LOCUS       NM_016789               2551 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus neuronal pentraxin 2 (Nptx2), mRNA.
ACCESSION   NM_016789 XM_357523
VERSION     NM_016789.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Wang,X., Zhang,Y., Luo,S., Zhao,K., Gao,C., Mei,D., Duan,Y. and
            Hu,S.
  TITLE     Restoration of nNOS Expression Rescues Autistic-Like Phenotypes
            Through Normalization of AMPA Receptor-Mediated Neurotransmission
  JOURNAL   Mol Neurobiol 61 (9), 6599-6612 (2024)
   PUBMED   38329681
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   Xing,M., Yang,X., Jin,S. and Xu,X.
  TITLE     Inhibition of neuronal pentraxin 2 relieved epileptic seizure via
            reducing GluA1 phosphorylation
  JOURNAL   Cell Biochem Funct 42 (3), e4003 (2024)
   PUBMED   38597235
  REMARK    GeneRIF: Inhibition of neuronal pentraxin 2 relieved epileptic
            seizure via reducing GluA1 phosphorylation.
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Zhou,J., Wade,S.D., Graykowski,D., Xiao,M.F., Zhao,B.,
            Giannini,L.A.A., Hanson,J.E., van Swieten,J.C., Sheng,M.,
            Worley,P.F. and Dejanovic,B.
  TITLE     The neuronal pentraxin Nptx2 regulates complement activity and
            restrains microglia-mediated synapse loss in neurodegeneration
  JOURNAL   Sci Transl Med 15 (689), eadf0141 (2023)
   PUBMED   36989373
  REMARK    GeneRIF: The neuronal pentraxin Nptx2 regulates complement activity
            and restrains microglia-mediated synapse loss in neurodegeneration.
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   Kanehisa,K., Koga,K., Maejima,S., Shiraishi,Y., Asai,K.,
            Shiratori-Hayashi,M., Xiao,M.F., Sakamoto,H., Worley,P.F. and
            Tsuda,M.
  TITLE     Neuronal pentraxin 2 is required for facilitating excitatory
            synaptic inputs onto spinal neurons involved in pruriceptive
            transmission in a model of chronic itch
  JOURNAL   Nat Commun 13 (1), 2367 (2022)
   PUBMED   35501343
  REMARK    GeneRIF: Neuronal pentraxin 2 is required for facilitating
            excitatory synaptic inputs onto spinal neurons involved in
            pruriceptive transmission in a model of chronic itch.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Xiao,M.F., Roh,S.E., Zhou,J., Chien,C.C., Lucey,B.P., Craig,M.T.,
            Hayes,L.N., Coughlin,J.M., Leweke,F.M., Jia,M., Xu,D., Zhou,W.,
            Conover Talbot,C. Jr., Arnold,D.B., Staley,M., Jiang,C., Reti,I.M.,
            Sawa,A., Pelkey,K.A., McBain,C.J., Savonenko,A. and Worley,P.F.
  TITLE     A biomarker-authenticated model of schizophrenia implicating NPTX2
            loss of function
  JOURNAL   Sci Adv 7 (48), eabf6935 (2021)
   PUBMED   34818031
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Saha,B., Hari,P., Huilgol,D. and Tole,S.
  TITLE     Dual role for LIM-homeodomain gene Lhx2 in the formation of the
            lateral olfactory tract
  JOURNAL   J Neurosci 27 (9), 2290-2297 (2007)
   PUBMED   17329426
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Bjartmar,L., Huberman,A.D., Ullian,E.M., Renteria,R.C., Liu,X.,
            Xu,W., Prezioso,J., Susman,M.W., Stellwagen,D., Stokes,C.C.,
            Cho,R., Worley,P., Malenka,R.C., Ball,S., Peachey,N.S.,
            Copenhagen,D., Chapman,B., Nakamoto,M., Barres,B.A. and Perin,M.S.
  TITLE     Neuronal pentraxins mediate synaptic refinement in the developing
            visual system
  JOURNAL   J Neurosci 26 (23), 6269-6281 (2006)
   PUBMED   16763034
  REMARK    GeneRIF: Neuronal pentraxin 1 and 2 are necessary for early
            synaptic refinements in mammalian retina and dorsal lateral
            geniculate nucleus. May exert their effects through mechanisms
            paralleling known role of short pentraxins outside the CNS.
            (Pentraxin 1 and 2)
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   Kirkpatrick,L.L., Matzuk,M.M., Dodds,D.C. and Perin,M.S.
  TITLE     Biochemical interactions of the neuronal pentraxins. Neuronal
            pentraxin (NP) receptor binds to taipoxin and taipoxin-associated
            calcium-binding protein 49 via NP1 and NP2
  JOURNAL   J Biol Chem 275 (23), 17786-17792 (2000)
   PUBMED   10748068
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Tsui,C.C., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Barnes,C. and
            Worley,P.F.
  TITLE     Narp, a novel member of the pentraxin family, promotes neurite
            outgrowth and is dynamically regulated by neuronal activity
  JOURNAL   J Neurosci 16 (8), 2463-2478 (1996)
   PUBMED   8786423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134806.1, DV649643.1 and AC164119.4.
            
            On Mar 19, 2008 this sequence version replaced NM_016789.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026054.1, AK134806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-587               AK134806.1         2-588
            588-1217            DV649643.1         27-656
            1218-1723           AK134806.1         1219-1724
            1724-2551           AC164119.4         13323-14150
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 84.58 cM"
     gene            1..2551
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /note="neuronal pentraxin 2"
                     /db_xref="GeneID:53324"
                     /db_xref="MGI:MGI:1858209"
     exon            1..597
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..814
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1059
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1239
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..2551
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /note="hexamer: ATTAAA"
     polyA_site      2548
                     /gene="Nptx2"
                     /gene_synonym="Narp; np2"
                     /note="major polyA site"
ORIGIN      
        1 agaacgccgc gcaaagcgga gagcgggttt ttgcgacggc aggcggcgct tgtgctgccg
       61 tttccgtgct gcacgcggtt ccctcgagtg ccgcgctcgg acagacgtag ccggccgcga
      121 aggcgcccag acggcaaacc agcgacccat gctgaagtga gcacacaggt cagcgagatg
      181 ctggcgctgc tgaccgtcgg cgtggcgctc gccgtggccg ccggacgagc ccaggacagc
      241 ccgatacctg gcagccgctt cgtgtgcacc gcgttgcccc ccgaagcggc gcgcgccggc
      301 tgcccgctgc ccgcgatgcc catgcaggga ggcgctctga gccccgagga ggagctgcga
      361 gccgctgtgc tgcagctgcg cgagaccgtc gtgcagcaga aggagacgct gggcgcccag
      421 cgagaagcca tccgagagct caccggcaag ctggcccgct gcgaggggct ggcgggcggc
      481 aaggcgcgcg gcacaggcaa ggacaccatg ggcgacctgc cgcgggaccc gggccacgtc
      541 gtggagcagc ttagccgctc cttgcaaacc ctcaaggacc gcttggagag cctcgagctc
      601 cagctccgca caaatgtgtc taacgctggg ctgccgagcg acttccgaga ggtgctccag
      661 cggaggctcg gggagctgga gaggcagttg ctacgcaagg tggcggagct ggaagatgag
      721 aagtccctgc ttcataatga gacctcggct caccggcaga agacagagag cacgctgaac
      781 gccctgctgc agagggtgac tgagctggag cgaggcaaca gtgcattcaa gtcaccagat
      841 gcattcaaag tgtcccttcc tctccgtaca aactacctgt atggcaagat caagaagaca
      901 ttgcctgagc tgtacgcctt taccatctgc ctgtggctgc ggtccagtgc ctcgccaggc
      961 atcggtacgc cattctccta cgctgtgccc gggcaagcca acgagattgt gctgatagag
     1021 tggggcaata accccattga gctgctcatc aacgacaagg tcgcacagct gccgctgttt
     1081 gtcagtgatg gcaagtggca ccacatctgc atcacctgga ccactcgaga cggcatgtgg
     1141 gaagcgttcc aggatgggga gaagctgggc actggggaaa acctggcacc ctggcacccc
     1201 attaagccag ggggcgtgct catcctgggg caggagcagg acacggtggg aggcagattt
     1261 gatgccacgc aggcctttgt tggagagctc agccagttca acatatggga ccgcgtcctc
     1321 cgggcgcagg agatcatcaa catcgccaac tgctccacga acatgcccgg caacatcatc
     1381 ccgtgggtgg acaacaatgt cgatgtgttc ggcggggctt ccaagtggcc tgtggagacc
     1441 tgtgaagagc ggctcctgga cttgtagctg ccctctccgt cccagaggcc acgatccatc
     1501 gggctgttct gaggacttca aggcatctct tccccattca cctaaaacct ctggcctgaa
     1561 cagaaaagag ccggagctct aatgcaggct gtgtggccgc ccttgtctta ggctcatttg
     1621 ttccttacca ttttgtcgag gttttttggg gggtagtgac agaatccctg gaagagtctt
     1681 gagccacttc ctgctggggt ttctagtaaa gtctgtgagc ctctccacca gtccctgtaa
     1741 atgctaatgc agcccagccc tgcctgttgt tttggatcct tggtgtctca tgtgtacttc
     1801 ctgtctgtcc cctttgatgg ctgtgcggtc atcctatcgg cgtggcctag gtcccttgtg
     1861 tgtgtagcac atccctgctt ttgactgaac actgcacaga agcccctgaa atagggcctc
     1921 tccctcgttg tcatgtgcac tttccgtctg agggaactgc agctgctgga aggccagctg
     1981 ctcagacaat ccccagcatc cccggaacag acaccccccc cccccccccc cgtggagaag
     2041 gtccccctct cagacccacg ctcgctcaga ggctcgttgc tgggctggct ttgaggggct
     2101 gctcttctca tctggtgcca aaagttcatt tgcagcttct acaacaatcc ccacaaaaga
     2161 tgaacagcca ttagaagcct cccctccttt tgatgctcag cccactgtga agagtgagct
     2221 tgttttgtaa gccacattgg ttcctgtgag catctgaccg tcccccatcg agtatttccc
     2281 ccggaactgg agattcgggc gtcatttggc tgctacttgc ttagtgactc caggctgcat
     2341 catatatcat aatttatttt aaagagaaag tgattcagtg gggaaattta taaagctata
     2401 aatattatat attttatttt tcatacatgt ttgaattgcg gatccatgga tgttccatct
     2461 gtaggaccaa cttgatgtgc ccatcctgac attgtatgcc acaagagctc ttgtgatgat
     2521 ggaattttga ttaaagtgca ccggaagacg c
//
