LOCUS       NM_021892                818 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus neuropeptide VF precursor (Npvf), mRNA.
ACCESSION   NM_021892 XM_983184
VERSION     NM_021892.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 818)
  AUTHORS   Dai,T., Yang,L., Wei,S., Chu,Y. and Dan,X.
  TITLE     The effect of gonadotropin-inhibitory hormone on steroidogenesis
            and spermatogenesis by acting through the
            hypothalamic-pituitary-testis axis in mice
  JOURNAL   Endocrine 84 (2), 745-756 (2024)
   PUBMED   38285410
  REMARK    GeneRIF: The effect of gonadotropin-inhibitory hormone on
            steroidogenesis and spermatogenesis by acting through the
            hypothalamic-pituitary-testis axis in mice.
REFERENCE   2  (bases 1 to 818)
  AUTHORS   Ubuka,T.
  TITLE     A mammalian gonadotropin-inhibitory hormone homolog RFamide-related
            peptide 3 regulates pain and anxiety in mice
  JOURNAL   Cell Tissue Res 391 (1), 159-172 (2023)
   PUBMED   36355189
REFERENCE   3  (bases 1 to 818)
  AUTHORS   Whittaker,D.E., Oleari,R., Gregory,L.C., Le Quesne-Stabej,P.,
            Williams,H.J., Torpiano,J.G., Formosa,N., Cachia,M.J., Field,D.,
            Lettieri,A., Ocaka,L.A., Paganoni,A.J., Rajabali,S.H.,
            Riegman,K.L., De Martini,L.B., Chaya,T., Robinson,I.C.,
            Furukawa,T., Cariboni,A., Basson,M.A. and Dattani,M.T.
  CONSRTM   GOSgene
  TITLE     A recessive PRDM13 mutation results in congenital hypogonadotropic
            hypogonadism and cerebellar hypoplasia
  JOURNAL   J Clin Invest 131 (24) (2021)
   PUBMED   34730112
REFERENCE   4  (bases 1 to 818)
  AUTHORS   Constantin,S., Pizano,K., Matson,K., Shan,Y., Reynolds,D. and
            Wray,S.
  TITLE     An Inhibitory Circuit From Brainstem to GnRH Neurons in Male Mice:
            A New Role for the RFRP Receptor
  JOURNAL   Endocrinology 162 (5) (2021)
   PUBMED   33564881
REFERENCE   5  (bases 1 to 818)
  AUTHORS   Mamgain,A., Sawyer,I.L., Timajo,D.A.M., Rizwan,M.Z., Evans,M.C.,
            Ancel,C.M., Inglis,M.A. and Anderson,G.M.
  TITLE     RFamide-Related Peptide Neurons Modulate Reproductive Function and
            Stress Responses
  JOURNAL   J Neurosci 41 (3), 474-488 (2021)
   PUBMED   33219002
REFERENCE   6  (bases 1 to 818)
  AUTHORS   Sethi,S., Tsutsui,K. and Chaturvedi,C.M.
  TITLE     Age-dependent variation in the RFRP-3 neurons is inversely
            correlated with gonadal activity of mice
  JOURNAL   Gen Comp Endocrinol 168 (3), 326-332 (2010)
   PUBMED   20433842
  REMARK    GeneRIF: It is concluded that aging mice exhibits inverse
            correlation of RFRP-3 neurons and gonadal activity suggesting that
            function of RFRP-3 is not initiated until 1-week of age and
            thereafter it could participate in the regulation of gonadal
            development.
REFERENCE   7  (bases 1 to 818)
  AUTHORS   Ducret,E., Anderson,G.M. and Herbison,A.E.
  TITLE     RFamide-related peptide-3, a mammalian gonadotropin-inhibitory
            hormone ortholog, regulates gonadotropin-releasing hormone neuron
            firing in the mouse
  JOURNAL   Endocrinology 150 (6), 2799-2804 (2009)
   PUBMED   19131572
  REMARK    GeneRIF: RFRP-3 has a likely direct suppressive action on the
            excitability of GnRH neurons, indicating a role for RFRPs in the
            regulation of gonadotropin secretion in mammals through modulation
            of GnRH neuron activity.
REFERENCE   8  (bases 1 to 818)
  AUTHORS   Lein,E.S., Hawrylycz,M.J., Ao,N., Ayres,M., Bensinger,A.,
            Bernard,A., Boe,A.F., Boguski,M.S., Brockway,K.S., Byrnes,E.J.,
            Chen,L., Chen,L., Chen,T.M., Chin,M.C., Chong,J., Crook,B.E.,
            Czaplinska,A., Dang,C.N., Datta,S., Dee,N.R., Desaki,A.L.,
            Desta,T., Diep,E., Dolbeare,T.A., Donelan,M.J., Dong,H.W.,
            Dougherty,J.G., Duncan,B.J., Ebbert,A.J., Eichele,G., Estin,L.K.,
            Faber,C., Facer,B.A., Fields,R., Fischer,S.R., Fliss,T.P.,
            Frensley,C., Gates,S.N., Glattfelder,K.J., Halverson,K.R.,
            Hart,M.R., Hohmann,J.G., Howell,M.P., Jeung,D.P., Johnson,R.A.,
            Karr,P.T., Kawal,R., Kidney,J.M., Knapik,R.H., Kuan,C.L.,
            Lake,J.H., Laramee,A.R., Larsen,K.D., Lau,C., Lemon,T.A.,
            Liang,A.J., Liu,Y., Luong,L.T., Michaels,J., Morgan,J.J.,
            Morgan,R.J., Mortrud,M.T., Mosqueda,N.F., Ng,L.L., Ng,R.,
            Orta,G.J., Overly,C.C., Pak,T.H., Parry,S.E., Pathak,S.D.,
            Pearson,O.C., Puchalski,R.B., Riley,Z.L., Rockett,H.R.,
            Rowland,S.A., Royall,J.J., Ruiz,M.J., Sarno,N.R., Schaffnit,K.,
            Shapovalova,N.V., Sivisay,T., Slaughterbeck,C.R., Smith,S.C.,
            Smith,K.A., Smith,B.I., Sodt,A.J., Stewart,N.N., Stumpf,K.R.,
            Sunkin,S.M., Sutram,M., Tam,A., Teemer,C.D., Thaller,C.,
            Thompson,C.L., Varnam,L.R., Visel,A., Whitlock,R.M.,
            Wohnoutka,P.E., Wolkey,C.K., Wong,V.Y., Wood,M., Yaylaoglu,M.B.,
            Young,R.C., Youngstrom,B.L., Yuan,X.F., Zhang,B., Zwingman,T.A. and
            Jones,A.R.
  TITLE     Genome-wide atlas of gene expression in the adult mouse brain
  JOURNAL   Nature 445 (7124), 168-176 (2007)
   PUBMED   17151600
REFERENCE   9  (bases 1 to 818)
  AUTHORS   Liu,Q., Guan,X.M., Martin,W.J., McDonald,T.P., Clements,M.K.,
            Jiang,Q., Zeng,Z., Jacobson,M., Williams,D.L. Jr., Yu,H.,
            Bomford,D., Figueroa,D., Mallee,J., Wang,R., Evans,J., Gould,R. and
            Austin,C.P.
  TITLE     Identification and characterization of novel mammalian neuropeptide
            FF-like peptides that attenuate morphine-induced antinociception
  JOURNAL   J Biol Chem 276 (40), 36961-36969 (2001)
   PUBMED   11481330
REFERENCE   10 (bases 1 to 818)
  AUTHORS   Hinuma,S., Shintani,Y., Fukusumi,S., Iijima,N., Matsumoto,Y.,
            Hosoya,M., Fujii,R., Watanabe,T., Kikuchi,K., Terao,Y., Yano,T.,
            Yamamoto,T., Kawamata,Y., Habata,Y., Asada,M., Kitada,C.,
            Kurokawa,T., Onda,H., Nishimura,O., Tanaka,M., Ibata,Y. and
            Fujino,M.
  TITLE     New neuropeptides containing carboxy-terminal RFamide and their
            receptor in mammals
  JOURNAL   Nat Cell Biol 2 (10), 703-708 (2000)
   PUBMED   11025660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156399.9 and AK138200.1.
            
            On Feb 22, 2019 this sequence version replaced NM_021892.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138200.1, BC116907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC156399.9         93074-93079
            7-818               AK138200.1         3-814
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.34 cM"
     gene            1..818
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /note="neuropeptide VF precursor"
                     /db_xref="GeneID:60531"
                     /db_xref="MGI:MGI:1926488"
     exon            1..190
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..619
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /note="FMRFamide-related peptides; RFamide-related
                     peptide; pro-FMRFamide-related neuropeptide VF"
                     /codon_start=1
                     /product="pro-FMRFamide-related neuropeptide VF precursor"
                     /protein_id="NP_068692.1"
                     /db_xref="CCDS:CCDS20133.1"
                     /db_xref="GeneID:60531"
                     /db_xref="MGI:MGI:1926488"
                     /translation="MEIISLKRFILLTVATSSFLTSNTFCTDEFMMPHFHSKEGDGKY
                     SQLRGIPKGEKERSVSFQELKDWGAKNVIKMSPAPANKVPHSAANLPLRFGRTIDEKR
                     SPAARVNMEAGTRSHFPSLPQRFGRTTARSPKTPADLPQKPLHSLGSSELLYVMICQH
                     QEIQSPGGKRTRRGAFVETDDAERKPEK"
     exon            191..567
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            568..818
                     /gene="Npvf"
                     /gene_synonym="Rfrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactcatag acacccggct gaacatatta acctaattta gacttagacg aaatggaaat
       61 tatttcatta aaacgattca ttttattgac tgtggcaact tcaagcttct taacatcaaa
      121 caccttctgt acagatgagt tcatgatgcc tcattttcac agcaaagaag gtgacggaaa
      181 atactcccag ctgagaggaa tcccaaaagg ggaaaaggaa agaagtgtca gttttcaaga
      241 actaaaagat tggggggcaa agaatgttat taagatgagt ccagcccctg ccaacaaagt
      301 gccccactca gcagccaacc tgcccctgag atttggaagg accatagatg agaaaagaag
      361 ccccgcagca cgggtcaaca tggaggcagg gaccaggagc catttcccca gcctgcccca
      421 aaggtttggg agaacaacag ccagaagccc caagacaccc gctgatttgc cacagaaacc
      481 cctgcactca ctgggctcca gcgagttgct ctacgtcatg atctgccagc accaagaaat
      541 tcagagtcct ggtggaaagc gaacgaggag aggagcgttt gtggaaacag atgatgcaga
      601 aaggaaacca gaaaaatagg aaacctcgag cccgacttca agaggctacg gagccgtgac
      661 ctgtggtctg agcagctctg tggtgttgac aaggaagagc atcgatgagc gccattattc
      721 ctgtcagttt aagttatgtt ggtggttgtt aaacaggatc aaggatgctt gtaatgtaaa
      781 ctggaagtaa cttttgtcag aataaaacag tattgtaa
//
