LOCUS       NM_173788               3853 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus natriuretic peptide receptor 2 (Npr2), transcript
            variant 1, mRNA.
ACCESSION   NM_173788
VERSION     NM_173788.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3853)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3853)
  AUTHORS   Egbert,J.R., Silbern,I., Uliasz,T.F., Lowther,K.M., Yee,S.P.,
            Urlaub,H. and Jaffe,L.A.
  TITLE     Phosphatases modified by LH signaling in ovarian follicles: testing
            their role in regulating the NPR2 guanylyl cyclasedagger
  JOURNAL   Biol Reprod 110 (1), 102-115 (2024)
   PUBMED   37774352
  REMARK    GeneRIF: Phosphatases modified by LH signaling in ovarian
            follicles: testing their role in regulating the NPR2 guanylyl
            cyclasedagger.
REFERENCE   3  (bases 1 to 3853)
  AUTHORS   Werner,F., Prentki Santos,E., Michel,K., Schrader,H., Volker,K.,
            Potapenko,T., Krebes,L., Abesser,M., Mollmann,D., Schlattjan,M.,
            Schmidt,H., Skryabin,B.V., Spiranec Spes,K., Schuh,K., Denton,C.P.,
            Baba,H.A. and Kuhn,M.
  TITLE     Ablation of C-type natriuretic peptide/cGMP signaling in
            fibroblasts exacerbates adverse cardiac remodeling in mice
  JOURNAL   JCI Insight 8 (13), e160416 (2023)
   PUBMED   37227779
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3853)
  AUTHORS   Chen,Y., Brauer,A.U. and Koch,K.W.
  TITLE     Retinal degeneration protein 3 controls membrane guanylate cyclase
            activities in brain tissue
  JOURNAL   Front Mol Neurosci 15, 1076430 (2022)
   PUBMED   36618828
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3853)
  AUTHORS   Wagner,B.M., Robinson,J.W., Prickett,T.C.R., Espiner,E.A.,
            Khosla,S., Gaddy,D., Suva,L.J. and Potter,L.R.
  TITLE     Guanylyl Cyclase-B Dependent Bone Formation in Mice is Associated
            with Youth, Increased Osteoblasts, and Decreased Osteoclasts
  JOURNAL   Calcif Tissue Int 111 (5), 506-518 (2022)
   PUBMED   35947145
REFERENCE   6  (bases 1 to 3853)
  AUTHORS   Johnson,D.R.
  TITLE     The growth of femur and tibia in three genetically distinct
            chondrodystrophic mutants of the house mouse
  JOURNAL   J Anat 125 (Pt 2), 267-275 (1978)
   PUBMED   624676
REFERENCE   7  (bases 1 to 3853)
  AUTHORS   Kleinman,H.K., Pennypacker,J.P. and Brown,K.S.
  TITLE     Proteoglycan and collagen of 'achondroplastic' (cn/cn) neonatal
            mouse cartilage
  JOURNAL   Growth 41 (3), 171-177 (1977)
   PUBMED   914051
REFERENCE   8  (bases 1 to 3853)
  AUTHORS   Brewer,A.K., Johnson,D.R. and Moore,W.J.
  TITLE     Further studies on skull growth in achondroplasic (cn) mice
  JOURNAL   J Embryol Exp Morphol 39, 59-70 (1977)
   PUBMED   886262
REFERENCE   9  (bases 1 to 3853)
  AUTHORS   Miller,W.A. and Flynn-Miller,K.L.
  TITLE     A chondroplastic, brachymorphic and stubby chondrodystophies in
            mice
  JOURNAL   J Comp Pathol 86 (3), 349-363 (1976)
   PUBMED   939824
REFERENCE   10 (bases 1 to 3853)
  AUTHORS   Silberberg,R., Hasler,M. and Lesker,P.
  TITLE     Ultrastructure of articular cartilage of achondroplastic mice
  JOURNAL   Acta Anat (Basel) 96 (2), 162-175 (1976)
   PUBMED   970100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732626.8, CN529877.1, BF469229.1, CK623561.1, CO425573.1,
            CK624702.1, CB246804.1, BE646739.1 and EH106384.1.
            
            On Sep 16, 2017 this sequence version replaced NM_173788.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042470.1, SRR1660817.224493.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-879               AL732626.8         69504-70382
            880-1279            CN529877.1         48-447
            1280-1726           BF469229.1         140-586
            1727-1732           CK623561.1         81-86
            1733-1734           BF469229.1         593-594
            1735-2290           CK623561.1         89-644
            2291-2776           CO425573.1         91-576
            2777-2777           AL732626.8         85653-85653
            2778-2784           CO425573.1         578-584
            2785-3407           CK624702.1         1-623
            3408-3655           CB246804.1         294-541
            3656-3683           BE646739.1         497-524
            3684-3820           AL732626.8         88837-88973
            3821-3853           EH106384.1         39-71               c
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..3853
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /note="natriuretic peptide receptor 2"
                     /db_xref="GeneID:230103"
                     /db_xref="MGI:MGI:97372"
     exon            1..917
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..3394
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /EC_number="4.6.1.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; atrial natriuretic peptide receptor 2;
                     natriuretic peptide receptor B type; ANP-B; NPR-B; ANPR-B;
                     guanylate cyclase B; atrial natriuretic peptide receptor
                     type B; guanylyl cyclase-B; Nppb receptor"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 2 isoform 1
                     precursor"
                     /protein_id="NP_776149.1"
                     /db_xref="CCDS:CCDS18105.1"
                     /db_xref="GeneID:230103"
                     /db_xref="MGI:MGI:97372"
                     /translation="MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPR
                     VGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCV
                     YPAASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHF
                     NWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIR
                     ANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD
                     NRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIA
                     GCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDF
                     VLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDK
                     TPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYH
                     KGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLF
                     ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLI
                     NDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYA
                     KKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKV
                     RNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSIL
                     DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEA
                     FDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMV
                     VSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGL
                     KMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGK
                     MRTYWLLGEQKGPPGLL"
     exon            918..1123
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1237
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1373
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1468
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1601
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1686
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1807
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1882
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1960
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2065
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2137
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2297
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2453
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2622
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2769
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2893
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2962
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3137
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3236
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3328
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3853
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3638..3643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /note="hexamer: TATAAA"
     polyA_site      3660
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /note="major polyA site"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
                     /note="hexamer: TATAAA"
     polyA_site      3853
                     /gene="Npr2"
                     /gene_synonym="cn; GC-B; GC-B2; GC-B3; mNPR-B; pwe"
ORIGIN      
        1 cttctgccac cctatcctta gtccctggac ctggctgtgg gctggtagcc cactccttcc
       61 cgacccaggt ttccccccat cctcttcttg cgtggtcccc agcactttct gtatccgggc
      121 cgactaagct tgcccccact tctcttcctg gccctcttcc ccaggctcca ggctgggtgg
      181 cgcttgtgcc tgcccagtag gccagagcgg cccctggttc gggggaccgt gggtcagctg
      241 ctctatcccc atggcactgc catccctgct gctggtggtg gcagccctgg caggtggggt
      301 gcgtcctccg ggggcacgga acctgacgct ggcggtggtg ctgccagaac acaacctgag
      361 ctatgcctgg gcctggccac gggtgggtcc tgctgtggca ctggctgtgg aggcactggg
      421 ccgggcactg cccgtggacc tgcggtttgt cagctccgaa ctagacggcg cctgctctga
      481 gtacctggca ccactgcgcg ctgtggacct caagctgtac catgaccccg accttctgtt
      541 gggccccggt tgtgtgtacc ccgctgcctc tgtggctcgc tttgcctcac actggcgcct
      601 tcccctcctg actgcggggg cagtggcctc tggctttgca gctaagaatg agcattatcg
      661 taccctggtt cgcactggcc cctctgcgcc caagctgggt gagtttgtag tgacattgca
      721 cgggcacttc aattggacag ctcgggctgc tttgctgtat ctggatgctc gcacagatga
      781 ccggccccac tacttcacca tcgagggcgt ctttgaggcc ctgcagggca gcaacctcag
      841 tgtgcagcac caggtgtatg cccgagagcc aggtggccct gagcaagcca cccacttcat
      901 cagagccaac gggcgcattg tgtatatctg cggccccctg gaaatgctgc atgagatcct
      961 gcttcaggcc cagagggaga acctgaccaa tggggactat gtcttctttt accttgatgt
     1021 ctttggggag agtctccgag caggccccac ccgtgcaaca ggccggccat ggcaggacaa
     1081 tcgaacccag gaacaggccc aggccctcag agaggccttt cagactgtat tggtgatcac
     1141 ataccgagaa cccccaaatc ctgagtatca ggagtttcag aatcgcctgc tgatcagagc
     1201 ccgggaagac tttggtgtgg agctggcccc atccctgatg aaccttattg ctggctgctt
     1261 ctatgatggg atcctgctct atgcccaagt cctgaatgag actatacagg aagggggtac
     1321 cagggaagat ggacttcgaa ttgtggagaa gatgcaggga cgaagatacc atggtgtaac
     1381 tggactggtt gtcatggaca agaacaatga ccgcgagact gatttcgtcc tgtgggccat
     1441 gggagacttg gattctgggg actttcagcc cgcagcccat tactctggag cagagaagca
     1501 gatttggtgg acaggccggc caattccctg ggtgaagggg gccccacctt tggacaatcc
     1561 cccctgtgcc tttgacttgg acgacccatc ctgtgataaa actccacttt ccactctggc
     1621 aatcgtggcc ctgggcacgg gagtcacctt catcatgttt ggtgtttcca gtttcctaat
     1681 tttccggaag ctgatgctgg agaaggagct ggctagcatg ctatggcgca ttcgctggga
     1741 agaactgcag tttggcaact cggatcgcta tcacaagggt gcaggcagtc gcctgacgct
     1801 gtcgctgcgg ggatccagtt acggctcgct catgacagcc catgggaaat accagatctt
     1861 tgccaacacc ggtcacttca agggaaatgt tgttgccatc aaacacgtga ataagaagcg
     1921 catcgagctg acccggcaag ttctgtttga actcaaacac atgagagatg tccagttcaa
     1981 ccatcttact cgcttcatcg gagcctgcat agaccctccc aacatctgca ttgtcaccga
     2041 gtattgtcct cgtgggagct tacaagatat tctagaaaat gacagcatca atttggactg
     2101 gatgtttcgc tactcgctca tcaatgacct tgtgaagggt atggcctttc tccacaacag
     2161 cattatttca tctcatggaa gcctcaagtc ctccaactgt gtggtggata gtcgatttgt
     2221 gctcaaaata acagattacg gtctggctag tttccgatca actgctgaac cggacgacag
     2281 ccatgccctc tatgccaaga agctgtggac tgccccagaa ctgcttagcg ggaacccctt
     2341 gccaaccaca ggcatgcaga aagcagatgt ctacagcttt gccatcattc tacaggaaat
     2401 agcacttcga agtggtcctt tctacttgga aggcctggac ctcagtccca aggagattgt
     2461 ccagaaggtg cggaatggtc agaggccgta tttccggcca agcattgacc ggacacaact
     2521 gaatgaagag ttagttttgc tgatggagag atgctgggcc caggacccaa cagaacgtcc
     2581 agactttggg caaatcaagg gcttcattcg ccggtttaac aaggaaggtg gtaccagcat
     2641 attggacaac ctcttgctgc gcatggaaca gtatgctaat aacctggaaa agctggtgga
     2701 ggaacgcaca caggcctatc tagaggagaa acgcaaagcg gaggccctgc tgtaccaaat
     2761 tctaccccat tctgtagcag agcagttaaa gcggggagag acggttcagg cggaggcctt
     2821 cgacagcgtc accatctact tcagtgacat cgtgggcttc acagcgctgt cagctgagag
     2881 cacccccatg caggtggtga cacttcttaa tgacctttat acctgctttg atgccattat
     2941 cgacaacttt gatgtctaca aggtggaaac cattggggat gcctacatgg tggtatctgg
     3001 ccttccaggc cgaaacggtc agcgccatgc accagaaatt gctcgaatgg ccctagcatt
     3061 gctagatgct gtctcttcct tccgcatccg ccatcgaccc catgaccagc tgaggttacg
     3121 cataggtgtc catactgggc cagtctgtgc tggggtggtt ggcctgaaga tgccccggta
     3181 ctgtcttttt ggagacacag taaacactgc ttctcgaatg gagtcgaatg gccaagctct
     3241 aaagatccat gtctcctcga ccaccaagga cgccctggat gagctgggat gcttccagct
     3301 cgagctccgt ggggatgtgg agatgaaggg aaaaggaaaa atgcgaactt actggctctt
     3361 gggagagcaa aagggacctc ccggactcct gtaaagccca ggccggccat cttctgctgc
     3421 tggtacttgg atgggcaatg gtcactgtgt ttccacacag caaaaacaga cgtagccata
     3481 tcagatggaa aacatgcata gacacaaacc ccctgcctta tgtggaaatc atagccccct
     3541 gccgctcagc cttgtacata gacctatccc tccctgccct ggtcctcttc ctgcctcctg
     3601 taaatatctg tatctagacc agaatatttt gtccaagtat aaaacaacaa caacaaaaaa
     3661 tcatggtgtc attgtctggg gtccaggcca tcccaagaga agaatactgg ttgtggacac
     3721 agttactcac agaatcaatg aattagcagc ttgaggatga gagtgcttta tgtaaaaccc
     3781 ctcatcgggg acagagaatc aactccatcc aatctacctc tgtagtataa acagaaactg
     3841 atttcaaatc cca
//
