receptor
  JOURNAL   Biochim Biophys Acta 1328 (2), 83-89 (1997)
   PUBMED   9315606
REFERENCE   9  (bases 1 to 2586)
  AUTHORS   Gregor,P., Feng,Y., DeCarr,L.B., Cornfield,L.J. and McCaleb,M.L.
  TITLE     Molecular characterization of a second mouse pancreatic polypeptide
            receptor and its inactivated human homologue
  JOURNAL   J Biol Chem 271 (44), 27776-27781 (1996)
   PUBMED   8910373
REFERENCE   10 (bases 1 to 2586)
  AUTHORS   Weinberg,D.H., Sirinathsinghji,D.J., Tan,C.P., Shiao,L.L.,
            Morin,N., Rigby,M.R., Heavens,R.H., Rapoport,D.R., Bayne,M.L.,
            Cascieri,M.A., Strader,C.D., Linemeyer,D.L. and MacNeil,D.J.
  TITLE     Cloning and expression of a novel neuropeptide Y receptor
  JOURNAL   J Biol Chem 271 (28), 16435-16438 (1996)
   PUBMED   8663568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132130.3.
            
            On Jan 22, 2019 this sequence version replaced NM_010935.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030279.1, BC103667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC132130.3         96482-96708         c
            228-2586            AC132130.3         89116-91474         c
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 23.74 cM"
     gene            1..2586
                     /gene="Npy6r"
                     /note="neuropeptide Y receptor Y6"
                     /db_xref="GeneID:18169"
                     /db_xref="MGI:MGI:1098590"
     exon            1..227
                     /gene="Npy6r"
                     /inference="alignment:Splign:2.1.0"
     exon            228..2586
                     /gene="Npy6r"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1515
                     /gene="Npy6r"
                     /note="PP2; NPY6-R; pancreatic polypeptide receptor 2"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 6"
                     /protein_id="NP_035065.1"
                     /db_xref="CCDS:CCDS29227.1"
                     /db_xref="GeneID:18169"
                     /db_xref="MGI:MGI:1098590"
                     /translation="MEVLTNQPTPNKTSGKSNNSAFFYFESCQPPFLAILLLLIAYTV
                     ILIMGIFGNLSLIIIIFKKQREAQNVTNILIANLSLSDILVCVMCIPFTVIYTLMDHW
                     VFGNTMCKLTSYVQSVSVSVSIFSLVLIAIERYQLIVNPRGWKPRVAHAYWGIILIWL
                     ISLTLSIPLFLSYHLTNEPFHNLSLPTDIYTHQVACVEIWPSKLNQLLFSTSLFMLQY
                     FVPLGFILICYLKIVLCLRKRTRQVDRRKENKSRLNENKRVNVMLISIVVTFGACWLP
                     LNIFNVIFDWYHEMLMSCHHDLVFVVCHLIAMVSTCINPLFYGFLNKNFQKDLMMLIH
                     HCWCGEPQESYENIAMSTMHTDESKGSLKLAHIPTGI"
ORIGIN      
        1 acagaattcc aacttctctg cctagatagt gactccaact ccagggaata gcttctgaag
       61 tgaagctacg ataaatacat cagggcagga aaaagaagta ttggaacttg gagggatggt
      121 tattgtgaca tctttctgca aggaagtaat ctttaagaat agcaccactg aagaaagcaa
      181 gcatgtagaa gatgaaagca gagttacaga ctgaaaattt ctaacaggat ctcaagagca
      241 tgctgacgtc atttatgtgt ttccatcaga tacagacaga gatcataaac atttaactca
      301 ttgattatat gttgagagtt gtccctcaag aaccaatggc caaacatcca ctgaggatac
      361 acggaagctt agaaaatctc taattaaaat cctgacataa tggaagtgct cacaaaccag
      421 ccaacaccta ataaaaccag tggcaagagc aacaactcgg catttttcta ctttgaatcc
      481 tgccaacccc cttttctagc catactcttg ctactcatag catatactgt gatcctaatc
      541 atgggcattt ttggaaacct ctctcttatc atcatcatct ttaagaaaca gagagaagct
      601 caaaatgtta ccaacatact gattgccaac ctgtccctct ctgacatctt ggtgtgtgtc
      661 atgtgcatcc cttttacggt catctacact ctgatggacc actgggtatt tgggaacact
      721 atgtgtaaac tcacttccta cgtgcaaagt gtctcagttt ctgtgtccat attctccctt
      781 gtgttgattg ctattgaacg atatcagctg attgtgaacc cccgtggctg gaaacccaga
      841 gtagctcatg cctattgggg gatcatcttg atttggctca tttctctgac attgtctatt
      901 cccttattcc tgtcctacca cctcaccaat gagccctttc ataatctctc tctccctact
      961 gacatctaca cccaccaggt agcttgtgtg gagatttggc cttctaaact gaaccaactc
     1021 ctcttttcta catcattatt tatgctccag tattttgtcc ctctgggttt cattcttatc
     1081 tgctacctga agatcgttct ctgcctccga aaaagaacta ggcaggtgga caggagaaag
     1141 gaaaataaga gccgtctcaa tgagaacaag agggtaaatg tgatgttgat ttccatcgta
     1201 gtgacttttg gagcctgctg gttgcccttg aacattttca atgtcatctt cgactggtat
     1261 catgagatgc tgatgagctg ccaccacgac ctggtatttg tagtttgcca cttgattgct
     1321 atggtttcta cttgcataaa tcctctcttt tatggatttc tcaacaaaaa cttccagaag
     1381 gatctaatga tgcttattca ccactgttgg tgtggtgaac ctcaggaaag ttatgaaaat
     1441 attgccatgt ctactatgca cacagatgaa tccaagggat cattaaaact ggctcacata
     1501 ccaacaggca tatagaaact ggtaagcaaa atcaaagccc ttctgttatg aaagaaagag
     1561 aagaaatagt atggaatagg gcaaggtgca gaggaagcca gacttaaaca cataatatct
     1621 ttgggcccag ttttgcttta agttaagcat gtctactcca ttcagccata gaacacacag
     1681 agatttatcc ctaccctttc tttttttcct ttggaagaat aataacttaa acaacctaga
     1741 catcattact gaggaagaga acaaaaatga gagagcatac aaggacagca gagatgtctg
     1801 gggtacaaaa ttcacgttat tcgctggaat agctagaaag ttattagttg tgctgcaggc
     1861 aggaaaaacc catactatgc ctcctttgca tcaaagaaat tcaactttcg catatgagac
     1921 tataacttgc aatcacataa ctattcaatt aattagataa atcaaaaagc atactaccat
     1981 aaattattaa ttaattatat ctggattata attgaaagct tgttttaaca tgtatactga
     2041 acactatagt tataattaat ttccctgtct gtatctgact ctgaagttgt tataatgctc
     2101 catttctttt acttacaatg ctattaagac taggaaaact agtcattcat tcaatagcac
     2161 tccaattata gcagagatca ttttatctaa tgaatgttct gtgtcgatag agatttcatt
     2221 acaaaacggc cttttatcct gatgtcttta tgtatattaa gcaggggttc gttataactt
     2281 tgtaaactgg gagattatta tcaacagtag cattataatt aactccagca ttccagaaaa
     2341 ttatcatcta tctcagtact taaacattat tcaagaatat tcactaaata agaccatcgg
     2401 ctagattatt tacaacaaga taattgacct tttgtttaaa catctgttag ctcagagact
     2461 tctactaatt cacacaagct ttaccatttc ctagggtaaa cctccctgat acttattaaa
     2521 tttgactgca gcctatgtgt gtcatataca aatgtaagca tgtcttcttt tcaataaata
     2581 ttctcc
//
