LOCUS       NM_008919               1903 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus neuropeptide Y receptor Y4 (Npy4r), mRNA.
ACCESSION   NM_008919
VERSION     NM_008919.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Zhang,L. and Herzog,H.
  TITLE     Important role of NPY-Y4R signalling in the dual control of feeding
            and physical activity
  JOURNAL   Neuropeptides 105, 102425 (2024)
   PUBMED   38554699
  REMARK    GeneRIF: Important role of NPY-Y4R signalling in the dual control
            of feeding and physical activity.
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Wang,L., Zeng,F., Huang,R.F., Lin,S., Zhang,Z.H. and Li,M.D.
  TITLE     Adipocyte reconstitution of Npy4r gene in Npy4r silenced mice
            promotes diet-induced obesity
  JOURNAL   Yi Chuan 45 (2), 144-155 (2023)
   PUBMED   36927661
  REMARK    GeneRIF: Adipocyte reconstitution of Npy4r gene in Npy4r silenced
            mice promotes diet-induced obesity.
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Verma,D., Wood,J., Lach,G., Herzog,H., Sperk,G. and Tasan,R.
  TITLE     Hunger Promotes Fear Extinction by Activation of an Amygdala
            Microcircuit
  JOURNAL   Neuropsychopharmacology 41 (2), 431-439 (2016)
   PUBMED   26062787
  REMARK    GeneRIF: Genetic deletion of the Y4 receptor impaired fear
            extinction, an effect that was rescued by short-term fasting
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Aragon,F., Karaca,M., Novials,A., Maldonado,R., Maechler,P. and
            Rubi,B.
  TITLE     Pancreatic polypeptide regulates glucagon release through PPYR1
            receptors expressed in mouse and human alpha-cells
  JOURNAL   Biochim Biophys Acta 1850 (2), 343-351 (2015)
   PUBMED   25445712
  REMARK    GeneRIF: These data demonstrate glucose-regulated secretion of PP
            and its effects on glucagon release through PPYR1 receptors
            expressed by alpha-cells.
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Zhang,L., Riepler,S.J., Turner,N., Enriquez,R.F., Lee,I.C.,
            Baldock,P.A., Herzog,H. and Sainsbury,A.
  TITLE     Y2 and Y4 receptor signaling synergistically act on energy
            expenditure and physical activity
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 299 (6), R1618-R1628 (2010)
   PUBMED   20881101
  REMARK    GeneRIF: Taken together, this work demonstrates the critical roles
            of Y2 and Y4 receptors in the regulation of body composition and
            energy metabolism, highlighting dual antagonism of Y2 and Y4
            receptors as a potentially effective anti-obesity treatment.
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Wraith,A., Tornsten,A., Chardon,P., Harbitz,I., Chowdhary,B.P.,
            Andersson,L., Lundin,L.G. and Larhammar,D.
  TITLE     Evolution of the neuropeptide Y receptor family: gene and
            chromosome duplications deduced from the cloning and mapping of the
            five receptor subtype genes in pig
  JOURNAL   Genome Res 10 (3), 302-310 (2000)
   PUBMED   10720571
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Kanatani,A., Mashiko,S., Murai,N., Sugimoto,N., Ito,J.,
            Fukuroda,T., Fukami,T., Morin,N., MacNeil,D.J., Van der Ploeg,L.H.,
            Saga,Y., Nishimura,S. and Ihara,M.
  TITLE     Role of the Y1 receptor in the regulation of neuropeptide
            Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient,
            and Y5 receptor-deficient mice
  JOURNAL   Endocrinology 141 (3), 1011-1016 (2000)
   PUBMED   10698177
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Darby,K., Eyre,H.J., Lapsys,N., Copeland,N.G., Gilbert,D.J.,
            Couzens,M., Antonova,O., Sutherland,G.R., Jenkins,N.A. and
            Herzog,H.
  TITLE     Assignment of the Y4 receptor gene (PPYR1) to human chromosome
            10q11.2 and mouse chromosome 14
  JOURNAL   Genomics 46 (3), 513-515 (1997)
   PUBMED   9441761
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Gregor,P., Millham,M.L., Feng,Y., DeCarr,L.B., McCaleb,M.L. and
            Cornfield,L.J.
  TITLE     Cloning and characterization of a novel receptor to pancreatic
            polypeptide, a member of the neuropeptide Y receptor family
  JOURNAL   FEBS Lett 381 (1-2), 58-62 (1996)
   PUBMED   8641440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132395.1.
            
            On Sep 7, 2007 this sequence version replaced NM_008919.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132395.1, AK035505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1903              BC132395.1         1-1903
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.8 cM"
     gene            1..1903
                     /gene="Npy4r"
                     /gene_synonym="NPY4-R; NPYR-D; NYYR-D; PP1; Ppyr1; Y4"
                     /note="neuropeptide Y receptor Y4"
                     /db_xref="GeneID:19065"
                     /db_xref="MGI:MGI:105374"
     exon            1..160
                     /gene="Npy4r"
                     /gene_synonym="NPY4-R; NPYR-D; NYYR-D; PP1; Ppyr1; Y4"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1903
                     /gene="Npy4r"
                     /gene_synonym="NPY4-R; NPYR-D; NYYR-D; PP1; Ppyr1; Y4"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1347
                     /gene="Npy4r"
                     /gene_synonym="NPY4-R; NPYR-D; NYYR-D; PP1; Ppyr1; Y4"
                     /note="Y4 receptor; pancreatic polypeptide receptor 1"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 4"
                     /protein_id="NP_032945.3"
                     /db_xref="CCDS:CCDS26933.1"
                     /db_xref="GeneID:19065"
                     /db_xref="MGI:MGI:105374"
                     /translation="MNTSHFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQDSAELLAFI
                     ITTYSIETILGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYT
                     IMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSIFQAYLGI
                     VVIWFVSCFLSLPFLANSTLNDLFHYNHSKVVEFLEDKVVCFVSWSSDHHRLIYTTFL
                     LLFQYCIPLAFILVCYIRIYQRLQRQKHVFHAHACSSRAGQMKRINSMLMTMVTAFAV
                     LWLPLHVFNTLEDWYQEAIPACHGNLIFLMCHLLAMASTCVNPFIYGFLNINFKKDIK
                     ALVLTCHCRSPRGESEHLPLSTVHTDLSKGSMRMGSKSNFI"
     regulatory      1773..1778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npy4r"
                     /gene_synonym="NPY4-R; NPYR-D; NYYR-D; PP1; Ppyr1; Y4"
                     /note="hexamer: AATAAA"
     polyA_site      1795
                     /gene="Npy4r"
                     /gene_synonym="NPY4-R; NPYR-D; NYYR-D; PP1; Ppyr1; Y4"
                     /note="major polyA site"
ORIGIN      
        1 atcttccagg acgctgaggg cgctgcttgg ctgaggcccc tgcagcaggg cgcccggagg
       61 gcttcctagc caggacttgg tgtcacatct acagacagta gaccagggct tggtgctcca
      121 gtctcctcac ctgggacgtg gtggtctggt acctcgccag gctgcatctc tgaagtaggc
      181 cctttactcc tggagttcct ggatcttctc acacctacca tgaatacctc tcatttcttg
      241 gcccctctct tcccaggatc cctacagggt aagaatggga ccaatccatt ggattccccc
      301 tataatttct ctgatggctg ccaggattcg gcagagctgt tggccttcat catcaccacc
      361 tacagcattg agaccatctt gggggtcctg ggaaacctct gcttgatatt tgtgaccaca
      421 agacaaaagg aaaagtccaa tgtgaccaac ctactcattg ccaacctggc cttctctgac
      481 ttcctcatgt gcctcatctg ccaaccactc acagtcacct acaccatcat ggattactgg
      541 atctttggtg aagtcctttg caagatgtta actttcatcc agtgtatgtc agtgacagtc
      601 tccatcctct cactggtcct tgtggccctg gagaggcacc agctcattat caatccaaca
      661 ggctggaaac ccagtatttt ccaggcctac ctggggattg tggtcatctg gttcgtctct
      721 tgtttccttt ccttgccgtt cctggccaac agcaccctga atgacctctt ccactacaac
      781 cactctaagg ttgtagagtt tctggaagac aaggtcgtct gctttgtgtc ctggtcttca
      841 gatcaccacc gtctcatcta taccactttt ctgctgctct ttcagtactg catccctcta
      901 gccttcatcc tggtctgcta catacgcatc taccagcgcc tgcagaggca gaagcatgtg
      961 ttccatgcgc acgcttgcag ctcacgagcg ggacagatga agcggatcaa cagcatgctc
     1021 atgacaatgg tgactgcctt tgcagttctc tggctacccc tgcatgtgtt caacactctg
     1081 gaggactggt accaggaagc catccctgct tgccatggca acctcatctt cttgatgtgc
     1141 cacctgttgg ccatggcttc cacctgtgtc aaccctttca tctatggctt tctcaacatc
     1201 aacttcaaga aggatatcaa ggctctggtg ctgacctgcc attgcaggtc acctcgaggg
     1261 gagtctgagc atctgcccct gtccactgtt cacacggacc tatccaaggg atcgatgagg
     1321 atgggtagca agtctaactt catatagtcg tgtctgggct tttccctacc attttttgac
     1381 acatcctttc acttagttaa gaagacacat tgcaggctgt gatagcatcc tgtcatttct
     1441 ggcttttggg gcccagatag gttggcaaga gacttgaagc ttggcattca gatggtttag
     1501 ccctttgctt ctgagagatc tctgagtcag gattctgcag atcacagagg gaactttgtg
     1561 gcttgagctg caagggtatt agagtcagaa gtggctggct gactctcaca gccactcagt
     1621 acagatgcct ggcccaaaag tcttcatcta tgtcctgacc attcagctaa cctgcctttg
     1681 gtgatgtgct tatgttcttt caagggatgt tgggtgtttc agtatgggtt gggtgctggt
     1741 agaagcaggt gctgggagtt gggagtctgc ttaataaagt gcttgctgaa aagaacaggg
     1801 acaatacgaa cgggctatga taaatgtggc tgccttacct atggtggtca aagttcagtg
     1861 tccctcctgg ctgctgaatg gggcccaagg catcctcagt gtg
//
