LOCUS       NP_109614                493 aa            linear   ROD 27-APR-2025
DEFINITION  neuronal pentraxin receptor precursor [Mus musculus].
ACCESSION   NP_109614
VERSION     NP_109614.2
DBSOURCE    REFSEQ: accession NM_030689.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Kanda,M., Shimizu,D., Sawaki,K., Nakamura,S., Umeda,S., Miwa,T.,
            Tanaka,H., Tanaka,C., Hayashi,M., Iguchi,Y., Yamada,S., Katsuno,M.
            and Kodera,Y.
  TITLE     Therapeutic monoclonal antibody targeting of neuronal pentraxin
            receptor to control metastasis in gastric cancer
  JOURNAL   Mol Cancer 19 (1), 131 (2020)
   PUBMED   32847597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Lee,S.J., Wei,M., Zhang,C., Maxeiner,S., Pak,C., Calado Botelho,S.,
            Trotter,J., Sterky,F.H. and Sudhof,T.C.
  TITLE     Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and
            Inhibitory Synapses
  JOURNAL   J Neurosci 37 (5), 1062-1080 (2017)
   PUBMED   27986928
  REMARK    GeneRIF: We find that NPR is a potent inducer of both excitatory
            and inhibitory heterologous synapses, and that knockdown of NPR in
            cultured neurons decreases the density of both excitatory and
            inhibitory synapses
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Pelkey,K.A., Barksdale,E., Craig,M.T., Yuan,X., Sukumaran,M.,
            Vargish,G.A., Mitchell,R.M., Wyeth,M.S., Petralia,R.S.,
            Chittajallu,R., Karlsson,R.M., Cameron,H.A., Murata,Y.,
            Colonnese,M.T., Worley,P.F. and McBain,C.J.
  TITLE     Pentraxins coordinate excitatory synapse maturation and circuit
            integration of parvalbumin interneurons
  JOURNAL   Neuron 85 (6), 1257-1272 (2015)
   PUBMED   25754824
  REMARK    GeneRIF: Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed
            circuit maturation with a prolonged critical period permissive for
            giant depolarizing potentials
            Erratum:[Neuron. 2016 May 4;90(3):661. doi:
            10.1016/j.neuron.2016.04.024. PMID: 27151642]
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Ling,K.H., Hewitt,C.A., Beissbarth,T., Hyde,L., Banerjee,K.,
            Cheah,P.S., Cannon,P.Z., Hahn,C.N., Thomas,P.Q., Smyth,G.K.,
            Tan,S.S., Thomas,T. and Scott,H.S.
  TITLE     Molecular networks involved in mouse cerebral corticogenesis and
            spatio-temporal regulation of Sox4 and Sox11 novel antisense
            transcripts revealed by transcriptome profiling
  JOURNAL   Genome Biol 10 (10), R104 (2009)
   PUBMED   19799774
REFERENCE   6  (residues 1 to 493)
  AUTHORS   Chen,B. and Bixby,J.L.
  TITLE     A novel substrate of receptor tyrosine phosphatase PTPRO is
            required for nerve growth factor-induced process outgrowth
  JOURNAL   J Neurosci 25 (4), 880-888 (2005)
   PUBMED   15673668
REFERENCE   7  (residues 1 to 493)
  AUTHORS   Chen,B. and Bixby,J.L.
  TITLE     Neuronal pentraxin with chromo domain (NPCD) is a novel class of
            protein expressed in multiple neuronal domains
  JOURNAL   J Comp Neurol 481 (4), 391-402 (2005)
   PUBMED   15593341
REFERENCE   8  (residues 1 to 493)
  AUTHORS   Onodera,K., Shavit,J.A., Motohashi,H., Katsuoka,F., Akasaka,J.E.,
            Engel,J.D. and Yamamoto,M.
  TITLE     Characterization of the murine mafF gene
  JOURNAL   J Biol Chem 274 (30), 21162-21169 (1999)
   PUBMED   10409670
REFERENCE   9  (residues 1 to 493)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (residues 1 to 493)
  AUTHORS   Dodds,D.C., Omeis,I.A., Cushman,S.J., Helms,J.A. and Perin,M.S.
  TITLE     Neuronal pentraxin receptor, a novel putative integral membrane
            pentraxin that interacts with neuronal pentraxin 1 and 2 and
            taipoxin-associated calcium-binding protein 49
  JOURNAL   J Biol Chem 272 (34), 21488-21494 (1997)
   PUBMED   9261167
  REMARK    GeneRIF: non-AUG translation initiation site. Comparison of rat
            determined N-terminal amino acid sequence with cDNA sequence
            indicates that a CUG codon is used as an initiator codon and codes
            for a methionine. The CTG is present in cDNAs of mouse, rat, and
            human.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058962.1 and AC118227.12.
            
            On Sep 26, 2003 this sequence version replaced NP_109614.1.
            
            Summary: This gene encodes a protein similar to the rat neuronal
            pentraxin receptor. The rat pentraxin receptor is an integral
            membrane protein that is thought to mediate neuronal uptake of the
            snake venom toxin, taipoxin, and its transport into the synapses.
            Studies in rat indicate that translation of this mRNA initiates at
            a non-AUG (CUG) codon. This may also be true for mouse and human,
            based on strong sequence conservation amongst these species.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058962.1, AK147605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     Protein         1..493
                     /product="neuronal pentraxin receptor precursor"
                     /calculated_mol_wt=48883
     sig_peptide     1..35
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3471
     Site            3..23
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J85.1)"
     Region          37..72
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J85.1)"
     Site            42
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99J85.1)"
     Region          <106..>276
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Site            211
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99J85.1)"
     Region          281..487
                     /region_name="PTX"
                     /note="Pentraxin / C-reactive protein / pentaxin family;
                     smart00159"
                     /db_xref="CDD:128463"
     Site            order(340,418,420,427,430)
                     /site_type="active"
                     /note="calcium mediated ligand binding site [active]"
                     /db_xref="CDD:238086"
     Site            456
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99J85.1)"
     CDS             1..493
                     /gene="Nptxr"
                     /gene_synonym="1200009K17Rik; 1700036C17Rik;
                     5730406O18Rik; D15Bwg0580e; Npcd; NPR"
                     /coded_by="NM_030689.4:127..1608"
                     /note="non-AUG (CUG) translation initiation codon"
                     /db_xref="CCDS:CCDS27653.1"
                     /db_xref="GeneID:73340"
                     /db_xref="MGI:MGI:1920590"
ORIGIN      
        1 mkflavllaa gmlaflgavi ciiasvplaa sparalpggt dnasaasaag gsgpqrslsa
       61 lhsaggsagp svlpgepaas vfppppvpll srflctplaa acpsgaeqgd aageraelll
      121 lqstaeqlrq talqqearir adrdtirelt gklgrcesgl prglqdagpr rdtmadgawd
      181 spallleled avralrdrie rieqelparg nissapapam ptalhskmde legqllakvl
      241 alekeraals hgshqqrqev ekelnalqgr vaelehgssa ysppdafkvs ipirnnymya
      301 rvrkalpely aftacmwlrs rsggsgqgtp fsysvpgqan eivlleagle pmellindkv
      361 aqlplslkds nwhhiciswt trdglwsayq dgelrgsgen laawhpikph gililgqeqd
      421 tlggrfdatq afvgdiaqfn lwdhaltpaq vlgmanctgp lmgnvlpwed klveafggak
      481 kaafdvckgr aka
//
