LOCUS       NM_001355739            4931 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus nephronophthisis 4 (juvenile) homolog (human) (Nphp4),
            transcript variant 3, mRNA.
ACCESSION   NM_001355739 XM_006538872
VERSION     NM_001355739.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4931)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   2  (bases 1 to 4931)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4931)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   4  (bases 1 to 4931)
  AUTHORS   Agbu,S.O., Liang,Y., Liu,A. and Anderson,K.V.
  TITLE     The small GTPase RSG1 controls a final step in primary cilia
            initiation
  JOURNAL   J Cell Biol 217 (1), 413-427 (2018)
   PUBMED   29038301
REFERENCE   5  (bases 1 to 4931)
  AUTHORS   Rao,K.N., Zhang,W., Li,L., Ronquillo,C., Baehr,W. and Khanna,H.
  TITLE     Ciliopathy-associated protein CEP290 modifies the severity of
            retinal degeneration due to loss of RPGR
  JOURNAL   Hum Mol Genet 25 (10), 2005-2012 (2016)
   PUBMED   26936822
REFERENCE   6  (bases 1 to 4931)
  AUTHORS   Mollet,G., Silbermann,F., Delous,M., Salomon,R., Antignac,C. and
            Saunier,S.
  TITLE     Characterization of the nephrocystin/nephrocystin-4 complex and
            subcellular localization of nephrocystin-4 to primary cilia and
            centrosomes
  JOURNAL   Hum Mol Genet 14 (5), 645-656 (2005)
   PUBMED   15661758
REFERENCE   7  (bases 1 to 4931)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 4931)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 4931)
  AUTHORS   Otto,E., Hoefele,J., Ruf,R., Mueller,A.M., Hiller,K.S., Wolf,M.T.,
            Schuermann,M.J., Becker,A., Birkenhager,R., Sudbrak,R.,
            Hennies,H.C., Nurnberg,P. and Hildebrandt,F.
  TITLE     A gene mutated in nephronophthisis and retinitis pigmentosa encodes
            a novel protein, nephroretinin, conserved in evolution
  JOURNAL   Am J Hum Genet 71 (5), 1161-1167 (2002)
   PUBMED   12205563
  REMARK    GeneRIF: Recessive mutations in the NPHP4 gene, encoding the
            protein nephroretinin, in humans cause nephronophthisis type 4 and
            Senior-Loken. There is evolutionary conservation of the NPHP4 gene,
            with an orhtolog in C. elegans.
REFERENCE   10 (bases 1 to 4931)
  AUTHORS   Mollet,G., Salomon,R., Gribouval,O., Silbermann,F., Bacq,D.,
            Landthaler,G., Milford,D., Nayir,A., Rizzoni,G., Antignac,C. and
            Saunier,S.
  TITLE     The gene mutated in juvenile nephronophthisis type 4 encodes a
            novel protein that interacts with nephrocystin
  JOURNAL   Nat Genet 32 (2), 300-305 (2002)
   PUBMED   12244321
  REMARK    Erratum:[Nat Genet 2002 Nov;32(3):459]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ108378.1, AK038879.1, CO430221.1, CV783895.1, AF537131.1 and
            BP753185.1.
            
            On Sep 26, 2017 this sequence version replaced XM_006538872.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.101731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               CJ108378.1         2-525
            525-1257            AK038879.1         396-1128
            1258-1258           CO430221.1         563-563
            1259-1543           AK038879.1         1130-1414
            1544-1544           CV783895.1         171-171
            1545-3331           AK038879.1         1416-3202
            3332-4777           AK038879.1         3204-4649
            4778-4862           AF537131.1         4641-4725
            4863-4931           BP753185.1         1-69                c
FEATURES             Location/Qualifiers
     source          1..4931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.14 cM"
     gene            1..4931
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /note="nephronophthisis 4 (juvenile) homolog (human)"
                     /db_xref="GeneID:260305"
                     /db_xref="MGI:MGI:2384210"
     exon            1..182
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            183..363
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..4506
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /note="nephroretinin"
                     /codon_start=1
                     /product="nephrocystin-4"
                     /protein_id="NP_001342668.1"
                     /db_xref="CCDS:CCDS38985.1"
                     /db_xref="GeneID:260305"
                     /db_xref="MGI:MGI:2384210"
                     /translation="MGDWHRAFTQNTLVPPHPQRARQLGKESTAFQCILKWLDGPLIK
                     QGILDMLSELECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHT
                     TLSHPSIVAVVEVVTEGRKRDGTLQLLSCGFGILRIFGNKPESPTSAAQDKRLRLYHG
                     TPRALLHPLLQDPIEQNKFMRLMENCSLQYTLKPHPPLEPAFHLLPENLLVSGFQQIP
                     GLLPPHGDTGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDREGVGLL
                     DSGTLEVLERRLHVCVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKISASSKNSSG
                     NQALVLRSHLRLPEMVSHPAFAIVFQLEYVFNSPSGADGGASSPTSISSVACMHMVRW
                     AVWNPDLEVGPGKVTLPLQGGVQQNPSRCLVYKVPSASMSSEEVKQVESGTIQFQFSL
                     SSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLTASP
                     LSPALQSSSKPPLQPPDSSQSPEGPQLQAESVLESRVSHLEADLSQPASLQGTPAVEH
                     LQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDASQQPVEAVNPIDP
                     VRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWPQTVYFTFQFYRFPPETTPRL
                     QLVKLDGTGKSGSGSLSHILVPINKDGSFDAGSPGLQLRYMVDPGFLKPGEQRWFAHY
                     LAAQTLQVDVWDGDSLLLIGSAGVQMKHLLRQGRPAVQVSHELEVVATEYEQEMMAVS
                     GDVAGFGSVKPIGVHTVVKGRLHLTLANVGHACEPRARGSNLLPPSRSRVISNDGASF
                     FSGGSLLIPGGPKRKRVVQAQRLADVDSELAAMLLTHTRAGQGPQAAGQEADAVHKRK
                     LERMRLVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQ
                     AITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKEATG
                     LHTPLEEDMFHLRGSLAPQLYLRPRETAHIPLKFQSFSVGPLAPTQAPAEVITEKDAE
                     SGPLWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKA
                     IRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPE
                     IKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRA
                     FTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFVHLNLVDIDYHQLVASWLV
                     CLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSF
                     QVAGGETYTIGLRFLPSGSAGQEEILIYINDHEDKNEETFCVKVLYQ"
     exon            364..516
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            517..689
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            690..754
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            755..910
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1041
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1223
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1350
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1533
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1660
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1722
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1839
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1988
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2180
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2368
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2529
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2710
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2836
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..3042
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3269
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3456
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3540
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3697
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3783
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3869
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4041
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4221
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..4365
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4912
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4758..4763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /note="hexamer: TATAAA"
     polyA_site      4781
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
     regulatory      4888..4893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /note="hexamer: AATGAA"
     polyA_site      4912
                     /gene="Nphp4"
                     /gene_synonym="4930564O18Rik; nmf192"
                     /note="major polyA site"
ORIGIN      
        1 gtgctgagtg agcggtatcc ctcaggcccg ggctccacgc gtgggtggcg gtggattggg
       61 tgaccccctc ggtcagcact ggacccacga ctcctcgggt tccgctgggc accggcagcc
      121 cgatcgctgg atccacggtg cgggacgtgt tcggtagcgt ggatccggtg cccgtctcct
      181 agatggtgcc aggagtggtg gaggcccacg tgaggttgga cgggcagcat gggtgactgg
      241 cacagagcct tcacccagaa cacactggtc cctccccacc cacagagagc gaggcagctt
      301 gggaaggagt ccacggcatt ccagtgcatc ctgaagtggc ttgacgggcc actcattaag
      361 cagggaatcc tagacatgct gtcggagctt gaatgccatc tgcgagtgac cctcttcgat
      421 gtcacctaca aacatttctt tgggaggacg tggaaaacca cagtgaagcc caccaatcaa
      481 ccctctaagc agccacctag gatcaccttc aatgagccct tgtacttcca cacgaccttg
      541 agccacccca gcatcgtggc tgtggtagaa gtggtcaccg aaggcaggaa gagggacggc
      601 accctgcagc tgctgtcctg tgggtttgga attcttcgca tctttggcaa taagccagaa
      661 tctcccacct ctgcagccca ggacaaacgg ttgaggctgt atcatggcac cccaagagcc
      721 ctcctgcacc cacttctcca ggatcccata gaacagaaca agttcatgag gctgatggag
      781 aattgtagcc tgcagtacac cctgaagcca cacccacccc tggagcccgc cttccacctg
      841 ctccctgaga acctcctggt gtctggtttc cagcagatcc ctggccttct cccgcctcat
      901 ggggacacgg gtgatgccct gcggaagcct cgcttccaga agcccaccac atggcactta
      961 gatgacctct tcttcaccct gtacccttcc ctggagaagt ttgaggagga acttgtgcag
     1021 ctgctcatca gcgaccggga gggggtcggc ctgctggaca gcggcaccct cgaggtcctg
     1081 gagcggcgcc tgcacgtctg cgtccacaac gggctgggct tcgtgcagag gccacaggtg
     1141 gttgtgcttg tgcctgagat ggacgtggcc ttgacccgct cggccagctt cagcaggaaa
     1201 atcagtgcct cttccaagaa cagctctgga aatcaggctc tagttttgag aagccacctg
     1261 cgactcccgg agatggtcag tcacccagcc ttcgccatcg tcttccagct ggagtacgtg
     1321 ttcaacagcc cctctggagc ggatggcggt gccagctcgc ccacctcaat atccagcgtg
     1381 gcgtgcatgc acatggtccg atgggctgtt tggaaccccg atctggaagt gggcccagga
     1441 aaggtgacgc tgcctcttca gggtggggtt cagcaaaacc cctcacgctg tctggtctat
     1501 aaggtgcctt cagctagcat gagctccgag gaggtgaagc aggtggagtc cggaaccatc
     1561 cagttccagt tctcactgag ctcagacggc cccacagagc atgccaacgg ccccagggtg
     1621 gggcgtcggt cctcccggaa gatgccggca tccccttcag gcaccccagc accagctgcc
     1681 cgggatcttg ctgcaacaca ggactctcct gtgggcccag ggctctcgct ctcccagctg
     1741 acggcttccc cgctgtcccc ggctctgcaa agctcttcca agccccctct tcagcccccg
     1801 gacagctctc agtccccaga gggtccccag ctccaggccg aatctgtatt agagagcagg
     1861 gtctctcacc tggaagccga cctgagccag ccggcctcgc tccagggaac gcctgctgtc
     1921 gagcatctac aggaacttcc cttcactcct ctgcatgccc ccatcgtcgt gggagcacag
     1981 accaggagct ctagaagcca gctctccaga gctgcgatgg tgcttctgca gtcttctggc
     2041 ttccccgaga tccttgatgc cagccagcag cccgtggagg ccgtcaaccc catagacccc
     2101 gtgaggttca accctcagaa ggaggagtcg gactgtcttc gagggaatga gattgtgctg
     2161 cagtttcttg ccttcagcag agccgcccag gactgcccag gaacgccgtg gccacagact
     2221 gtgtatttca ccttccagtt ttaccgtttc ccacccgaga ccacgccacg cctgcagctg
     2281 gtcaagctgg atgggacggg caagagcggc tctggctccc tgtcccacat cctcgtcccc
     2341 attaataaag atggctcctt tgatgctggc tcccccggcc tccagctgag gtacatggtg
     2401 gatcccgggt tcctgaagcc aggagagcag cgctggttcg cccactacct ggctgctcag
     2461 acgctgcagg tcgacgtctg ggatggagac tccttgctcc tcattgggtc tgctggcgtc
     2521 cagatgaagc acctcctccg ccaagggcgg ccagctgttc aggtctcaca cgaactggag
     2581 gtcgtggcca ctgagtacga acaggaaatg atggccgtga gcggcgatgt ggctggcttc
     2641 ggcagcgtca agcccatcgg agtccacacg gtagtgaagg gccgcctgca cctgaccttg
     2701 gccaacgtgg gtcacgcttg tgagccgaga gcaagaggtt ccaacttgct gccgccatcc
     2761 aggtctcggg tcatctcaaa tgatggagcc agcttcttct ctgggggaag cctcctcata
     2821 cccggaggcc ccaagcgaaa gcgtgtggta caggcccaga ggctggctga tgtggacagc
     2881 gagctggccg ccatgctgct gacacacact cgagctggcc aggggcccca ggctgcaggc
     2941 caggaggcag acgctgtgca caagcggaag ctggagagga tgcggctggt gcgcctgcag
     3001 gaggctggag gggactctga cagtcgcagg atcagcttgc tggcccaaca cagtgtccgt
     3061 gcacagcact cacgggactt gcaggtcatt gatgcctacc gggaacgtac caaggccgag
     3121 agcattgccg gagtgctaag ccaggccatc accacccacc acacgctgta cgctacactg
     3181 ggcaccgctg agttcttcga gtttgcactt aaaaacccac acaacactca gcacacggtg
     3241 gccatcgaga tcgacagccc tgagctcagt atcatcctgg acagccagga gtggaggtac
     3301 ttcaaggagg ccaccggcct gcacacgccc ctggaggagg atatgttcca cctgcgtggg
     3361 agcctggcac cccagctcta cctgcgaccc cgggagactg cccacatccc ccttaagttc
     3421 cagagcttct ccgtgggccc tcttgctccg acacaggccc ctgctgaggt gatcacagag
     3481 aaggacgcag agtctggacc cctttggaag tgcagcgcca tgcctacgaa acacgccaag
     3541 gtccttttcc gggtggagac tggccagctc attgctgtgc tctgcctgac cgtggagccc
     3601 cagccccacg tggtggacca ggttttccgc ttctaccacc cagagctcac gttcctgaag
     3661 aaggccatcc gcctgcctcc ctggcacacg cttccaggtg ctcctgtggg gatgcctggc
     3721 gaggatcccc cagtgcatgt tcgatgcagt gatccaaatg tcatctgtga ggcccagaac
     3781 gtgggccccg gtgagccgag agatgtgttc cttaaggtgg ccagtggtcc aagcccggag
     3841 atcaaagact tctttgtcgt catctatgcg gatcgctggc tggcggtgcc cgtgcagacg
     3901 tggcaggtct gcctccactc cctgcagcgc gtggatgttt cctgtgtcgc aggacagctg
     3961 acccgtctgt ccctcgtcct tcgggggaca cagaccgtta ggaaagtgag agctttcacc
     4021 tcccaccccc aggagctgaa gacagaccct gccggtgtct ttgtgttgcc acctcatggg
     4081 gtacaggacc tgcatgtggg tgtgaggcca aggagggctg gcagccgctt tgtccatctc
     4141 aacctagtgg acatagacta ccatcagctg gttgcgtcat ggcttgtgtg cctctcctgc
     4201 cgccagccac tcatctccaa ggccttcgag atcaccatgg cagcagggga tgagaagggc
     4261 accaacaagc gcatcaccta caccaacccc tatccttctc ggaggaccta ccgcctgcac
     4321 agtgaccgtc ccgagctgtt gcgcttcaag gaggactcct tccaggtggc gggaggagag
     4381 acctacacca tcggcctgcg gttcctgcca agtggcagcg ccgggcagga ggagatcctg
     4441 atctacatca atgaccacga ggacaagaat gaggagacat tctgtgtgaa ggtcctctac
     4501 cagtgagggg accaccgtga ggccagtgcc cctccctgca gacatccgtc gctgtgactc
     4561 caggtctggc ctgcatggcc tgtgagctgg ctgagtgcag agagacaaag gcgtccctag
     4621 ccatggtata cctccgagag taatcctcca ctcgagagtg agtgaatgtg acctccagct
     4681 cactctgcct gtgacacgca caaggctgtg ttacacccct cgactctcag gctgtgactg
     4741 tccagaacaa actgttttat aaatggtttc caatgacaaa attatgtttt tcttactata
     4801 ttttttaaaa tgaacataat atattttaat ttgccatgta ttttattata ctgggattct
     4861 tttgtatctt ttttttttaa gttattgaat gaagcaccac atttctgccg taaaaaaaaa
     4921 aaaaaaaaaa a
//
