LOCUS       NM_001406062            2402 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus neuroplastin (Nptn), transcript variant 5, mRNA.
ACCESSION   NM_001406062 XM_006510882
VERSION     NM_001406062.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Kitamura,R.A., Hummel,D., Ustione,A., Piston,D.W. and Urano,F.
  TITLE     Dual role of neuroplastin in pancreatic beta cells: Regulating
            insulin secretion and promoting islet inflammation
  JOURNAL   Proc Natl Acad Sci U S A 121 (33), e2411234121 (2024)
   PUBMED   39666939
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Chen,J., Lin,X., Bhattacharya,S., Wiesehofer,C., Wennemuth,G.,
            Muller,K. and Montag,D.
  TITLE     Neuroplastin Expression in Male Mice Is Essential for Fertility,
            Mating, and Adult Testosterone Levels
  JOURNAL   Int J Mol Sci 25 (1), 177 (2023)
   PUBMED   38203350
  REMARK    GeneRIF: Neuroplastin Expression in Male Mice Is Essential for
            Fertility, Mating, and Adult Testosterone Levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   Wu,D.D., Cheng,J., Zheng,Y.N., Liu,Y.T., Hou,S.X., Liu,L.F.,
            Huang,L. and Yuan,Q.L.
  TITLE     Neuroplastin 65 deficiency reduces amyloid plaque formation and
            cognitive deficits in an Alzheimer's disease mouse model
  JOURNAL   Front Cell Neurosci 17, 1129773 (2023)
   PUBMED   37213217
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2402)
  AUTHORS   Ren,H., Xia,X., Dai,X. and Dai,Y.
  TITLE     The role of neuroplastin65 in macrophage against E. coli infection
            in mice
  JOURNAL   Mol Immunol 150, 78-89 (2022)
   PUBMED   36007354
  REMARK    GeneRIF: The role of neuroplastin65 in macrophage against E. coli
            infection in mice.
REFERENCE   6  (bases 1 to 2402)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   7  (bases 1 to 2402)
  AUTHORS   Fenske,T.S., McMahon,C., Edwin,D., Jarvis,J.C., Cheverud,J.M.,
            Minn,M., Mathews,V., Bogue,M.A., Province,M.A., McLeod,H.L. and
            Graubert,T.A.
  TITLE     Identification of candidate alkylator-induced cancer susceptibility
            genes by whole genome scanning in mice
  JOURNAL   Cancer Res 66 (10), 5029-5038 (2006)
   PUBMED   16707424
REFERENCE   8  (bases 1 to 2402)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2402)
  AUTHORS   Coghill,E.L., Hugill,A., Parkinson,N., Davison,C., Glenister,P.,
            Clements,S., Hunter,J., Cox,R.D. and Brown,S.D.
  TITLE     A gene-driven approach to the identification of ENU mutants in the
            mouse
  JOURNAL   Nat Genet 30 (3), 255-256 (2002)
   PUBMED   11850622
REFERENCE   10 (bases 1 to 2402)
  AUTHORS   Shirozu,M., Tada,H., Tashiro,K., Nakamura,T., Lopez,N.D.,
            Nazarea,M., Hamada,T., Sato,T., Nakano,T. and Honjo,T.
  TITLE     Characterization of novel secreted and membrane proteins isolated
            by the signal sequence trap method
  JOURNAL   Genomics 37 (3), 273-280 (1996)
   PUBMED   8938438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030640.9.
            
            On May 10, 2022 this sequence version replaced XM_006510882.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.165587.1,
                                           SRR17784643.439539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               CT030640.9         100854-101117       c
            265-612             CT030640.9         64370-64717         c
            613-781             CT030640.9         59525-59693         c
            782-876             CT030640.9         55452-55546         c
            877-1010            CT030640.9         42578-42711         c
            1011-1284           CT030640.9         39578-39851         c
            1285-1306           CT030640.9         32862-32883         c
            1307-1381           CT030640.9         32048-32122         c
            1382-2402           CT030640.9         30501-31521         c
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.79 cM"
     gene            1..2402
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /note="neuroplastin"
                     /db_xref="GeneID:20320"
                     /db_xref="MGI:MGI:108077"
     exon            1..264
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1367
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 5; stromal cell derived factor receptor 1"
                     /codon_start=1
                     /product="neuroplastin isoform 4 precursor"
                     /protein_id="NP_001392991.1"
                     /db_xref="GeneID:20320"
                     /db_xref="MGI:MGI:108077"
                     /translation="MSGSSLPGALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLT
                     GDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLR
                     ITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRE
                     SLLPVTLQCNLTSSSHTLMYSYWTRNGVELTATRKNASNMEYRINKPRAEDSGEYHCV
                     YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWIWRKKENG
                     VFEEISNSSGRFFITNKENYTELSIVNLQITEDPGEYECNATNSIGSASVSTVLRVRS
                     HLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLR
                     QRNTN"
     exon            265..612
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..781
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..876
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1010
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1284
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1306
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1381
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..2402
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /note="hexamer: AATAAA"
     polyA_site      2402
                     /gene="Nptn"
                     /gene_synonym="NP65; Sdfr1; SDR-1"
                     /note="major polyA site"
ORIGIN      
        1 gaggcttgga cgctgcggcg gtaggaggag gacagggaag gacggagctc ggccgcggct
       61 gcctccctcg ttcactccct cgcgcgcgcg ctcgcccgcc ccctccctcc ctcccctccc
      121 tttccccggc cccggccccg gcccattcgc tgcgcgctct ccggctaggg aggatgtcgg
      181 gctcgtcgct ccccggcgcc ctggccctct cgctcttgct ggtctctggc tcgctccttc
      241 cagggccagg cgctgctcag aacgctgggt ttgtcaagtc gcccatgtca gaaactaagc
      301 tcacggggga cgcctttgag ctgtactgtg acgtggtcgg gagtcccacg ccagagatcc
      361 agtggtggta cgcagaagtc aaccgggcag agtctttcag acagctgtgg gacggtgctc
      421 ggaagcgccg tgtcaccgta aacaccgcct acgggtcaaa cggcgtgagt gtgctgagaa
      481 taacccggct caccttggag gactctggga cttacgagtg cagggccagc aacgacccca
      541 agaggaatga cttgaggcaa aacccttcca taacatggat tcgagcccag gccaccataa
      601 gcgtccttca gaaaccaaga attgtcacca gtgaagaggt cattattcga gaaagcctcc
      661 ttcctgtcac cctgcagtgt aacctcactt ccagctctca cacccttatg tacagctact
      721 ggacaaggaa tggggtagaa ctcactgcca cccgtaagaa tgccagcaac atggagtaca
      781 ggatcaataa gccaagagct gaggattcag gcgaatacca ctgtgtatat cattttgtca
      841 gcgctcctaa agcaaatgcc accattgaag tgaaagctgc tcctgacatc actggccata
      901 aacgaagtga aaacaaaaat gaagggcagg atgctatgat gtactgcaag tcagttggct
      961 acccccaccc agagtggata tggcgcaaga aggagaatgg tgtgtttgag gagatttcta
     1021 atagctctgg tcgcttcttc atcaccaaca aggagaatta cactgaattg agtattgtga
     1081 atctccaaat cacagaagat cctggagagt atgaatgtaa tgccaccaac tccattggct
     1141 ctgcctccgt ttccaccgtc ctcagggtac ggagccacct tgccccactt tggcctttct
     1201 tgggaattct ggctgaaatc atcatccttg tggtgatcat tgttgtgtat gagaagagga
     1261 agaggccaga tgaggttcct gatgatgatg aaccagctgg gccaatgaaa accaactcta
     1321 ccaacaatca caaagataaa aacttgcgcc agagaaacac aaattaagta ctgcttttaa
     1381 tctctttagg ttcctgaaaa acgatggcaa catgacctgc taagttttct gcttggacct
     1441 ctttggtctc tctccctttc aagtgagcaa caccacaatg accgtctaaa gcatgcctta
     1501 tttagcctct cctataaggg tgacctagcc aggtacattt taaacaatgc ttcagtgtag
     1561 aaggtgtaaa ctattttggg cttgatgtgc tgtgaatgtt gctttccctc cctttgttaa
     1621 aaatatttaa atagaaatga aaaggtcctc tgaggatcag atcatgcatg cgccattttt
     1681 tacttatgca gctgttaaat tggcaaagct ctaaacgcac tgctgccatc tagtgatcat
     1741 tttgtaaagt acagcaaaac ctacagatat atacagtata taaatatata tatatattta
     1801 tatttttggg ggtgggagaa atccaaaata aagtcaacgc ttgtttcatt ttaagctgct
     1861 gatactcatt ccttattatt tgtcgtcaga tgaggaagct gcagttctgg tacaaactga
     1921 tgagagtgta tagacttaag tctggcattc taagggctta ccgtataact ttaggaacct
     1981 ggaacagtcc actgaacggc tagaatgaat tgcagtatat atgtatgatt gattgctttt
     2041 taagtgacta tttttcctct tgtcaaatca tgtaaattct gaaatctttt gcactgatgt
     2101 gtcaaacctt attcttgtat attcaatcaa ggcaactttt ataatttccc atttgttttc
     2161 aatgaccctg aaatgttaat agcatggtga tattctatgc aactctagtt acaccttttg
     2221 gtttgacact gtattttcac attgatttca tgactgatga tagattttat aacctgactg
     2281 ggttctcatg cggtactaac tgtagatgca tgtacttgtg ttctgtgtaa ttattgaagt
     2341 gcaatggtgt acaaaaaaag tggattcacc tgtttttaac aataaaacat tgataaaagg
     2401 tg
//
