LOCUS       NM_001412387            1648 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuropeptide FF receptor 2 (Npffr2), transcript
            variant 1, mRNA.
ACCESSION   NM_001412387 XM_017320589
VERSION     NM_001412387.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1648)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1648)
  AUTHORS   Lin,Y.T., Wu,K.H., Jhang,J.J., Jhang,J.L., Yu,Z., Tsai,S.C.,
            Chen,J.C., Hsu,P.H. and Li,H.Y.
  TITLE     Hypothalamic NPFFR2 attenuates central insulin signaling and its
            knockout diminishes metabolic dysfunction in mouse models of
            diabetes mellitus
  JOURNAL   Clin Nutr 43 (3), 603-619 (2024)
   PUBMED   38301284
  REMARK    GeneRIF: Hypothalamic NPFFR2 attenuates central insulin signaling
            and its knockout diminishes metabolic dysfunction in mouse models
            of diabetes mellitus.
REFERENCE   3  (bases 1 to 1648)
  AUTHORS   Karnosova,A., Strnadova,V., Zelezna,B., Kunes,J., Kasparek,P. and
            Maletinska,L.
  TITLE     NPFFR2-deficient mice fed a high-fat diet develop strong
            intolerance to glucose
  JOURNAL   Clin Sci (Lond) 137 (10), 847-862 (2023)
   PUBMED   37191311
  REMARK    GeneRIF: NPFFR2-deficient mice fed a high-fat diet develop strong
            intolerance to glucose.
REFERENCE   4  (bases 1 to 1648)
  AUTHORS   Yu,Z., Lin,Y.T. and Chen,J.C.
  TITLE     Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses
            in Mice
  JOURNAL   Int J Mol Sci 22 (14), 7611 (2021)
   PUBMED   34299230
  REMARK    GeneRIF: Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like
            Responses in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1648)
  AUTHORS   Lin,Y.T., Huang,Y.L., Tsai,S.C. and Chen,J.C.
  TITLE     Ablation of NPFFR2 in Mice Reduces Response to Single Prolonged
            Stress Model
  JOURNAL   Cells 9 (11), 2479 (2020)
   PUBMED   33202667
  REMARK    GeneRIF: Ablation of NPFFR2 in Mice Reduces Response to Single
            Prolonged Stress Model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1648)
  AUTHORS   Talmont,F., Mouledous,L., Piedra-Garcia,L., Schmitt,M., Bihel,F.,
            Bourguignon,J.J., Zajac,J.M. and Mollereau,C.
  TITLE     Pharmacological characterization of the mouse NPFF2 receptor
  JOURNAL   Peptides 31 (2), 215-220 (2010)
   PUBMED   19944730
  REMARK    GeneRIF: species-related differences in the binding properties of
            NPFF(2) receptors
REFERENCE   7  (bases 1 to 1648)
  AUTHORS   Anko,M.L., Ostergard,M., Lintunen,M. and Panula,P.
  TITLE     Alternative splicing of human and mouse NPFF2 receptor genes:
            Implications to receptor expression
  JOURNAL   FEBS Lett 580 (30), 6955-6960 (2006)
   PUBMED   17157836
  REMARK    GeneRIF: NPFF system may also have species-specific features since
            the NPFF2 receptor mRNA expression differs from that reported for
            rat
REFERENCE   8  (bases 1 to 1648)
  AUTHORS   Gouarderes,C., Kieffer,B.L. and Zajac,J.M.
  TITLE     Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor
            density in the triple MOR/DOR/KOR-opioid receptor knockout mouse
            brains
  JOURNAL   J Chem Neuroanat 27 (2), 119-128 (2004)
   PUBMED   15121216
REFERENCE   9  (bases 1 to 1648)
  AUTHORS   Gouarderes,C., Puget,A. and Zajac,J.M.
  TITLE     Detailed distribution of neuropeptide FF receptors (NPFF1 and
            NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset
            monkey brains: a comparative autoradiographic study
  JOURNAL   Synapse 51 (4), 249-269 (2004)
   PUBMED   14696013
  REMARK    GeneRIF: The distribution pattern of NPFF2 receptors in the
            diencephalon and the superficial layers of the spinal cord is
            consistent with a hypothesized potential role for NPFF in the
            modulation of sensory input and opioid analgesia.
REFERENCE   10 (bases 1 to 1648)
  AUTHORS   Parker,R.M., Copeland,N.G., Eyre,H.J., Liu,M., Gilbert,D.J.,
            Crawford,J., Couzens,M., Sutherland,G.R., Jenkins,N.A. and
            Herzog,H.
  TITLE     Molecular cloning and characterisation of GPR74 a novel G-protein
            coupled receptor closest related to the Y-receptor family
  JOURNAL   Brain Res Mol Brain Res 77 (2), 199-208 (2000)
   PUBMED   10837915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134840.3.
            
            On Sep 29, 2022 this sequence version replaced XM_017320589.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF236084.1, AF330054.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164131, SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC134840.3         38749-38987
            240-574             AC134840.3         79612-79946
            575-674             AC134840.3         83385-83484
            675-1648            AC134840.3         94444-95417
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.32 cM"
     gene            1..1648
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; HG31; NPFF2"
                     /note="neuropeptide FF receptor 2"
                     /db_xref="GeneID:104443"
                     /db_xref="MGI:MGI:1860130"
     exon            1..239
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; HG31; NPFF2"
                     /inference="alignment:Splign:2.1.0"
     exon            240..574
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; HG31; NPFF2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..674
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; HG31; NPFF2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1648
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; HG31; NPFF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; HG31; NPFF2"
                     /note="hexamer: AATAAA"
     polyA_site      1648
                     /gene="Npffr2"
                     /gene_synonym="Gpr74; HG31; NPFF2"
                     /note="major polyA site"
ORIGIN      
        1 agagtagctg cgctgtgact aaccagcagc tgaccgacca gtgcagttct gagagtgcag
       61 caagagcgga gagtgcagag cccgccggcg tcagccccgc tgcagaggga agtggctagc
      121 cagtcgcacc taggtcacct ggtagagcag agcccgcgaa ccagacagaa cctgttgctc
      181 aggctccgct tggcttctgc tttcaacagg gttgggaatc tgtccttgcc caggaacagg
      241 tccaccatga gcgagaaatg ggactcaaac tcttcagaaa gctggaatca catctggagt
      301 ggcaatgata cacagcatca ctggtattca gatatcaaca ttacctatgt gaactactat
      361 ctccaccagc cccaagtggc agctgtcttc atcagctcct acctcctgat ctttgtcttg
      421 tgcatggtgg gaaatactgt cgtttgcttt attgtgataa ggaatagaca catgcacaca
      481 gtcactaatt tcttcatctt aaaccttgcc ataagtgatt tactggttgg aatattctgt
      541 atgcctatca cattgctgga caacatcata gcaggatggc cattcggaag cagcatgtgc
      601 aagatcagtg ggctggtgca agggatatca gttgcggctt ccgtcttcac cttggttgca
      661 atagctgtgg acagattccg ctgtgtggtc taccccttta agccaaagct cactgtcaag
      721 acagcctttg tcacgattgt gatcatctgg ggcctggcca tcgccattat gactccatct
      781 gcaataatgt tacatgtaca agaagaaaaa tactaccgtg tgagactcag ctcccacaat
      841 aaaaccagca cagtctactg gtgtcgggag gactggccaa gacacgaaat gaggaggatc
      901 tataccacgg tgctatttgc caccatctat cttgctcctc tctcactcat tgttatcatg
      961 tatgcaagga ttggggcttc cctcttcaag acggcagcac actgcacagg caagcagcgt
     1021 ccagtgcagt ggcatgtatc caagaagaaa cagaaggtca tcaagatgct gctgactgtg
     1081 gccctccttt tcatcctttc ctggcttccc ctgtggaccc tgatgatgct ctcagactat
     1141 actgacctgt ctcctaacaa actgcgtatc atcaacatct acatctaccc tttcgcccac
     1201 tggctcgcct tctgcaacag cagtgtcaac cctattattt atggattctt taatgaaaat
     1261 tttcgcaatg gtttccaaga tgctttccag atctgccaaa agaaagccaa gccccaggaa
     1321 gcctattccc tgagagcgaa acgcaacata gtcataaaca catcgggcct gctggtgcag
     1381 gaaccggtgt ctcaaaaccc aggtggggaa aatttgggat gtggaaaaag tgcagacaat
     1441 cccacacagg aatccttgat agaggaaatg ggagaagcta ctaacagtac tgtggcttaa
     1501 aaagatcgtg tggaccccag tgctacctga tgccatatag tactagatag tgctgcttgt
     1561 tgtggctttt cacttcttat agtctgatga gaacatttac tgaaaaccct ctttgtcaaa
     1621 aataaaagta tgaaagtggc ctttctaa
//
