LOCUS       NM_008727               4065 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus natriuretic peptide receptor 1 (Npr1), mRNA.
ACCESSION   NM_008727
VERSION     NM_008727.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Kumar,P., Neelamegam,K., Ramasamy,C., Samivel,R., Xia,H.,
            Kapusta,D.R. and Pandey,K.N.
  TITLE     Epigenetic mechanisms differentially regulate blood pressure and
            renal dysfunction in male and female Npr1 haplotype mice
  JOURNAL   FASEB J 38 (15), e23858 (2024)
   PUBMED   39109516
  REMARK    GeneRIF: Epigenetic mechanisms differentially regulate blood
            pressure and renal dysfunction in male and female Npr1 haplotype
            mice.
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Mishra,A., Tavasoli,M., Sokolenko,S., McMaster,C.R. and
            Pasumarthi,K.B.S.
  TITLE     Atrial natriuretic peptide signaling co-regulates lipid metabolism
            and ventricular conduction system gene expression in the embryonic
            heart
  JOURNAL   iScience 27 (1), 108748 (2023)
   PUBMED   38235330
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Huang,Y., Li,T., Gao,S., Li,S., Zhu,X., Li,Y., Liu,D., Li,W.,
            Yang,L., Liu,K., Zhang,Z. and Liu,C.
  TITLE     Investigating the role of NPR1 in dilated cardiomyopathy and its
            potential as a therapeutic target for glucocorticoid therapy
  JOURNAL   Front Pharmacol 14, 1290253 (2023)
   PUBMED   38026943
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Sugioka,S., Yamada,H., Ishii,A., Kato,Y., Yamada,R., Mori,K.P.,
            Ohno,S., Handa,T., Ikushima,A., Ishimura,T., Osaki,K., Tokudome,T.,
            Matsusaka,T., Nebreda,A.R., Yanagita,M. and Yokoi,H.
  TITLE     Dual deletion of guanylyl cyclase-A and p38 mitogen-activated
            protein kinase in podocytes with aldosterone administration causes
            glomerular intra-capillary thrombi
  JOURNAL   Kidney Int 104 (3), 508-525 (2023)
   PUBMED   37356621
  REMARK    GeneRIF: Dual deletion of guanylyl cyclase-A and p38
            mitogen-activated protein kinase in podocytes with aldosterone
            administration causes glomerular intra-capillary thrombi.
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Chen,Y., Brauer,A.U. and Koch,K.W.
  TITLE     Retinal degeneration protein 3 controls membrane guanylate cyclase
            activities in brain tissue
  JOURNAL   Front Mol Neurosci 15, 1076430 (2022)
   PUBMED   36618828
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Lopez,M.J., Wong,S.K., Kishimoto,I., Dubois,S., Mach,V.,
            Friesen,J., Garbers,D.L. and Beuve,A.
  TITLE     Salt-resistant hypertension in mice lacking the guanylyl cyclase-A
            receptor for atrial natriuretic peptide
  JOURNAL   Nature 378 (6552), 65-68 (1995)
   PUBMED   7477288
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Kozak,C.A., Adamson,M.C., Buckler,C.E., Segovia,L., Paralkar,V. and
            Wistow,G.
  TITLE     Genomic cloning of mouse MIF (macrophage inhibitory factor) and
            genetic mapping of the human and mouse expressed gene and nine
            mouse pseudogenes
  JOURNAL   Genomics 27 (3), 405-411 (1995)
   PUBMED   7558020
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Schoenfeld,J.R., Sehl,P., Quan,C., Burnier,J.P. and Lowe,D.G.
  TITLE     Agonist selectivity for three species of natriuretic peptide
            receptor-A
  JOURNAL   Mol Pharmacol 47 (1), 172-180 (1995)
   PUBMED   7838126
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Gu,Y.C. and Pandey,K.N.
  TITLE     Genomic restriction endonuclease analysis and mapping of murine
            guanylate cyclase-A/atrial natriuretic factor receptor gene
  JOURNAL   Biochem Biophys Res Commun 196 (2), 758-766 (1993)
   PUBMED   7902087
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Pandey,K.N. and Singh,S.
  TITLE     Molecular cloning and expression of murine guanylate cyclase/atrial
            natriuretic factor receptor cDNA
  JOURNAL   J Biol Chem 265 (21), 12342-12348 (1990)
   PUBMED   1973687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ065787.1, L31932.1 and AK135008.1.
            
            On Sep 2, 2006 this sequence version replaced NM_008727.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110659.1, L31932.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               CJ065787.1         2-353
            353-3561            L31932.1           1-3209
            3562-4065           AK135008.1         1505-2008
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.23 cM"
     gene            1..4065
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /note="natriuretic peptide receptor 1"
                     /db_xref="GeneID:18160"
                     /db_xref="MGI:MGI:97371"
     exon            1..1072
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..3537
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /EC_number="4.6.1.2"
                     /note="atrial natriuretic peptide receptor 1; ANP-A;
                     ANPR-A; atrial natriuretic peptide receptor type A; Nppa
                     receptor; guanylyl cyclase-A; guanylate cyclase A"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 1 precursor"
                     /protein_id="NP_032753.5"
                     /db_xref="CCDS:CCDS17529.1"
                     /db_xref="GeneID:18160"
                     /db_xref="MGI:MGI:97371"
                     /translation="MPGSRRVRPRLRALLLLPPLLLLRSGHASDLTVAVVLPLTNTSY
                     PWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKW
                     EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVK
                     LGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVE
                     GDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSL
                     QGAQGPVPRKPWERDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFN
                     FTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYL
                     KIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPLGYPPPDIPK
                     CGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRW
                     EDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN
                     RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENES
                     ITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRD
                     PEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGL
                     DLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALR
                     KFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQ
                     LKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVY
                     KVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIH
                     TGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELEL
                     RGDVEMKGKGKVRTYWLLGERGCSTRG"
     exon            1073..1272
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1386
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1522
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1614
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1750
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1835
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1956
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2031
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2109
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2214
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2286
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2443
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2599
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2768
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2915
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3039
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3108
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3283
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3382
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3474
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..4065
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4045..4050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /note="putative"
     polyA_site      4065
                     /gene="Npr1"
                     /gene_synonym="GC-A; NPR-A; NPRA; Pndr"
                     /note="putative"
ORIGIN      
        1 atactcctgg ggcaagcgcg agcgcacact cccctttcct cgctggcgca cccgctcccc
       61 tcgctcttct tagatcgccc tctcgttctc tcgctctcca cggactccct tcgggtgctg
      121 cgctcgctct cacctgctct aaagcaccct ccgctctcgg acgctcccaa ttccgcgctc
      181 ctgctcgacg gcgggacagt cgcagcctcg gcaggcagct tgctctcgcc gctgcggctt
      241 caacccagcc ccctccctcg ctacggctcg ggcgctcttg actcccgacc ctcgcctctg
      301 agcccgagga cggcgatcag accatggtga cagcgctgct ccgtcgctgc gctcgctgag
      361 gccatgccgg gttcccgacg cgtccgtccg cgcctaaggg cgctgctgct gctaccgccg
      421 ctgctgctgc tccgaagcgg ccacgcgagc gacctgaccg tggccgtggt gctgccgctg
      481 accaacacct cgtacccgtg gtcttgggcg cgtgtagggc cggcggtgga actggctctc
      541 gggagggtga aggctcggcc ggacttgctg ccgggttgga cggtccgtat ggtgctgggc
      601 agcagcgaga acgcggcggg cgtctgctcc gacaccgctg caccgctggc cgcggtggat
      661 ctcaagtggg agcacagccc cgcggtgttc ctgggccccg gctgcgtata ctctgctgcc
      721 ccggtgggac gcttcaccgc gcactggcgg gtgccgctgc tgacggctgg cgccccggct
      781 ctgggcatcg gggtgaagga tgagtacgcg ttaaccaccc gcacaggacc cagccatgtc
      841 aagctgggcg acttcgtgac ggcgctgcat cgacggctgg gctgggagca ccaggcgctt
      901 gtgctctatg cagatcggct gggcgacgac cggccgtgct tcttcatagt ggaggggctg
      961 tacatgcggg tgcgtgagcg actcaacatc acagtaaatc accaggagtt cgtcgagggc
     1021 gacccggacc actacaccaa gctactgcgg accgtgcagc gcaagggcag agttatctac
     1081 atctgcagtt ctccggatgc cttcaggaat ctgatgcttt tggccctgga tgctggcctg
     1141 actggggagg actatgtttt cttccacctg gatgtgtttg ggcaaagcct tcagggtgct
     1201 cagggccctg ttcccaggaa gccctgggaa agagacgatg ggcaggatag gagagcccgc
     1261 caggcctttc aggctgccaa aattattact tacaaagaac ccgataatcc tgagtacttg
     1321 gaattcctga agcagctaaa actcttggct gacaagaaat tcaacttcac catggaggat
     1381 ggcctgaaaa atatcatccc agcatccttc catgacgggc tcctgctcta tgtccaggca
     1441 gtgacagaga ctctggcaca ggggggcact gtcactgatg gagagaacat cactcagcgg
     1501 atgtggaacc gaagcttcca aggtgtgaca ggatacctga aaattgatag aaatggagat
     1561 cgggacactg atttctccct ctgggatatg gaccccgaga caggtgcctt cagggttgtc
     1621 ctgaacttta atggtacttc ccaggagctg atggctgtgt cagaacacag attatactgg
     1681 cctctgggat acccacctcc tgacatccct aaatgtggct ttgacaatga ggacccagcc
     1741 tgcaaccaag accacttttc cacactggag gttctggctt tggtgggcag cctctctctg
     1801 gttagctttc tgatcgtgtc tttcttcata tacaggaaga tgcagctgga aaaggagctg
     1861 gtctcagagt tgtggcgggt gcgctgggag gacttgcagc ccagcagcct ggagaggcac
     1921 cttcggagcg ctggcagtcg gctgaccctg agtgggcgag gctccaatta tggctccctg
     1981 ctaaccacgg agggccagtt ccaagtcttt gccaagacag catactataa gggcaacctc
     2041 gtggctgtga aacgtgtgaa ccggaaacgc attgagttga cacgaaaagt cctgtttgaa
     2101 cttaaacata tgcgggatgt gcagaatgag cacttgacca gatttgtggg agcttgtacc
     2161 gaccctccca acatctgtat cctcacagag tactgtcccc gtgggagcct acaggacatt
     2221 ctagagaatg agagtattac cctggactgg atgtttcggt actcactcac caatgacatt
     2281 gtcaagggaa tgctctttct acacaacggg gccattggtt cccatgggaa cctcaagtca
     2341 tccaactgcg tggtagatgg acgttttgtg ttaaagatca cagactatgg gctcgagagc
     2401 ttcagagacc cggagccaga gcaaggacac accctctttg ccaaaaaact gtggactgca
     2461 cctgagctcc tgcgaatggc ttccccacct gcccgtggct cccaagctgg ggatgtctac
     2521 agttttggta tcatccttca ggaaattgcc ctaagaagtg gggtcttcta tgtggaaggt
     2581 ttggacctca gcccaaaaga gatcattgag cgtgtgactc ggggcgagca gcccccattc
     2641 cgaccttcca tggatctgca gagccacctg gaggaactgg ggcagctgat gcagaggtgc
     2701 tgggcagagg atcctcagga gcggccaccc tttcaacaga tccgcctggc gctgcgcaag
     2761 ttcaacaagg agaacagcag caacatcctg gacaacctgc tgtcacgcat ggaacagtac
     2821 gccaacaacc tggaggaact ggtagaggag agaacacagg cttatctgga ggagaagcgc
     2881 aaagctgagg ccctgcttta ccagattctg cctcactctg tggctgagca gctgaagaga
     2941 ggcgagacag tccaggctga ggcatttgat agtgttacta tctatttcag tgatatcgtg
     3001 ggctttacag ctctttcagc agagagcaca cccatgcagg tggtcaccct gctcaatgat
     3061 ctgtacacct gttttgatgc tgtcatagac aactttgatg tgtacaaggt agagaccatt
     3121 ggtgatgctt acatggtggt atcagggctc ccagtgagga atggacagct ccatgcccga
     3181 gaggtagccc gaatggcact tgcactgctc gatgctgtac gctccttccg catccgccat
     3241 aggccccagg aacagctgcg cttgcgcatt ggaattcaca caggtcccgt gtgtgctggt
     3301 gtggtagggc taaagatgcc ccgatactgc ctctttggag acacagtcaa cacagcttca
     3361 agaatggagt ctaatgggga agccctcagg atccacttgt cttcggagac caaggctgtg
     3421 ctggaagagt tcgatggttt tgagctggag ctccgaggtg acgtggaaat gaagggcaaa
     3481 ggcaaggttc gaacctattg gctcctcggg gagcggggat gcagcactcg aggctgacct
     3541 actgccctgc tattccttgt cacctcccct ccctgtgcca gcaatgacac gggtgtccaa
     3601 cttccgcctc tcccacagca gctcagccac tgtggaaaga ttagggacct aaccagcgca
     3661 gtcatcagat gtgacctctg agagaggatg gagatggtgg ggactggagg gggactccta
     3721 agtttatagg gctgactgaa atacccagtc actcccgtag cacatgcccc gccccccccc
     3781 cgccccccca ctcagctgcc tagcagacag tgattccttc tgccgccctc aacttagctc
     3841 cactgtgact tagagggagg gaaattgcca cctgaaggaa agagaaaaga gattctcggg
     3901 gtttgcagga ggcaggcagt cctgtgtcac aaatactccc ctcactccca gtccaccacc
     3961 tgccccaccg acttcccttc ccacacagtg cactgaggag aagagaggca tggggttgcc
     4021 ttgcttctcc tatgagcaaa acccattaaa gtctttattc ctgtg
//
