LOCUS       NM_130456               3124 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus nephrosis 2, podocin (Nphs2), mRNA.
ACCESSION   NM_130456
VERSION     NM_130456.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3124)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3124)
  AUTHORS   N'Guetta,P.Y., McLarnon,S.R., Tassou,A., Geron,M., Shirvan,S.,
            Hill,R.Z., Scherrer,G. and O'Brien,L.L.
  TITLE     Comprehensive mapping of sensory and sympathetic innervation of the
            developing kidney
  JOURNAL   Cell Rep 43 (10), 114860 (2024)
   PUBMED   39412983
REFERENCE   3  (bases 1 to 3124)
  AUTHORS   Liang,L., He,M., Zhou,P., Pan,S., Chen,J., Lv,L., Hu,M., Zhou,S.,
            Liu,D. and Liu,Z.
  TITLE     c-Cbl induced podocin ubiquitination contributes to the podocytes
            injury in diabetic nephropathy
  JOURNAL   FASEB J 38 (10), e23662 (2024)
   PUBMED   38752545
  REMARK    GeneRIF: c-Cbl induced podocin ubiquitination contributes to the
            podocytes injury in diabetic nephropathy.
REFERENCE   4  (bases 1 to 3124)
  AUTHORS   Higashi,A.Y., Saito,A.C., Higashi,T., Furuse,K., Furuse,M.,
            Chiba,H. and Kazama,J.J.
  TITLE     Bicellular Localization of Tricellular Junctional Protein
            Angulin-3/ILDR2 Allows Detection of Podocyte Injury
  JOURNAL   Am J Pathol 194 (5), 673-683 (2024)
   PUBMED   38311119
REFERENCE   5  (bases 1 to 3124)
  AUTHORS   Schomig,T., Diefenhardt,P., Plagmann,I., Trinsch,B., Merz,T.,
            Crispatzu,G., Unnersjo-Jess,D., Nies,J., Putz,D., Sierra
            Gonzalez,C., Schermer,B., Benzing,T., Brinkkoetter,P.T. and
            Brahler,S.
  TITLE     The podocytes' inflammatory responses in experimental GN are
            independent of canonical MYD88-dependent toll-like receptor
            signaling
  JOURNAL   Sci Rep 14 (1), 2292 (2024)
   PUBMED   38280906
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3124)
  AUTHORS   Sellin,L., Huber,T.B., Gerke,P., Quack,I., Pavenstadt,H. and
            Walz,G.
  TITLE     NEPH1 defines a novel family of podocin interacting proteins
  JOURNAL   FASEB J 17 (1), 115-117 (2003)
   PUBMED   12424224
REFERENCE   7  (bases 1 to 3124)
  AUTHORS   Sadl,V., Jin,F., Yu,J., Cui,S., Holmyard,D., Quaggin,S., Barsh,G.
            and Cordes,S.
  TITLE     The mouse Kreisler (Krml1/MafB) segmentation gene is required for
            differentiation of glomerular visceral epithelial cells
  JOURNAL   Dev Biol 249 (1), 16-29 (2002)
   PUBMED   12217315
REFERENCE   8  (bases 1 to 3124)
  AUTHORS   Roselli,S., Gribouval,O., Boute,N., Sich,M., Benessy,F., Attie,T.,
            Gubler,M.C. and Antignac,C.
  TITLE     Podocin localizes in the kidney to the slit diaphragm area
  JOURNAL   Am J Pathol 160 (1), 131-139 (2002)
   PUBMED   11786407
REFERENCE   9  (bases 1 to 3124)
  AUTHORS   Schwarz,K., Simons,M., Reiser,J., Saleem,M.A., Faul,C., Kriz,W.,
            Shaw,A.S., Holzman,L.B. and Mundel,P.
  TITLE     Podocin, a raft-associated component of the glomerular slit
            diaphragm, interacts with CD2AP and nephrin
  JOURNAL   J Clin Invest 108 (11), 1621-1629 (2001)
   PUBMED   11733557
REFERENCE   10 (bases 1 to 3124)
  AUTHORS   Huber,T.B., Kottgen,M., Schilling,B., Walz,G. and Benzing,T.
  TITLE     Interaction with podocin facilitates nephrin signaling
  JOURNAL   J Biol Chem 276 (45), 41543-41546 (2001)
   PUBMED   11562357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161414.3 and FJ715770.1.
            
            On Sep 1, 2015 this sequence version replaced NM_130456.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ715770.1, BC067401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC161414.3         23251-23258         c
            9-3124              FJ715770.1         1-3116
FEATURES             Location/Qualifiers
     source          1..3124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.71 cM"
     gene            1..3124
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /note="nephrosis 2, podocin"
                     /db_xref="GeneID:170484"
                     /db_xref="MGI:MGI:2157018"
     exon            1..349
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1227
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /note="nephrosis 2 homolog, podocin"
                     /codon_start=1
                     /product="podocin"
                     /protein_id="NP_569723.1"
                     /db_xref="CCDS:CCDS15391.1"
                     /db_xref="GeneID:170484"
                     /db_xref="MGI:MGI:2157018"
                     /translation="MDSRARSSSREAHGRSSRSSSRDDKKAKAGRGSRGRARPDAGAE
                     RQSTGRTATRGEPRAPAATATVVDVDEVRGPGEEGTEVVALLESERPEEGIKPSGLGA
                     CEWLLVLASLIFIIMTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPC
                     LDTYHKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQF
                     LVQTTMKRLLAHRSLTEILLERKSIAQDVKVALDAVTCIWGIKVERTEIKDVRLPAGL
                     QHSLAVEAEAQRQAKVRVIAAEGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLST
                     EKPATVVLPLPFDMLSLLSSPGNRAQGSINYPSSSKPVEPLNPKKKDSPML"
     exon            350..453
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..526
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..609
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..813
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..869
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..948
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..3124
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3102..3107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /note="hexamer: AATAAA"
     polyA_site      3123
                     /gene="Nphs2"
                     /gene_synonym="PDCN; SRN1"
                     /note="major polyA site"
ORIGIN      
        1 atcggctcag aaagctgggg ctgcgactct gccagcagct ggctccgggg ttgcaccgct
       61 gcattgagaa tggacagcag ggcgcggagc tcttcccgag aggcccacgg gagaagtagc
      121 aggtcctcct ctagggatga caagaaggca aaggccggga ggggcagcag aggccgcgca
      181 cgtccggatg ctggagcaga gcggcagagc accgggcgga cagcgacccg aggggagccc
      241 cgagctcccg ctgccaccgc caccgtagtg gacgtggacg aggttcgggg ccctggtgag
      301 gagggcacgg aagtggtggc gctgctggag agcgagcgac cagaggaagg catcaagccc
      361 tctggattag gggcctgcga gtggcttctt gtcctcgcct ccctgatctt catcatcatg
      421 acgttccctt tttccatctg gttctgcata aaggttgtgc aagagtatga aagagtaatt
      481 atattccgac tgggacatct gcttcctgga agagccaaag gtcctggcct gttctttttt
      541 ttaccctgtc tggacaccta tcacaaggtt gatctccgtc tccagacctt ggaaatacct
      601 ttccatgagg tggtaaccaa agatatgttt ataatggaga tagacgctgt ctgctactac
      661 cgcatggaaa atgcctctct tcttctaagc agtctagccc atgtgtccaa agccatccag
      721 ttcctggtgc aaaccaccat gaagcgcctc ttggcacatc gatccctcac tgaaattctc
      781 ctggaaagga agagcattgc ccaagatgta aaggttgcct tagatgcagt gacctgtatt
      841 tggggcatca aagtggagag aactgaaatt aaggatgtga ggctgccagc tgggcttcag
      901 cactctctgg cggtggaagc tgaggcacaa agacaggcca aagtgcgggt gattgctgca
      961 gaaggggaaa aggctgcttc agagtccctg aggatggcgg ctgagattct gtcgggcacc
     1021 ccagccgctg tccagcttcg atacttgcac actcttcagt cgctgtccac agagaagcca
     1081 gccactgtgg ttttgccttt gccatttgac atgctaagcc ttttgtcctc tcccggcaac
     1141 agagcacaag ggagcatcaa ctacccaagt tcctccaaac cagttgaacc actaaatccc
     1201 aaaaagaagg actctcctat gttataggcg aatgggcaaa ggctgtgtga atctgccata
     1261 taaagccaca tccctgagag aggcatttgg tgtccctcac ccccaccccg cacttgtttg
     1321 gttgccaaat agaatgcctt ttgaatgtat aaagtcacaa gatggctaca tgcatgagaa
     1381 cacagtgaaa tgacagtggc agagaagaca gtcaaccaca caagtaggtt gtctcatcat
     1441 attaattaca ggaaagagat ttagaatttt gaattgacat gtggtccgat tatgatttct
     1501 gaagacttag ttcaaatacc ttccactgct tgtttcctgg ctccttcagc aaggcctttg
     1561 cggatcctcc agcctttttt gcaagtgcct atcagtgcac atggagtgga aagccagggc
     1621 ttaggacaca ggcatctccc ctttccgtat tcgtacaaac tcccactgaa acagcccact
     1681 tagctatgtt gctggctgtt aacaactttt ccagcctaaa attccaaact ctcagaaagt
     1741 agtcccaagg cataaaagcc ctgtggtcag gcatgttggg gcaacaaccc cacttcctca
     1801 gtaccaattc tgctctagtt tcatttttgt ctttatgatt aaaatattcc agcaacaaga
     1861 aacttaaagg agaaagagtt tattttaggg cacaattcca ggtgacagtc catcactgtg
     1921 gagaagttaa ggcaagaact tgaagcaact cttacttagt cacttcatgc aggcaagaac
     1981 atgaagcagc tggtcatgtc acagtcaaat gcagaaagca atgaatacgt ggttcttagt
     2041 tgtctgagtt cagctcagtt tacccactca tccagttcag ggctcccctg cctagggagt
     2101 gctgtcacct atcatgggct ggatcttcgc acattaatta atttaaaaac agtctctctg
     2161 cagacatgcc cacaggataa cctaatgtag ataatccctc attagtctct tctggggtta
     2221 ttctaggttg tatcaagttg gcaaacaaaa ctaaccttca catctacata gcaataccct
     2281 gtctcaaagc caacaacaaa aatggagtca cttgtgtcag tgttccaaaa agtaattaaa
     2341 gcctagacca gtacttctca agcttcctga tgctgtgaca ttttaacaca gattctcacg
     2401 ttgtgatgac cccaaccata aggttatttt cactgctact taataactgt cattttgcag
     2461 aatttttcat accaagtcct aattgcttgc tgtcatgtac actatactac aatgtataca
     2521 agtatgtgct agagaactct cttactggta agaagttatg ctgataatca accagggata
     2581 tgtgtctggg tcatattcct tatgggatac agatctcttg ggtagaagag ttactaccaa
     2641 cagtagggaa tgatagggca cagaaaggac agatatgggc actgtcatac tctgtaatac
     2701 aaggacacat ttgtactcaa cattgttgaa aggactcttc actggtagct tagcatacac
     2761 tgctaatggt ttgttctaag ttaatcacct tccatagctt aggtgctcct ggatgagaac
     2821 acttttgata ccaacagaaa ctagagtttc cataagtata tgggcccaaa catctacaca
     2881 aagaggggaa aatacaaaga atgataggaa gacagacatc atcacatgtc tcaaaaaaat
     2941 gtggctgatc tcttgaccag aggggcaaga ctgagtctgg catgactgac tggctgcctc
     3001 tggccctaac atctccacct ctccctatat catctgttgg agattgtgat gatgatggtc
     3061 tgagatgcta atctgctgca tctctggttg cttgctcact gaataaaata tagttttatg
     3121 attc
//
