LOCUS       NM_023456                580 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus neuropeptide Y (Npy), mRNA.
ACCESSION   NM_023456
VERSION     NM_023456.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 580)
  AUTHORS   Wang,H., Lou,R., Wang,Y., Hao,L., Wang,Q., Li,R., Su,J., Liu,S.,
            Zhou,X., Gao,X., Hao,Q., Chen,Z., Xu,Y., Wu,C., Zheng,Y., Guo,Q.
            and Bai,L.
  TITLE     Parallel gut-to-brain pathways orchestrate feeding behaviors
  JOURNAL   Nat Neurosci 28 (2), 320-335 (2025)
   PUBMED   39627537
REFERENCE   2  (bases 1 to 580)
  AUTHORS   Kaminski,C.L., Banik,D.D., Schmitd,L.B. and Pierchala,B.A.
  TITLE     Identification of a postnatal period of interdependent neurogenesis
            and apoptosis in peripheral neurons
  JOURNAL   Biol Open 13 (11) (2024)
   PUBMED   39527572
REFERENCE   3  (bases 1 to 580)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 580)
  AUTHORS   N'Guetta,P.Y., McLarnon,S.R., Tassou,A., Geron,M., Shirvan,S.,
            Hill,R.Z., Scherrer,G. and O'Brien,L.L.
  TITLE     Comprehensive mapping of sensory and sympathetic innervation of the
            developing kidney
  JOURNAL   Cell Rep 43 (10), 114860 (2024)
   PUBMED   39412983
REFERENCE   5  (bases 1 to 580)
  AUTHORS   Zhang,Y., Shen,J., Xie,F., Liu,Z., Yin,F., Cheng,M., Wang,L.,
            Cai,M., Herzog,H., Wu,P., Zhang,Z., Zhan,C. and Liu,T.
  TITLE     Feedforward inhibition of stress by brainstem neuropeptide Y
            neurons
  JOURNAL   Nat Commun 15 (1), 7603 (2024)
   PUBMED   39217143
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 580)
  AUTHORS   Bahary,N., Pachter,J.E., Felman,R., Leibel,R.L., Albright,K.,
            Cram,S. and Friedman,J.M.
  TITLE     Molecular mapping of mouse chromosomes 4 and 6: use of a
            flow-sorted Robertsonian chromosome
  JOURNAL   Genomics 13 (3), 761-769 (1992)
   PUBMED   1639403
REFERENCE   7  (bases 1 to 580)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 580)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   9  (bases 1 to 580)
  AUTHORS   Norman,D.J., Fletcher,C. and Heintz,N.
  TITLE     Genetic mapping of the lurcher locus on mouse chromosome 6 using an
            intersubspecific backcross
  JOURNAL   Genomics 9 (1), 147-153 (1991)
   PUBMED   1672287
REFERENCE   10 (bases 1 to 580)
  AUTHORS   Allen,J., Novotny,J., Martin,J. and Heinrich,G.
  TITLE     Molecular structure of mammalian neuropeptide Y: analysis by
            molecular cloning and computer-aided comparison with crystal
            structure of avian homologue
  JOURNAL   Proc Natl Acad Sci U S A 84 (8), 2532-2536 (1987)
   PUBMED   3031687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127376.3 and BC043012.1.
            
            On Oct 10, 2015 this sequence version replaced NM_023456.2.
            
            Summary: This gene encodes a neuropeptide that plays a pivotal role
            in many physiological functions such as food intake, energy
            homeostasis, circadian rhythm, and cognition. The encoded protein
            precursor undergoes proteolytic processing to generate the
            biologically active peptide. Mice lacking the encoded protein
            exhibit mild seizures occasionally and become hyperphagic following
            food deprivation. A deficiency of the encoded protein partially
            prevents mice lacking leptin from becoming obese. [provided by
            RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043012.1, CO040466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC127376.3         140809-140827
            20-580              BC043012.1         1-561
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.04 cM"
     gene            1..580
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /note="neuropeptide Y"
                     /db_xref="GeneID:109648"
                     /db_xref="MGI:MGI:97374"
     exon            1..92
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..386
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /note="pro-neuropeptide Y"
                     /codon_start=1
                     /product="pro-neuropeptide Y preproprotein"
                     /protein_id="NP_075945.1"
                     /db_xref="CCDS:CCDS39488.1"
                     /db_xref="GeneID:109648"
                     /db_xref="MGI:MGI:97374"
                     /translation="MLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAED
                     MARYYSALRHYINLITRQRYGKRSSPETLISDLLMKESTENAPRTRLEDPSMW"
     exon            93..280
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            281..361
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            362..566
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      544..549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      566
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgctctccgc atcccaccgg tggatctctt ctctcacaga ggcacccaga gcagagcacc
       61 cgccgctcag cgacgactgc ccgcccgcca cgatgctagg taacaagcga atggggctgt
      121 gtggactgac cctcgctcta tctctgctcg tgtgtttggg cattctggct gaggggtacc
      181 cctccaagcc ggacaatccg ggcgaggacg cgccagcaga ggacatggcc agatactact
      241 ccgctctgcg acactacatc aatctcatca ccagacagag atatggcaag agatccagcc
      301 ctgagacact gatttcagac ctcttaatga aggaaagcac agaaaacgcc cccagaacaa
      361 ggcttgaaga cccttccatg tggtgatggg aaatgaaact tgttctcccg acttttccaa
      421 gtttccaccc tcatctcatc tcatcccctg aaaccagtct gcctgtccca ccaatgcatg
      481 ccaccactag gctggactcc gccccatttc ccttgttgtt gttgttgtat atatgtgtgt
      541 ttaaataaag taccatgcat tcaaaaaaaa aaaaaaaaaa
//
