LOCUS       NM_018787                451 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus neuropeptide FF-amide peptide precursor (Npff), mRNA.
ACCESSION   NM_018787
VERSION     NM_018787.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Lee,H., Amatya,B., Villar,V.A.M., Asico,L.D., Jeong,J.K.,
            Feranil,J., Moore,S.C., Zheng,X., Bishop,M., Gomes,J.P., Polzin,J.,
            Smeriglio,N., de Castro,P.A.S.V., Armando,I., Felder,R.A., Hao,L.
            and Jose,P.A.
  TITLE     Renal autocrine neuropeptide FF (NPFF) signaling regulates blood
            pressure
  JOURNAL   Sci Rep 14 (1), 15407 (2024)
   PUBMED   38965251
  REMARK    GeneRIF: Renal autocrine neuropeptide FF (NPFF) signaling regulates
            blood pressure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 451)
  AUTHORS   Song,T., Qin,W., Lai,Z., Li,H., Li,D., Wang,B., Deng,W., Wang,T.,
            Wang,L. and Huang,R.
  TITLE     Dietary cysteine drives body fat loss via FMRFamide signaling in
            Drosophila and mouse
  JOURNAL   Cell Res 33 (6), 434-447 (2023)
   PUBMED   37055592
  REMARK    GeneRIF: Dietary cysteine drives body fat loss via FMRFamide
            signaling in Drosophila and mouse.
REFERENCE   4  (bases 1 to 451)
  AUTHORS   Quillet,R., Dickie,A.C., Polgar,E., Gutierrez-Mecinas,M.,
            Bell,A.M., Goffin,L., Watanabe,M. and Todd,A.J.
  TITLE     Characterisation of NPFF-expressing neurons in the superficial
            dorsal horn of the mouse spinal cord
  JOURNAL   Sci Rep 13 (1), 5891 (2023)
   PUBMED   37041197
  REMARK    GeneRIF: Characterisation of NPFF-expressing neurons in the
            superficial dorsal horn of the mouse spinal cord.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 451)
  AUTHORS   Zhang,L., Koller,J., Gopalasingam,G. and Herzog,H.
  TITLE     NPFF signalling is critical for thermosensory and dietary
            regulation of thermogenesis
  JOURNAL   Neuropeptides 96, 102292 (2022)
   PUBMED   36155087
REFERENCE   6  (bases 1 to 451)
  AUTHORS   Kotlinska,J., Pachuta,A. and Silberring,J.
  TITLE     Neuropeptide FF (NPFF) reduces the expression of cocaine-induced
            conditioned place preference and cocaine-induced sensitization in
            animals
  JOURNAL   Peptides 29 (6), 933-939 (2008)
   PUBMED   18295932
  REMARK    GeneRIF: Npff reduces the expression of cocaine-induced conditioned
            place preference and cocaine-induce sensitization in mice.
REFERENCE   7  (bases 1 to 451)
  AUTHORS   Nystedt,J.M., Brandt,A., Vilim,F.S., Ziff,E.B. and Panula,P.
  TITLE     Identification of transcriptional regulators of neuropeptide FF
            gene expression
  JOURNAL   Peptides 27 (5), 1020-1035 (2006)
   PUBMED   16515822
  REMARK    GeneRIF: We postulate that Oct-1, PDX1, Pit-1, MEIS and DREAM are
            likely transcriptional regulators of NPFF gene expression.
REFERENCE   8  (bases 1 to 451)
  AUTHORS   Lefrere,I., De Coppet,P., Camelin,J.C., Le Lay,S., Mercier,N.,
            Elshourbagy,N., Bril,A., Berrebi-Bertrand,I., Feve,B. and Krief,S.
  TITLE     Neuropeptide AF and FF modulation of adipocyte metabolism. Primary
            insights from functional genomics and effects on beta-adrenergic
            responsiveness
  JOURNAL   J Biol Chem 277 (42), 39169-39178 (2002)
   PUBMED   12149260
  REMARK    GeneRIF: plays a role in body energy storage and utilization
            through adipocyte metabolism
REFERENCE   9  (bases 1 to 451)
  AUTHORS   Askwith,C.C., Cheng,C., Ikuma,M., Benson,C., Price,M.P. and
            Welsh,M.J.
  TITLE     Neuropeptide FF and FMRFamide potentiate acid-evoked currents from
            sensory neurons and proton-gated DEG/ENaC channels
  JOURNAL   Neuron 26 (1), 133-141 (2000)
   PUBMED   10798398
REFERENCE   10 (bases 1 to 451)
  AUTHORS   Vilim,F.S., Aarnisalo,A.A., Nieminen,M.L., Lintunen,M.,
            Karlstedt,K., Kontinen,V.K., Kalso,E., States,B., Panula,P. and
            Ziff,E.
  TITLE     Gene for pain modulatory neuropeptide NPFF: induction in spinal
            cord by noxious stimuli
  JOURNAL   Mol Pharmacol 55 (5), 804-811 (1999)
   PUBMED   10220558
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF148701.1.
            
            Summary: This gene encodes neuropeptides involved in analgesia,
            cardiovascular regulation, neuroendocrine function and opiate
            addiction. The encoded protein is a preproprotein that undergoes
            further processing to generate multiple amidated peptides.
            [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF148701.1, SRR1660815.21063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               AF148701.1         1-451
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.65 cM"
     gene            1..451
                     /gene="Npff"
                     /note="neuropeptide FF-amide peptide precursor"
                     /db_xref="GeneID:54615"
                     /db_xref="MGI:MGI:1891708"
     exon            1..115
                     /gene="Npff"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..358
                     /gene="Npff"
                     /note="FMRFamide-related peptides; pro-FMRFamide-related
                     neuropeptide FF"
                     /codon_start=1
                     /product="pro-FMRFamide-related neuropeptide FF
                     preproprotein"
                     /protein_id="NP_061257.1"
                     /db_xref="CCDS:CCDS27887.1"
                     /db_xref="GeneID:54615"
                     /db_xref="MGI:MGI:1891708"
                     /translation="MDSKWAALLLLLLLLLNWGHTEEAGSWGEDQVFAGEDKGPHPPQ
                     YAHIPDRIQTPGSLFRVLLQAMDTPRRSPAFLFQPQRFGRSAWGSWSKEQLNPQARQF
                     WSLAAPQRFGKK"
     exon            116..255
                     /gene="Npff"
                     /inference="alignment:Splign:2.1.0"
     exon            256..446
                     /gene="Npff"
                     /inference="alignment:Splign:2.1.0"
     regulatory      419..424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npff"
                     /note="hexamer: AATAAA"
     polyA_site      446
                     /gene="Npff"
                     /note="major polyA site"
ORIGIN      
        1 ggcagatggc agcatggact ccaagtgggc tgctctgctg ctgctgctac tgctgctgct
       61 gaattggggc cacactgaag aggcagggag ctggggtgaa gaccaagtct ttgcaggaga
      121 agataaggga ccccacccac cacagtatgc ccacattcca gacaggatcc agactcctgg
      181 gtccctcttt cgtgttctgc tccaggccat ggacacacct agaaggagcc cagccttcct
      241 gtttcagccc cagaggtttg gcagaagtgc atgggggtcc tggagcaagg aacagctaaa
      301 tccgcaggcc agacagttct ggagcctggc cgctcctcag cgctttggga agaagtagca
      361 tcgtcagctg tgatgcctgc atgcaaaacc acttccccat gttccctgtg tgcccccaaa
      421 taaaaatggt ccggctggct tcagaaaaaa a
//
