LOCUS       NM_010933               1042 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus natriuretic peptide type C (Nppc), mRNA.
ACCESSION   NM_010933
VERSION     NM_010933.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Zhang,H., Li,C., Liu,Q., Li,J., Wu,H., Xu,R., Sun,Y., Cheng,M.,
            Zhao,X., Pan,M., Wei,Q. and Ma,B.
  TITLE     C-type natriuretic peptide improves maternally aged oocytes quality
            by inhibiting excessive PINK1/Parkin-mediated mitophagy
  JOURNAL   Elife 12, 88523 (2023)
   PUBMED   37860954
  REMARK    GeneRIF: C-type natriuretic peptide improves maternally aged
            oocytes quality by inhibiting excessive PINK1/Parkin-mediated
            mitophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Werner,F., Prentki Santos,E., Michel,K., Schrader,H., Volker,K.,
            Potapenko,T., Krebes,L., Abesser,M., Mollmann,D., Schlattjan,M.,
            Schmidt,H., Skryabin,B.V., Spiranec Spes,K., Schuh,K., Denton,C.P.,
            Baba,H.A. and Kuhn,M.
  TITLE     Ablation of C-type natriuretic peptide/cGMP signaling in
            fibroblasts exacerbates adverse cardiac remodeling in mice
  JOURNAL   JCI Insight 8 (13), e160416 (2023)
   PUBMED   37227779
  REMARK    GeneRIF: Ablation of C-type natriuretic peptide/cGMP signaling in
            fibroblasts exacerbates adverse cardiac remodeling in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Astrof,S., Arriagada,C., Saijoh,Y., Francou,A., Kelly,R.G. and
            Moon,A.
  TITLE     Aberrant differentiation of second heart field mesoderm prefigures
            cellular defects in the outflow tract in response to loss of FGF8
  JOURNAL   Dev Biol 499, 10-21 (2023)
   PUBMED   37060937
REFERENCE   5  (bases 1 to 1042)
  AUTHORS   Jiao,Y., Yan,J., Jiao,F., Yang,H., Donahue,L.R., Li,X., Roe,B.A.,
            Stuart,J. and Gu,W.
  TITLE     A single nucleotide mutation in Nppc is associated with a long bone
            abnormality in lbab mice
  JOURNAL   BMC Genet 8, 16 (2007)
   PUBMED   17439653
  REMARK    GeneRIF: A single nucleotide mutation of Nppc is associated with
            dwarfism in lbab/lbab mice
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1042)
  AUTHORS   Sugiyama,F., Churchill,G.A., Higgins,D.C., Johns,C.,
            Makaritsis,K.P., Gavras,H. and Paigen,B.
  TITLE     Concordance of murine quantitative trait loci for salt-induced
            hypertension with rat and human loci
  JOURNAL   Genomics 71 (1), 70-77 (2001)
   PUBMED   11161799
REFERENCE   7  (bases 1 to 1042)
  AUTHORS   Huang,H., Acuff,C.G. and Steinhelper,M.E.
  TITLE     Isolation, mapping, and regulated expression of the gene encoding
            mouse C-type natriuretic peptide
  JOURNAL   Am J Physiol 271 (4 Pt 2), H1565-H1575 (1996)
   PUBMED   8897953
REFERENCE   8  (bases 1 to 1042)
  AUTHORS   Cameron,V.A., Aitken,G.D., Ellmers,L.J., Kennedy,M.A. and
            Espiner,E.A.
  TITLE     The sites of gene expression of atrial, brain, and C-type
            natriuretic peptides in mouse fetal development: temporal changes
            in embryos and placenta
  JOURNAL   Endocrinology 137 (3), 817-824 (1996)
   PUBMED   8603590
REFERENCE   9  (bases 1 to 1042)
  AUTHORS   Vollmar,A.M. and Schulz,R.
  TITLE     Expression and differential regulation of natriuretic peptides in
            mouse macrophages
  JOURNAL   J Clin Invest 95 (6), 2442-2450 (1995)
   PUBMED   7769089
REFERENCE   10 (bases 1 to 1042)
  AUTHORS   Ogawa,Y., Itoh,H., Yoshitake,Y., Inoue,M., Yoshimasa,T.,
            Serikawa,T. and Nakao,K.
  TITLE     Molecular cloning and chromosomal assignment of the mouse C-type
            natriuretic peptide (CNP) gene (Nppc): comparison with the human
            CNP gene (NPPC)
  JOURNAL   Genomics 24 (2), 383-387 (1994)
   PUBMED   7698765
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY718381.1, AK036176.1 and
            AC158132.6.
            
            On Apr 2, 2011 this sequence version replaced NM_010933.4.
            
            Summary: This gene encodes a member of the natriuretic peptide
            family. Natriuretic peptides are involved in the control of blood
            pressure, extracellular fluid volume and electrolyte homeostasis.
            The encoded protein also plays a role in sensory neuron
            bifurcation, and is a critical regulator of endochondral bone
            growth. The encoded protein is a ligand for the natriuretic peptide
            receptor B, and is synthesized as a preprohormone which is cleaved
            to produce a mature peptide. Mutations in this gene are associated
            with dwarfism resulting from impaired endochondral ossification.
            [provided by RefSeq, Apr 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036176.1, AK020093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BY718381.1         2-2
            2-640               AK036176.1         4-642
            641-1042            AC158132.6         213312-213713       c
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.98 cM"
     gene            1..1042
                     /gene="Nppc"
                     /gene_synonym="CNP; lbab"
                     /note="natriuretic peptide type C"
                     /db_xref="GeneID:18159"
                     /db_xref="MGI:MGI:97369"
     exon            1..225
                     /gene="Nppc"
                     /gene_synonym="CNP; lbab"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..516
                     /gene="Nppc"
                     /gene_synonym="CNP; lbab"
                     /note="C-type natriuretic peptide; natriuretic peptide
                     precursor C; natriuretic peptide precursor type C"
                     /codon_start=1
                     /product="C-type natriuretic peptide preproprotein"
                     /protein_id="NP_035063.1"
                     /db_xref="CCDS:CCDS15123.1"
                     /db_xref="GeneID:18159"
                     /db_xref="MGI:MGI:97369"
                     /translation="MHLSQLIACALLLALLSLRPSEAKPGTPPKVPRTPPGEELADSQ
                     AAGGNQKKGDKTPGSGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGN
                     KKGLSKGCFGLKLDRIGSMSGLGC"
     exon            226..536
                     /gene="Nppc"
                     /gene_synonym="CNP; lbab"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1042
                     /gene="Nppc"
                     /gene_synonym="CNP; lbab"
                     /inference="alignment:Splign:2.1.0"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nppc"
                     /gene_synonym="CNP; lbab"
                     /note="hexamer: AATAAA"
     polyA_site      758
                     /gene="Nppc"
                     /gene_synonym="CNP; lbab"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcacc cagccggcgc cgcacagcag taggacctgt gctcgcttgg caatcctgct
       61 ccgcatccgc ctatccgact gctcaccggc agtcccggct gcagaccgtc tgcacacctc
      121 ggtcccatcg gcaccatgca cctctcccag ctgatcgcct gcgccctgct gctcgcgcta
      181 ctctcgctcc ggccctctga agccaagccc gggacaccac cgaaggtccc gagaaccccg
      241 ccaggggagg agctggcgga ttcccaggca gctggtggca atcagaaaaa gggtgacaag
      301 actccaggca gcgggggagc caatctcaag ggagaccgat cgcgactgct ccgggacctg
      361 cgtgtggaca ccaagtcccg ggctgcttgg gcccgccttc tgcacgagca ccccaacgcg
      421 cgcaaataca aaggcggcaa caagaagggc ttgtccaaag gctgctttgg cctcaagctg
      481 gaccggatcg gctccatgag cggtctggga tgttagtgca gctacccctg gcggcggatt
      541 gggaactgct ctgtgcactg aggccatccc tggtcatcag cctccagcat ctggaaacac
      601 ctccaacgca atgtggcttt tacatttctt tttttttttt tcctcctggt actggcaata
      661 cacaacacca gctgttttat tattatttgg ggaggggagg gtatgatttt attgtttggg
      721 gttttttttg aaaatgaaaa ataaaaagtt atatattata tatatattat atacatgaga
      781 cacacactcc cacaccgact tgatgacaag ggacagtttt taaagtgact gacaaaacca
      841 gctagctgta aaacattgct gtttgtaaat tcacgtcatg cataaatgta tttatgttgt
      901 aaagctattt atattgttta taaagagata tttataaaaa ttttatttat gtaactaaat
      961 gaaagaagcc aaccattgta atgtttttgt cctaactagt tgaaaaaaat gttaaaaaaa
     1021 aaaagccatt ccatgaacat ct
//
