LOCUS       NM_008730               5284 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus neuronal pentraxin 1 (Nptx1), mRNA.
ACCESSION   NM_008730
VERSION     NM_008730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5284)
  AUTHORS   Ju,L., Yang,J., Zhu,T., Liu,P. and Yang,J.
  TITLE     BDNF-TrkB signaling-mediated upregulation of Narp is involved in
            the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a
            chronic restraint stress mouse model
  JOURNAL   BMC Psychiatry 22 (1), 182 (2022)
   PUBMED   35291971
  REMARK    GeneRIF: BDNF-TrkB signaling-mediated upregulation of Narp is
            involved in the antidepressant-like effects of
            (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse
            model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5284)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5284)
  AUTHORS   Kovacs,R.A., Vadaszi,H., Bulyaki,E., Torok,G., Toth,V., Matyas,D.,
            Kun,J., Hunyadi-Gulyas,E., Fedor,F.Z., Csincsi,A.,
            Medzihradszky,K., Homolya,L., Juhasz,G., Kekesi,K.A., Jozsi,M.,
            Gyorffy,B.A. and Kardos,J.
  TITLE     Identification of Neuronal Pentraxins as Synaptic Binding Partners
            of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice
  JOURNAL   Front Immunol 11, 599771 (2021)
   PUBMED   33628204
  REMARK    GeneRIF: Identification of Neuronal Pentraxins as Synaptic Binding
            Partners of C1q and the Involvement of NP1 in Synaptic Pruning in
            Adult Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5284)
  AUTHORS   Wang,R., Man,Y., Zhou,M., Zhu,Y., Wang,L. and Yang,J.
  TITLE     Neuropathic pain-induced cognitive dysfunction and down-regulation
            of neuronal pentraxin 2 in the cortex and hippocampus
  JOURNAL   Neuroreport 32 (3), 274-283 (2021)
   PUBMED   33512875
  REMARK    GeneRIF: Neuropathic pain-induced cognitive dysfunction and
            down-regulation of neuronal pentraxin 2 in the cortex and
            hippocampus.
REFERENCE   5  (bases 1 to 5284)
  AUTHORS   Al Rahim,M., Thatipamula,S., Pasinetti,G.M. and Hossain,M.A.
  TITLE     Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by
            Impairing Mitochondrial Biogenesis via Interactions With Active
            Bax[6A7] and Mitochondrial Hexokinase II
  JOURNAL   ASN Neuro 13, 17590914211012888 (2021)
   PUBMED   34098747
  REMARK    GeneRIF: Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal
            Injury by Impairing Mitochondrial Biogenesis via Interactions With
            Active Bax[6A7] and Mitochondrial Hexokinase II.
REFERENCE   6  (bases 1 to 5284)
  AUTHORS   Wyzykowski,J.C., Winata,T.I., Mitin,N., Taparowsky,E.J. and
            Konieczny,S.F.
  TITLE     Identification of novel MyoD gene targets in proliferating myogenic
            stem cells
  JOURNAL   Mol Cell Biol 22 (17), 6199-6208 (2002)
   PUBMED   12167713
  REMARK    GeneRIF: The Id3 and NP1 genes become transcriptionally active
            after MyoD induction in undifferentiated myoblasts. This is a
            stable, heritable event that does not need continued MyoD activity
            & is not subject to negative regulation by activated H-Ras G12V.
REFERENCE   7  (bases 1 to 5284)
  AUTHORS   Kirkpatrick,L.L., Matzuk,M.M., Dodds,D.C. and Perin,M.S.
  TITLE     Biochemical interactions of the neuronal pentraxins. Neuronal
            pentraxin (NP) receptor binds to taipoxin and taipoxin-associated
            calcium-binding protein 49 via NP1 and NP2
  JOURNAL   J Biol Chem 275 (23), 17786-17792 (2000)
   PUBMED   10748068
REFERENCE   8  (bases 1 to 5284)
  AUTHORS   Onodera,K., Shavit,J.A., Motohashi,H., Katsuoka,F., Akasaka,J.E.,
            Engel,J.D. and Yamamoto,M.
  TITLE     Characterization of the murine mafF gene
  JOURNAL   J Biol Chem 274 (30), 21162-21169 (1999)
   PUBMED   10409670
REFERENCE   9  (bases 1 to 5284)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 5284)
  AUTHORS   Omeis,I.A., Hsu,Y.C. and Perin,M.S.
  TITLE     Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic
            structure, and chromosomal localization
  JOURNAL   Genomics 36 (3), 543-545 (1996)
   PUBMED   8884281
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY261600.1, BY288383.1, BY273353.1, AK140128.1 and AL669881.19.
            
            On Dec 20, 2006 this sequence version replaced NM_008730.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093479.1, SRR1660817.231933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BY261600.1         96-162
            68-191              BY288383.1         2-125
            192-483             BY273353.1         126-417
            484-1814            AK140128.1         1-1331
            1815-5284           AL669881.19        3001-6470           c
FEATURES             Location/Qualifiers
     source          1..5284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.95 cM"
     gene            1..5284
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /note="neuronal pentraxin 1"
                     /db_xref="GeneID:18164"
                     /db_xref="MGI:MGI:107811"
     exon            1..675
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1530
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /note="NP-I; neuronal pentraxin I"
                     /codon_start=1
                     /product="neuronal pentraxin-1 precursor"
                     /protein_id="NP_032756.1"
                     /db_xref="CCDS:CCDS25719.1"
                     /db_xref="GeneID:18164"
                     /db_xref="MGI:MGI:107811"
                     /translation="MLAGRAARTCALLALCLLGSGAQDFGPTRFICTSVPVDADMCAA
                     SVAAGGAEELRSNVLQLRETVLQQKETILSQKETIRELTTKLGRCESQSTLDSGPGEA
                     RSGGGRKQPGSGKNTMGDLSRTPAAETLSQLGQTLQSLKTRLENLEQYSRLNSSSQTN
                     SLKDLLQSKIDDLERQVLSRVNTLEEGKGGPKNDTEERAKIESALTSLHQRISELEKG
                     QKDNRPGDKFQLTFPLRTNYMYAKVKKSLPEMYAFTVCMWLKSSAAPGVGTPFSYAVP
                     GQANELVLIEWGNNPMEILINDKVAKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQ
                     GGNGENLAPYHPIKPQGVLVLGQEQDTLGGGFDATQAFVGELAHFNIWDRKLTPGEVY
                     NLATCSSKALSGNVIAWAESQIEIFGGATKWTFEACRQIN"
     exon            676..883
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1128
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1308
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..5284
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5265..5270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /note="hexamer: AGTAAA"
     polyA_site      5283
                     /gene="Nptx1"
                     /gene_synonym="D11Bwg1004e; Np1"
                     /note="major polyA site"
ORIGIN      
        1 gctgacgtcg gcggcgccga ggcccctccc gcggctgcat aaaaggcgcg ggctccgcag
       61 cgcaggcggc agtgggggcc gaggagcgcg gccgagaaga ctgtgcggcg tagaagcgcg
      121 gtgctagagc gcgggccgcc tgcggagcga ctgccccagc cagcccgatc ccggtctcag
      181 cccgatcccc accggagccg agcggccccg gtgctccaag tgtccggagc catgctggcc
      241 ggccgcgccg cacgcacctg tgcgctgctc gccctctgcc tcctgggcag tggggcccaa
      301 gatttcgggc cgacccgctt catctgcact tcggtgccgg tggatgcaga catgtgtgcc
      361 gcgtccgtgg ctgcgggcgg cgcggaggag cttcggagca acgtgctgca gctccgcgag
      421 accgtgctgc agcagaagga gaccatcctc agccagaagg agaccatcag ggagctgacc
      481 accaagcttg gccgctgcga gagccagagc accctggact cgggtcccgg cgaggccagg
      541 tcgggaggcg gccgcaagca gcctggctcg ggcaagaaca cgatgggcga cctgtcccgg
      601 acgccggccg cggagacgct cagccaactc gggcaaactt tgcaatctct caaaacccga
      661 ctggagaacc tcgagcagta cagccgcctc aattcttcca gccaaaccaa cagcctcaag
      721 gatctgctgc agagcaagat cgatgacctg gagcggcagg tgctgtctcg ggtgaacact
      781 ctggaggagg ggaaaggggg ccccaagaac gacacagagg aaagggccaa gatcgagagc
      841 gccttgacct ccctacacca acggatcagc gagctggaga aaggtcagaa agacaatcgc
      901 cccggagaca agtttcagct gacattccca ctgcggacca actacatgta tgccaaggtg
      961 aagaagagcc tgccagagat gtatgccttc accgtgtgca tgtggctcaa gtccagtgcg
     1021 gcgcctggag tgggcacacc cttctcttat gctgtgcctg ggcaggccaa cgaactggtc
     1081 ctcatcgagt ggggcaacaa ccccatggag atactcatta atgacaaggt ggccaagctg
     1141 ccgtttgtaa tcaacgatgg caaatggcat cacatctgtg tcacctggac cacccgggat
     1201 ggggtctggg aggcctatca ggatggcacc cagggtggca atggagagaa cttggcaccc
     1261 tatcacccca tcaaaccaca gggcgtgctg gtgctgggtc aggaacagga cactctaggt
     1321 ggagggtttg atgccaccca agcatttgtg ggtgagctag cccatttcaa catctgggac
     1381 cgcaagctga cccccgggga ggtgtacaac ctggccacct gcagcagcaa ggctctctct
     1441 ggcaatgtca tcgcctgggc tgagtcccag atcgagatct ttggtggagc caccaagtgg
     1501 acattcgagg cttgtcgcca gatcaactga aggcttcagg ctagggctga gcccccagcc
     1561 ccagcgcctg cccaccctgc ttgtgcggtg acccatcgtc tctcttctcc cctcccccca
     1621 ggaatgactc aaggccatgg cccctgcaca cgcacacgca cacagcctgg ttgtcctcct
     1681 tgtgcacttg aagcagtccc ggctcttctc tggcccccaa ggacaccccc ttctctctag
     1741 gggccccact atatcctggg catacctagc taaagcaggc agcatcagct ttgacaatgc
     1801 agaatttcgt gagaaagaga gagagagaga gacagagaga gagagacaga gagagagagc
     1861 gcgagtgtgt gtgtagggag gctttcttct agaatgagtt agtttgttcc cttctttctg
     1921 tgtgattgtt gtaagtttcc tgatgggtcg gctgcctgtg tgcctcaggg ctggtgcggc
     1981 ttcctggacc acccatttgt ccttgtttgc agacctcttt gggagtgatg taggtctctg
     2041 ttgacataag tcaacaatgg tttgtcaagg ttgggggggt gctttccaca ggaatatttg
     2101 ggggggatga taagtggagt ctctgaaatt caaaggctgg ttgtccaggg atggcaccac
     2161 ctaccaatca gccccttccc acgtccccat caggctgtct gctgtctaca tctgagggtg
     2221 gcatgggctg agcccctcag cagctctacc ccaggactgc tcctcacctc acccttggcc
     2281 ttcctgcctc cttgtatctt atcaagggac ctgttattcc ctttcagctt ccaaagctac
     2341 ttcagcccag tggttctgag aggagagtgc ccttccagag tcccaggaca cagggccttg
     2401 gcacccaccc ttcttcctcc ctctggcaat gagagaccag aggcttcaag tgggggtctc
     2461 acgtgctcgg tctcagcgct agagaatacc gagacctgat ccacagtccg tgggaatggt
     2521 ctcccacggc atttttcaca gccatactcc ctccccccag cgcacccagg cccgggtgag
     2581 ctagctcaga cccctcaggg gccaggggct cagaaacctc tcatgtggag cctgctggcc
     2641 ggggtgggtc ctgccatcca ctcctgcatt tcatggggca caagcccagc agcagcccca
     2701 acctgccacc ggcctgagac actgagcccg tggcttttcc ttattgaaag taggcatgag
     2761 tacccccttc tgggccttct gaggaggggg acgaaatgcg tgtgtgcaca tgtgtctgtt
     2821 gaatgctgag gaggctgtgt ccaggcaggg tggacccctg cattgttccc ccccgtgttg
     2881 tgggcacaca cccagtgaca cctggactat gtctccagta gcctgactag caggaggctg
     2941 gcaagtcttt ctagaaacct acgcactgcc tggctcgtct gcagctgcag acacttaatt
     3001 cctcaacagg agcaggtttt ccacctgctg ttccttccag gggcacctgt ctccttccac
     3061 acaggtccat gttgtgtctg aaactagtgc atccgtgtct gtctgtgtgc tgtctgtgtc
     3121 actgttcttg tgggtgtctg cacagttccc tggtcactgc tctgtggtgc atcctctctg
     3181 agggtgcgga tcaggctgtg ctccacccgt tgtccagcag tggctttttc ttagataatt
     3241 gtgcttcctc agcgcccgcc gggttgtggc atccttggat ctgcggggat cttctgtgtt
     3301 tgcatgttcc tcagggtggt gtgtcccttg ctcccttggt ctgacgcgtg ttcccttgcc
     3361 tgcatggact tctctggttc tgtgtttgtg tgctgaatgc cacccagtgt tctgtgatca
     3421 cccatgtagc tactgaaaaa tggctgggta agcaagccag gggtgttggg gaggtcagga
     3481 gagagatcaa catgcctctc ccctccccct ccccagacat agcaagaagc atttctaaca
     3541 tctaggttga gaacaagcct gaatggtacc catggttggg agagagaact tgaacttcaa
     3601 atcgactttc cagaccagat cgagccccac ccttactttt agccttctgg gagccaccac
     3661 caggcgaggc ccagagccgg ctatgcccgg tgtactcctg ccaacccctg ccaccagccc
     3721 cagcccctgc caatgcggac cccagaccac ttgcacccag acgggtgggg tgggagctgt
     3781 ccgttcagga ccacaagcca tcctctgccc tggcttagag ggcagagcac accccaatgc
     3841 ttctgcctct gtcacttcat ctctccactc ctctcccttc tcctctcccc tgcggcaccc
     3901 acggtgccag ggacagacgc tgacatctag ctcttgccct gccccttact ggagtctgtg
     3961 ccaagccctc ctctccgtca ctgtgttcac acttggcact ttgctggccc tgagaaaggt
     4021 aacgacagcc gcaaatctaa tccgcatatt tcccatcgac tccgtaatct gattgatgtt
     4081 ccctcttgca ctgaataata catgcctctc tcaggtaagc cattttataa aataagagat
     4141 aaaacgcact gtcgagacag tgtttgcttc tgccgatggt gtccgacagc accctgggca
     4201 ttagggtggt agagctgcca cggaggctcc caggccctag gggctgagag ctcacttgaa
     4261 ttgtaagcct tcttgctttt gataacacag tattatttct cttactgtag aagaaaaagt
     4321 ttattaccaa acaagagtat ttttatgaaa gaataggaca aacctataaa ttatctcaac
     4381 ctatatctcc cttgaaaata ctttcaggct ccgccaaaac ctaggactga aagcaagtat
     4441 tttggaagaa agagatacat ttttgtatgc tttcttttcc ttttgtagac gcccgactta
     4501 ttttctaaga ctgcaaagat cactttgtca ccagccctgg gacctgaggc caaggggttg
     4561 tcttgtgggc agtgaggggg aaggacaggc tggcctgagg ttcacagtca ttccagtgag
     4621 ctctgatgag gggccaccag atcttgaggg tgtgtaaggg accaggaggt taaaaagaaa
     4681 ggcccctgat ggtgggctct ttgtgttgga gctgaaaggt tatatggaag gagataagaa
     4741 tttggatacc agttctgagc ttgatagaag gaattagggt cactctggct aacatagggg
     4801 tacagcatcc ttagtaaccc gagcgtggct cgaagtggtc atgatttcat ccaaaacaca
     4861 atgtgtaaac ttactcagct aacaatggga aatgtattgc ttctgtgcgc agtggactta
     4921 cgtgcaattt gttcaaaagg gaacaagtca ttgaggagaa acaaaagccc aatacttaga
     4981 gtcccaattt tgtcttattt gccaaaaaaa aagcaacccc ccaagagttg atattgttac
     5041 aatgtacata ctgtaaaata tgaaagaatc gatgtatctt actttttcat tatttgctaa
     5101 ccaaagctgt acatttttca tacaatccgc agccttttga gtatcaaagg ggtaaaccac
     5161 acccatcagc cattctggaa gtgcactatt tatactggta tccttgcttt ttttttccca
     5221 ttttcttgct gagatgacat gaattgttaa gtttattttt acacagtaaa gagtgaagaa
     5281 agac
//
