LOCUS       NM_008722               1440 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus nucleophosmin 1 (Npm1), transcript variant 1, mRNA.
ACCESSION   NM_008722
VERSION     NM_008722.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1440)
  AUTHORS   Bowman,R.L., Dunbar,A.J., Mishra,T., Xiao,W., Waarts,M.R.,
            Maestre,I.F., Eisman,S.E., Cai,L., Mowla,S., Shah,N., Youn,A.,
            Bennett,L., Fontenard,S., Gounder,S., Gandhi,A., Bowman,M.,
            O'Connor,K., Zaroogian,Z., Sanchez-Vela,P., Martinez Benitez,A.R.,
            Werewski,M., Park,Y., Csete,I.S., Krishnan,A., Lee,D., Boorady,N.,
            Potts,C.R., Jenkins,M.T., Cai,S.F., Carroll,M.P., Meyer,S.E.,
            Miles,L.A., Ferrell,P.B. Jr., Trowbridge,J.J. and Levine,R.L.
  TITLE     In vivo models of subclonal oncogenesis and dependency in
            hematopoietic malignancy
  JOURNAL   Cancer Cell 42 (11), 1955-1969 (2024)
   PUBMED   39532065
REFERENCE   2  (bases 1 to 1440)
  AUTHORS   Zhang,S., Zhang,Y., Duan,X., Wang,B. and Zhan,Z.
  TITLE     Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac
            Repair by Reprogramming Reparative Macrophage Metabolism
  JOURNAL   Circulation 149 (25), 1982-2001 (2024)
   PUBMED   38390737
  REMARK    GeneRIF: Targeting NPM1 Epigenetically Promotes Postinfarction
            Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.
REFERENCE   3  (bases 1 to 1440)
  AUTHORS   Korai,A., Lin,X., Tago,K. and Funakoshi-Tago,M.
  TITLE     The acetylation of STAT3 at K685 attenuates NPM-ALK-induced
            tumorigenesis
  JOURNAL   Cell Signal 114, 110985 (2024)
   PUBMED   38000524
  REMARK    GeneRIF: The acetylation of STAT3 at K685 attenuates
            NPM-ALK-induced tumorigenesis.
REFERENCE   4  (bases 1 to 1440)
  AUTHORS   Fang,Y., Zhang,J., Zhu,D., Mei,Q., Liao,T., Cheng,H., He,Y., Cao,Y.
            and Wei,Z.
  TITLE     MANF Promotes Unexplained Recurrent Miscarriages by Interacting
            with NPM1 and Downregulating Trophoblast Cell Migration and
            Invasion
  JOURNAL   Int J Biol Sci 20 (1), 296-311 (2024)
   PUBMED   38164189
  REMARK    GeneRIF: MANF Promotes Unexplained Recurrent Miscarriages by
            Interacting with NPM1 and Downregulating Trophoblast Cell Migration
            and Invasion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1440)
  AUTHORS   Izzo,A., Akol,I., Villarreal,A., Lebel,S., Garcia-Miralles,M.,
            Cheffer,A., Bovio,P., Heidrich,S. and Vogel,T.
  TITLE     Nucleophosmin 1 cooperates with the methyltransferase DOT1L to
            preserve peri-nucleolar heterochromatin organization by regulating
            H3K27me3 levels and DNA repeats expression
  JOURNAL   Epigenetics Chromatin 16 (1), 36 (2023)
   PUBMED   37759327
  REMARK    GeneRIF: Nucleophosmin 1 cooperates with the methyltransferase
            DOT1L to preserve peri-nucleolar heterochromatin organization by
            regulating H3K27me3 levels and DNA repeats expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1440)
  AUTHORS   Sowden,J.C., Morrison,K., Putt,W., Beddington,R. and Edwards,Y.H.
  TITLE     The identification of novel sequences expressed in the mouse
            notochord
  JOURNAL   Mamm Genome 8 (1), 42-44 (1997)
   PUBMED   9021147
REFERENCE   7  (bases 1 to 1440)
  AUTHORS   Inouye,C.J. and Seto,E.
  TITLE     Relief of YY1-induced transcriptional repression by protein-protein
            interaction with the nucleolar phosphoprotein B23
  JOURNAL   J Biol Chem 269 (9), 6506-6510 (1994)
   PUBMED   8120001
REFERENCE   8  (bases 1 to 1440)
  AUTHORS   Van den Eynde,B., Lethe,B., Van Pel,A., De Plaen,E. and Boon,T.
  TITLE     The gene coding for a major tumor rejection antigen of tumor P815
            is identical to the normal gene of syngeneic DBA/2 mice
  JOURNAL   J Exp Med 173 (6), 1373-1384 (1991)
   PUBMED   1903428
REFERENCE   9  (bases 1 to 1440)
  AUTHORS   Biggiogera,M., Burki,K., Kaufmann,S.H., Shaper,J.H., Gas,N.,
            Amalric,F. and Fakan,S.
  TITLE     Nucleolar distribution of proteins B23 and nucleolin in mouse
            preimplantation embryos as visualized by immunoelectron microscopy
  JOURNAL   Development 110 (4), 1263-1270 (1990)
   PUBMED   2100262
REFERENCE   10 (bases 1 to 1440)
  AUTHORS   Schmidt-Zachmann,M.S. and Franke,W.W.
  TITLE     DNA cloning and amino acid sequence determination of a major
            constituent protein of mammalian nucleoli. Correspondence of the
            nucleoplasmin-related protein NO38 to mammalian protein B23
  JOURNAL   Chromosoma 96 (6), 417-426 (1988)
   PUBMED   3219912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA540276.1, AK165860.1 and CX567338.1.
            
            On Nov 9, 2011 this sequence version replaced NM_008722.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054755.1, GU214027.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               CA540276.1         1-129
            130-1404            AK165860.1         2-1276
            1405-1440           CX567338.1         690-725
FEATURES             Location/Qualifiers
     source          1..1440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.21 cM"
     gene            1..1440
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /note="nucleophosmin 1"
                     /db_xref="GeneID:18148"
                     /db_xref="MGI:MGI:106184"
     exon            1..285
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1106
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /note="isoform 1 is encoded by transcript variant 1;
                     numatrin; nucleolar phosphoprotein B23; nucleolar protein
                     NO38"
                     /codon_start=1
                     /product="nucleophosmin isoform 1"
                     /protein_id="NP_032748.1"
                     /db_xref="CCDS:CCDS24532.1"
                     /db_xref="GeneID:18148"
                     /db_xref="MGI:MGI:106184"
                     /translation="MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSL
                     RTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRL
                     KCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDE
                     DDEDDDEDDEDDEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTP
                     RSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRM
                     TDQEAIQDLWQWRKSL"
     exon            286..365
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            366..485
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            486..579
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            580..686
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            687..748
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            749..806
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            807..890
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            891..992
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1067
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1422
                     /gene="Npm1"
                     /gene_synonym="B23; NO38; Npm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcacgcg caaaagcgcg actgtgcggg gagtgggagg gatccagagg aggctcgcgg
       61 aggcaggact agcgcagatc tcgcgagatc tcctgcgacc atatatacgt gcggagagcc
      121 cgcgtccttt ccttggcgtg attccgtcct gcgcgtctgt tctgtggaac aggaggcagt
      181 tgttttccgt ccggcttctc ccacaccgaa gtgcgcgcct ccacctcatg gaagactcga
      241 tggatatgga catgagtcct cttaggcctc agaactacct tttcggctgt gaactaaagg
      301 ctgacaaaga ctatcacttt aaagtggata atgatgaaaa tgagcaccag ttgtcattaa
      361 gaacggtcag tttaggagca ggggcaaaag atgagttaca catcgtagag gcagaagcaa
      421 tgaactatga aggcagtcca attaaagtaa cactggcaac tttgaaaatg tctgtacaac
      481 caacagtttc cctagggggc tttgaaatta caccacctgt ggtcttacgg ttgaagtgtg
      541 gttcagggcc tgtgcacatt agtggacagc atctagtagc tgtagaggaa gatgcagagt
      601 ctgaagatga agatgaggag gacgtaaaac tcttaggcat gtctggaaag cgatctgctc
      661 ctggaggtgg taacaaggtt ccacagaaaa aagtaaaact tgatgaagat gatgaggacg
      721 atgatgagga cgatgaggat gatgaggatg atgatgatga tgattttgat gaagaggaaa
      781 ctgaagaaaa ggtcccagtg aagaaatctg tacgagatac cccagccaaa aatgcacaaa
      841 aatcaaacca aaatggaaaa gacttaaaac catcaacacc gagatcaaag ggtcaagagt
      901 ccttcaaaaa acaggaaaag actcctaaaa caccaaaagg acctagttct gtagaagaca
      961 ttaaggcaaa aatgcaagca agtatagaaa aaggcggttc tcttcccaaa gtggaagcca
     1021 agttcattaa ttatgtgaag aattgtttcc ggatgactga ccaggaggct attcaagatc
     1081 tctggcagtg gaggaaatct ctttaagaaa agggtttaaa cagtttgaaa tattctgtct
     1141 tcatttctgt aatagttaat atctggctgt cctttttata atgcaaagtg agaactttcc
     1201 ctactgtgtt tgataaatgt tgtccaggtt cacttgccaa gaatgtgttg tctaaaatgc
     1261 ctgtttagtt ttcaaggatg gaactccacc ctttacttgg ttttaagtat gtatggaatg
     1321 ttatgatagg acatagtaat agtggtcaga tgtggaaatg gtagggagac aaatatacat
     1381 gtgaaataaa ctcagtattt taataaagta gcactgtttc taaaaaaaaa aaaaaaaaaa
//
