LOCUS       NP_032754                536 aa            linear   ROD 03-APR-2025
DEFINITION  atrial natriuretic peptide receptor 3 isoform a precursor [Mus
            musculus].
ACCESSION   NP_032754
VERSION     NP_032754.2
DBSOURCE    REFSEQ: accession NM_008728.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 536)
  AUTHORS   Wang,L., Tang,Y., Buckley,A.F. and Spurney,R.F.
  TITLE     Podocyte specific knockout of the natriuretic peptide clearance
            receptor is podocyte protective in focal segmental
            glomerulosclerosis
  JOURNAL   PLoS One 20 (3), e0319424 (2025)
   PUBMED   40063586
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 536)
  AUTHORS   Patino,M., Rossa,M.A., Lagos,W.N., Patne,N.S. and Callaway,E.M.
  TITLE     Transcriptomic cell-type specificity of local cortical circuits
  JOURNAL   Neuron 112 (23), 3851-3866 (2024)
   PUBMED   39353431
REFERENCE   3  (residues 1 to 536)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 536)
  AUTHORS   Li,S.J., Wei,J.Q., Kang,Y.Y., Wang,R.Q., Rong,W.W., Zhao,J.J.,
            Deng,Q.W., Gao,P.J., Li,X.D. and Wang,J.G.
  TITLE     Natriuretic peptide receptor-C perturbs mitochondrial respiration
            in white adipose tissue
  JOURNAL   J Lipid Res 65 (9), 100623 (2024)
   PUBMED   39154732
  REMARK    GeneRIF: Natriuretic peptide receptor-C perturbs mitochondrial
            respiration in white adipose tissue.
REFERENCE   5  (residues 1 to 536)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 536)
  AUTHORS   Matsukawa,N., Grzesik,W.J., Takahashi,N., Pandey,K.N., Pang,S.,
            Yamauchi,M. and Smithies,O.
  TITLE     The natriuretic peptide clearance receptor locally modulates the
            physiological effects of the natriuretic peptide system
  JOURNAL   Proc Natl Acad Sci U S A 96 (13), 7403-7408 (1999)
   PUBMED   10377427
REFERENCE   7  (residues 1 to 536)
  AUTHORS   Savinova,O.V., Matsukawa,N., Smithies,O. and John,S.W.
  TITLE     Mouse natriuretic peptide receptor 3 gene maps to proximal
            chromosome 15
  JOURNAL   Mamm Genome 8 (10), 788 (1997)
   PUBMED   9321481
REFERENCE   8  (residues 1 to 536)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
REFERENCE   9  (residues 1 to 536)
  AUTHORS   Yanaka,N., Kotera,J., Taguchi,I., Sugiura,M., Kawashima,K. and
            Omori,K.
  TITLE     Structure of the 5'-flanking regulatory region of the mouse gene
            encoding the clearance receptor for atrial natriuretic peptide
  JOURNAL   Eur J Biochem 237 (1), 25-34 (1996)
   PUBMED   8620881
REFERENCE   10 (residues 1 to 536)
  AUTHORS   Levin,E.R. and Frank,H.J.
  TITLE     Natriuretic peptides inhibit rat astroglial proliferation:
            mediation by C receptor
  JOURNAL   Am J Physiol 261 (2 Pt 2), R453-R457 (1991)
   PUBMED   1652217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134793.10.
            
            On Jan 25, 2006 this sequence version replaced NP_032754.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.4510650.1,
                                           SRR17253012.3520051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.83 cM"
     Protein         1..536
                     /product="atrial natriuretic peptide receptor 3 isoform a
                     precursor"
                     /note="atrial natriuretic peptide receptor type C; atrial
                     natriuretic peptide clearance receptor; longjohn;
                     strigosus; Nppc receptor"
                     /calculated_mol_wt=57374
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2452
     Region          46..441
                     /region_name="PBP1_NPR_C"
                     /note="ligand-binding domain of type C natriuretic peptide
                     receptor; cd06386"
                     /db_xref="CDD:380609"
     Site            order(101,130..131)
                     /site_type="other"
                     /note="Cl binding site [ion binding]"
                     /db_xref="CDD:380609"
     Site            order(109,113,132..133,136,140,144..145,209..210,213,216)
                     /site_type="other"
                     /note="dimer interface (closed form) [polypeptide
                     binding]"
                     /db_xref="CDD:380609"
     Site            order(132..133,136,140,158..159,203,209..210,213,216..217,
                     228)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:380609"
     Site            order(243..244,264,271)
                     /site_type="other"
                     /note="dimer interface (open form) [polypeptide binding]"
                     /db_xref="CDD:380609"
     Region          471..502
                     /region_name="TM_EphA1"
                     /note="Transmembrane domain of Ephrin Receptor A1 Protein
                     Tyrosine Kinase; cd12841"
                     /db_xref="CDD:214014"
     Site            order(475,477..478,481..482,484..486,489..490,493..494,
                     497,502)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:214014"
     CDS             1..536
                     /gene="Npr3"
                     /gene_synonym="ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri"
                     /coded_by="NM_008728.3:468..2078"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS27386.1"
                     /db_xref="GeneID:18162"
                     /db_xref="MGI:MGI:97373"
ORIGIN      
        1 mrslllftfs acvllarvll aggassgagd trpgsrrrar ealaaqkiev lvllprddsy
       61 lfslarvrpa ieyalrsveg ngtgrkllpp gtrfqvayed sdcgnralfs lvdrvaaarg
      121 akpdlilgpv ceyaaapvar lashwdlpml sagalaagfq hkdteyshlt rvapayakmg
      181 emmlalfrhh hwsraalvys ddklerncyf tlegvhevfq eeglhtsayn fdetkdldld
      241 divryiqgse rvvimcasgd tirrimlavh rhgmtsgdya ffnielfnss sygdgswrrg
      301 dkhdseakqa ysslqtvtll rtvkpefekf smevkssvek qglneedyvn mfvegfhdai
      361 llyvlalhev lragyskkdg gkiiqqtwnr tfegiagqvs idangdrygd fsvvamtdte
      421 agtqevigdy fgkegrfqmr snvkypwgpl klrldetriv ehtnsspcks sggleesavt
      481 givvgallga gllmafyffr kkyritierr nqqeesnigk hrelredsir shfsva
//
