LOCUS       NM_028721               5894 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nephronophthisis 3 (adolescent) (Nphp3), transcript
            variant 1, mRNA.
ACCESSION   NM_028721 XM_975214 XM_975243 XM_975277
VERSION     NM_028721.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5894)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5894)
  AUTHORS   Takenaka,T., Kobori,H., Inoue,T., Miyazaki,T., Suzuki,H.,
            Nishiyama,A., Ishii,N. and Hayashi,M.
  TITLE     Klotho supplementation ameliorates blood pressure and renal
            function in DBA/2-pcy mice, a model of polycystic kidney disease
  JOURNAL   Am J Physiol Renal Physiol 318 (3), F557-F564 (2020)
   PUBMED   31928223
REFERENCE   3  (bases 1 to 5894)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   4  (bases 1 to 5894)
  AUTHORS   Raman,A., Reif,G.A., Dai,Y., Khanna,A., Li,X., Astleford,L.,
            Parnell,S.C., Calvet,J.P. and Wallace,D.P.
  TITLE     Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis
            in Polycystic Kidney Disease
  JOURNAL   J Am Soc Nephrol 28 (9), 2708-2719 (2017)
   PUBMED   28522687
REFERENCE   5  (bases 1 to 5894)
  AUTHORS   Ciolek,J., Reinfrank,H., Quinton,L., Viengchareun,S., Stura,E.A.,
            Vera,L., Sigismeau,S., Mouillac,B., Orcel,H., Peigneur,S.,
            Tytgat,J., Droctove,L., Beau,F., Nevoux,J., Lombes,M., Mourier,G.,
            De Pauw,E., Servent,D., Mendre,C., Witzgall,R. and Gilles,N.
  TITLE     Green mamba peptide targets type-2 vasopressin receptor against
            polycystic kidney disease
  JOURNAL   Proc Natl Acad Sci U S A 114 (27), 7154-7159 (2017)
   PUBMED   28630289
REFERENCE   6  (bases 1 to 5894)
  AUTHORS   Aukema,H.M., Yamaguchi,T., Takahashi,H., Celi,B. and Holub,B.J.
  TITLE     Abnormal lipid and fatty acid compositions of kidneys from mice
            with polycystic kidney disease
  JOURNAL   Lipids 27 (6), 429-435 (1992)
   PUBMED   1385849
REFERENCE   7  (bases 1 to 5894)
  AUTHORS   Nagao,S. and Takahashi,H.
  TITLE     Linkage analysis of two murine polycystic kidney disease genes, pcy
            and cpk
  JOURNAL   Jikken Dobutsu 40 (4), 557-560 (1991)
   PUBMED   1748176
REFERENCE   8  (bases 1 to 5894)
  AUTHORS   Takahashi,H., Calvet,J.P., Dittemore-Hoover,D., Yoshida,K.,
            Grantham,J.J. and Gattone,V.H. 2nd.
  TITLE     A hereditary model of slowly progressive polycystic kidney disease
            in the mouse
  JOURNAL   J Am Soc Nephrol 1 (7), 980-989 (1991)
   PUBMED   1883968
REFERENCE   9  (bases 1 to 5894)
  AUTHORS   Towner,R.A., Yamaguchi,T., Philbrick,D.J., Holub,B.J., Janzen,E.G.
            and Takahashi,H.
  TITLE     In vivo proton magnetic resonance imaging and localized
            spectroscopic analysis of polycystic kidney disease in DBA/2FG-pyc
            mice
  JOURNAL   Magn Reson Imaging 9 (3), 429-434 (1991)
   PUBMED   1881263
REFERENCE   10 (bases 1 to 5894)
  AUTHORS   Takahashi,H., Ueyama,Y., Hibino,T., Kuwahara,Y., Suzuki,S.,
            Hioki,K. and Tamaoki,N.
  TITLE     A new mouse model of genetically transmitted polycystic kidney
            disease
  JOURNAL   J Urol 135 (6), 1280-1283 (1986)
   PUBMED   3712587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133217.1, AK173327.1 and BM219539.2.
            
            On Nov 2, 2007 this sequence version replaced NM_028721.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY259499.1, AK173327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3551              AK133217.1         2-3552
            3552-5813           AK173327.1         3131-5392
            5814-5894           BM219539.2         1-81                c
FEATURES             Location/Qualifiers
     source          1..5894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.11 cM"
     gene            1..5894
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /note="nephronophthisis 3 (adolescent)"
                     /db_xref="GeneID:74025"
                     /db_xref="MGI:MGI:1921275"
     exon            1..618
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..4215
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /note="isoform a is encoded by transcript variant 1;
                     nephrocystin-3"
                     /codon_start=1
                     /product="nephrocystin-3 isoform a"
                     /protein_id="NP_082997.3"
                     /db_xref="CCDS:CCDS40749.1"
                     /db_xref="GeneID:74025"
                     /db_xref="MGI:MGI:1921275"
                     /translation="MGTASSLVSPTGGEVIEDTYGAGGGEACEIPVEVKPKARLLRSS
                     FRRGAGAGPGSLPRAAGGGGLLGASFKSTGSSVPELEYAAAEFERLKKEYEIFRVSKN
                     QELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKEGALEAKYQAMERAVTFEHD
                     RDRVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDV
                     TAAGTQCEYWASRALGSEHSIGSMIQLPQPFRGPEFAHSSIDVEGPFANINRDDWDAA
                     VAGLLQATPLFSHSLWSHPVRCYLIYTDETQPEMELFLKDHSPKLKRMCETMGYFFLA
                     VYFPLDVENQYLTVRKWEIEKSSLVILFLHSTLPSFLLEDCEEAFLQNPEGKPGLIYH
                     RLEDGKVTCDSVQQFLDQVSNLGKTTKAKIIEHSGDPAEGVCKIYVGVEKIIKQDILG
                     LENTDVEEKDGGREDSTPEEDDFGDVLWDIHDEQEQMEAFQQTSSSAHELGFEKYYQR
                     LDDLVVAPAPIPPLLVSGGPGSGKSLLLSKWIQLQQKHFPNTLILSHFVGRPMSTSSE
                     SSLIIKRLTLKLMQHFWAVSALTLDPAKLLEEFPHWLEKLSARHQGSIIIIIDSIDQV
                     QQVEKHMKWLIDPLPVNVRVIVSVNVETCPTAWRLWPTLHLDPLSPKDAISIITAECY
                     SMDVRLSREQEKMLEQHCRPATTRHALYVTLFSKMMACAGRGGNVAETLHQCLQCQDT
                     VSLYKLVLHHVRESMPSDRDKEWMTQILCLINVSHNGVSESELMELYPEMSWLSLTSI
                     VHSLHKMHLLTYSCGLLRFQHLQAWETVRLQYLEDPALVSSYREKLISYFASQLSQDR
                     VTWRSADELPWLFQQQGSKQKLHSCLLNLLVAQNLYKRGHFAELLSYWQFVGKDKGAM
                     ATEYFESLKQYENSEGEENMLCLADLYETLGRFLKDLGLLSQAVVPLQRSLEIRETAL
                     DPDHPRVAQSLHQLAGVYVQWKKFGDAEQLYKQALEISENAYGADHPHAARELEALAT
                     LYHKQNKYEQAEHFRKKSVIIRQQATRRKGSLYGFALLRRRALQLEELTLGKDKPENA
                     RTLNELGVLYFLQNNLETAEQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQY
                     EKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKTGKVDKAVPLYELAVEIRQK
                     SFGPKHPSVATALVNLAVLHSQMKKHSEALPLYERALKIYEDSLGRMHPRVGETLKNL
                     AVLSYEEGNFEKAAELYKRAMEIKEAETSLLGGKAPSRQSSSGDTFLFKTTHSPNVFL
                     PQGQS"
     exon            619..744
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            745..895
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1048
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1182
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1343
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1500
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1575
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1749
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1853
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1968
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2112
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2210
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2313
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2396
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2535
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2700
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2795
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2918
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3105
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3347
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3423
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3551
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3792
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3918
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4034
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..5894
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5797..5802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /note="hexamer: AATAAA"
     polyA_site      5815
                     /gene="Nphp3"
                     /gene_synonym="3632410F03Rik; C230078J01; D330020E01Rik;
                     pcy"
                     /note="major polyA site"
ORIGIN      
        1 actgctccgc tcttccctcc aaactccgcc ctctcctcta cagcacctcg ccccaccatc
       61 taggccccgc ccttaaggcc tggccacgcc ccggccacct ccctgctcct ggccacgctc
      121 ctctctgatt ttggtttctc cctgcggcgc tccgccccgc ttgacaggcc ccgccctcct
      181 ggtcccgcct cctcctggca cccagccgac tctcagcctc agccggccgc gggcatcatg
      241 ggcacagcct cgtcgctggt gagtcccact ggcggggagg tgatcgagga cacgtacggg
      301 gcaggcggcg gcgaggcctg cgagatcccg gtggaagtga aacccaaggc ccgcctgctg
      361 cgcagctcgt tccgcagggg cgcgggagcc gggcccgggt cgctgcctcg cgcggcaggg
      421 ggcggcgggc tgctgggcgc cagcttcaag tccaccggct cgtctgtgcc cgagctagag
      481 tatgcggcgg ccgagttcga gcggctcaag aaagagtatg agatcttccg ggtcagcaag
      541 aaccaggagt tgctgtccat gggccgccga gaggccaagc tggacacgga gaacaagcgg
      601 ctgcgggcgg agctgcaggc acttcagaaa acttaccaga agatacttcg ggaaaaagag
      661 ggtgcgttag aagcaaaata ccaagccatg gagagagcgg tcacatttga acatgacaga
      721 gacagggtta aaaggcaatt caagattttt agggaaacca aagaaaatga aattcaggac
      781 ttactgaggg ccaagcgaga gttggagagc aaacttcaga ggctgcaggc tcaggggatc
      841 caagtgttcg accctgggga gtctgactcg gatgacaact gcacagatgt cactgctgcg
      901 ggaacgcaat gtgagtactg ggccagcaga gccctgggca gcgagcattc cataggcagc
      961 atgatccagc tcccgcagcc tttcagaggc cccgagttcg cccacagttc tatagatgtg
     1021 gaaggaccct ttgcaaacat caaccgagat gactgggacg ctgctgtagc tggtttatta
     1081 caggccacac ccttgttctc acattccctg tggagtcacc ctgtcaggtg ctacctcatc
     1141 tacacagatg aaacacagcc cgaaatggaa ctgttcctta aggaccattc acctaaactt
     1201 aaaagaatgt gcgagacaat gggatatttc ttcctcgctg tttattttcc attagatgtt
     1261 gaaaatcagt atctcactgt aagaaaatgg gaaattgaga agagttcttt agttatttta
     1321 ttccttcact caacattacc cagtttttta ctggaagact gtgaagaagc cttcctgcaa
     1381 aacccagaag gaaagccagg attaatctac caccgtttgg aggatgggaa agtcacttgt
     1441 gactctgtcc agcagttcct ggatcaagtt tccaacctag gcaagaccac taaagccaag
     1501 atcattgaac actccggaga tcctgcagag ggagtgtgta agatttacgt gggtgtggaa
     1561 aagattatta aacaggacat ccttggcctc gagaacacag acgtggagga gaaggatggg
     1621 ggcagagagg attccactcc agaagaagat gatttcgggg atgttctgtg ggacatacac
     1681 gatgagcaag agcagatgga agcctttcag cagacttcta gctccgccca tgaactggga
     1741 ttcgagaagt attaccagcg cctggatgat ctggtggtgg cgccagcccc gatcccaccc
     1801 ctcctggttt ctggcggacc aggttctggg aagtcccttc ttttatcaaa atggattcag
     1861 ctgcagcaga agcatttccc aaacaccctg atcctgtctc attttgtggg gagaccaatg
     1921 tcaaccagct cagagtcctc tttgattatc aagcggctga ccctgaagct gatgcagcac
     1981 ttctgggcag tttctgcact gacactggat cctgctaagc ttctggagga atttccacat
     2041 tggctggaga agctctctgc ccggcatcag ggcagcatca tcatcatcat cgattccata
     2101 gatcaagttc agcaagtgga gaagcacatg aagtggctga tagaccccct gccggtgaat
     2161 gtcagagtca ttgtttctgt gaacgtggag acctgcccca cagcgtggag gttgtggcct
     2221 acactgcatc ttgatccttt aagccccaag gacgccatat ctataataac agcagaatgc
     2281 tactccatgg atgtgcggtt gagcagagag caggagaaga tgctagaaca gcactgccgt
     2341 ccagccacaa cacgccacgc cctctatgtc acccttttca gcaagatgat ggcctgtgcc
     2401 gggagagggg gcaacgtagc tgaaaccctc catcagtgcc tgcagtgtca ggacacagtg
     2461 tcactgtaca aactcgttct ccaccacgtc cgggagtcca tgccaagtga cagggataaa
     2521 gagtggatga cacagatcct ctgcctcatc aacgttagtc acaatggcgt gagtgagtca
     2581 gagctgatgg agctgtatcc agagatgtcc tggctctctc taacctccat cgttcacagt
     2641 ttacacaaaa tgcacctgct gacttacagc tgtggcctac tcaggtttca gcatctacag
     2701 gcctgggaaa cagtgaggct gcagtacctg gaggaccccg ccctcgtgtc ttcatatagg
     2761 gaaaagctca ttagctattt tgcctcacag ctcagtcagg acagagtgac ctggagaagc
     2821 gcagatgagc tcccatggct cttccagcag caggggagca aacagaagct gcacagttgc
     2881 ctcctcaacc tcctcgtggc tcagaacctt tacaaaagag gacacttcgc cgagttgctg
     2941 agttactggc agtttgtagg caaagacaaa ggtgccatgg cgaccgagta ctttgagtca
     3001 ctgaagcagt atgagaacag cgaaggcgag gagaacatgc tgtgcctagc cgacctatat
     3061 gaaaccctcg gccgctttct gaaggaccta ggacttctca gtcaggccgt ggtgcctttg
     3121 cagaggtccc tagaaattcg ggagacagcc ttagatcctg atcacccgag agtagcccag
     3181 tccctccacc aactggccgg tgtgtacgtg cagtggaaga agttcgggga tgcggagcag
     3241 ctgtataaac aggccttgga gatctcagaa aacgcttatg gtgcagacca tccgcatgct
     3301 gctcgtgaac tggaggcgct ggcgactctg taccacaaac aaaataagta cgaacaagct
     3361 gaacatttta ggaaaaaatc agttataatt cgtcagcaag ccacgaggcg aaaaggcagc
     3421 ctgtacgggt ttgcccttct acgcaggcgg gctctgcagt tggaagagct caccttgggc
     3481 aaggacaagc ctgagaacgc ccgcaccctc aatgagctgg gtgttctcta cttccttcaa
     3541 aataacctcg agacagcaga gcagtttctg aagcgttcct tggaaatgag ggagcgggtt
     3601 ctggggccag atcacccaga ctgcgcacag tccctgaata acctggcagc tctttgcaat
     3661 gagaagaagc agtacgagaa agcagaggag ctgtatgagc gcgccctgga catccggaga
     3721 cgcgcactgg ctccggacca cccttccctg gcctacaccg tgaagcacct tgcaatcttg
     3781 tataagaaaa cgggaaaagt tgacaaagct gtacctctgt atgaattggc tgttgaaatt
     3841 cggcagaaat cctttggccc aaagcacccc agtgtagcta ctgccttggt aaacttggca
     3901 gtccttcata gccaaatgaa aaagcacagt gaagccctgc cactatatga aagagcatta
     3961 aagatttatg aagatagctt ggggagaatg catcctcgag ttggagaaac attgaaaaat
     4021 ttagctgtgc tcagctatga agaagggaat tttgaaaagg ctgctgaact gtacaaaagg
     4081 gcaatggaga taaaagaagc agagacatca cttttgggtg gaaaagctcc ttcaaggcag
     4141 tcatcaagtg gagacacatt tctctttaaa acaactcatt cccctaacgt ttttcttccc
     4201 caagggcaaa gctaaccgtc aattctttgc aaggatactt caagataaaa cagctaaaca
     4261 tctggaatat tctcagtgtt tttaaagaaa atcttttttt tccatcttag tgttatttag
     4321 ctggcattta tatgacgttg tattgagttg cattgaattg tcgtgtcaag tttaaattga
     4381 ttaaagaacc tgtttcctat gggataaaat ccaggatgac gacatcagca ctcagtggca
     4441 tgaggagtgg cttggtctct gcaacaagag ctggcaggac cccatggttt aagaaatcca
     4501 cagttctttt ctctccctca agagcagcct tagctctggc cattcactgt ctgttcctag
     4561 cagggctctg agccagttct ctacctcaaa gaactttcaa gggctaaagg gatgttgata
     4621 atataaataa tataaaggga tgttgataat gagtcggaac agtcttcagt gaaacgagct
     4681 agataggaac tctgtttgtt ttcctttttc tgggtttgtg tgtgaggatg tgcgcgcgcg
     4741 cgcacacaca cacacacaca cacacacaca cgtgtgcatg tacacatgga ggacagaggt
     4801 cagccttggg tatcattcct caggcgctgt ccaccgtgac ttgtttttgt ttttggtttt
     4861 tgagacaggg tctcagtgac ctggtgccct taattagtct gcctggcagt ccacatccta
     4921 gtgacccaca cccctgcctc tctctcctaa gaccggagca caagcttcca tctctacccc
     4981 cagttctcta aagtgggctc tgggggttga acttgggtcc ttatgctgac atggcagacg
     5041 cttcacaaac tgagctatca ccctagcctc ttaccacatt gtgaatctct gtagctcggg
     5101 gtgaccatga actcttgatc actccccact cccccggagt gttgggacca cagaggcatg
     5161 cctccacagc tggcttggct tttaggcctt cctcttccct aagctggttt agccagcctc
     5221 cgctttctgt gctgtctcca ggaagcttct cacagtgctg cagcgtcgcc agtgacaaca
     5281 tgcgtgccac cacaggtgcc agtgacgaca tgcgtgccac cacaggtgcc aggctcttta
     5341 ccattctcat cttgcttact gtgggacagg tctaaaaagt caactactcg tgagctgagg
     5401 cacaggtttt caaggtcagt accagcttag agtatggggt gagttcaagg ccagcctggg
     5461 caccttagtg agaccttgtc acaaaataga atagagctga aggcacagca gtagaatgcc
     5521 tcggaccctg ggtttagtcc tcagcacaca cacacataca aaaagccatg acaaatccat
     5581 ttccttcgta aatggtcaaa atcagtcttg ccttacctcg cttagttggt gtttttatac
     5641 tggaaattaa atatttttat agatttgata aatattgcca cattttagat atttgttttt
     5701 atttgtatat agtaaaattt tcaatgattt aaaatcttat aagatctcaa tatgtattat
     5761 tgtaaagatg acaggcataa aaaatgtatg ttttaaaata aaagtgtaat tgcaagttct
     5821 ctcattttgc agtctgtatt agagggctat tttgcatagt tatttaagaa taaactttga
     5881 acatgtttca gcag
//
