LOCUS       NM_030689               4973 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus neuronal pentraxin receptor (Nptxr), mRNA.
ACCESSION   NM_030689
VERSION     NM_030689.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4973)
  AUTHORS   Kanda,M., Shimizu,D., Sawaki,K., Nakamura,S., Umeda,S., Miwa,T.,
            Tanaka,H., Tanaka,C., Hayashi,M., Iguchi,Y., Yamada,S., Katsuno,M.
            and Kodera,Y.
  TITLE     Therapeutic monoclonal antibody targeting of neuronal pentraxin
            receptor to control metastasis in gastric cancer
  JOURNAL   Mol Cancer 19 (1), 131 (2020)
   PUBMED   32847597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4973)
  AUTHORS   Lee,S.J., Wei,M., Zhang,C., Maxeiner,S., Pak,C., Calado Botelho,S.,
            Trotter,J., Sterky,F.H. and Sudhof,T.C.
  TITLE     Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and
            Inhibitory Synapses
  JOURNAL   J Neurosci 37 (5), 1062-1080 (2017)
   PUBMED   27986928
  REMARK    GeneRIF: We find that NPR is a potent inducer of both excitatory
            and inhibitory heterologous synapses, and that knockdown of NPR in
            cultured neurons decreases the density of both excitatory and
            inhibitory synapses
REFERENCE   3  (bases 1 to 4973)
  AUTHORS   Pelkey,K.A., Barksdale,E., Craig,M.T., Yuan,X., Sukumaran,M.,
            Vargish,G.A., Mitchell,R.M., Wyeth,M.S., Petralia,R.S.,
            Chittajallu,R., Karlsson,R.M., Cameron,H.A., Murata,Y.,
            Colonnese,M.T., Worley,P.F. and McBain,C.J.
  TITLE     Pentraxins coordinate excitatory synapse maturation and circuit
            integration of parvalbumin interneurons
  JOURNAL   Neuron 85 (6), 1257-1272 (2015)
   PUBMED   25754824
  REMARK    GeneRIF: Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed
            circuit maturation with a prolonged critical period permissive for
            giant depolarizing potentials
            Erratum:[Neuron. 2016 May 4;90(3):661. doi:
            10.1016/j.neuron.2016.04.024.. PMID: 27151642]
REFERENCE   4  (bases 1 to 4973)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 4973)
  AUTHORS   Ling,K.H., Hewitt,C.A., Beissbarth,T., Hyde,L., Banerjee,K.,
            Cheah,P.S., Cannon,P.Z., Hahn,C.N., Thomas,P.Q., Smyth,G.K.,
            Tan,S.S., Thomas,T. and Scott,H.S.
  TITLE     Molecular networks involved in mouse cerebral corticogenesis and
            spatio-temporal regulation of Sox4 and Sox11 novel antisense
            transcripts revealed by transcriptome profiling
  JOURNAL   Genome Biol 10 (10), R104 (2009)
   PUBMED   19799774
REFERENCE   6  (bases 1 to 4973)
  AUTHORS   Chen,B. and Bixby,J.L.
  TITLE     A novel substrate of receptor tyrosine phosphatase PTPRO is
            required for nerve growth factor-induced process outgrowth
  JOURNAL   J Neurosci 25 (4), 880-888 (2005)
   PUBMED   15673668
REFERENCE   7  (bases 1 to 4973)
  AUTHORS   Chen,B. and Bixby,J.L.
  TITLE     Neuronal pentraxin with chromo domain (NPCD) is a novel class of
            protein expressed in multiple neuronal domains
  JOURNAL   J Comp Neurol 481 (4), 391-402 (2005)
   PUBMED   15593341
REFERENCE   8  (bases 1 to 4973)
  AUTHORS   Onodera,K., Shavit,J.A., Motohashi,H., Katsuoka,F., Akasaka,J.E.,
            Engel,J.D. and Yamamoto,M.
  TITLE     Characterization of the murine mafF gene
  JOURNAL   J Biol Chem 274 (30), 21162-21169 (1999)
   PUBMED   10409670
REFERENCE   9  (bases 1 to 4973)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 4973)
  AUTHORS   Dodds,D.C., Omeis,I.A., Cushman,S.J., Helms,J.A. and Perin,M.S.
  TITLE     Neuronal pentraxin receptor, a novel putative integral membrane
            pentraxin that interacts with neuronal pentraxin 1 and 2 and
            taipoxin-associated calcium-binding protein 49
  JOURNAL   J Biol Chem 272 (34), 21488-21494 (1997)
   PUBMED   9261167
  REMARK    GeneRIF: non-AUG translation initiation site. Comparison of rat
            determined N-terminal amino acid sequence with cDNA sequence
            indicates that a CUG codon is used as an initiator codon and codes
            for a methionine. The CTG is present in cDNAs of mouse, rat, and
            human.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058962.1 and AC118227.12.
            
            On Mar 22, 2007 this sequence version replaced NM_030689.3.
            
            Summary: This gene encodes a protein similar to the rat neuronal
            pentraxin receptor. The rat pentraxin receptor is an integral
            membrane protein that is thought to mediate neuronal uptake of the
            snake venom toxin, taipoxin, and its transport into the synapses.
            Studies in rat indicate that translation of this mRNA initiates at
            a non-AUG (CUG) codon. This may also be true for mouse and human,
            based on strong sequence conservation amongst these species.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058962.1, AK147605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BC058962.1         1-78
            79-80               AC118227.12        192849-192850       c
            81-3280             BC058962.1         80-3279
            3281-3282           AC118227.12        176237-176238       c
            3283-4973           BC058962.1         3282-4972
FEATURES             Location/Qualifiers
     source          1..4973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..4973
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /note="neuronal pentraxin receptor"
                     /db_xref="GeneID:73340"
                     /db_xref="MGI:MGI:1920590"
     exon            1..735
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1608
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="neuronal pentraxin receptor precursor"
                     /protein_id="NP_109614.2"
                     /db_xref="CCDS:CCDS27653.1"
                     /db_xref="GeneID:73340"
                     /db_xref="MGI:MGI:1920590"
                     /translation="MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGTDNAS
                     AASAAGGSGPQRSLSALHSAGGSAGPSVLPGEPAASVFPPPPVPLLSRFLCTPLAAAC
                     PSGAEQGDAAGERAELLLLQSTAEQLRQTALQQEARIRADRDTIRELTGKLGRCESGL
                     PRGLQDAGPRRDTMADGAWDSPALLLELEDAVRALRDRIERIEQELPARGNISSAPAP
                     AMPTALHSKMDELEGQLLAKVLALEKERAALSHGSHQQRQEVEKELNALQGRVAELEH
                     GSSAYSPPDAFKVSIPIRNNYMYARVRKALPELYAFTACMWLRSRSGGSGQGTPFSYS
                     VPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDSNWHHICISWTTRDGLWSAYQDG
                     ELRGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQ
                     VLGMANCTGPLMGNVLPWEDKLVEAFGGAKKAAFDVCKGRAKA"
     exon            736..955
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1203
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1383
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..4949
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4928..4933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /note="hexamer: AATAAA"
     polyA_site      4949
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /note="major polyA site"
ORIGIN      
        1 cggccgcggc gacagctccg gctcccactc cggctcccgt tccggctccc gcgctcccgg
       61 gccctgcgcc ccgacccccg ccgccgcgcc tgccgggggc ctcgcgcgcc ccctccgcgc
      121 ctcacgctga agttcctggc cgtgctgctg gccgcgggca tgctggcgtt cctcggtgcc
      181 gtcatctgca tcatcgccag cgtgcccctg gcggccagcc ccgctcgcgc gctgcccggc
      241 ggcaccgaca acgcctcggc cgcctcggcc gccggtggct cgggtccgca gcgcagcctg
      301 agcgccctgc acagcgcagg cggctcggcc gggccctcgg tgttgcccgg ggagcccgcg
      361 gccagcgtct tcccgccgcc gcccgtgccg ctgctcagtc gcttcctctg tacgccgctg
      421 gccgccgcct gcccgtcggg ggccgagcag ggggacgcgg caggcgagcg cgcagagctg
      481 ttgctgctgc agagcaccgc ggagcagctg cgccagacgg cgctgcagca ggaggcgcgc
      541 atccgcgcag accgggacac catccgcgag ctcaccggca agctgggccg ctgtgagagc
      601 ggcctgccgc gcggcctcca ggacgccggg ccccgccgcg acaccatggc cgacggcgcc
      661 tgggactcac ctgcgctgct gctggagctg gaggacgcgg tgcgcgcgct gcgagaccgc
      721 atcgagcgca tcgagcagga gctcccagcc cgtgggaaca tctcctcggc gccagctcca
      781 gccatgccca ccgccctgca ctccaagatg gacgaactag aaggccagct gctggccaag
      841 gtgctggcgc tggagaagga gcgagccgcc ctcagtcacg ggagccacca gcaacgacag
      901 gaagtggaga aggagctgaa tgccctgcag ggtcgcgtgg ccgagctgga gcacgggtcc
      961 tcggcctaca gtccccctga tgccttcaag gtcagcatcc ccatccgcaa caactacatg
     1021 tacgcccgcg tgcgcaaggc gctgccggaa ctctacgcct tcactgcctg catgtggctg
     1081 cgctccaggt caggtggctc cggccagggc acccccttct cctactcggt gcccgggcag
     1141 gccaatgaga tcgtgcttct ggaggccggc cttgagccaa tggagctgct gatcaacgac
     1201 aaggtggccc agctgcccct gagcctgaaa gacagcaact ggcaccatat ctgcatctcc
     1261 tggactacaa gggatgggct gtggtctgca taccaggacg gagaactgcg gggttctggc
     1321 gagaacctag cagcctggca ccccatcaag ccacacggca tccttatcct gggccaagag
     1381 caggatacct tgggaggccg atttgacgcc acacaggcct tcgttggtga cattgcacag
     1441 ttcaacctgt gggaccacgc tctgacaccg gcccaggtgc tgggcatggc caactgcacc
     1501 gggccactga tgggcaatgt cctcccctgg gaagataagc tggtagaggc ctttggaggt
     1561 gcgaagaagg ccgcctttga tgtgtgcaag gggagggcaa aggcatgagg ggccaccttg
     1621 ttcagggccc ctccattgcc tgtcagtttc aggactttga aggggcaatc cctcctcagc
     1681 ctgtctacac gccggccttc ccttctaccc cactcctggc tatacctccc acttctcctc
     1741 atgggcaccc actgctccag agtgccctgc cctggatggg tgtcccctca gccacctgga
     1801 tagggaccag tatctcacat caatgtaggg gttgaggcag tcccgcctcc tggcaatgta
     1861 ttggcttggt ctctcccatc atatacactg tcctgccgat cacatcggac cccactaatt
     1921 ccaaggacat cccctaagga gtcgtgggta gaggtagcct ttgaccctca aatcccctat
     1981 gctccaggcc tacctcgggc tgcagaaggg atgccagaga tgtataaaga tcagacgctc
     2041 cttctctatc ttcctgggtt actcacaggg gctgcggggt catcgctccc actgcccctg
     2101 ccttgccctc cctcctctca ccagtttctc tgtgtgttgt ggtttgaatg ttggtttcat
     2161 gtcggttcaa gcctcacctc agtttccagg atgttccttc cccagcccct accctaacag
     2221 ctagggacca aaaccctgga ggccaaaggg ctgtaatcac cccctgtacc cactggcaac
     2281 tttgcccacc agcagggttg tccaccccac cccctccatg cctgagacag gacctgctgg
     2341 gtcactctag cctgtcctga gaacatctaa aacagaggca caatgaatga ggggatgctt
     2401 cccaggcaga gcctggtggc ttagccacca tatcacctct ttctgcatgg ccctggaaag
     2461 gatggaggat gctgggatgg aaagcagaac actgagagag agagagagag agagagagag
     2521 agagagagag agagagagag aacccctagg ttcttatgac ttgctgtgtg gctttcagta
     2581 agaacctacc ctctctgggc ctcgctttct cctagtccct accaacttcc ccaagagcac
     2641 agaagaatgt cagagctgag aaaaaccatc cattgtaagc tcttgctggt gagagatgga
     2701 aaagagcaca gagagggcca ttaacttgtc taggatcaaa cagcacaaca tagcaggccc
     2761 aggccctctg agtccctcca aagtgctctt ccctgtgaac cacactgcct gtccttgagc
     2821 cctgcttata cctgtgcagg gaggcacttg agaggacacg tgctttcaca cagggtacca
     2881 aaatatcttc tggggacacc ccaacacctt gacagcctga ggaggtgaga ggaaaagccc
     2941 agacagacag agttccaaca gacagcagag gatgcaaggc cctgttggtc ctctcccatg
     3001 gattggaaca gtagcaggtt gggtgaatca ctgggcaccg gtgcctcttg ccctacccca
     3061 cccaccactt ttgtccgtct gtgctctcca tggccactca gcccgagacg tgacgcagga
     3121 gaggctgcag cccatgtcag ggaagcatgg ccgagactcg cctctgggct gcagatctgc
     3181 atttccattt tgagagcaac tacacggcac agcacccccc atccccatcc cctggagaga
     3241 gctgcagagg cttcacccag aacctgctga gatcccggtt gcccagtaac aaccaatgac
     3301 atcagcccca gtgctaggtc aagtgtcttt tgtgaggaca ccggttgttg ctgggtgaca
     3361 gctggattca gaacttagac ctgggggact ctaagctgca ctgggctcct gctattgttc
     3421 tagaagaggc ctttgctatt gatttagagg aggccttggg aagacagcat cttaggaagg
     3481 atgtagcaga aactgcctgc tcactggagc ccaccagaca caccatcccc atccttttgc
     3541 tttgtctcag tggtgatgag aaacagcacc tcagtcacat ttccatgcca ggtcaccctg
     3601 gttaaactgc cacctcccca ccccaacccc acccaggagg ggaaaaaaca gaggcacctg
     3661 gtcaaggctc tgtgtatgga ttactgggga aggggctgcc tctctatttc ccaagtcccc
     3721 acctgctctc atctattgtg ctgtgaacat tctctgagca tgtggagccc ccactcaatc
     3781 ttctgctgtc tccccaagca catccaacaa gacagctgcg gccctgagtt gcccctgggt
     3841 ctgacaaaga tggaactagg ctggttaggt agtcttaggc ctggagacag cacggagcac
     3901 ggtatccgca ccatctggtt tatcctcaca gcacaaagcg agactgttct tagccctgtg
     3961 gtgcacaaga gaaggatgag aggtaaagta acttgcccag tgttgattgg ccagccggga
     4021 acagcgcgat ttccatttgg aggcaggtta gatgcctaaa ggtccacgcc acctccttca
     4081 gagtgcagaa ggagcagagg tgggggtgtg gggcgtgaag ccagggaggg aggggtctct
     4141 cacctatgcc cagcctcagc ctcagcctga gctgcagtct aagggcaaga aaggagtatc
     4201 tttagaggtc gtcagaaaag gcagggtgga agtggttctt gctcggcccc tgttctgggc
     4261 acgacctatg tcaggttctc taagctgttt tctgccagat ctcctatctg tgaggcatgg
     4321 agtggccact cccatgtccc aagggtcatc ttaccacagt tacatgtgaa tggggaccac
     4381 agactgaagt atgaggatct gttgggggtt ggggggggtg taactcaacc cttggcttgt
     4441 agatgaggga gctgaggtct ggccaggaag ctcaaatgac cctggaagtt cccttgactg
     4501 tccttctctt ctccaggacc cggtggtcac tcccttccct tgcaaactga attcctatct
     4561 actagtccca gcacctttgg cctgagagaa aactggagaa ggttctcctc ccaaattagg
     4621 gactagtatc ctccttaccc cttaactcca gctgcctgcc acccctgatc ccgccttcca
     4681 cccaccctat tccctgcccc tgctggatgg agaacagact ccttccctgg ctgagccgcc
     4741 agcagcgagc atgtgaagtc atctggttgg acactttgga acgaggaccc tccactgccc
     4801 tcctccccca ccttgcccta ttttgtacat aagtaacacg agatgctctg tatgtgtgag
     4861 tgcgtgtgtg atctgtgcca tggcttttgt taccatttct tgtttttttg taaatttgaa
     4921 tgttcaaaat aaaacgtggt ttactcggaa aaaaaaaaaa aaaaaaaaaa aaa
//
