LOCUS       NM_008725                860 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus natriuretic peptide type A (Nppa), mRNA.
ACCESSION   NM_008725 XM_131840
VERSION     NM_008725.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Teng,X., He,H., Yu,H., Zhang,X., Xing,J., Shen,J., Li,C., Wang,M.,
            Shao,L., Wang,Z., Yang,H., Zhang,Y. and Wu,Q.
  TITLE     LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic
            Heart Development
  JOURNAL   Int J Mol Sci 25 (15), 8184 (2024)
   PUBMED   39125754
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 860)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 860)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   7  (bases 1 to 860)
  AUTHORS   Hanley-Hyde,J., Mushinski,J.F., Sadofsky,M., Huppi,K., Krall,M.,
            Kozak,C.A. and Mock,B.
  TITLE     Expression of murine cyclin B1 mRNAs and genetic mapping of related
            genomic sequences
  JOURNAL   Genomics 13 (4), 1018-1030 (1992)
   PUBMED   1387105
REFERENCE   8  (bases 1 to 860)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   9  (bases 1 to 860)
  AUTHORS   Krall,M., Ruff,N., Zimmerman,K., Aggarwal,A., Dosik,J., Reeves,R.
            and Mock,B.A.
  TITLE     Isolation and mapping of four new DNA markers from mouse chromosome
            4
  JOURNAL   Mamm Genome 3 (11), 653-655 (1992)
   PUBMED   1360280
REFERENCE   10 (bases 1 to 860)
  AUTHORS   Seidman,C.E., Duby,A.D., Choi,E., Graham,R.M., Haber,E., Homcy,C.,
            Smith,J.A. and Seidman,J.G.
  TITLE     The structure of rat preproatrial natriuretic factor as defined by
            a complementary DNA clone
  JOURNAL   Science 225 (4659), 324-326 (1984)
   PUBMED   6234658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL714013.9, AK147180.1 and
            AV005725.1.
            
            On Oct 8, 2015 this sequence version replaced NM_008725.2.
            
            Summary: This gene encodes members of the natriuretic family of
            peptides that play an important role in the control of
            extracellular fluid volume and electrolyte homeostasis. The encoded
            protein precursor undergoes proteolytic processing to generate
            multiple functional peptides. Mice lacking the encoded peptides
            exhibit salt-sensitive hypertension. The transgenic overexpression
            of the encoded peptides in mice decreases arterial blood pressure
            without inducing diuresis and natriuresis. This gene is located
            adjacent to another member of the natriuretic family of peptides on
            chromosome 4. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089615.1, AK147180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL714013.9         17549-17569
            22-817              AK147180.1         2-797
            818-830             AV005725.1         353-365
            831-860             AV005725.1         373-402
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.66 cM"
     gene            1..860
                     /gene="Nppa"
                     /gene_synonym="Anf; ANP; CDD; Pnd"
                     /note="natriuretic peptide type A"
                     /db_xref="GeneID:230899"
                     /db_xref="MGI:MGI:97367"
     exon            1..233
                     /gene="Nppa"
                     /gene_synonym="Anf; ANP; CDD; Pnd"
                     /inference="alignment:Splign:2.1.0"
     exon            234..560
                     /gene="Nppa"
                     /gene_synonym="Anf; ANP; CDD; Pnd"
                     /inference="alignment:Splign:2.1.0"
     exon            561..860
                     /gene="Nppa"
                     /gene_synonym="Anf; ANP; CDD; Pnd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      832..837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nppa"
                     /gene_synonym="Anf; ANP; CDD; Pnd"
                     /note="hexamer: AATAAA"
     polyA_site      857
                     /gene="Nppa"
                     /gene_synonym="Anf; ANP; CDD; Pnd"
                     /note="major polyA site"
ORIGIN      
        1 gggagatgct ggcagctagg agacagtgac ggacaaaagc tgagagagag agagaaagaa
       61 accagagtgg gcagagacag caaacatcag atcgtgcccc gacccacgcc agcatgggct
      121 ccttctccat caccctgggc ttcttcctcg tcttggcctt ttggcttcca ggccatattg
      181 gagcaaatcc tgtgtacagt gcggtgtcca acacagatct gatggatttc aagaacctgc
      241 tagaccacct ggaggagaag atgccggtag aagatgaggt catgcccccg caggccctga
      301 gtgagcagac tgaggaagca ggggccgcac ttagctccct ccccgaggtg cctccctgga
      361 ctggggaggt caacccacct ctgagagacg gcagtgctct agggcgcagc ccctgggacc
      421 cctccgatag atctgccctc ttgaaaagca aactgagggc tctgctcgct ggccctcgga
      481 gcctacgaag atccagctgc ttcgggggta ggattgacag gattggagcc cagagtggac
      541 taggctgcaa cagcttccgg taccgaagat aacagccaag gaggaaaagg cagtcgattc
      601 tgcttgagca gatcgcaaaa gatcctaagc ccttgtggtg tgtcacgcag cttggtcaca
      661 ttgccactgt ggcgtggtga acaccctcct ggagctgcgg cttcctgcct tcatctatca
      721 cgatcgatgt taaatgtaga tgagtggtct agtggggtct tgcctctccc actctgcata
      781 ttaaggtaga tcctcaccct tttcagaaag cagttggaaa aaaaaaaaaa gaataaactt
      841 cagcaccaag gacagacgcc
//
