LOCUS       NM_001412003            1328 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus nucleophosmin/nucleoplasmin 2 (Npm2), transcript
            variant 2, mRNA.
ACCESSION   NM_001412003
VERSION     NM_001412003.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Hildebrandt,M.R., Wang,Y., Li,L., Yasmin,L., Glubrecht,D.D. and
            Godbout,R.
  TITLE     Cytoplasmic aggregation of DDX1 in developing embryos: Early
            embryonic lethality associated with Ddx1 knockout
  JOURNAL   Dev Biol 455 (2), 420-433 (2019)
   PUBMED   31330130
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Ogushi,S., Yamagata,K., Obuse,C., Furuta,K., Wakayama,T.,
            Matzuk,M.M. and Saitou,M.
  TITLE     Reconstitution of the oocyte nucleolus in mice through a single
            nucleolar protein, NPM2
  JOURNAL   J Cell Sci 130 (14), 2416-2429 (2017)
   PUBMED   28600324
  REMARK    GeneRIF: Findings demonstrate that the NPM2-based oocyte nucleolus
            is an essential platform for parental chromatin organization in
            early embryonic development.
REFERENCE   4  (bases 1 to 1328)
  AUTHORS   Wajapeyee,N., Malonia,S.K., Palakurthy,R.K. and Green,M.R.
  TITLE     Oncogenic RAS directs silencing of tumor suppressor genes through
            ordered recruitment of transcriptional repressors
  JOURNAL   Genes Dev 27 (20), 2221-2226 (2013)
   PUBMED   24105743
REFERENCE   5  (bases 1 to 1328)
  AUTHORS   Koss,M., Bolze,A., Brendolan,A., Saggese,M., Capellini,T.D.,
            Bojilova,E., Boisson,B., Prall,O.W., Elliott,D.A., Solloway,M.,
            Lenti,E., Hidaka,C., Chang,C.P., Mahlaoui,N., Harvey,R.P.,
            Casanova,J.L. and Selleri,L.
  TITLE     Congenital asplenia in mice and humans with mutations in a
            Pbx/Nkx2-5/p15 module
  JOURNAL   Dev Cell 22 (5), 913-926 (2012)
   PUBMED   22560297
REFERENCE   6  (bases 1 to 1328)
  AUTHORS   Tsunemoto,K., Anzai,M., Matsuoka,T., Tokoro,M., Shin,S.W.,
            Amano,T., Mitani,T., Kato,H., Hosoi,Y., Saeki,K., Iritani,A. and
            Matsumoto,K.
  TITLE     Cis-acting elements (E-box and NBE) in the promoter region of three
            maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1)
            are required for oocyte-specific gene expression in the mouse
  JOURNAL   Mol Reprod Dev 75 (7), 1104-1108 (2008)
   PUBMED   18324673
  REMARK    GeneRIF: Promoter activities of three mouse maternal genes (H1oo,
            Npm2, and Zar1) in oocytes and pre-implantation embryos, and
            examined the promoters and to obttain the best promoter for oocytte
            gene expression.
REFERENCE   7  (bases 1 to 1328)
  AUTHORS   Gazdag,E., Rajkovic,A., Torres-Padilla,M.E. and Tora,L.
  TITLE     Analysis of TATA-binding protein 2 (TBP2) and TBP expression
            suggests different roles for the two proteins in regulation of gene
            expression during oogenesis and early mouse development
  JOURNAL   Reproduction 134 (1), 51-62 (2007)
   PUBMED   17641088
REFERENCE   8  (bases 1 to 1328)
  AUTHORS   Vitale,A.M., Calvert,M.E., Mallavarapu,M., Yurttas,P., Perlin,J.,
            Herr,J. and Coonrod,S.
  TITLE     Proteomic profiling of murine oocyte maturation
  JOURNAL   Mol Reprod Dev 74 (5), 608-616 (2007)
   PUBMED   17044029
REFERENCE   9  (bases 1 to 1328)
  AUTHORS   De La Fuente,R., Viveiros,M.M., Burns,K.H., Adashi,E.Y.,
            Matzuk,M.M. and Eppig,J.J.
  TITLE     Major chromatin remodeling in the germinal vesicle (GV) of
            mammalian oocytes is dispensable for global transcriptional
            silencing but required for centromeric heterochromatin function
  JOURNAL   Dev Biol 275 (2), 447-458 (2004)
   PUBMED   15501230
REFERENCE   10 (bases 1 to 1328)
  AUTHORS   Burns,K.H., Viveiros,M.M., Ren,Y., Wang,P., DeMayo,F.J.,
            Frail,D.E., Eppig,J.J. and Matzuk,M.M.
  TITLE     Roles of NPM2 in chromatin and nucleolar organization in oocytes
            and embryos
  JOURNAL   Science 300 (5619), 633-636 (2003)
   PUBMED   12714744
  REMARK    GeneRIF: Npm2 is a maternal effect gene critical for nuclear and
            nucleolar organization and embryonic development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154563.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN154664.1, CO805680.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               AC154563.2         70138-70690
            554-639             AC154563.2         70808-70893
            640-753             AC154563.2         70986-71099
            754-847             AC154563.2         73658-73751
            848-999             AC154563.2         74811-74962
            1000-1040           AC154563.2         75137-75177
            1041-1074           AC154563.2         75552-75585
            1075-1328           AC154563.2         75673-75926
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.42 cM"
     gene            1..1328
                     /gene="Npm2"
                     /note="nucleophosmin/nucleoplasmin 2"
                     /db_xref="GeneID:328440"
                     /db_xref="MGI:MGI:1890811"
     exon            1..553
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..1119
                     /gene="Npm2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     nucleoplasmin-2"
                     /codon_start=1
                     /product="nucleoplasmin-2 isoform 1"
                     /protein_id="NP_001398932.1"
                     /db_xref="GeneID:328440"
                     /db_xref="MGI:MGI:1890811"
                     /translation="MSRHSTSSVTETTAKNMLWGSELNQEKQTCTFRGQGEKKDSCKL
                     LLSTICLGEKAKEEVNRVEVLSQEGRKPPITIATLKASVLPMVTVSGIELSPPVTFRL
                     RTGSGPVFLSGLECYETSDLTWEDDEEEEEEEEEEDEDEDADISLEEIPVKQVKRVAP
                     QKQMSIAKKKKVEKEEDETVVRPSPQDKSPWKKEKSTPRAKKPVTKK"
     exon            554..639
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..753
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..847
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..999
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1040
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1074
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1328
                     /gene="Npm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1303..1308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npm2"
                     /note="hexamer: AATAAA"
     polyA_site      1328
                     /gene="Npm2"
                     /note="major polyA site"
ORIGIN      
        1 agatggagcc ctgaagccat attgaggacc tgcagtagag gtggaaccca tgactggcag
       61 cgcagtaagc ttgagcaggg ggtacatagg actcggatcc aactgggcac acatcctggt
      121 cccctctctc tctccacact ggggttctgg gagggccaca ggggcagtca tgtaatctct
      181 cagctagctt ccaaacttgg gctagacaaa ccaccattcc ttgcactgtg gtgttgagtg
      241 tgtctgtctc gggtctggga tgctctgatc agttgcaggg aggggggaag cgggaaactt
      301 ggcttctagt ttttaatggc tgttggctat agccaacatt cccaggactc aaggtagctt
      361 tccttatggc tagcctttgc attactcaga acacagtgat aacagctgag ctccaagcaa
      421 ggacccagga ccttgcctca ccacagacat aatctttccc cacaacacct ccaccaagcc
      481 gccctgtaaa tcgacatgag tcgccacagc accagcagcg tgaccgaaac cacagcaaaa
      541 aacatgctct ggggtagtga actcaatcag gaaaagcaga cttgcacctt tagaggccaa
      601 ggcgagaaga aggacagctg taaactcttg ctcagcacga tctgcctggg ggagaaagcc
      661 aaagaggagg tgaaccgtgt ggaagtcctc tcccaggaag gcagaaaacc accaatcact
      721 attgctacgc tgaaggcctc cgtcctgccc atggtcactg tgtcaggtat agagctttct
      781 cctccagtaa cttttcggct caggactggc tcaggacctg tgttcctcag tggcctggaa
      841 tgttatgaga cttcggacct gacctgggaa gatgacgagg aagaggagga agaggaggag
      901 gaagaggatg aagatgagga tgcagatata tcgctagagg agatacctgt caaacaagtc
      961 aaaagggtgg ctccccagaa gcagatgagc atagcaaaga aaaagaaggt ggaaaaagaa
     1021 gaggatgaaa cagtagtgag gcccagccct caggacaaga gtccctggaa gaaggagaaa
     1081 tctacaccca gagcaaagaa gccagtgacc aagaaatgac ctcatcttag catcttctgc
     1141 gtccaaggca ggatgtccag cagctgtgct ctggtgcagg tgtccagccc caccacccta
     1201 gtctgaatgt aataaggtgg tgtggctgta accctgtaac ccagccctcc agtttccgga
     1261 ggctcttggt gaagagcccc cagcaagctc gcctagggcc acaataaaat ttgcatgatc
     1321 agaacctc
//
