LOCUS       NM_010934               3007 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant
            1, mRNA.
ACCESSION   NM_010934
VERSION     NM_010934.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3007)
  AUTHORS   Crosson,T., Bhat,S., Wang,J.C., Salaun,C., Fontaine,E., Roversi,K.,
            Herzog,H., Rafei,M., Blunck,R. and Talbot,S.
  TITLE     Cytokines reprogram airway sensory neurons in asthma
  JOURNAL   Cell Rep 43 (12), 115045 (2024)
   PUBMED   39661516
REFERENCE   2  (bases 1 to 3007)
  AUTHORS   Zhang,Y., Shen,J., Xie,F., Liu,Z., Yin,F., Cheng,M., Wang,L.,
            Cai,M., Herzog,H., Wu,P., Zhang,Z., Zhan,C. and Liu,T.
  TITLE     Feedforward inhibition of stress by brainstem neuropeptide Y
            neurons
  JOURNAL   Nat Commun 15 (1), 7603 (2024)
   PUBMED   39217143
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3007)
  AUTHORS   Schappe,M.S., Brinn,P.A., Joshi,N.R., Greenberg,R.S., Min,S.,
            Alabi,A.A., Zhang,C. and Liberles,S.D.
  TITLE     A vagal reflex evoked by airway closure
  JOURNAL   Nature 627 (8005), 830-838 (2024)
   PUBMED   38448588
REFERENCE   4  (bases 1 to 3007)
  AUTHORS   Dai,D., Zhao,T., Li,Z., Li,W., Chen,A., Tang,Y., Gao,X.F. and
            Xiong,L.
  TITLE     The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons
            contributes to mechanical hyperknesis during chronic itch
  JOURNAL   Theranostics 14 (1), 363-378 (2024)
   PUBMED   38164144
  REMARK    GeneRIF: The plasticity of neuropeptide Y-Y1 receptor system on
            Tac2 neurons contributes to mechanical hyperknesis during chronic
            itch.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3007)
  AUTHORS   Silveira,M.A., Drotos,A.C., Pirrone,T.M., Versalle,T.S., Bock,A.
            and Roberts,M.T.
  TITLE     Neuropeptide Y Signaling Regulates Recurrent Excitation in the
            Auditory Midbrain
  JOURNAL   J Neurosci 43 (45), 7626-7641 (2023)
   PUBMED   37704372
REFERENCE   6  (bases 1 to 3007)
  AUTHORS   Musso,R., Grilli,M., Oberto,A., Gamalero,S.R. and Eva,C.
  TITLE     Regulation of mouse neuropeptide Y Y1 receptor gene transcription:
            a potential role for nuclear factor-kappa B/Rel proteins
  JOURNAL   Mol Pharmacol 51 (1), 27-35 (1997)
   PUBMED   9016343
REFERENCE   7  (bases 1 to 3007)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   8  (bases 1 to 3007)
  AUTHORS   Gregor,P., Millham,M.L., Feng,Y., DeCarr,L.B., McCaleb,M.L. and
            Cornfield,L.J.
  TITLE     Cloning and characterization of a novel receptor to pancreatic
            polypeptide, a member of the neuropeptide Y receptor family
  JOURNAL   FEBS Lett 381 (1-2), 58-62 (1996)
   PUBMED   8641440
REFERENCE   9  (bases 1 to 3007)
  AUTHORS   Nakamura,M., Sakanaka,C., Aoki,Y., Ogasawara,H., Tsuji,T.,
            Kodama,H., Matsumoto,T., Shimizu,T. and Noma,M.
  TITLE     Identification of two isoforms of mouse neuropeptide Y-Y1 receptor
            generated by alternative splicing. Isolation, genomic structure,
            and functional expression of the receptors
  JOURNAL   J Biol Chem 270 (50), 30102-30110 (1995)
   PUBMED   8530415
REFERENCE   10 (bases 1 to 3007)
  AUTHORS   Eva,C., Oberto,A., Sprengel,R. and Genazzani,E.
  TITLE     The murine NPY-1 receptor gene. Structure and delineation of
            tissue-specific expression
  JOURNAL   FEBS Lett 314 (3), 285-288 (1992)
   PUBMED   1468559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116731.9.
            
            On Jul 30, 2009 this sequence version replaced NM_010934.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132397.1, ERR3363658.3963446.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC116731.9         199535-199635       c
            102-944             AC116731.9         192432-193274       c
            945-3007            AC116731.9         190259-192321       c
FEATURES             Location/Qualifiers
     source          1..3007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.15 cM"
     gene            1..3007
                     /gene="Npy1r"
                     /gene_synonym="NPY1-R; Npyr; Y1-R"
                     /note="neuropeptide Y receptor Y1"
                     /db_xref="GeneID:18166"
                     /db_xref="MGI:MGI:104963"
     exon            1..101
                     /gene="Npy1r"
                     /gene_synonym="NPY1-R; Npyr; Y1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            102..944
                     /gene="Npy1r"
                     /gene_synonym="NPY1-R; Npyr; Y1-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1397
                     /gene="Npy1r"
                     /gene_synonym="NPY1-R; Npyr; Y1-R"
                     /note="NPY-1 receptor; neuropeptide Y receptor subtype"
                     /codon_start=1
                     /product="neuropeptide Y receptor type 1"
                     /protein_id="NP_035064.1"
                     /db_xref="CCDS:CCDS22336.1"
                     /db_xref="GeneID:18166"
                     /db_xref="MGI:MGI:104963"
                     /translation="MNSTLFSKVENHSIHYNASENSPLLAFENDDCHLPLAVIFTLAL
                     AYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLM
                     DHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITV
                     IWVLAVASSLPFVIYQILTDEPFQNVSLAAFKDKYVCFDKFPSDSHRLSYTTLLLVLQ
                     YFGPLCFIFICYFKIYIRLKRRNNMMDKIRDSKYRSSETKRINIMLLSIVVAFAVCWL
                     PLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF
                     NFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKISMNDNEKV"
     exon            945..3007
                     /gene="Npy1r"
                     /gene_synonym="NPY1-R; Npyr; Y1-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctttagg gtttgagcag gagaaatacc aacagatctt ttctccctcc agtgacactc
       61 gtcccgcttc aacagaggtg aacagacgca ttctttaaaa gagtattcag ttcaagggaa
      121 tgaagaactg agaattatct tggtgaatgg attcaaatat atggaataag agtatgctga
      181 agatttgatc cgttttgaag aactataact gtccatttat ctaatcggta acaacaaaac
      241 ataaaaaaat gaactcaact ctgttctcca aggttgaaaa tcactcaatt cactataatg
      301 cctcagagaa ttctccactt ctggcttttg aaaatgatga ctgccacctg cccttggctg
      361 tgatattcac cttggctctc gcttatgggg cggtgattat tcttggcgtc tctggaaacc
      421 tggcattgat cataatcatt ctgaaacaga aggagatgag aaatgtcacc aacattctga
      481 tcgtgaacct ctccttctca gacttgctcg ttgcggtcat gtgtctcccg ttcacttttg
      541 tatatacact gatggaccac tgggtcttcg gggagaccat gtgcaaactg aatccctttg
      601 tacagtgtgt ctccatcaca gtatccattt tctcgctggt tctcatcgct gtggaacggc
      661 atcagctaat catcaaccca agagggtgga gaccaaacaa tagacatgct tacataggca
      721 ttactgtcat ttgggtcctt gcagtggctt cttctctgcc ctttgtgatc tatcaaattc
      781 tgaccgacga gcccttccaa aatgtgtcac ttgcggcgtt caaggacaag tatgtgtgct
      841 ttgacaaatt cccatctgac tctcacaggc tgtcttacac gactctcctc ctggtgctgc
      901 agtatttcgg cccactctgc tttatattca tatgctactt caagatatac attcgcttga
      961 aaaggagaaa caacatgatg gacaagatcc gggacagtaa gtacaggtcc agtgagacca
     1021 agcgaatcaa catcatgctg ctctccattg tggtcgcctt cgccgtctgc tggctgcccc
     1081 ttaccatctt caacactgtg ttcgactgga accaccagat cattgccacc tgcaaccaca
     1141 atctgctgtt tctgctctgt cacctcaccg ccatgatctc cacctgcgtc aaccccatct
     1201 tttatggatt cctgaacaaa aatttccaga gagacttgca gttcttcttc aacttttgtg
     1261 acttccggtc tcgagacgat gactacgaga ccatagccat gtctaccatg catacggatg
     1321 tgtccaagac gtctctgaag caggctagcc cagtcgcatt taaaaaaatc agtatgaatg
     1381 acaatgaaaa agtctgaagc tgctcagagc atatggtccc aggccatatc tgtggaaaaa
     1441 caagcacagc ctgccgcatg ctttctttac ctatgctctg ggggaacgga atgaggcgcg
     1501 cttggaaagc ccaggacatc tgtgttgggt ttgactgctt ttgatggttg ccctgattac
     1561 ttagaaatct agattacttt gtaatctatc tctggcaaca gttttgacta gatgtcctgt
     1621 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat gtgtgtgcgc
     1681 gcgcgcgcgc gcgcacgtgc aaaagagaaa gagagagaga gaaggagaga gacagacaga
     1741 ctgcctgtct gtctgtctgt ctgtctttct ttatgtatgt gtttgaatta tgcatatgac
     1801 aaagagtttt acattgtgtt tgttggagtg aatttctctg aagtaatgtc atgagctcat
     1861 ttcaaaagca gtcaccacct gatattctca agatactgaa ttttcaagat cagatgagat
     1921 ttccaagacc ccggactacc ttcgttccct gctaggcatc atcttagtct gtcacaaggg
     1981 tgacagtata caaaagtcac cttttaaaat gtgcctgagt caaaagagtg tctgaagtca
     2041 tttggcagca tcttttcctt ttcctctcta tttctgtaag gactcaattt cttatactcc
     2101 taattgagtc ttgcctaaga taaagataag taaagaacac cttttcagct gtggatatca
     2161 ccaggagtta ggccacccac aagaatgaag tggcagctgg gcgtggtggc acacaccttt
     2221 aatcccagca cttgggaggc agaggcaggt ggatttctga gtttgaggcc agcctggtct
     2281 acaaagtgag ttccagaaca gccagggcta tacagagaaa ccctgtctcg aaagaccccc
     2341 ccccccaaaa aaaaagaatg aagtggcaaa acaggtccct gattttaaaa tttttctgac
     2401 aaccaaagca ttttagggta attagtttaa aatgtaaact agtcttgctg cagataggta
     2461 aattgcatcc aaaggacttg ataatcgaaa ggttttgcat tgttcatcag agtgctgagc
     2521 tctatcaagc tttctggcac aagcatgcga ctcagagcat ttctaactca tactgcacag
     2581 acgcgtaaga tgcgttttct acacagccgt gcctgcatag taactagtgt ttaactctca
     2641 ccatttatcc ttcactgcag aggacacagg gacaatgtca atgtatctac ccttcagcta
     2701 acagatgtct gtacctaaaa ctttcacgca gcctaacttg tataaactgt atacaagttc
     2761 aagttcatcc taacttgtat aaactgtata atgtgtggag ttttataatc atatactatt
     2821 atatcataga gtactgagta gccctgccat attgatatat ttactttcat gtatcttgta
     2881 atcatgattt agactcagaa aagatacttt gaagaacaag acagtttcaa tgtattgtac
     2941 aaaatgttgc ctgtgtgtga ttttagaagg gcagacactt ctgaattaaa actgagcttt
     3001 ttcagag
//
