LOCUS       NM_001358957            2317 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant
            2, mRNA.
ACCESSION   NM_001358957 XM_006509599
VERSION     NM_001358957.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2317)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2317)
  AUTHORS   Horio,N. and Liberles,S.D.
  TITLE     Hunger enhances food-odour attraction through a neuropeptide Y
            spotlight
  JOURNAL   Nature 592 (7853), 262-266 (2021)
   PUBMED   33658716
REFERENCE   3  (bases 1 to 2317)
  AUTHORS   Dietrich,P., Wormser,L., Fritz,V., Seitz,T., De Maria,M.,
            Schambony,A., Kremer,A.E., Gunther,C., Itzel,T., Thasler,W.E.,
            Teufel,A., Trebicka,J., Hartmann,A., Neurath,M.F., von Horsten,S.,
            Bosserhoff,A.K. and Hellerbrand,C.
  TITLE     Molecular crosstalk between Y5 receptor and neuropeptide Y drives
            liver cancer
  JOURNAL   J Clin Invest 130 (5), 2509-2526 (2020)
   PUBMED   31999643
  REMARK    GeneRIF: Molecular crosstalk between Y5 receptor and neuropeptide Y
            drives liver cancer.
REFERENCE   4  (bases 1 to 2317)
  AUTHORS   Longo,A., Fadda,M., Brasso,C., Mele,P., Palanza,P., Nanavaty,I.,
            Bertocchi,I., Oberto,A. and Eva,C.
  TITLE     Conditional inactivation of Npy1r gene in mice induces behavioural
            inflexibility and orbitofrontal cortex hyperactivity that are
            reversed by escitalopram
  JOURNAL   Neuropharmacology 133, 12-22 (2018)
   PUBMED   29353053
REFERENCE   5  (bases 1 to 2317)
  AUTHORS   Shi,Y.C., Ip,C.K., Reed,F., Sarruf,D.A., Wulff,B.S. and Herzog,H.
  TITLE     Y5 receptor signalling counteracts the anorectic effects of PYY3-36
            in diet-induced obese mice
  JOURNAL   J Neuroendocrinol 29 (10) (2017)
   PUBMED   28485050
  REMARK    GeneRIF: Study suggests that PYY3-36 mediated signalling via Y5
            receptors may counteract the anorectic effects that it mediates via
            the Y2 receptor, consequently lowering bodyweight in the absence of
            Y5 signalling.
REFERENCE   6  (bases 1 to 2317)
  AUTHORS   Marsh,D.J., Hollopeter,G., Kafer,K.E. and Palmiter,R.D.
  TITLE     Role of the Y5 neuropeptide Y receptor in feeding and obesity
  JOURNAL   Nat Med 4 (6), 718-721 (1998)
   PUBMED   9623983
REFERENCE   7  (bases 1 to 2317)
  AUTHORS   Xin,X.G. and Huang,X.F.
  TITLE     Down-regulated NPY receptor subtype-5 mRNA expression in
            genetically obese mouse brain
  JOURNAL   Neuroreport 9 (4), 737-741 (1998)
   PUBMED   9559948
REFERENCE   8  (bases 1 to 2317)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   9  (bases 1 to 2317)
  AUTHORS   Nakamura,M., Yokoyama,M., Watanabe,H. and Matsumoto,T.
  TITLE     Molecular cloning, organization and localization of the gene for
            the mouse neuropeptide Y-Y5 receptor
  JOURNAL   Biochim Biophys Acta 1328 (2), 83-89 (1997)
   PUBMED   9315606
REFERENCE   10 (bases 1 to 2317)
  AUTHORS   Matsumoto,M., Nomura,T., Momose,K., Ikeda,Y., Kondou,Y., Akiho,H.,
            Togami,J., Kimura,Y., Okada,M. and Yamaguchi,T.
  TITLE     Inactivation of a novel neuropeptide Y/peptide YY receptor gene in
            primate species
  JOURNAL   J Biol Chem 271 (44), 27217-27220 (1996)
   PUBMED   8910290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100541.17.
            
            On Dec 14, 2017 this sequence version replaced XM_006509599.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045587.1, ERR3363660.325427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC100541.17        5086-5215
            131-2317            AC100541.17        11029-13215
FEATURES             Location/Qualifiers
     source          1..2317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.15 cM"
     gene            1..2317
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /note="neuropeptide Y receptor Y5"
                     /db_xref="GeneID:18168"
                     /db_xref="MGI:MGI:108082"
     exon            1..130
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /inference="alignment:Splign:2.1.0"
     exon            131..2317
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1543
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /note="Y5 receptor; NPY-Y5 receptor"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 5"
                     /protein_id="NP_001345886.1"
                     /db_xref="CCDS:CCDS22335.1"
                     /db_xref="GeneID:18168"
                     /db_xref="MGI:MGI:108082"
                     /translation="MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAAR
                     NTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIG
                     NLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVR
                     YHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYL
                     CVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMI
                     NLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPE
                     NPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTI
                     LILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNN
                     GIKADLRALIHCLHMS"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /note="hexamer: AATAAA"
     polyA_site      2317
                     /gene="Npy5r"
                     /gene_synonym="NPY5-R; NPYY5-R; Y5R"
                     /note="major polyA site"
ORIGIN      
        1 gggcccctcc ttcccaccgc cgcctccagg tcctgctcct gctgccaccg cttccatctc
       61 aagcagaagc gaccgcactc agccgcgtac cccggagtcc aggcacccgc agcggccagg
      121 gcatcccgag caggactcta gtatggaggt taaacttgaa gagcatttta acaagacatt
      181 tgtcacggag aacaatactg ctgccagtca gaacacggcc tcccctgcct gggaggacta
      241 cagaggcaca gagaacaata cttctgctgc tcggaacact gcctttccag tctgggagga
      301 ctatagaggc agcgtagacg acttacaata cttcctgatt gggctctata catttgtaag
      361 tcttcttggt tttatgggaa atctacttat cttaatggct gttatgaaaa agcgcaatca
      421 gaagactaca gtgaactttc tcataggcaa cctggccttc tccgacattt tggttgtcct
      481 gttttgctcc cctttcaccc tgacctctgt cttgttggat cagtggatgt tcggcaaagc
      541 catgtgccat atcatgccat tccttcagtg tgtatcagtt ctggtttcaa ctctgatttt
      601 aatatcgatt gccattgtca ggtatcatat gataaagcac cctatatcta acaatttaac
      661 agcaaaccat ggctacttcc tgatagctac tgtctggaca ctgggctttg ccatctgttc
      721 tcccctccca gtgtttcaca gccttgtgga acttaaggaa acctttggct cagcattgct
      781 aagcagcaag tatttgtgtg ttgagtcatg gccctctgat tcatacagaa ttgctttcac
      841 aatctcttta ttgttagttc agtatatcct gcctctagta tgtttaacag taagtcatac
      901 tagtgtctgc aggagtataa gctgtggatt gtcccacaaa gaaaacagac tcgaagaaaa
      961 tgagatgatc aacttaactc tacatccatc caaaaagagt cgggaccagg caaaaccccc
     1021 cagcactcaa aagtggagct actcattcat cagaaagcac cgaagaaggt acagcaagaa
     1081 gacggcatgc gtgttacccg ccccagcagg accttcccag gagaagcacc taaccgttcc
     1141 agaaaaccca ggctcggtcc gtagccagct gtcaccatcc agtaaggtta ttccaggggt
     1201 cccgatctgc tttgaggtga aacctgaaga aagctcagat gctcaggaga tgagagtcaa
     1261 gcgttccctc acgagaataa agaagagatc tcgcagtgtt ttctacagac tgactatatt
     1321 gatattagtg ttcgctgtta gctggatgcc actccacgtc ttccacgtgg tgaccgattt
     1381 caatgataac ctgatttcca ataggcattt caagctggtg tactgcatct gtcacttgtt
     1441 aggcatgatg tcctgttgtc ttaatccgat cttatatgga ttccttaata atggtatcaa
     1501 agcagacttg agagccctta tccactgcct acacatgtca tgattctctc tgtgcaccga
     1561 ggagagaaga aatgtggaga ctgcccacaa tacatctgtg ctaattgatg cataatttac
     1621 ataaacgtgt tctggatctg aatgccagtt tgtaatctat gtaagatcat ttatgttata
     1681 atgtggttaa ttccgtcact tgtgcagagt caatgtcgat ctaaggaaat ttctgtcttg
     1741 aaatagttac attaccgtcc atttcatgtc attggtaata agttgagtgt cttcggtttc
     1801 gagtaaaagt tatagctatc caaattgtta ttttgtacaa aaatgtaaga agtgaaaaag
     1861 ttgttccaaa gaatatttaa cctcagattt aaggaatttc ttttatctag atatctttat
     1921 ttctatttca catgcttctt gacttttttt ttgtaaaact acaaaaatat tcaaaagtca
     1981 gaactctatt acagatgtaa gcataaaaca tgatataaat ttataggaga aagatccact
     2041 cctattattg aagactggta aaattgtcag attaatccag ctgttctgct actaatattt
     2101 aacttatcaa atacgaaagg ttttagcttt tgttcagatt tatatcacat taaacattgt
     2161 caaataaagg ctgttttcat atgcatcttt gatgttctaa aatgtgaagt ctatatggtg
     2221 tgtatttcca attactatta taagactatt tttaaaagtc catagatggt atgaatagct
     2281 agttgtttgt taaaataaaa taaaaataga taactaa
//
