LOCUS       NM_018879               1473 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus NPR2 like, GATOR1 complex subunit (Nprl2), mRNA.
ACCESSION   NM_018879 XM_978349 XM_978379 XM_978404 XM_978435
VERSION     NM_018879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Jiang,C., Dai,X., He,S., Zhou,H., Fang,L., Guo,J., Liu,S.,
            Zhang,T., Pan,W., Yu,H., Fu,T., Li,D., Inuzuka,H., Wang,P., Xiao,J.
            and Wei,W.
  TITLE     Ring domains are essential for GATOR2-dependent mTORC1 activation
  JOURNAL   Mol Cell 83 (1), 74-89 (2023)
   PUBMED   36528027
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Ishida,S., Zhao,D., Sawada,Y., Hiraoka,Y., Mashimo,T. and Tanaka,K.
  TITLE     Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel
            mouse models for GATORopathy
  JOURNAL   Hum Mol Genet 31 (9), 1519-1530 (2022)
   PUBMED   34965576
  REMARK    GeneRIF: Dorsal telencephalon-specific Nprl2- and Nprl3-knockout
            mice: novel mouse models for GATORopathy.
REFERENCE   3  (bases 1 to 1473)
  AUTHORS   Dentel,B., Angeles-Perez,L., Ren,C., Jakkamsetti,V., Holley,A.J.,
            Caballero,D., Oh,E., Gibson,J., Pascual,J.M., Huber,K.M., Tu,B.P.
            and Tsai,P.T.
  TITLE     Increased glycine contributes to synaptic dysfunction and early
            mortality in Nprl2 seizure model
  JOURNAL   iScience 25 (5), 104334 (2022)
   PUBMED   35602938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1473)
  AUTHORS   Hui,J.B., Silva,J.C.H., Pelaez,M.C., Sevigny,M.,
            Venkatasubramani,J.P., Plumereau,Q., Chahine,M., Proulx,C.D.,
            Sephton,C.F. and Dutchak,P.A.
  TITLE     NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and
            Brain Amino Acid Homeostasis
  JOURNAL   eNeuro 9 (2) (2022)
   PUBMED   35165201
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1473)
  AUTHORS   Yuan,F., Wang,Z., Sun,Y., Wei,H., Cui,Y., Wu,Z., Zhang,C.,
            Xie,K.P., Wang,F. and Zhang,M.
  TITLE     Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity
            and p21 expression that block germ cell development
  JOURNAL   Cell Death Dis 12 (6), 574 (2021)
   PUBMED   34083520
  REMARK    GeneRIF: Sgpl1 deletion elevates S1P levels, contributing to NPR2
            inactivity and p21 expression that block germ cell development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1473)
  AUTHORS   Dutchak,P.A., Estill-Terpack,S.J., Plec,A.A., Zhao,X., Yang,C.,
            Chen,J., Ko,B., Deberardinis,R.J., Yu,Y. and Tu,B.P.
  TITLE     Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis
            and Altered Fiber Composition in Skeletal Muscle
  JOURNAL   Cell Rep 23 (7), 1907-1914 (2018)
   PUBMED   29768191
REFERENCE   7  (bases 1 to 1473)
  AUTHORS   Dutchak,P.A., Laxman,S., Estill,S.J., Wang,C., Wang,Y., Wang,Y.,
            Bulut,G.B., Gao,J., Huang,L.J. and Tu,B.P.
  TITLE     Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1
            Inhibitor NPRL2
  JOURNAL   Cell Rep 12 (3), 371-379 (2015)
   PUBMED   26166573
REFERENCE   8  (bases 1 to 1473)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131176.1, AK010331.1 and AI843290.1.
            
            On Oct 19, 2007 this sequence version replaced NM_018879.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026548.1, AF131207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BY131176.1         1-84
            85-1455             AK010331.1         3-1373
            1456-1473           AI843290.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.12 cM"
     gene            1..1473
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /note="NPR2 like, GATOR1 complex subunit"
                     /db_xref="GeneID:56032"
                     /db_xref="MGI:MGI:1914482"
     exon            1..245
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1310
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /note="tumor suppressor candidate 4; nitrogen permease
                     regulator 2-like protein; gene 21 protein; NPR2-like
                     protein; nitrogen permase homolog; GATOR complex protein
                     NPRL2; nitrogen permease regulator-like 2"
                     /codon_start=1
                     /product="GATOR1 complex protein NPRL2"
                     /protein_id="NP_061367.1"
                     /db_xref="CCDS:CCDS23492.1"
                     /db_xref="GeneID:56032"
                     /db_xref="MGI:MGI:1914482"
                     /translation="MGSSCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYI
                     ITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIV
                     KKLAGYLTTLELESSFVSNEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVI
                     EQRPDPPVAQEYDVPVFTKDKEDFFSSQWDLTTQQILPYIDGFRHVQKISAEADVELN
                     LVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRA
                     SLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVS
                     REERSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK"
     exon            246..337
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            338..506
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            507..615
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            616..752
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..850
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..887
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            888..981
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1099
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1242
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1458
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1430..1435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /note="hexamer: AATAAA"
     polyA_site      1458
                     /gene="Nprl2"
                     /gene_synonym="2810446G01Rik; G21; NPR2L; Tusc4"
                     /note="major polyA site"
ORIGIN      
        1 tgagtcgccc tgcgcaggcg ctgttgagtt gacggctcgt tgggtttgcg ctcacaaacc
       61 tgtgtgacct acccgggcct ctttctcttt ttgacagggt attccaaggc gtagaggcga
      121 tccccacacg aaaaacaggg attacagact tggatccaga cagcgccatg ggcagcagct
      181 gccgcatcga atgtatattc ttcagcgagt tccacccaac gctgggaccc aaaattacct
      241 atcaggtccc tgaggatttc atctcgcgag aactgtttga cacggtccag gtgtacatca
      301 tcaccaagcc cgagttacag aacaagctca tcactgtcac agccatggag aagaagctga
      361 ttggctgccc cgtgtgcatt gaacacaaga agtacagccg caatgctctc ctcttcaacc
      421 tgggctttgt gtgtgacgct caggctaaga cttgtgccct ggaacccatc gttaaaaagc
      481 tggccggcta cttgaccacg ctggagcttg agagcagctt tgtatccaac gaggagagca
      541 agcagaagct ggtgcccatc atgaccatcc tgctggaaga gctgaatgcc tccggccgct
      601 gcactctgcc cattgatgaa tccaacacca tccacttgaa ggtgatcgag cagcggccag
      661 accctcctgt tgcgcaggag tatgatgtgc ccgtctttac aaaggacaag gaggatttct
      721 tcagctcaca gtgggacctt accacacagc agatcctgcc ctacattgac gggtttcgcc
      781 atgtccagaa gatctccgct gaggcagacg tggaactcaa cctggtgcgc atcgccattc
      841 agaacctgct gtactatggt gttgtgacac tggtatccat cctccagtac tccaatgtgt
      901 attgcccaac accaaaagtc caggatctgg tggatgacaa gtccctgcag gaggcatgtc
      961 tgtcctacgt caccaagcaa ggacacaaaa gggccagtct ccgagatgtg ttccagctat
     1021 actgcagcct gagccctggt accactgtgc gagacctcat tggccgccac ccccagcagt
     1081 tacaacacgt tgatgaaagg aagctgatcc agtttgggct gatgaagaac cttatccgga
     1141 gactacagaa atatccagtc cgagtgtctc gggaggagcg gagccaccct gccaggcttt
     1201 acacgggctg tcacagctat gatgagatct gctgcaagac aggcatgagc taccatgagc
     1261 tggacgagcg actagaaaat gaccccaaca tcatcatctg ctggaagtga ggctggctag
     1321 ctggaacatg ttactatggc tacttgcccc tactaaggcc tccttggtcc actggagcta
     1381 gacaagtatg gttgtacata tggtctggag ggtgagactc ggttttgtaa ataaagttat
     1441 gtgtttcatc ctgtggaaaa aaaaaaaaaa aaa
//
