LOCUS       NM_028749               1403 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus N-acetylneuraminate pyruvate lyase (Npl), mRNA.
ACCESSION   NM_028749
VERSION     NM_028749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1403)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   2  (bases 1 to 1403)
  AUTHORS   Da Silva,A., Dort,J., Orfi,Z., Pan,X., Huang,S., Kho,I., Heckel,E.,
            Muscarnera,G., van Vliet,P.P., Sturiale,L., Messina,A., Romeo,D.A.,
            van Karnebeek,C.D.M., Wen,X.Y., Hinek,A., Molina,T.,
            Andelfinger,G., Ellezam,B., Yamanaka,Y., Olivos,H.J., Morales,C.R.,
            Joyal,J.S., Lefeber,D.J., Garozzo,D., Dumont,N.A. and
            Pshezhetsky,A.V.
  TITLE     N-acetylneuraminate pyruvate lyase controls sialylation of muscle
            glycoproteins essential for muscle regeneration and function
  JOURNAL   Sci Adv 9 (26), eade6308 (2023)
   PUBMED   37390204
  REMARK    GeneRIF: N-acetylneuraminate pyruvate lyase controls sialylation of
            muscle glycoproteins essential for muscle regeneration and
            function.
REFERENCE   3  (bases 1 to 1403)
  AUTHORS   Zhang,H., Jiang,J.C., Wu,Y.W., Yu,Y.S., Wang,H.N., Ding,N.Z. and
            Fan,H.Y.
  TITLE     The RNA ligase RNA terminal phosphate cyclase B regulates mRNA
            alternative splicing and is required for mouse oocyte development
            and maintenance
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36178098
REFERENCE   4  (bases 1 to 1403)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1403)
  AUTHORS   Sha,Q.Q., Zhu,Y.Z., Li,S., Jiang,Y., Chen,L., Sun,X.H., Shen,L.,
            Ou,X.H. and Fan,H.Y.
  TITLE     Characterization of zygotic genome activation-dependent maternal
            mRNA clearance in mouse
  JOURNAL   Nucleic Acids Res 48 (2), 879-894 (2020)
   PUBMED   31777931
REFERENCE   6  (bases 1 to 1403)
  AUTHORS   Xiao,S., Li,R., Diao,H., Zhao,F. and Ye,X.
  TITLE     Progesterone receptor-mediated regulation of N-acetylneuraminate
            pyruvate lyase (NPL) in mouse uterine luminal epithelium and
            nonessential role of NPL in uterine function
  JOURNAL   PLoS One 8 (5), e65607 (2013)
   PUBMED   23741500
  REMARK    GeneRIF: This study demonstrates PR-mediated dynamic expression of
            Npl in the periimplantation uterus and dispensable role of Npl in
            uterine function and embryo development.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1403)
  AUTHORS   Bergfeld,A.K., Pearce,O.M., Diaz,S.L., Pham,T. and Varki,A.
  TITLE     Metabolism of vertebrate amino sugars with N-glycolyl groups:
            elucidating the intracellular fate of the non-human sialic acid
            N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 287 (34), 28865-28881 (2012)
   PUBMED   22692205
REFERENCE   8  (bases 1 to 1403)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1403)
  AUTHORS   Traving,C., Bruse,P., Wachter,A. and Schauer,R.
  TITLE     The sialate-pyruvate lyase from pig kidney. Elucidation of the
            primary structure and expression of recombinant enzyme activity
  JOURNAL   Eur J Biochem 268 (24), 6473-6486 (2001)
   PUBMED   11737202
REFERENCE   10 (bases 1 to 1403)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK002734.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002734.1, AK088859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1403
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.38 cM"
     gene            1..1403
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /note="N-acetylneuraminate pyruvate lyase"
                     /db_xref="GeneID:74091"
                     /db_xref="MGI:MGI:1921341"
     exon            1..67
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            68..151
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1046
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /EC_number="4.1.3.3"
                     /note="NALase; sialate lyase; sialic acid lyase; sialic
                     acid aldolase; sialate-pyruvate lyase; N-acetylneuraminic
                     acid aldolase"
                     /codon_start=1
                     /product="N-acetylneuraminate lyase"
                     /protein_id="NP_083025.1"
                     /db_xref="CCDS:CCDS15374.1"
                     /db_xref="GeneID:74091"
                     /db_xref="MGI:MGI:1921341"
                     /translation="MAFPKKKLRGLVAATITPMTENGEINFPVIGQYVDYLVKEQGVK
                     NIFVNGTTGEGLSLSVSERRQVAEEWVNQGRNKLDQVVIHVGALNVKESQELAQHAAE
                     IGADGIAVIAPFFFKSQNKDALISFLREVAAAAPTLPFYYYHMPSMTGVKIRAEELLD
                     GIQDKIPTFQGLKFTDTDLLDFGQCVDQNHQRQFALLFGVDEQLLSALVMGATGAVGS
                     TYNYLGKKTNQMLEAFEQKDLASALSYQFRIQRFINYVIKLGFGVSQTKAIMTLVSGI
                     PMGPPRLPLQKATQEFTAKAEAKLKSLDFLSSPSVKEGKPLASA"
     exon            152..225
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            226..313
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            314..371
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            372..447
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            448..540
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            541..689
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..736
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            737..821
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            822..861
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1403
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1403
                     /gene="Npl"
                     /gene_synonym="0610033B02Rik"
                     /note="putative"
ORIGIN      
        1 agatcgcgtc tccagtgcac agcagcctag gtgagcgcgg cgccaccgag cagaggagtg
       61 aagtcagacc ttccagcaac ccgatggcct tccctaagaa gaaactccgg ggtcttgttg
      121 ctgccaccat cactccaatg acagagaatg gagaaatcaa ctttcctgtc attggtcagt
      181 atgtggatta cctggtgaag gaacaggggg tgaagaatat ttttgtgaat ggcaccacag
      241 gagaaggcct gtccctgagc gtctctgaac gtcgccaggt cgcggaggaa tgggttaacc
      301 aagggaggaa caagttggac caggtggtga ttcacgtggg agcactaaac gtgaaggagt
      361 cacaagaact ggcccaacat gcagcagaaa ttggagctga tggcattgct gtcattgcgc
      421 ctttcttttt caagtcacag aacaaagatg ccctgataag cttcctgaga gaggtggcag
      481 ccgcagctcc tactttgcca ttttattact accacatgcc ttccatgacc ggggtaaaga
      541 ttcgcgctga ggagctgctg gacgggattc aggacaagat ccccaccttc caaggactga
      601 agttcaccga cacggacctc ttggatttcg gccaatgtgt cgatcagaat caccagcgac
      661 agtttgcttt gctctttggg gtggacgaac aactgctgag tgctctggtc atgggagcca
      721 ctggagcagt aggcagtacc tataactacc tgggaaaaaa gacaaaccag atgttggaag
      781 cttttgaaca gaaggacttg gcttcagcgc tcagttacca gtttcgtatc cagagattta
      841 tcaactatgt gatcaagcta ggttttggag tgtcgcaaac caaagccatc atgacgctgg
      901 tctctgggat tccaatgggc ccaccccggc ttcctctgca gaaagccacc caggagttta
      961 ctgctaaggc tgaggccaag ctaaagagcc tggatttcct ttcttcccct agtgtaaagg
     1021 aggggaagcc tttagctagt gcctgataag tctgggtgtg taagcttaga cttatctatc
     1081 ttcaatagta cattcttttc tcagggactt ttttaggtga atttgaaccc atctttattt
     1141 taggaagtag aatcccacac caatcaaata ttgattatga acctaaactt ttttgttata
     1201 aaggagtcac aagctctaag tcattcattt tgtaaaatta ttatagagaa atctctactt
     1261 atacagatgc aatggaacca agtgaaaatt gtaatagtaa ttacaattat taattaatta
     1321 cattaattaa tataattcat atcactatat taattgctac attggttata ttattgctga
     1381 ataaatttca cctgcctttt ggg
//
