LOCUS       NM_001358958            2398 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant
            3, mRNA.
ACCESSION   NM_001358958 XM_006509598
VERSION     NM_001358958.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Horio,N. and Liberles,S.D.
  TITLE     Hunger enhances food-odour attraction through a neuropeptide Y
            spotlight
  JOURNAL   Nature 592 (7853), 262-266 (2021)
   PUBMED   33658716
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   Dietrich,P., Wormser,L., Fritz,V., Seitz,T., De Maria,M.,
            Schambony,A., Kremer,A.E., Gunther,C., Itzel,T., Thasler,W.E.,
            Teufel,A., Trebicka,J., Hartmann,A., Neurath,M.F., von Horsten,S.,
            Bosserhoff,A.K. and Hellerbrand,C.
  TITLE     Molecular crosstalk between Y5 receptor and neuropeptide Y drives
            liver cancer
  JOURNAL   J Clin Invest 130 (5), 2509-2526 (2020)
   PUBMED   31999643
  REMARK    GeneRIF: Molecular crosstalk between Y5 receptor and neuropeptide Y
            drives liver cancer.
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Longo,A., Fadda,M., Brasso,C., Mele,P., Palanza,P., Nanavaty,I.,
            Bertocchi,I., Oberto,A. and Eva,C.
  TITLE     Conditional inactivation of Npy1r gene in mice induces behavioural
            inflexibility and orbitofrontal cortex hyperactivity that are
            reversed by escitalopram
  JOURNAL   Neuropharmacology 133, 12-22 (2018)
   PUBMED   29353053
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Shi,Y.C., Ip,C.K., Reed,F., Sarruf,D.A., Wulff,B.S. and Herzog,H.
  TITLE     Y5 receptor signalling counteracts the anorectic effects of PYY3-36
            in diet-induced obese mice
  JOURNAL   J Neuroendocrinol 29 (10) (2017)
   PUBMED   28485050
  REMARK    GeneRIF: Study suggests that PYY3-36 mediated signalling via Y5
            receptors may counteract the anorectic effects that it mediates via
            the Y2 receptor, consequently lowering bodyweight in the absence of
            Y5 signalling.
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Marsh,D.J., Hollopeter,G., Kafer,K.E. and Palmiter,R.D.
  TITLE     Role of the Y5 neuropeptide Y receptor in feeding and obesity
  JOURNAL   Nat Med 4 (6), 718-721 (1998)
   PUBMED   9623983
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Xin,X.G. and Huang,X.F.
  TITLE     Down-regulated NPY receptor subtype-5 mRNA expression in
            genetically obese mouse brain
  JOURNAL   Neuroreport 9 (4), 737-741 (1998)
   PUBMED   9559948
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   9  (bases 1 to 2398)
  AUTHORS   Nakamura,M., Yokoyama,M., Watanabe,H. and Matsumoto,T.
  TITLE     Molecular cloning, organization and localization of the gene for
            the mouse neuropeptide Y-Y5 receptor
  JOURNAL   Biochim Biophys Acta 1328 (2), 83-89 (1997)
   PUBMED   9315606
REFERENCE   10 (bases 1 to 2398)
  AUTHORS   Matsumoto,M., Nomura,T., Momose,K., Ikeda,Y., Kondou,Y., Akiho,H.,
            Togami,J., Kimura,Y., Okada,M. and Yamaguchi,T.
  TITLE     Inactivation of a novel neuropeptide Y/peptide YY receptor gene in
            primate species
  JOURNAL   J Biol Chem 271 (44), 27217-27220 (1996)
   PUBMED   8910290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100541.17.
            
            On Dec 14, 2017 this sequence version replaced XM_006509598.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116978.1, SRR1660811.69742.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC100541.17        5086-5299
            215-2398            AC100541.17        11032-13215
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.15 cM"
     gene            1..2398
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /note="neuropeptide Y receptor Y5"
                     /db_xref="GeneID:18168"
                     /db_xref="MGI:MGI:108082"
     exon            1..214
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /inference="alignment:Splign:2.1.0"
     exon            215..2398
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2380..2385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /note="major polyA site"
ORIGIN      
        1 gggcccctcc ttcccaccgc cgcctccagg tcctgctcct gctgccaccg cttccatctc
       61 aagcagaagc gaccgcactc agccgcgtac cccggagtcc aggcacccgc agcggccagg
      121 gcatcccgag gtacccactc caggcctcgc ctgcccctac gagaagccca cgtccctatc
      181 ctgggttctg gagcatcttg tggtttccaa gagggactct agtatggagg ttaaacttga
      241 agagcatttt aacaagacat ttgtcacgga gaacaatact gctgccagtc agaacacggc
      301 ctcccctgcc tgggaggact acagaggcac agagaacaat acttctgctg ctcggaacac
      361 tgcctttcca gtctgggagg actatagagg cagcgtagac gacttacaat acttcctgat
      421 tgggctctat acatttgtaa gtcttcttgg ttttatggga aatctactta tcttaatggc
      481 tgttatgaaa aagcgcaatc agaagactac agtgaacttt ctcataggca acctggcctt
      541 ctccgacatt ttggttgtcc tgttttgctc ccctttcacc ctgacctctg tcttgttgga
      601 tcagtggatg ttcggcaaag ccatgtgcca tatcatgcca ttccttcagt gtgtatcagt
      661 tctggtttca actctgattt taatatcgat tgccattgtc aggtatcata tgataaagca
      721 ccctatatct aacaatttaa cagcaaacca tggctacttc ctgatagcta ctgtctggac
      781 actgggcttt gccatctgtt ctcccctccc agtgtttcac agccttgtgg aacttaagga
      841 aacctttggc tcagcattgc taagcagcaa gtatttgtgt gttgagtcat ggccctctga
      901 ttcatacaga attgctttca caatctcttt attgttagtt cagtatatcc tgcctctagt
      961 atgtttaaca gtaagtcata ctagtgtctg caggagtata agctgtggat tgtcccacaa
     1021 agaaaacaga ctcgaagaaa atgagatgat caacttaact ctacatccat ccaaaaagag
     1081 tcgggaccag gcaaaacccc ccagcactca aaagtggagc tactcattca tcagaaagca
     1141 ccgaagaagg tacagcaaga agacggcatg cgtgttaccc gccccagcag gaccttccca
     1201 ggagaagcac ctaaccgttc cagaaaaccc aggctcggtc cgtagccagc tgtcaccatc
     1261 cagtaaggtt attccagggg tcccgatctg ctttgaggtg aaacctgaag aaagctcaga
     1321 tgctcaggag atgagagtca agcgttccct cacgagaata aagaagagat ctcgcagtgt
     1381 tttctacaga ctgactatat tgatattagt gttcgctgtt agctggatgc cactccacgt
     1441 cttccacgtg gtgaccgatt tcaatgataa cctgatttcc aataggcatt tcaagctggt
     1501 gtactgcatc tgtcacttgt taggcatgat gtcctgttgt cttaatccga tcttatatgg
     1561 attccttaat aatggtatca aagcagactt gagagccctt atccactgcc tacacatgtc
     1621 atgattctct ctgtgcaccg aggagagaag aaatgtggag actgcccaca atacatctgt
     1681 gctaattgat gcataattta cataaacgtg ttctggatct gaatgccagt ttgtaatcta
     1741 tgtaagatca tttatgttat aatgtggtta attccgtcac ttgtgcagag tcaatgtcga
     1801 tctaaggaaa tttctgtctt gaaatagtta cattaccgtc catttcatgt cattggtaat
     1861 aagttgagtg tcttcggttt cgagtaaaag ttatagctat ccaaattgtt attttgtaca
     1921 aaaatgtaag aagtgaaaaa gttgttccaa agaatattta acctcagatt taaggaattt
     1981 cttttatcta gatatcttta tttctatttc acatgcttct tgactttttt tttgtaaaac
     2041 tacaaaaata ttcaaaagtc agaactctat tacagatgta agcataaaac atgatataaa
     2101 tttataggag aaagatccac tcctattatt gaagactggt aaaattgtca gattaatcca
     2161 gctgttctgc tactaatatt taacttatca aatacgaaag gttttagctt ttgttcagat
     2221 ttatatcaca ttaaacattg tcaaataaag gctgttttca tatgcatctt tgatgttcta
     2281 aaatgtgaag tctatatggt gtgtatttcc aattactatt ataagactat ttttaaaagt
     2341 ccatagatgg tatgaatagc tagttgtttg ttaaaataaa ataaaaatag ataactaa
//
