LOCUS       NM_008728               7359 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus natriuretic peptide receptor 3 (Npr3), transcript
            variant 1, mRNA.
ACCESSION   NM_008728
VERSION     NM_008728.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7359)
  AUTHORS   Patino,M., Rossa,M.A., Lagos,W.N., Patne,N.S. and Callaway,E.M.
  TITLE     Transcriptomic cell-type specificity of local cortical circuits
  JOURNAL   Neuron (2024) In press
   PUBMED   39353431
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 7359)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7359)
  AUTHORS   Li,S.J., Wei,J.Q., Kang,Y.Y., Wang,R.Q., Rong,W.W., Zhao,J.J.,
            Deng,Q.W., Gao,P.J., Li,X.D. and Wang,J.G.
  TITLE     Natriuretic peptide receptor-C perturbs mitochondrial respiration
            in white adipose tissue
  JOURNAL   J Lipid Res 65 (9), 100623 (2024)
   PUBMED   39154732
  REMARK    GeneRIF: Natriuretic peptide receptor-C perturbs mitochondrial
            respiration in white adipose tissue.
REFERENCE   4  (bases 1 to 7359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 7359)
  AUTHORS   Cheng,C., Zhang,J., Li,X., Xue,F., Cao,L., Meng,L., Sui,W.,
            Zhang,M., Zhao,Y., Xi,B., Yu,X., Xu,F., Yang,J., Zhang,Y. and
            Zhang,C.
  TITLE     NPRC deletion mitigated atherosclerosis by inhibiting oxidative
            stress, inflammation and apoptosis in ApoE knockout mice
  JOURNAL   Signal Transduct Target Ther 8 (1), 290 (2023)
   PUBMED   37553374
  REMARK    GeneRIF: NPRC deletion mitigated atherosclerosis by inhibiting
            oxidative stress, inflammation and apoptosis in ApoE knockout mice.
            Erratum:[Signal Transduct Target Ther. 2023 Sep 4;8(1):329. doi:
            10.1038/s41392-023-01599-x. PMID: 37666826]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7359)
  AUTHORS   Matsukawa,N., Grzesik,W.J., Takahashi,N., Pandey,K.N., Pang,S.,
            Yamauchi,M. and Smithies,O.
  TITLE     The natriuretic peptide clearance receptor locally modulates the
            physiological effects of the natriuretic peptide system
  JOURNAL   Proc Natl Acad Sci U S A 96 (13), 7403-7408 (1999)
   PUBMED   10377427
REFERENCE   7  (bases 1 to 7359)
  AUTHORS   Savinova,O.V., Matsukawa,N., Smithies,O. and John,S.W.
  TITLE     Mouse natriuretic peptide receptor 3 gene maps to proximal
            chromosome 15
  JOURNAL   Mamm Genome 8 (10), 788 (1997)
   PUBMED   9321481
REFERENCE   8  (bases 1 to 7359)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
REFERENCE   9  (bases 1 to 7359)
  AUTHORS   Yanaka,N., Kotera,J., Taguchi,I., Sugiura,M., Kawashima,K. and
            Omori,K.
  TITLE     Structure of the 5'-flanking regulatory region of the mouse gene
            encoding the clearance receptor for atrial natriuretic peptide
  JOURNAL   Eur J Biochem 237 (1), 25-34 (1996)
   PUBMED   8620881
REFERENCE   10 (bases 1 to 7359)
  AUTHORS   Levin,E.R. and Frank,H.J.
  TITLE     Natriuretic peptides inhibit rat astroglial proliferation:
            mediation by C receptor
  JOURNAL   Am J Physiol 261 (2 Pt 2), R453-R457 (1991)
   PUBMED   1652217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134793.10.
            
            On Aug 25, 2022 this sequence version replaced NM_008728.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.4510650.1,
                                           SRR17253012.3520051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1221              AC134793.10        7291-8511
            1222-1344           AC134793.10        17593-17715
            1345-1511           AC134793.10        29933-30099
            1512-1647           AC134793.10        54645-54780
            1648-1742           AC134793.10        61875-61969
            1743-1878           AC134793.10        64793-64928
            1879-1966           AC134793.10        67012-67099
            1967-7359           AC134793.10        68109-73501
FEATURES             Location/Qualifiers
     source          1..7359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.83 cM"
     gene            1..7359
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /note="natriuretic peptide receptor 3"
                     /db_xref="GeneID:18162"
                     /db_xref="MGI:MGI:97373"
     exon            1..1221
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..2078
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; atrial natriuretic peptide receptor type C;
                     atrial natriuretic peptide clearance receptor; longjohn;
                     strigosus; Nppc receptor"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 3 isoform a
                     precursor"
                     /protein_id="NP_032754.2"
                     /db_xref="CCDS:CCDS27386.1"
                     /db_xref="GeneID:18162"
                     /db_xref="MGI:MGI:97373"
                     /translation="MRSLLLFTFSACVLLARVLLAGGASSGAGDTRPGSRRRAREALA
                     AQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSD
                     CGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQ
                     HKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEV
                     FQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTS
                     GDYAFFNIELFNSSSYGDGSWRRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEV
                     KSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTF
                     EGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFQMRSNVKYPWGPL
                     KLRLDETRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIE
                     RRNQQEESNIGKHRELREDSIRSHFSVA"
     exon            1222..1344
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1511
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1647
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1742
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1878
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1966
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..7359
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2846..2851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /note="hexamer: ATTAAA"
     polyA_site      2873
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /note="major polyA site"
     regulatory      7337..7342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /note="hexamer: ATTAAA"
     polyA_site      7359
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgaatca atgggatcaa acgcgaagga ggtgcaccgt caattacaag cacttggaca
       61 agtttaactt ttttttttct tttacaaata aggccttcaa acgcaacctt agcaacgccc
      121 aaataagaag ccacctctaa gccaaatagc ctatgtgcaa agggagggag aatatatata
      181 ttgataataa gtctatatgt atattacaga cgcacaggtt tacattctgt gaactttttt
      241 ctttctttct ttgctttaaa attttttttt ttatttttta aacctaggga cattgtagag
      301 gaatcttcct atcttttggc gagttactga agggggtatt ctgttttctt ggagcgccca
      361 agggggcgca gggacagagg aaagaaaaga gctgggagga aaagggcagg gtgggtgggg
      421 ggcagagggc gagccggcgg ccagggcgag cgcttgctgg caacacgatg cggtccttgc
      481 tgctgttcac tttctcggcg tgcgtgctgc tggcccgggt gctgctggct ggcggcgcga
      541 gcagcggcgc cggggacacc cggccaggca gcaggcgccg ggcgagagag gcgctggcgg
      601 ctcaaaagat cgaggtgctt gttctattgc cccgggacga ttcgtacttg ttctcgctgg
      661 cccgggtgag gccggccatc gagtacgcgc tgcgtagcgt ggagggcaat ggcaccggga
      721 ggaagctgct gccgccaggc actcgcttcc aggtggccta cgaagactcg gactgcggca
      781 accgcgcgct cttcagtctt gtggaccgcg tggcggcggc gcgcggcgcc aagccggatc
      841 tcatcctggg gcccgtgtgc gagtacgcgg cggcgccggt ggctcggctg gcgtctcact
      901 gggacctgcc gatgctgtcc gcaggagcgc tggccgccgg tttccagcac aaggacacgg
      961 aatactcgca cctcacgcgc gtggcgcctg cctacgccaa gatgggagag atgatgctcg
     1021 ctctgtttcg ccaccaccac tggagccgtg cagccctggt ctacagcgac gacaaactcg
     1081 agaggaactg ttatttcacc ctcgaggggg tccacgaggt ttttcaggag gaggggttgc
     1141 acacgtctgc ctacaatttc gacgagacca aagacttgga cctggacgac atagtgcgct
     1201 acatccaagg cagcgagcga gtggtgatca tgtgtgccag tggtgacacc attcggagaa
     1261 tcatgttggc ggtgcacaga cacggcatga ccagtggaga ctacgctttc ttcaacattg
     1321 aactcttcaa cagttcttcc tacggagatg gctcgtggag gagaggagac aaacacgact
     1381 ctgaagctaa acaagcatac tcgtccctcc aaacagtcac cctactgagg accgtgaaac
     1441 ctgagtttga gaagttttcc atggaggtga aaagttctgt tgagaaacaa gggctcaatg
     1501 aggaggatta cgtgaacatg tttgttgaag ggttccatga cgccatcctc ctctacgttc
     1561 tggctttaca tgaagtactc agagctggct acagcaagaa ggatgggggg aaaatcatcc
     1621 agcagacttg gaacaggaca tttgaaggta tcgccgggca ggtgtccata gatgccaacg
     1681 gggaccggta tggggacttc tctgtggttg ccatgactga cactgaagca ggcacccaag
     1741 aggtcattgg tgattacttt gggaaagaag gccggttcca aatgcgatcg aatgtcaaat
     1801 atccttgggg ccctttgaaa ctgagactag atgagaccag aatcgtggag cataccaaca
     1861 gctctccttg caaatcatca ggtggcctag aagaatctgc agtgacagga atcgttgtgg
     1921 gggccctact aggtgctggc ttgctaatgg ccttctactt tttcaggaag aaatacagaa
     1981 taaccattga gaggcgaaat cagcaagagg aaagcaacat cgggaagcat cgagagctgc
     2041 gagaagattc catcagatca catttttcgg tggcttaaaa gagatgcccc tctcgcttcg
     2101 tctacttgag attccttaaa gagatagatg gaaggacaga catcaacgga gcagaaaggg
     2161 cgttctcgga gaagtcattc ttttaagcag tagtcatttc attttacatt ttctttagaa
     2221 gctcaggaat gattgttaat cactatctgc cttctggcct ctcatctcat ggcaaactaa
     2281 tataatgaaa caacgcaatg ctgttaagtg ttctggctgc tggaggggca tcagaggaga
     2341 tttatgtctt gaaagtctgc tgcgtccata tcttgattgc tttgggggca gttcacacga
     2401 ggatagaaaa atgtggcttt tctgaaatga aatgtttcgt agctaggata aaacaatttt
     2461 tacaaggaga atattcttgg aaagaattta acacccaata agaggacaat ggaatgaaag
     2521 aaatctccag gctgggaatg cagtgcccct ctctctggaa ctgggggaca ggtttgtggt
     2581 tgatgaaggc tgcgtccaac gtccacattc aggtctgaat tcatatctca agaaaggatc
     2641 ctccctgtct cttttagtgt ctcatcagag ctactctgga aaactgtaaa tattagtgag
     2701 caaggaggat ttatataaga aaattgagtc taaaatgctt cttatacgat gtaaaaaaag
     2761 tcctacttca cactaacatt ttatttttaa gtattttaat cttatatttt ggtattagaa
     2821 atgtgtctat tttttcattt tgaagattaa atttcactta tattttaaga gcacggagga
     2881 ggtgtgtgac aaatctgtgg agagggagga acggttctcg ttttctctgc tgtcctctgt
     2941 cccttggctg tctctagtct aactgctagt ctggctgaag atgtacagaa gtctgttcag
     3001 cttacaaact ctgaaggaat acgttgatgt taagccgttg ttcattttca actgttttaa
     3061 atggatgtta ttggagggct acattctttc taactatggt caaatgatgc ccttcaaaac
     3121 cagtagactt aagtggagtc tataaagaaa cacaacccct ttccctcaag aataagcaga
     3181 cagtgagaat ttgacagcaa gacacagtgg tgatacgttt aaaaaaaaac tgcatgcaat
     3241 ttatcaaaat ttgaggtgat gattttaatt taaaaaggga atgttgatat ctgctgtgtc
     3301 cctttaacct tatagagttt tgcagccacc acaaatgatg catagcttgg acagtgagct
     3361 aggacagaca agggcatcgt ggctaagact gagccagcct ttgctgggta tcctctttgc
     3421 actcaatcct gggtgcagag gtttcaattc tggttccgac tttatcattt gaggagagaa
     3481 caagggtacc gtcttgtaat tttgcctttc ttggtaacat tctgagcatc tgaaacccag
     3541 cttaaagggg ggaaattaaa taatttcttg gaggtcctat ccatccaggt taactgtgga
     3601 ggagtccaag caagcttagc aagctctgga agctggcttc ccagggaagg agtggaccac
     3661 acctcattct ctcagtggag tcaaagtgaa tgggctgcac ctgtgtgggg ctcaggaaac
     3721 gggatgcaaa ccgcatgata aaatgaatta gcttctgaac aactgaaggg ggtgtggtag
     3781 gaggtatgtc gtggttctgc ctgtgggata ttgagggaaa agtgctgact taaaaaaaaa
     3841 aagtaggcca gaaaggcaaa ctttaaaatg ctaatccagg aggcgcgttt gtggagcaca
     3901 actcaggaag gctgcagctg atggtcaggg actcacataa tgaagacaga tgggcagact
     3961 gcatccaccc cagttctcag aaccagaggg ctgcttgttt ctctcttaca ttttcaatga
     4021 tgttttccct gtgtttcaga gatactcatt ttttaatgtt tttttttttt gaacctgtgt
     4081 gttaattgca ggagggtgac agtgggaaaa gttctctacc tggctatatt ctttgggtat
     4141 gaatatgtct aatcctttct tgaatttgta tagtttcccc ttgaatgtca gcatagttac
     4201 aacagtattt tttatttctg ctccagctag aggaattgtt ccaaggttaa tagtggatcc
     4261 ccagattaga tgttaaagaa tagattagat gtttaaaaaa taaataggca gggtgaatcg
     4321 tgaagtccct ggagtcattt cctacaattt taaagcaatt cttattatat tattatatta
     4381 ttattaatat tattaaggtt gattgctcat ttacatgcct gctgtatagt ttgtctttct
     4441 tgaatgtctt tacatggcta gacaaggtgg cccatgtctt caattccagc acttgggagg
     4501 cagaagcagg aggatatcag tgagtttagg gccaggatgg tctccatagt gagtttcaga
     4561 tcagctgtag ttacacagtt agaccttgtc tcagaaaaaa ataaatcatt atatgagtag
     4621 ccaaaatgtc attaagtttt aaaaacacca ccaagttggg aaacctttgc tgacagtata
     4681 gatgtctgtt ccatggtggc tctgggttaa aaactcttgg tattgtattg tagaacttaa
     4741 attcttaact gctaagcaac aactttgaca attagtcatt cataatctgc cagtagtcat
     4801 ctattatata attaacaaaa tggaacttta gttcttaagc cattctataa atttttactc
     4861 ttaagtccaa tgatcaaggt ttcaaagggg gggcatttca ttagtgtttt ttatatcttg
     4921 tcaaatataa gttcatacac aagctaaact aagcgtatac ttatggtgat ggaaataaac
     4981 acaagtttta tagccaatat tattgtctta gatctgggag agaagctgaa ctcagaaaca
     5041 aaactttctg ggtagagtca tatctgttcc caacacaaac agaggtttca cacggaatcc
     5101 gtcaacatgt attgttttga agagccattg gcgtgtcttt tcctgaacca cagacagaat
     5161 tccacatgtc ttgaaatagt tgtttacatt tcagaattca tggaggagag ggagaatcct
     5221 atggaatgag aacagatgcc ccacccccac ttcctttttc tcttgaatga aaagctttgg
     5281 aatgccaagt cacttcccct tgcttacagg catcctgtgc ctttgctcct ggcacatcta
     5341 ccttctgtgt ccctaactta cctcttttct tctagttggg actgattgtc agggtctaag
     5401 acatgcagtg ggacgtggaa agggaggcct tgtgtatctc agagagtggt ttcagaagct
     5461 gtttctagtg atgccattgc tttcttgaaa cagagctact cgtgcaggtg ttttagatgc
     5521 gtcacaagtg cgcgcgcgca cacacacaca cacacacaca cacacacaca cacgaaaaaa
     5581 gagaatgaaa gaatagcatt tataaattgg aaaacactag ggtctgtgtt tgttgagaca
     5641 caaagagctc agatccctaa taggtgcaac tacaaaggca aatgccaatt gaactttggc
     5701 ccactaccta tttgtgtagt tataccctac aggtctttag aagaaggctg gtaatgagct
     5761 gaatttttcc tttagtggaa aaaacagaaa ctgtctagaa atacaggatg ctttaggggc
     5821 agcatagaag tagggagaac gagccagagg cactggaggg atctgtctat ttttcagttg
     5881 gtctttagaa cagaataatg aacagtttag accttcttca aaagccagtc tccacaagaa
     5941 gtgctggaca tgcccagaga gaagaaccag gagcttatgt ctctcaaagt gacagagaga
     6001 agaagtttgc agctgacacg ggctcaactg ttcttcatag agctccacct gctatccatc
     6061 acatttctat gggtgtgcta gcacctttcc catgcaggtg gaaacttgtg aggaggcctc
     6121 ctcatttact cagagaaaaa agacaaaatc gcaccgctgt gaggaggtag ctggcttcta
     6181 ctcagaagcc tgacagcaac ttgaccatgc atgtccttgg acagtttaca tctgtgattt
     6241 tcatgtacgc gaaggaacct ggcttttttc tcagcatatg gatttttccg atgtttcctg
     6301 caggcctatg gaatgaaaat actcctccaa aggacactga gttggaggtt gttcaaatat
     6361 cgcattaacc actaatgtta attcatccca aatgcagagc atttcccaaa tgctgatgct
     6421 ggtgtttctg ttttaagtca cttcaaaggt aatcaaaagg atttcagtgg gagctgactc
     6481 tcagaggtaa aaataaatat gttacaaaaa ctctttggtc tatcaggtat catacgattc
     6541 ctagtggaga gatttgaacc aagtagacct cagagttaat aaaacatgtt ccatttcttt
     6601 gattcatatt taaaggcata aatttatatg cacaggacca ggaggtccat ttccccaagt
     6661 gtgaatcata ataggatacc gagttcattt ttactttcta gaataaagct gtcatagtct
     6721 ctacttatta ttggggagag aaagagttat ttctccagag aaagaggaaa ccatggcttt
     6781 tgatggacta tctcattcat tactcagtgc ctgtgtctga acgtgttcaa tatggtgtag
     6841 catagaagac agcaaggaag tgctctcaat tggccaaaat cggagccttc ttccctgggc
     6901 attgctgaaa ccaaggggct gtgagctaag catggcagaa ggccagtccc tcagcctgtg
     6961 tcttttgagc cattttgttc atggataatt taaatatgac cacaaaacaa taaaaacgta
     7021 ccatgaatct ggtagaagag tcaaagctgc accagctaca tatagcttcc tattctaatg
     7081 taagtagaac tgtctgcata taatgtgatt taatttattg ttgttctgtg tagaaagtga
     7141 ggactcatga ctgtggataa agccctgttt tgtataatat atatatatat atatatatat
     7201 tttttttttc tggtgcaaaa ttggtcattt aagcaatcta cttcatttgg tgtttggata
     7261 gaaatgtgcg cgtgttcttg taaaggtttc tattcagcaa gaataccaca tagcccaaat
     7321 ataacagtat gttctcatta aacgtatact ctacagaaa
//
