LOCUS       NM_001177511            4575 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus neuropeptide FF receptor 1 (Npffr1), mRNA.
ACCESSION   NM_001177511 XM_137119 XM_905368
VERSION     NM_001177511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4575)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4575)
  AUTHORS   Guo,X., Dai,T., Wei,S., Ma,Z., Zhao,H. and Dan,X.
  TITLE     Rfamide-related peptide-3(RFRP-3) receptor gene is expressed in
            mouse ovarian granulosa cells: Potential role of RFRP-3 in
            steroidogenesis and apoptosis
  JOURNAL   Steroids 202, 109349 (2024)
   PUBMED   38072091
  REMARK    GeneRIF: Rfamide-related peptide-3(RFRP-3) receptor gene is
            expressed in mouse ovarian granulosa cells: Potential role of
            RFRP-3 in steroidogenesis and apoptosis.
REFERENCE   3  (bases 1 to 4575)
  AUTHORS   Leon,S., Velasco,I., Vazquez,M.J., Barroso,A., Beiroa,D., Heras,V.,
            Ruiz-Pino,F., Manfredi-Lozano,M., Romero-Ruiz,A.,
            Sanchez-Garrido,M.A., Dieguez,C., Pinilla,L., Roa,J., Nogueiras,R.
            and Tena-Sempere,M.
  TITLE     Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of
            RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its
            Congenital Ablation in mice
  JOURNAL   Metabolism 87, 87-97 (2018)
   PUBMED   30075164
  REMARK    GeneRIF: Our data support a discernible orexigenic role of NPFF1R
            signaling selectively in males, which might modulate the effects of
            leptin and ghrelin on food intake
REFERENCE   4  (bases 1 to 4575)
  AUTHORS   Zhang,W., Wang,L., Yu,X., Jia,A., Ming,J. and Ji,Q.
  TITLE     RFamide-related peptide-3 promotes alpha TC1 clone 6 cell survival
            likely via GPR147
  JOURNAL   Peptides 107, 39-44 (2018)
   PUBMED   30081043
  REMARK    GeneRIF: RFRP-3 activated PI3K/AKT and ERK1/2 signaling cascades
            and promotes pancreatic alpha cell survival, likely via GPR147.
REFERENCE   5  (bases 1 to 4575)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   6  (bases 1 to 4575)
  AUTHORS   Poling,M.C., Kim,J., Dhamija,S. and Kauffman,A.S.
  TITLE     Development, sex steroid regulation, and phenotypic
            characterization of RFamide-related peptide (Rfrp) gene expression
            and RFamide receptors in the mouse hypothalamus
  JOURNAL   Endocrinology 153 (4), 1827-1840 (2012)
   PUBMED   22355072
  REMARK    GeneRIF: RFRP-3 may exert its effects on reproduction either
            directly, via Gpr147 in a subset of GnRH neurons, and/or
            indirectly, via upstream regulators of GnRH.
REFERENCE   7  (bases 1 to 4575)
  AUTHORS   Mouledous,L., Barthas,F. and Zajac,J.M.
  TITLE     Opposite control of body temperature by NPFF1 and NPFF2 receptors
            in mice
  JOURNAL   Neuropeptides 44 (5), 453-456 (2010)
   PUBMED   20554321
  REMARK    GeneRIF: central NPFF1 and NPFF2 receptors control in an opposite
            manner the body temperature in mice.
REFERENCE   8  (bases 1 to 4575)
  AUTHORS   Gouarderes,C., Kieffer,B.L. and Zajac,J.M.
  TITLE     Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor
            density in the triple MOR/DOR/KOR-opioid receptor knockout mouse
            brains
  JOURNAL   J Chem Neuroanat 27 (2), 119-128 (2004)
   PUBMED   15121216
REFERENCE   9  (bases 1 to 4575)
  AUTHORS   Gouarderes,C., Puget,A. and Zajac,J.M.
  TITLE     Detailed distribution of neuropeptide FF receptors (NPFF1 and
            NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset
            monkey brains: a comparative autoradiographic study
  JOURNAL   Synapse 51 (4), 249-269 (2004)
   PUBMED   14696013
  REMARK    GeneRIF: The constant presence of NPFF1 receptors in the septum,
            the nucleus of the tractus solitarius, and the hypothalamus suggest
            its participation in neuroendocrine functions.
REFERENCE   10 (bases 1 to 4575)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124421.4.
            
            On Jun 20, 2019 this sequence version replaced NM_001177511.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.982776.1,
                                           SRR10662774.2970051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC124421.4         102088-102291       c
            205-519             AC124421.4         83316-83630         c
            520-619             AC124421.4         74195-74294         c
            620-4575            AC124421.4         68122-72077         c
FEATURES             Location/Qualifiers
     source          1..4575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.24 cM"
     gene            1..4575
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /note="neuropeptide FF receptor 1"
                     /db_xref="GeneID:237362"
                     /db_xref="MGI:MGI:2685082"
     exon            1..204
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1496
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /note="RFamide-related peptide receptor; G-protein coupled
                     receptor NPFF1R; G protein-coupled receptor 147"
                     /codon_start=1
                     /product="neuropeptide FF receptor 1"
                     /protein_id="NP_001170982.1"
                     /db_xref="CCDS:CCDS48574.1"
                     /db_xref="GeneID:237362"
                     /db_xref="MGI:MGI:2685082"
                     /translation="MEAEPSQPPNGSWPPSLNESDAETAPVASLTFSSYYQHSSPVAA
                     MFIAAYALIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAVSDLLVGIFCMPTTLV
                     DNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALL
                     TIAVIWALALLIMCPSAVTLTVTREEHHFMLDARNRSYPLYSCWEAWPEKGMRKVYTA
                     VLFAHIYLAPLALIVVMYARIARKLCQAPGPARDAEEAVAEGGRASRRRARVVHMLVM
                     VALFFTLSWLPLWVLLLLIDYGELSELQLHLLSVYAFPLAHWLAFFHSSANPIIYGYF
                     NENFRRGFQAAFRAQLCWLPWAAHKQAYSERPGRLLRRRVVVDVQPSDSGLPSESGPS
                     SGVPGPNRLPLRNGRVAHQDGPREGPGCNHMPLTIPAWNI"
     exon            205..519
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /inference="alignment:Splign:2.1.0"
     exon            520..619
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /inference="alignment:Splign:2.1.0"
     exon            620..4575
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /note="hexamer: AATAAA"
     polyA_site      3988
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
     regulatory      4546..4551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /note="hexamer: AATAAA"
     polyA_site      4575
                     /gene="Npffr1"
                     /gene_synonym="Gm236; Gpr147; NPFF1; NPFF1R; OT7T022"
                     /note="major polyA site"
ORIGIN      
        1 gcagagtccg gcggaccgcg gcgctgggag ggcgctgcac cctgcacccc agggagtgag
       61 cgcttcctgc ccgcctgcga gcgtccggtg aagcggggac gaagggtagc ccacccagac
      121 cccagaccct tcctggaccc aacacatcca ttggaaggtg cctgcctcct ttggagagtt
      181 gtcccggagc agacagtatg gaggcggaac cctcccagcc tcccaacggc agctggcccc
      241 cgagtctgaa cgagagtgat gctgaaaccg ccccggtggc cagcctcacc ttctcttcct
      301 actaccagca ctcctctccg gtggccgcca tgttcatcgc cgcctacgcg ctcatcttcc
      361 tcctctgcat ggtgggcaac accctggtct gcttcatcgt gcttaagaac cggcacatgc
      421 gcactgtcac caacatgttc atcctcaacc tggccgtcag cgacctgctg gtgggcatct
      481 tctgcatgcc cacaaccctc gtggacaacc ttatcaccgg ttggcctttt gacaatgcca
      541 catgcaagat gagcggcttg gtacagggca tgtccgtgtc tgcgtcggtt ttcacactgg
      601 tggccattgc cgtggagagg ttccgctgca tcgtacaccc tttccgtgag aagctgaccc
      661 tccggaaggc gctgctcacc atagcggtga tctgggcgct ggcgctgctc atcatgtgtc
      721 cctcggcggt cactctgacc gtcacgcgag aggagcatca cttcatgctg gatgctcgca
      781 accgctccta ccctctctac tcgtgctggg aggcctggcc cgagaagggc atgcgcaagg
      841 tctacaccgc cgtgctcttc gcgcacatct atctggcgcc gctggcgctc atcgtggtga
      901 tgtacgcgcg catcgcgcgc aagctgtgcc aggcccccgg tccagcgcgc gacgcggagg
      961 aggcggtggc cgagggtggc cgcgcgtcgc gccgcagggc ccgcgtggtg catatgctgg
     1021 tcatggtggc gctcttcttc accttgtcct ggctgccact ctgggtgctg ctgctgctca
     1081 tcgactacgg ggagctgagc gagctgcagc tgcacttgct gtccgtctac gccttcccgt
     1141 tggcacactg gctggccttc ttccacagca gcgccaaccc cattatctac ggctacttca
     1201 acgagaactt ccgccgcggc ttccaggctg ccttccgggc acagctctgc tggcttccct
     1261 gggccgccca caagcaagcc tactccgagc ggcctggccg cctcctgcgc aggcgggtgg
     1321 tggtggacgt gcaacccagc gactcagggc tgccatcgga gtctggcccc agcagtgggg
     1381 tcccagggcc taaccggctg ccattgcgca atgggcgtgt ggcccaccag gatggcccga
     1441 gggaagggcc tggctgcaac cacatgcccc tcactatccc agcctggaac atttgaggtg
     1501 gtccagagag ggaacgtcct gtaggcctgt ggccctgacc cttaactatg atgcctgggc
     1561 acaatagcag tattagaaga gggtgccgag atgcctcctt gataaaaaaa aaaaaaaaaa
     1621 aaaaaaaaaa aaaacgagac agtgaggcat tgagacccag ggagaggtga caaggtctca
     1681 ccgttgggaa tcctacttga cccagactcc agtaagtctc cccaggaaaa tgtgtcacta
     1741 ggtggttagg aagaggtgac cacttctaca cactgagcac ctgtgaccga gtcccctgtg
     1801 ctgtgttgct gagagagctc cccttggccc tttcctggga aacatccaag ctctccgctt
     1861 gccagggcca gtgtttgagt tgttttattc caggaagtgc catacccact tcagcatgtc
     1921 acaactgagc agctccaaga agaaccctag ggagcccatt taaatggcac tgggttgagc
     1981 ctaagggaga ctcccccccc cccccccaga gccaagcaga gcttccaaca gtaccaagag
     2041 ctcatgggtg gcaggcaagg ggaaaaggaa gacagcaatg ccaactctcc cctcaggaaa
     2101 tatcttagtg ggccagtgag catgaacctt tgtcggggca tttcttcttt gtttactggg
     2161 aaggagaagg tggtcagtcg ggatgtggtg aggccccagc acgacacaga caaactcttc
     2221 caccgtgtgt gacttatgaa ccctgaacgc agaggagagt aggagagcct gcatgcacga
     2281 cagcgctcac ccacgatgcc tgccatcatc ttgacagatg catgcacccc agctctcacc
     2341 cggtatatct gccgtcagac gcacagctct catcgtacag tcaccttggc agagcacagc
     2401 ttctccccag gaggtgagga aatggcttgc ccctgccggt ttctcctgcc acttcaatca
     2461 tgtgcactta actggacaca ttctcgcttc cattaccaca gtggccagaa attttaggaa
     2521 tttaaaaaaa ggggcggggg acatttcaag ggtccagggc tctgagctcc tgttgatttc
     2581 ttaacacgct ctggctggcc ctttgctgtt cccaggtctg tcctaagcaa tgtctatagc
     2641 agcagaagaa atggcctcac ggttggttgt acacgtccaa gcaggtctct gaacactgtc
     2701 atctgactca taaaatgttc tggctgtttc acagagcaac cgaggcccag taggaccagg
     2761 gtcacagggc cacagacagc aatgtttgga ttaggcttgc cttagatagc ttgaaccaac
     2821 catatcctgc ctttcagaga aggtaggcat ggcagggggg agcgccggat gagaaggaac
     2881 tccaaggaat gactccaagt tctggggctg gggcaggaaa ccatctgcat tatgttggcc
     2941 ttgtgacctc cagccagagc tgttctgaac tcgattccta tgctgaggaa gctgtcaagc
     3001 tccctccagg tgctgtgtag tctgcgagga ggctgggagt gattggtgta gtcaggccag
     3061 atgtggcctg aactggtcct ctgcaaggcc ctctaagttg gtgctgtctt agtatcacat
     3121 gcacgataca gtggcctgag acttgctggc tgtttaccga gaaggcttgt gactcccggg
     3181 ctctaaaatt aggccacagc aaggacagtg tcaaccctgt ccctgagact cctggggact
     3241 gtgggagtta cagtctgctc tctgctctgg ccttcagcat ggcctcttag agacaaaatc
     3301 acagctctcc tcagaaatcc tgtccaccaa ggcctctgct tcagtttccc caaacgcctt
     3361 gctttgagag gccatggttg gcaaaaagca gggcacctga cacaggtggc catccctgtg
     3421 aatcatcctt gtccttactt gagtaggagc agaagtggca cctgcctgcc catgggcttg
     3481 gtctgagtac tgacaagaac atcacaatgc tatagaaaag ccagcagtgg ggctggagag
     3541 atggctcggc ggttaagaac actgactgct cttctggagg ttctgagctc caattccagc
     3601 aactacatgg tagctcataa ccatctgtat agctacagtg tactcataca caaaaaaata
     3661 agtaaataaa ccttttaaaa atgaaagaaa gaaagaaaaa agaagagcca gaagcgtgtg
     3721 aatgctgggg tcttgtttct tcgtacatgt gttagaatac atccaatgtt caaacttccc
     3781 attagccctt ttgaagtgta catacagggc tggagaaatg gctcaatggt taagagtact
     3841 gactgctctt ctgaaggtcc tgagttcaaa tcccagcaac cacatggtgg ctcacaacca
     3901 tctgtaatgg gatcttatgc cctcttcagg tgtgtctgaa gacagcgaca gagtacccac
     3961 atacatgaaa taaataaaca aatctttttt ttttaagtgt acatacagtt caggggcact
     4021 gagtattcat gttgcaatgt aaccagcacc ctttctagca ctgtattagc ctaaatggaa
     4081 actatggacc cattgacacc agctccccat ccctgctcct cccagccact gtcctttcac
     4141 tttgattttg acactcttgt gagtccctgc aaatgaaacc actcagcatc tttccttttg
     4201 tggctcttgc aacacacgaa cacctttcaa gttccactca tgctgttgca tggatcagaa
     4261 ttcctttcct tctgtggcta gacacactat tccatgtcta tctgatatct tccttctctg
     4321 gcagtgtgtt cttgtttctg gttcagctgt tacaagtcac tatgtatgca tggggggggt
     4381 gagtgggagg gtgttagata ataaacccaa gtcttgaaaa taatacccgt gtgagcccca
     4441 aggatggaga ctcccaacaa gtctcttaac ttggcgttta ggggtaactg agcctgtgct
     4501 caacccagct gctctgtgtt cttctgtgtt ccttcttggc tggagaataa aaaatgatgt
     4561 gttctgttca cagga
//
