LOCUS       NM_001163611             860 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus neuropeptide S (Nps), mRNA.
ACCESSION   NM_001163611 XM_001479305 XM_001479833
VERSION     NM_001163611.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Huang,D., Zhang,R., Gasparini,S., McDonough,M.C., Paradee,W.J. and
            Geerling,J.C.
  TITLE     Neuropeptide S (NPS) neurons: Parabrachial identity and novel
            distributions
  JOURNAL   J Comp Neurol 530 (18), 3157-3178 (2022)
   PUBMED   36036349
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Garau,C., Liu,X., Calo,G., Schulz,S. and Reinscheid,R.K.
  TITLE     Neuropeptide S Encodes Stimulus Salience in the Paraventricular
            Thalamus
  JOURNAL   Neuroscience 496, 83-95 (2022)
   PUBMED   35710064
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Roncace,V., Polli,F.S., Zojicic,M. and Kohlmeier,K.A.
  TITLE     Neuropeptide S (NPS) is a neuropeptide with cellular actions in
            arousal and anxiety-related nuclei: Functional implications for
            effects of NPS on wakefulness and mood
  JOURNAL   Neuropharmacology 126, 292-317 (2017)
   PUBMED   28655610
  REMARK    GeneRIF: Study showed that the actions of neuropeptide S influenced
            the excitability of dorsal raphe and laterodorsal tegmentum
            neurons, which could play a role in the anxiolytic and
            arousal-promoting effects of this peptide.
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Liu,X., Si,W., Garau,C., Jungling,K., Pape,H.C., Schulz,S. and
            Reinscheid,R.K.
  TITLE     Neuropeptide S precursor knockout mice display memory and arousal
            deficits
  JOURNAL   Eur J Neurosci 46 (1), 1689-1700 (2017)
   PUBMED   28548278
  REMARK    GeneRIF: NPS-/- mice display significant deficits in exploratory
            activity, long-term memory and arousal.
REFERENCE   5  (bases 1 to 860)
  AUTHORS   Shao,Y.F., Wang,C., Xie,J.F., Kong,X.P., Xin,L., Dong,C.Y., Li,J.,
            Ren,W.T. and Hou,Y.P.
  TITLE     Neuropeptide S ameliorates olfactory spatial memory impairment
            induced by scopolamine and MK801 through activation of cognate
            receptor-expressing neurons in the subiculum complex
  JOURNAL   Brain Struct Funct 221 (6), 3327-3336 (2016)
   PUBMED   26323488
  REMARK    GeneRIF: Findings demonstrate that neuropeptide S, via selective
            activation of the neurons bearing neuropeptide S receptor in the
            subiculum complex, ameliorates olfactory spatial memory impairment
            induced by scopolamine and MK801 in mice.
REFERENCE   6  (bases 1 to 860)
  AUTHORS   Okamura,N., Garau,C., Duangdao,D.M., Clark,S.D., Jungling,K.,
            Pape,H.C. and Reinscheid,R.K.
  TITLE     Neuropeptide S enhances memory during the consolidation phase and
            interacts with noradrenergic systems in the brain
  JOURNAL   Neuropsychopharmacology 36 (4), 744-752 (2011)
   PUBMED   21150909
  REMARK    GeneRIF: Neuropeptide S knock-out mice display deficits in
            inhibitory avoidance memory indicating involvement in central
            noradrenergic systems.
REFERENCE   7  (bases 1 to 860)
  AUTHORS   Castro,A.A., Casagrande,T.S., Moretti,M., Constantino,L.,
            Petronilho,F., Guerra,G.C., Calo',G., Guerrini,R., Dal-Pizzol,F.,
            Quevedo,J. and Gavioli,E.C.
  TITLE     Lithium attenuates behavioral and biochemical effects of
            neuropeptide S in mice
  JOURNAL   Peptides 30 (10), 1914-1920 (2009)
   PUBMED   19616051
  REMARK    GeneRIF: Data suggest that lithium evokes antagonistic effects on
            the mediation of hyperlocomotion and protection against lipid
            peroxidation induced by neuropeptide S.
REFERENCE   8  (bases 1 to 860)
  AUTHORS   Han,R.W., Yin,X.Q., Chang,M., Peng,Y.L., Li,W. and Wang,R.
  TITLE     Neuropeptide S facilitates spatial memory and mitigates spatial
            memory impairment induced by N-methyl-D-aspartate receptor
            antagonist in mice
  JOURNAL   Neurosci Lett 455 (1), 74-77 (2009)
   PUBMED   19429110
  REMARK    GeneRIF: NPS facilitates spatial memory and mitigates MK801-induced
            spatial memory impairment in mice.
REFERENCE   9  (bases 1 to 860)
  AUTHORS   Meis,S., Bergado-Acosta,J.R., Yanagawa,Y., Obata,K., Stork,O. and
            Munsch,T.
  TITLE     Identification of a neuropeptide S responsive circuitry shaping
            amygdala activity via the endopiriform nucleus
  JOURNAL   PLoS One 3 (7), e2695 (2008)
   PUBMED   18628994
  REMARK    GeneRIF: analysis of a neuropeptide S responsive circuitry shaping
            amygdala activity via the endopiriform nucleus
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 860)
  AUTHORS   Xu,Y.L., Reinscheid,R.K., Huitron-Resendiz,S., Clark,S.D., Wang,Z.,
            Lin,S.H., Brucher,F.A., Zeng,J., Ly,N.K., Henriksen,S.J., de
            Lecea,L. and Civelli,O.
  TITLE     Neuropeptide S: a neuropeptide promoting arousal and
            anxiolytic-like effects
  JOURNAL   Neuron 43 (4), 487-497 (2004)
   PUBMED   15312648
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC136641.3 and AC131669.3.
            
            On or before Jul 26, 2009 this sequence version replaced
            XM_001479305.1, XM_001479833.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2161539.1,
                                           ERR3363658.3968973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC136641.3         214235-214262
            29-110              AC136641.3         214375-214456
            111-860             AC131669.3         53387-54136
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 81.27 cM"
     gene            1..860
                     /gene="Nps"
                     /note="neuropeptide S"
                     /db_xref="GeneID:100043254"
                     /db_xref="MGI:MGI:3642232"
     exon            1..28
                     /gene="Nps"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..290
                     /gene="Nps"
                     /codon_start=1
                     /product="neuropeptide S precursor"
                     /protein_id="NP_001157083.1"
                     /db_xref="CCDS:CCDS52420.1"
                     /db_xref="GeneID:100043254"
                     /db_xref="MGI:MGI:3642232"
                     /translation="MIGSLKLSFVLALSLSVMHVLWCYPVLSSKVPGKPDYFLILLSS
                     CPARLEGSDRLAFLKPILEKTSMKRSFRNGVGSGAKKTSFRRAKQ"
     exon            29..110
                     /gene="Nps"
                     /inference="alignment:Splign:2.1.0"
     exon            111..860
                     /gene="Nps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggtctcgg aaaatccaaa atgattggct cgttaaaact cagcttcgtc ttagctctgt
       61 cgctgtctgt aatgcacgtg ctttggtgtt atccggtcct ctcttccaag gtgcctggga
      121 agcctgatta ctttctcatc ttgctgagca gctgcccagc caggctggag gggagcgaca
      181 ggctagcttt tctaaagcca attttggaga agacatcgat gaaaaggtcc tttcgcaacg
      241 gagtcggctc aggggcgaaa aaaacttcgt ttcgaagagc aaagcaatga ataagtgtgc
      301 aaaggactct gggaattaat ctcaagctat gtagagtgtg actgatgtgc taaaaacggt
      361 tgtatcttac cataagatgt tgcttccctc ctcatcctca gatatccccc ttctcctaac
      421 gggctcagag taaattaagt tttgggggaa aattgcaaac ctgtctcaaa cttctgcctg
      481 tgagtgaaaa aacgatttct gtgcttagct agaaacttcc acgaatacgg aggggaggga
      541 ttcatcggct ttgatcttga gtcggccaca atgcgtgagt gtttttttac tgtgcttttt
      601 ctcctgtggt cttcctgtgc tgtgccacca agtgcagtgg caggtatatg ccatttctcc
      661 tttaaaatga gatttcctca aatgactcag ctgtgctgtt tctgtttgta aaagaatctc
      721 aagaaattcc agtaagaaga tgaatggtgc ccctggatct atggctcagc caattggtac
      781 ctgcagcaag ggctcgcccc ctctgggtct gtttttccct ctcctttttc cgattccaaa
      841 tatacttaaa tatgactgat
//
