LOCUS       NM_008726                669 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus natriuretic peptide type B (Nppb), transcript variant
            1, mRNA.
ACCESSION   NM_008726
VERSION     NM_008726.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Nattkemper,L.A., Kim,B.S., Yap,Q.V., Hoon,M.A., Mishra,S.K. and
            Yosipovitch,G.
  TITLE     Increased Systemic Levels of Centrally Acting B-Type Natriuretic
            Peptide Are Associated with Chronic Itch of Different Types
  JOURNAL   J Invest Dermatol 144 (10), 2267-2272 (2024)
   PUBMED   38522572
  REMARK    GeneRIF: Increased Systemic Levels of Centrally Acting B-Type
            Natriuretic Peptide Are Associated with Chronic Itch of Different
            Types.
REFERENCE   2  (bases 1 to 669)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 669)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 669)
  AUTHORS   Li,Y., Ma,K., Dong,Z., Gao,S., Zhang,J., Huang,S., Yang,J.,
            Fang,G., Li,Y., Li,X., Welch,C., Griffin,E.L., Ramaswamy,P.,
            Valivullah,Z., Liu,X., Dong,J., Wang,D.W., Du,J., Chung,W.K. and
            Li,Y.
  TITLE     Frameshift variants in C10orf71 cause dilated cardiomyopathy in
            human, mouse, and organoid models
  JOURNAL   J Clin Invest 134 (12), e177172 (2024)
   PUBMED   38950288
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 669)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 669)
  AUTHORS   Cameron,V.A., Aitken,G.D., Ellmers,L.J., Kennedy,M.A. and
            Espiner,E.A.
  TITLE     The sites of gene expression of atrial, brain, and C-type
            natriuretic peptides in mouse fetal development: temporal changes
            in embryos and placenta
  JOURNAL   Endocrinology 137 (3), 817-824 (1996)
   PUBMED   8603590
REFERENCE   7  (bases 1 to 669)
  AUTHORS   Vollmar,A.M. and Schulz,R.
  TITLE     Expression and differential regulation of natriuretic peptides in
            mouse macrophages
  JOURNAL   J Clin Invest 95 (6), 2442-2450 (1995)
   PUBMED   7769089
REFERENCE   8  (bases 1 to 669)
  AUTHORS   Ogawa,Y., Itoh,H., Tamura,N., Suga,S., Yoshimasa,T., Uehira,M.,
            Matsuda,S., Shiono,S., Nishimoto,H. and Nakao,K.
  TITLE     Molecular cloning of the complementary DNA and gene that encode
            mouse brain natriuretic peptide and generation of transgenic mice
            that overexpress the brain natriuretic peptide gene
  JOURNAL   J Clin Invest 93 (5), 1911-1921 (1994)
   PUBMED   8182124
REFERENCE   9  (bases 1 to 669)
  AUTHORS   Boer,P.H.
  TITLE     Activation of the gene for type-b natriuretic factor in mouse stem
            cell cultures induced for cardiac myogenesis
  JOURNAL   Biochem Biophys Res Commun 199 (2), 954-961 (1994)
   PUBMED   8135846
REFERENCE   10 (bases 1 to 669)
  AUTHORS   Steinhelper,M.E.
  TITLE     Structure, expression, and genomic mapping of the mouse natriuretic
            peptide type-B gene
  JOURNAL   Circ Res 72 (5), 984-992 (1993)
   PUBMED   8097440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL714013.9.
            
            On Apr 7, 2020 this sequence version replaced NM_008726.5.
            
            Summary: This gene encodes a secreted protein that belongs to the
            family of natriuretic peptides. Its precursor protein is processed
            to generate the active mature peptide. The mature peptide is a
            cardiac hormone that plays a role in ventricular remodeling as well
            as blood pressure regulation. Mice lacking this gene exhibit
            cardiac fibrosis. In humans this gene is associated with congestive
            heart failure, low bone-mineral density and postmenopausal
            osteoporosis. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Dec
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as Long
            isoform).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK128345.1, BC061165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AL714013.9         2727-2928
            203-425             AL714013.9         3123-3345
            426-669             AL714013.9         3789-4032
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.57 cM"
     gene            1..669
                     /gene="Nppb"
                     /gene_synonym="BNF; BNP; Iso-ANP"
                     /note="natriuretic peptide type B"
                     /db_xref="GeneID:18158"
                     /db_xref="MGI:MGI:97368"
     exon            1..202
                     /gene="Nppb"
                     /gene_synonym="BNF; BNP; Iso-ANP"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..442
                     /gene="Nppb"
                     /gene_synonym="BNF; BNP; Iso-ANP"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; natriuretic peptides B; brain natriuretic
                     peptide; gamma-brain natriuretic peptide; natriuretic
                     peptide precursor type B; type-B natriuretic factor;
                     proBNP; preproBNP; brain natriuretic factor prohormone"
                     /codon_start=1
                     /product="natriuretic peptides B isoform 1 preproprotein"
                     /protein_id="NP_032752.1"
                     /db_xref="CCDS:CCDS18926.1"
                     /db_xref="GeneID:18158"
                     /db_xref="MGI:MGI:97368"
                     /translation="MDLLKVLSQMILFLLFLYLSPLGGHSYPLGSPSQSPEQFKMQKL
                     LELIREKSEEMAQRQLLKDQGLTKEHPKRVLRSQGSTLRVQQRPQNSKVTHISSCFGH
                     KIDRIGSVSRLGCNALKLL"
     exon            203..425
                     /gene="Nppb"
                     /gene_synonym="BNF; BNP; Iso-ANP"
                     /inference="alignment:Splign:2.1.0"
     exon            426..669
                     /gene="Nppb"
                     /gene_synonym="BNF; BNP; Iso-ANP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      635..640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nppb"
                     /gene_synonym="BNF; BNP; Iso-ANP"
                     /note="hexamer: AATAAA"
     polyA_site      669
                     /gene="Nppb"
                     /gene_synonym="BNF; BNP; Iso-ANP"
                     /note="major polyA site"
ORIGIN      
        1 accagtgcac aagctgcttg gggaggcgag acaagggaga acacggcatc attgcctggc
       61 ccatcgcttc tgcggcatgg atctcctgaa ggtgctgtcc cagatgattc tgtttctgct
      121 tttcctttat ctgtcaccgc tgggaggtca ctcctatcct ctgggaagtc ctagccagtc
      181 tccagagcaa ttcaagatgc agaagctgct ggagctgata agagaaaagt cggaggaaat
      241 ggcccagaga cagctcttga aggaccaagg cctcacaaaa gaacacccaa aaagagtcct
      301 tcggtctcaa ggcagcaccc tccgggtcca gcagagacct caaaattcca aggtgacaca
      361 tatctcaagc tgctttgggc acaagataga ccggatcgga tccgtcagtc gtttgggctg
      421 taacgcactg aagttgttgt aggaagacct cctggctgca ggagactcca gtttctgact
      481 ctgcctgggt ctctttcccc agctctggga ccacctttga agtgatccta tttatttatt
      541 tatttatatt tatttttatt tttatttttt aatttatttt gttgtttttc tacaagactg
      601 tttcttatct tggagcacaa acttgccaca acataataaa catagcgtat ttcctgcttt
      661 tgaaaagga
//
