LOCUS       NM_008723                862 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nucleoplasmin 3 (Npm3), mRNA.
ACCESSION   NM_008723 XM_914732
VERSION     NM_008723.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   McCallum-Loudeac,J., Moody,E., Williams,J., Johnstone,G.,
            Sircombe,K.J., Clarkson,A.N. and Wilson,M.J.
  TITLE     Deletion of a conserved genomic region associated with adolescent
            idiopathic scoliosis leads to vertebral rotation in mice
  JOURNAL   Hum Mol Genet 33 (9), 787-801 (2024)
   PUBMED   38280229
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Patel,N.S., Rhinn,M., Semprich,C.I., Halley,P.A., Dolle,P.,
            Bickmore,W.A. and Storey,K.G.
  TITLE     FGF signalling regulates chromatin organisation during neural
            differentiation via mechanisms that can be uncoupled from
            transcription
  JOURNAL   PLoS Genet 9 (7), e1003614 (2013)
   PUBMED   23874217
  REMARK    Erratum:[PLoS Genet. 2013 Aug 12;9(8). doi:
            10.1371/annotation/c066bb84-13ea-4b36-a481-f149df8ce929.. PMID:
            29364922]
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Erdreich-Epstein,A., Ganguly,A.K., Shi,X.H., Zimonjic,D.B. and
            Shackleford,G.M.
  TITLE     Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells
            correlates with an adjacent t(5;19) translocation
  JOURNAL   Genes Chromosomes Cancer 45 (2), 169-181 (2006)
   PUBMED   16252261
REFERENCE   7  (bases 1 to 862)
  AUTHORS   Huang,N., Negi,S., Szebeni,A. and Olson,M.O.
  TITLE     Protein NPM3 interacts with the multifunctional nucleolar protein
            B23/nucleophosmin and inhibits ribosome biogenesis
  JOURNAL   J Biol Chem 280 (7), 5496-5502 (2005)
   PUBMED   15596447
  REMARK    GeneRIF: Overexpression of a mutant of NPM3 that did not interact
            with B23 did not alter pre-rRNA synthesis and processing,
            suggesting that the interaction of NPM3 with B23 plays a role in
            the ribosome biogenesis
REFERENCE   8  (bases 1 to 862)
  AUTHORS   Burns,K.H., Viveiros,M.M., Ren,Y., Wang,P., DeMayo,F.J.,
            Frail,D.E., Eppig,J.J. and Matzuk,M.M.
  TITLE     Roles of NPM2 in chromatin and nucleolar organization in oocytes
            and embryos
  JOURNAL   Science 300 (5619), 633-636 (2003)
   PUBMED   12714744
REFERENCE   9  (bases 1 to 862)
  AUTHORS   MacArthur,C.A. and Shackleford,G.M.
  TITLE     Npm3: a novel, widely expressed gene encoding a protein related to
            the molecular chaperones nucleoplasmin and nucleophosmin
  JOURNAL   Genomics 42 (1), 137-140 (1997)
   PUBMED   9177783
REFERENCE   10 (bases 1 to 862)
  AUTHORS   MacArthur,C.A., Shankar,D.B. and Shackleford,G.M.
  TITLE     Fgf-8, activated by proviral insertion, cooperates with the Wnt-1
            transgene in murine mammary tumorigenesis
  JOURNAL   J Virol 69 (4), 2501-2507 (1995)
   PUBMED   7884899
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146603.1 and AC149086.4.
            
            On Feb 7, 2019 this sequence version replaced NM_008723.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U64450.1, AK146603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-673               AK146603.1         2-674
            674-754             AK146603.1         676-756
            755-860             AK146603.1         758-863
            861-862             AC149086.4         121866-121867       c
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..862
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /note="nucleoplasmin 3"
                     /db_xref="GeneID:18150"
                     /db_xref="MGI:MGI:894653"
     exon            1..127
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..537
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /codon_start=1
                     /product="nucleoplasmin-3"
                     /protein_id="NP_032749.1"
                     /db_xref="CCDS:CCDS29865.1"
                     /db_xref="GeneID:18150"
                     /db_xref="MGI:MGI:894653"
                     /translation="MAAGAAAALAFLNQESRARAGGVGGLRVPAPVTMDSFFFGCELS
                     GHTRSFTFKVEEEDDTEHVLALNMLCLTEGATDECNVVEVVARDHDNQEIAVPVANLR
                     LSCQPMLSVDDFQLQPPVTFRLKSGSGPVRITGRHQIVCINNDLSEEESDDESEEDEI
                     KLCGILPAKKHRGRP"
     exon            128..213
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..333
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..427
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..544
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..862
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      831..836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /note="hexamer: AATAAA"
     polyA_site      849
                     /gene="Npm3"
                     /gene_synonym="Nub1"
                     /note="major polyA site"
ORIGIN      
        1 cgtttcagca tggcggccgg cgcggcggct gctttagcgt tcttgaacca agagagccga
       61 gcccgagctg ggggcgtcgg gggcctgagg gtcccggccc cggtcacaat ggacagtttc
      121 ttcttcggtt gtgagctctc cggccacacc cgctccttca ctttcaaggt tgaggaggag
      181 gatgacacgg agcacgtgct ggcgttgaac atgctgtgcc ttaccgaggg ggccacggac
      241 gagtgtaatg tggtggaagt tgtggcccgg gatcacgaca atcaggagat tgcagttcct
      301 gtggccaacc tcaggttgtc ttgccagccc atgctcagtg tggatgattt ccaactccaa
      361 ccacctgtca ccttccgcct gaagtccggt tctggcccag ttcggatcac tggccggcat
      421 cagatcgttt gtataaacaa cgacctttct gaagaagaaa gtgatgatga gagcgaagaa
      481 gatgaaatta agctgtgtgg catccttcct gccaagaagc acaggggcag gccttagccc
      541 cctgatcagg taactgcttg ctacaggtgc catgctccgt atgttcctgg acaagttcaa
      601 gaatggtttt ctcgatgaag agaatagggg gtgggaggga gggatggact gtggttcctg
      661 aggcttccct tttctattgg ggtgggacaa cctttgaaca cctcttctga cccacctaac
      721 ccagattcag tccccagcac tgcaaaaaaa aaaacaaaaa acaaaaaaca aaagaacatg
      781 aagttcagaa cacattttta acactttgta ctttttttga taaatatcta aataaagtgg
      841 tgtacggttg gttgttttgc aa
//
