LOCUS       NM_175678               3791 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus neuropeptide S receptor 1 (Npsr1), mRNA.
ACCESSION   NM_175678
VERSION     NM_175678.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3791)
  AUTHORS   Peng,Y., Chen,L., Chen,X., Lin,J., Wei,J., Cheng,J., Zhou,F.,
            Ge,L., Zhou,R., Ding,F. and Wang,X.
  TITLE     NPSR1 promotes chronic colitis through regulating CD4+ T cell
            effector function in inflammatory bowel disease
  JOURNAL   Int Immunopharmacol 142 (Pt B), 113252 (2024)
   PUBMED   39332092
  REMARK    GeneRIF: NPSR1 promotes chronic colitis through regulating CD4[+] T
            cell effector function in inflammatory bowel disease.
REFERENCE   2  (bases 1 to 3791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3791)
  AUTHORS   Li,C., Ma,Y., Cai,Z., Wan,Q., Tian,S., Ning,H., Wang,S., Chen,J.L.
            and Yang,G.
  TITLE     Neuropeptide S and its receptor NPSR enhance the susceptibility of
            hosts to pseudorabies virus infection
  JOURNAL   Res Vet Sci 146, 15-23 (2022)
   PUBMED   35298925
  REMARK    GeneRIF: Neuropeptide S and its receptor NPSR enhance the
            susceptibility of hosts to pseudorabies virus infection.
REFERENCE   4  (bases 1 to 3791)
  AUTHORS   Garau,C., Liu,X., Calo,G., Schulz,S. and Reinscheid,R.K.
  TITLE     Neuropeptide S Encodes Stimulus Salience in the Paraventricular
            Thalamus
  JOURNAL   Neuroscience 496, 83-95 (2022)
   PUBMED   35710064
REFERENCE   5  (bases 1 to 3791)
  AUTHORS   Dong,Q., Gentry,N.W., McMahon,T., Yamazaki,M., Benitez-Rivera,L.,
            Wang,T., Gan,L., Ptacek,L. and Fu,Y.H.
  TITLE     Familial natural short sleep mutations reduce Alzheimer pathology
            in mice
  JOURNAL   iScience 25 (4), 103964 (2022)
   PUBMED   35496999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3791)
  AUTHORS   Zhu,H., Mingler,M.K., McBride,M.L., Murphy,A.J., Valenzuela,D.M.,
            Yancopoulos,G.D., Williams,M.T., Vorhees,C.V. and Rothenberg,M.E.
  TITLE     Abnormal response to stress and impaired NPS-induced
            hyperlocomotion, anxiolytic effect and corticosterone increase in
            mice lacking NPSR1
  JOURNAL   Psychoneuroendocrinology 35 (8), 1119-1132 (2010)
   PUBMED   20171785
  REMARK    GeneRIF: NPSR1 is essential in mediating NPS effects on behavior.
REFERENCE   7  (bases 1 to 3791)
  AUTHORS   Duangdao,D.M., Clark,S.D., Okamura,N. and Reinscheid,R.K.
  TITLE     Behavioral phenotyping of neuropeptide S receptor knockout mice
  JOURNAL   Behav Brain Res 205 (1), 1-9 (2009)
   PUBMED   19646487
REFERENCE   8  (bases 1 to 3791)
  AUTHORS   Allen,I.C., Pace,A.J., Jania,L.A., Ledford,J.G., Latour,A.M.,
            Snouwaert,J.N., Bernier,V., Stocco,R., Therien,A.G. and Koller,B.H.
  TITLE     Expression and function of NPSR1/GPRA in the lung before and after
            induction of asthma-like disease
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 291 (5), L1005-L1017 (2006)
   PUBMED   16829631
  REMARK    GeneRIF: GPRA may contribute to the asthmatic phenotype by altering
            the activity of other pathways, such as neurally mediated
            mechanisms, that contribute to disease
REFERENCE   9  (bases 1 to 3791)
  AUTHORS   Usui,M., Aoshima,H., Yamamoto,Y., Luziga,C. and Mamba,K.
  TITLE     Characterization and distribution of an arginine vasotocin receptor
            in mouse
  JOURNAL   J Vet Med Sci 68 (7), 655-661 (2006)
   PUBMED   16891776
  REMARK    GeneRIF: The isolation and characterization of an arginine
            vasotocin receptor in mice is reported.
REFERENCE   10 (bases 1 to 3791)
  AUTHORS   Laitinen,T., Polvi,A., Rydman,P., Vendelin,J., Pulkkinen,V.,
            Salmikangas,P., Makela,S., Rehn,M., Pirskanen,A., Rautanen,A.,
            Zucchelli,M., Gullsten,H., Leino,M., Alenius,H., Petays,T.,
            Haahtela,T., Laitinen,A., Laprise,C., Hudson,T.J., Laitinen,L.A.
            and Kere,J.
  TITLE     Characterization of a common susceptibility locus for
            asthma-related traits
  JOURNAL   Science 304 (5668), 300-304 (2004)
   PUBMED   15073379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033957.1.
            
            On Apr 6, 2007 this sequence version replaced NM_175678.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033957.1, ERR3363658.4632505.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849383,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3791              AK033957.1         2-3792
FEATURES             Location/Qualifiers
     source          1..3791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 9.99 cM"
     gene            1..3791
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /note="neuropeptide S receptor 1"
                     /db_xref="GeneID:319239"
                     /db_xref="MGI:MGI:2441738"
     exon            1..49
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..237
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1206
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /note="G protein-coupled receptor 154; vasotocin receptor;
                     G protein-coupled receptor PGR14"
                     /codon_start=1
                     /product="neuropeptide S receptor"
                     /protein_id="NP_783609.1"
                     /db_xref="CCDS:CCDS22930.1"
                     /db_xref="GeneID:319239"
                     /db_xref="MGI:MGI:2441738"
                     /translation="MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALVAEEWGSF
                     YSSFKTEQLITLWVLFVVTIVGNSVVLFSTCRRKRKSRMTFFVTQLAITDSFTGLINI
                     LTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGE
                     KQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLV
                     YFIPLAIISVIYGLVIRTIWMKSKTHETVISNCSDGKLCCSYNRGLISKAKIKAIKYS
                     IVIILAFICCWSPYFLFDILDNFNVLPDTKERFYASVIIQNLPALNSAINPLIYCIFS
                     SSICSPCKMQRSQDSRMTYRERSERHEMQILSKPEFI"
     exon            238..370
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..474
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..568
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..770
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..847
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..934
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1115
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..3791
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3773..3778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /note="putative"
     polyA_site      3791
                     /gene="Npsr1"
                     /gene_synonym="9330128H10Rik; Gpr154; GPRA; MVTR; PGR14;
                     VRR1"
                     /note="putative"
ORIGIN      
        1 gaactcttca ctgaggtggg ctcagggagg gctctgtgcc tgcgttctgc tgcaggtgca
       61 gagacagtga gacctgaccc tgcctgagcc atgccagcca acctcacaga gggcagcttt
      121 catgccaacc agactgtgcc gatgctagat tcttccccag tagcttgcac tgaaattgtg
      181 acgttcactg aagcactggt ggctgaggag tggggctcct tctactcctc ctttaagaca
      241 gaacagctga taaccctgtg ggtcctgttt gtcgtcacta ttgtgggaaa ctctgttgtg
      301 ctgttctcca cgtgcagaag aaaaagaaag tccagaatga ccttctttgt gacacaattg
      361 gccatcacag actccttcac gggcctgatc aacatcttga cagacattat ttggcgattc
      421 acaggagact tcatggcccc tgacctggtt tgcagagtcg tccgctactt gcaggttgtc
      481 ctgctgtatg cctctaccta cgtcctggtg tccctcagca tagacagata ccatgccatc
      541 gtttacccca tgaagtttct tcaaggagag aagcaagcca aagtcctcat cggaatagcg
      601 tggagcctct cgttcctgtt ctccattccc acgctgatca tatttgggaa aaggacactt
      661 tccaatggtg aggtgcagtg ctgggcactg tggccggatg actcctactg gaccccgtac
      721 atgaccatcg tcgcctttct ggtgtacttc attcccttgg caattatcag cgttatctat
      781 ggccttgtga tccgaactat ttggatgaaa agcaaaaccc atgagacggt gatttccaac
      841 tgctcagatg gcaaactatg ctgcagctac aaccgagggc tcatctctaa ggcaaaaatc
      901 aaggccatca agtatagcat cgtcataatc cttgctttca tctgctgctg gagcccatac
      961 ttcctctttg acatattaga caacttcaac gtccttccag acaccaagga gcgtttctat
     1021 gcctctgtga ttatccagaa cctgcccgcc ttgaacagtg ccattaaccc cctcatctac
     1081 tgcatcttca gcagctccat ctgctccccc tgcaagatgc aaagatcaca ggattccaga
     1141 atgacatacc gagagagaag cgagagacac gagatgcaga ttctctccaa gccggaattc
     1201 atctaaaccc tgaggcagta gtgctaggct gaacttagtc agctctcctg gatctttacc
     1261 agttagtgta tgcgcttgaa tcctgagcca gttcctcctc ctgactcctg cctcacctag
     1321 cagatatatg aagccaactt tctaatgagg gcatgccacc tgcaattcac gcactagcca
     1381 ccattctcct aacacctctt tgtgtcagct tgaaaagata cgtttctctt tctgatgtct
     1441 cccagacctt cttccgttag cccagcacct gcatcatcag tggccctgtg tccttgtgaa
     1501 ctgatgacat aggcaagcag aaagatattg gatggctatc cctgagtcat ctaattacaa
     1561 ttttgaaaat aaatgtgaga cttaacaaag gttagactct taaaaaaggt tagactctta
     1621 acaaaggtaa gactctggtg gaaatcagtt ttatattgga agtttagggg gtgtagatga
     1681 gatgtttgct cctgaaatgc caagaaattc tcattcagac cctgctactg tatacatctc
     1741 caagtgcagg aggaaatgtt agcaagagca aactcccaag cattgtgatt tgtgaaaaag
     1801 gcagtacagt ttcctgcaaa acaaggacac catgcaggca cattatcacc tagcagaatg
     1861 agcacaccaa atagtgatag accctgatga tgaactccag aatgagagct gagaccttaa
     1921 actcacagca cttcggactg tgtaaaggtt cttcccttcc ctgaatcaac attcaagcca
     1981 ccctgagttc attccacaca cctcagggcc acttctgccc gtccttactc tcagactcct
     2041 cattccacac acctcagggc cacttctgcc cgtccttact ctcagaatcc tcttcatcta
     2101 gggactcagc ttcttgagtt tccaaaacag tttttgcaag ctctttgctg tgtgctgtag
     2161 cctttgtcta tctggcacct ctggcacctc tgcaaggatg tgctggtggg gcttattttg
     2221 atagggctgc aattcagtat ttataagtat aattcaaatg aactatgact aaatgttttc
     2281 gagtcaattt ttttttcctt cagattttgc cagaagtgga aatggcatca tttgactgtg
     2341 tgtacatctc cacccacagc cctatgatgc atgtgaacac actattttta gcttctcata
     2401 cagtctttga cattgaaatc tccttggcaa aatcctccat tccagagttg aaaccttttc
     2461 ttgtcctttt ggctgactgc tggttgagtc gttagcatgt tcagtctatt ttataagcac
     2521 ccattcctca ttatcttatc agctcaaaga ctgcctgctt aaggtcatgg tggtaatttt
     2581 tccacaaaat tctttttcaa ttccatctga cattagggaa agcatctctt taggcagaaa
     2641 ttagacacgg taccaactgt ctctaagtta ttagtcccca tgtttgagga gacagaataa
     2701 tctacctttc tgttcacaca acagaaagcg actttcttct tcatccaatc agctaaactt
     2761 gagcaagcag aagcattgag tggctaagaa gtacctctca gcatttctct ttaaatcaag
     2821 atgtgccaga gaaaactcaa agaactgttg ctgaaatagc tgccagtaga ggagccaatt
     2881 aacaagtaga atctggtagg tgtcctagct agcaaaacag gaggcccagg cccttgatag
     2941 atgctttcca tctctgtcaa gttctggtct accagacctg tcacatgcct gcaccatcca
     3001 ctgatcgatt cttaacatta aagagagaga gcagtgaaag ttatttttct atccatggac
     3061 tgtgacggta gcctacagga gcctgtggct ctcctgctca caggagcctg gagagcaata
     3121 aggttgttgt aggaaagtac aggttgttgt aggaaagttg ccatctatgc agaacttgct
     3181 ctacgttgag atggagtctg aaatcttcac aggccttgtt ttccaaaatt ggaaaacatg
     3241 cgttaatcat gatagtcctt agtcctatga ccctgggtga atcatgctgt gtctctgggc
     3301 accactagtc tctctctaac atgggggcag aatgacagtg gagcagagga cattgaggtt
     3361 tagagactgt catagattaa attagacttg cagaaaagtg ctgctagaat tctccccttt
     3421 gaagactaac actaccgtga gtcaaggttg agtcatccct tttggaagta taaattttct
     3481 ccttaccata tgagctcagt aatatcccaa acaggaaagg atgtaataga aaattagaat
     3541 gtaaaccaca gtgttgctat ctgtagccct tgatgctccc atgggacaag taaaaagaca
     3601 gtaaggtggc atttaaaata aaggtgccta ccttccacac caagatgtta aaaaatgtgt
     3661 gaatgtgtga gtatattatc acacagcttc aaggacaggt aaaaatttag gctgatcggg
     3721 caaatgtgtt taaaatattc agtaacacta cagaaaatat ctcttttatt gaaataaatt
     3781 caatatgaat g
//
