LOCUS       NM_001099664             734 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus neuropeptide W (Npw), mRNA.
ACCESSION   NM_001099664 XM_001478349 XM_993080
VERSION     NM_001099664.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 734)
  AUTHORS   Wang R, Zheng C, Jiang W, Xie X, Liao R and Zhou G.
  TITLE     Neuropeptide W regulates proliferation and differentiation of
            ATDC5: Possible involvement of GPR7 activation, PKA and
            PKC-dependent signalling cascades
  JOURNAL   J Cell Mol Med 23 (3), 2093-2102 (2019)
   PUBMED   30609248
  REMARK    GeneRIF: The neuropeptide W (NPW) mRNA quickly elevated in the
            early differentiation (7-14 days) of ATDC5 cells, while NPW and
            neuropeptides B/W receptor 1 (GPR7) mRNA were reduced during the
            late stage (14-21 days) of differentiation.
REFERENCE   2  (bases 1 to 734)
  AUTHORS   Wang R, Yan F, Liao R, Wan P, Little PJ and Zheng W.
  TITLE     Role of brain-derived neurotrophic factor and nerve growth factor
            in the regulation of Neuropeptide W in vitro and in vivo
  JOURNAL   Mol Cell Endocrinol 447, 71-78 (2017)
   PUBMED   28249734
  REMARK    GeneRIF: the effect and underlying mechanisms of NGF/BDNF on the
            production of NPW in PC12 cells and hypothalamus, is reported.
REFERENCE   3  (bases 1 to 734)
  AUTHORS   Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC,
            Hammer RE, Sakurai T and Yanagisawa M.
  TITLE     Mesolimbic neuropeptide W coordinates stress responses under novel
            environments
  JOURNAL   Proc Natl Acad Sci U S A 113 (21), 6023-6028 (2016)
   PUBMED   27140610
  REMARK    GeneRIF: These results indicate that the NPW/NPBWR1 system could
            play a critical role in the gating of stressful stimuli during
            exposure to novel environments.
REFERENCE   4  (bases 1 to 734)
  AUTHORS   Li H, Frisby CL, O'Donnell TA, Kentish SJ, Wittert GA and Page AJ.
  TITLE     Neuropeptide W modulation of gastric vagal afferent
            mechanosensitivity: Impact of age and sex
  JOURNAL   Peptides 71, 141-148 (2015)
   PUBMED   26209028
  REMARK    GeneRIF: These findings suggest that the physiological role of NPW
            varies depending on the age of the mice.
REFERENCE   5  (bases 1 to 734)
  AUTHORS   Motoike T, Skach AG, Godwin JK, Sinton CM, Yamazaki M, Abe M,
            Natsume R, Sakimura K and Yanagisawa M.
  TITLE     Transient expression of neuropeptide W in postnatal mouse
            hypothalamus--a putative regulator of energy homeostasis
  JOURNAL   Neuroscience 301, 323-337 (2015)
   PUBMED   26073698
  REMARK    GeneRIF: These data suggest that the dorsomedial hypothalamus
            neurons that transiently co-express NPW and NPY in the peri-weaning
            period might play a role in regulating energy homeostasis during
            postnatal development.
            Erratum:[Neuroscience. 2015 Sep 10;303():630]
REFERENCE   6  (bases 1 to 734)
  AUTHORS   Li H, Feinle-Bisset C, Frisby C, Kentish S, Wittert GA and Page AJ.
  TITLE     Gastric neuropeptide W is regulated by meal-related nutrients
  JOURNAL   Peptides 62, 6-14 (2014)
   PUBMED   25270269
  REMARK    GeneRIF: these studies indicated an inconsistency between plasma
            and gastric NPW expression in response to nutrient ingestion,
            suggesting food induced gastric NPW expression may play a more
            important role locally
REFERENCE   7  (bases 1 to 734)
  AUTHORS   Li H, Kentish SJ, Kritas S, Young RL, Isaacs NJ, O'Donnell TA,
            Blackshaw LA, Wittert GA and Page AJ.
  TITLE     Modulation of murine gastric vagal afferent mechanosensitivity by
            neuropeptide W
  JOURNAL   Acta Physiol (Oxf) 209 (2), 179-191 (2013)
   PUBMED   23927541
  REMARK    GeneRIF: Neuropeptide W modulates gastric vagal afferent activity
REFERENCE   8  (bases 1 to 734)
  AUTHORS   Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F,
            Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD and
            Nakazato M.
  TITLE     Neuropeptide W: an anorectic peptide regulated by leptin and
            metabolic state
  JOURNAL   Endocrinology 151 (5), 2200-2210 (2010)
   PUBMED   20189998
  REMARK    GeneRIF: Study indicates that NPW may play an important role in the
            regulation of feeding and energy metabolism.
REFERENCE   9  (bases 1 to 734)
  AUTHORS   Singh G and Davenport AP.
  TITLE     Neuropeptide B and W: neurotransmitters in an emerging
            G-protein-coupled receptor system
  JOURNAL   Br J Pharmacol 148 (8), 1033-1041 (2006)
   PUBMED   16847439
  REMARK    Review article
REFERENCE   10 (bases 1 to 734)
  AUTHORS   Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K,
            Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner
            MR, King DS, O'Dowd BF, Sakurai T and Yanagisawa M.
  TITLE     Characterization of a family of endogenous neuropeptide ligands for
            the G protein-coupled receptors GPR7 and GPR8
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6251-6256 (2003)
   PUBMED   12719537
  REMARK    GeneRIF: a non-AUG translation initiation site is used to express
            the mouse Npw preproprotein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154566.2.
            
            On Jun 25, 2019 this sequence version replaced NM_001099664.1.
            
            Summary: Orthologs of this gene express a preproprotein that is
            processed into a neuropeptide ligand for two G-protein coupled
            receptors in the central nervous system. The neuropeptide is
            thought to directly or indirectly regulate feeding, weight
            regulation, and pain response. The preproprotein is translated
            using a non-AUG initiation codon. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY708553.1, AK131881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 12719537
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               AC154566.2         104569-105126
            559-734             AC154566.2         105617-105792
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.45 cM"
     gene            1..734
                     /gene="Npw"
                     /gene_synonym="Gm935"
                     /note="neuropeptide W"
                     /db_xref="GeneID:381073"
                     /db_xref="MGI:MGI:2685781"
     exon            1..558
                     /gene="Npw"
                     /gene_synonym="Gm935"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..658
                     /gene="Npw"
                     /gene_synonym="Gm935"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="neuropeptide W preproprotein"
                     /protein_id="NP_001093134.1"
                     /db_xref="CCDS:CCDS50017.1"
                     /db_xref="GeneID:381073"
                     /db_xref="MGI:MGI:2685781"
                     /translation="MASNREVRGPGPGTPRNRPLLPLLLLLLLLPLPASAWYKHVASP
                     RYHTVGRASGLLMGLRRSPYQWRRALGGAAGPLSRLPGPVARGALLLPSSGQELWEVR
                     SRSSPAGLPVHAPWSPRDLEGVRQPEQSLSLHSWISEEPAARAFGETLRAQPWFLQQV
                     IFADPVRPKNRWRPHA"
     exon            559..734
                     /gene="Npw"
                     /gene_synonym="Gm935"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgaaaggc tgtagtcgca ccaactgact ggtcttctcc atcctctgga gctccgacgt
       61 tctcgttctc ggagacataa acccagttct tgtcctaacc ctccaagggg caattgacgt
      121 gagcgcgctg gcgtctaaca gagaagtgcg gggccctggg cccgggactc ccaggaaccg
      181 gcccctgctg cccctgctgc tgcttctgct cttgctaccg ctgcccgcca gcgcctggta
      241 taagcacgtg gcgagtcccc gctatcacac agtgggtcgt gcctccgggc tgctcatggg
      301 gctgcgccgc tcgccctacc agtggcgccg tgccctgggc ggggctgctg gacccctctc
      361 ccggctccca ggaccggtcg cccgcggcgc tctcctgctt ccttcctcag ggcaggagct
      421 gtgggaggta cgaagcagga gctcacctgc agggcttccc gtccatgcac cctggagtcc
      481 gcgggacctg gagggagtcc gccaaccgga gcagtcgcta agccttcact cctggatctc
      541 agaggagccc gctgctagag ccttcggaga gacgcttcgt gcccagccat ggttcctgca
      601 gcaagtcatc tttgccgatc ctgtcaggcc caagaaccga tggcgccccc atgcttgacc
      661 taggcaggag cacagcttga agctccagtc aggcctcgtg gtctggtcaa taaaaccaac
      721 ctgattcctg cgcc
//
