LOCUS       NM_207242               4571 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus NPC1 like intracellular cholesterol transporter 1
            (Npc1l1), mRNA.
ACCESSION   NM_207242 XM_137497
VERSION     NM_207242.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4571)
  AUTHORS   Butt,E., Gunder,T., Sturzebecher,P., Kowalski,I., Schneider,P.,
            Buschmann,N., Schafer,S., Bender,A., Hermanns,H.M. and Zernecke,A.
  TITLE     Cholesterol uptake in the intestine is regulated by the
            LASP1-AKT-NPC1L1 signaling pathway
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (1), G25-G35 (2024)
   PUBMED   38713618
  REMARK    GeneRIF: Cholesterol uptake in the intestine is regulated by the
            LASP1-AKT-NPC1L1 signaling pathway.
REFERENCE   2  (bases 1 to 4571)
  AUTHORS   Xiao,J., Dong,L.W., Liu,S., Meng,F.H., Xie,C., Lu,X.Y., Zhang,W.J.,
            Luo,J. and Song,B.L.
  TITLE     Bile acids-mediated intracellular cholesterol transport promotes
            intestinal cholesterol absorption and NPC1L1 recycling
  JOURNAL   Nat Commun 14 (1), 6469 (2023)
   PUBMED   37833289
  REMARK    GeneRIF: Bile acids-mediated intracellular cholesterol transport
            promotes intestinal cholesterol absorption and NPC1L1 recycling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4571)
  AUTHORS   Jia,L., Ma,Y., Haywood,J., Jiang,L., Xue,B., Shi,H., Dawson,P.A.
            and Yu,L.
  TITLE     NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15
            Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed
            Mice
  JOURNAL   Cells 10 (12), 3468 (2021)
   PUBMED   34943976
  REMARK    GeneRIF: NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth
            Factor 15 Expression and Increases Bile Acid Pool Size in
            High-Fat-Diet-Fed Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4571)
  AUTHORS   Ge,H., Liu,G., Yamawaki,T.M., Tao,C., Alexander,S.T., Ly,K.,
            Fordstrom,P., Shkumatov,A.A., Li,C.M., Rajamani,S., Zhou,M. and
            Ason,B.
  TITLE     Phytosterol accumulation results in ventricular arrhythmia,
            impaired cardiac function and death in mice
  JOURNAL   Sci Rep 11 (1), 17449 (2021)
   PUBMED   34465831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4571)
  AUTHORS   Ticho,A.L., Calzadilla,N., Malhotra,P., Lee,H., Anbazhagan,A.N.,
            Saksena,S., Dudeja,P.K., Lee,D., Gill,R.K. and Alrefai,W.A.
  TITLE     NPC1L1-dependent transport of 27-alkyne cholesterol in intestinal
            epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 320 (5), C916-C925 (2021)
   PUBMED   33760662
  REMARK    GeneRIF: NPC1L1-dependent transport of 27-alkyne cholesterol in
            intestinal epithelial cells.
REFERENCE   6  (bases 1 to 4571)
  AUTHORS   Karten,B., Hayashi,H., Francis,G.A., Campenot,R.B., Vance,D.E. and
            Vance,J.E.
  TITLE     Generation and function of astroglial lipoproteins from
            Niemann-Pick type C1-deficient mice
  JOURNAL   Biochem J 387 (Pt 3), 779-788 (2005)
   PUBMED   15544574
  REMARK    GeneRIF: The neuropathology characteristic of NPC disease can quite
            probably be ascribed to impaired processes within neurons in the
            brain rather than defective lipoprotein production by astroglia.
REFERENCE   7  (bases 1 to 4571)
  AUTHORS   Davies,J.P., Scott,C., Oishi,K., Liapis,A. and Ioannou,Y.A.
  TITLE     Inactivation of NPC1L1 causes multiple lipid transport defects and
            protects against diet-induced hypercholesterolemia
  JOURNAL   J Biol Chem 280 (13), 12710-12720 (2005)
   PUBMED   15671032
  REMARK    GeneRIF: NPC1L1 has a role in lipid transport and in diet-induced
            hypercholesterolemia
REFERENCE   8  (bases 1 to 4571)
  AUTHORS   van der Veen,J.N., Kruit,J.K., Havinga,R., Baller,J.F., Chimini,G.,
            Lestavel,S., Staels,B., Groot,P.H., Groen,A.K. and Kuipers,F.
  TITLE     Reduced cholesterol absorption upon PPARdelta activation coincides
            with decreased intestinal expression of NPC1L1
  JOURNAL   J Lipid Res 46 (3), 526-534 (2005)
   PUBMED   15604518
  REMARK    GeneRIF: The NPC1L1 protein was identified as a critical component
            of the intestinal cholesterol absorption machinery.
REFERENCE   9  (bases 1 to 4571)
  AUTHORS   Davis,H.R. Jr., Zhu,L.J., Hoos,L.M., Tetzloff,G., Maguire,M.,
            Liu,J., Yao,X., Iyer,S.P., Lam,M.H., Lund,E.G., Detmers,P.A.,
            Graziano,M.P. and Altmann,S.W.
  TITLE     Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and
            cholesterol transporter and a key modulator of whole-body
            cholesterol homeostasis
  JOURNAL   J Biol Chem 279 (32), 33586-33592 (2004)
   PUBMED   15173162
  REMARK    GeneRIF: Niemann-Pick C1 Like 1 (NPC1L1) is required for intestinal
            uptake of both cholesterol and phytosterols and plays a major role
            in cholesterol homeostasis
REFERENCE   10 (bases 1 to 4571)
  AUTHORS   Altmann,S.W., Davis,H.R. Jr., Zhu,L.J., Yao,X., Hoos,L.M.,
            Tetzloff,G., Iyer,S.P., Maguire,M., Golovko,A., Zeng,M., Wang,L.,
            Murgolo,N. and Graziano,M.P.
  TITLE     Niemann-Pick C1 Like 1 protein is critical for intestinal
            cholesterol absorption
  JOURNAL   Science 303 (5661), 1201-1204 (2004)
   PUBMED   14976318
  REMARK    GeneRIF: expression is enriched in the small intestine and is in
            the brush border membrane of enterocytes; plays a critical role in
            the absorption of intestinal cholesterol
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872216.1, BC131788.1, AV377091.2 and CJ191424.1.
            
            On Jul 15, 2009 this sequence version replaced NM_207242.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078947.1, AY437866.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               BB872216.1         5-127
            124-4032            BC131788.1         1-3909
            4033-4547           AV377091.2         134-648
            4548-4571           CJ191424.1         415-438
FEATURES             Location/Qualifiers
     source          1..4571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.93 cM"
     gene            1..4571
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /note="NPC1 like intracellular cholesterol transporter 1"
                     /db_xref="GeneID:237636"
                     /db_xref="MGI:MGI:2685089"
     exon            1..173
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            174..1702
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1803
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1976
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2105
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2288
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2403
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2531
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2669
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2759
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2950
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3078
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3205
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3261
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3412
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3644
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3758
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            3759..3921
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4571
                     /gene="Npc1l1"
                     /gene_synonym="9130221N23Rik; Gm243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagggttat cactaagagg aggaagctgc cttaatgtgc aaactcaggg gccagtcctc
       61 agcttccccg gctgtctcca aggcctggtc ctgcttttcc ttgatcactt cctggctctg
      121 ggatggcagc tgcctggcag ggatggctgc tctgggccct gctcctgaat tcggcccagg
      181 gtgagctcta cacacccact cacaaagctg gcttctgcac cttttatgaa gagtgtggga
      241 agaacccaga gctttctgga ggcctcacat cactatccaa tatctcctgc ttgtctaata
      301 ccccagcccg ccatgtcaca ggtgaccacc tggctcttct ccagcgcgtc tgtccccgcc
      361 tatacaatgg ccccaatgac acctatgcct gttgctctac caagcagctg gtgtcattag
      421 acagtagcct gtctatcacc aaggccctcc ttacacgctg cccggcatgc tctgaaaatt
      481 ttgtgagcat acactgtcat aatacctgca gccctgacca gagcctcttc atcaatgtta
      541 ctcgcgtggt tcagcgggac cctggacagc ttcctgctgt ggtggcctat gaggcctttt
      601 atcaacgcag ttttgcagag aaggcctatg agtcctgtag ccgggtgcgc atccctgcag
      661 ctgcctcgct ggctgtgggc agcatgtgtg gagtgtatgg ctctgccctc tgcaatgctc
      721 agcgctggct caacttccaa ggagacacag ggaatggcct ggctccgctg gacatcacct
      781 tccacctctt ggagcctggc caggccctgg cagatgggat gaagccactg gatgggaaga
      841 tcacaccctg caatgagtcc cagggtgaag actcggcagc ctgttcctgc caggactgtg
      901 cagcatcctg ccctgtcatc cctccgcccc cggccctgcg cccttctttc tacatgggtc
      961 gaatgccagg ctggctggct ctcatcatca tcttcactgc tgtctttgta ttgctctctg
     1021 ttgtccttgt gtatctccga gtggcttcca acaggaacaa gaacaagaca gcaggctccc
     1081 aggaagcccc caacctccct cgtaagcgca gattctcacc tcacactgtc cttggccggt
     1141 tcttcgagag ctggggaaca agggtggcct catggccact cactgtcttg gcactgtcct
     1201 tcatagttgt gatagccttg tcagtaggcc tgacctttat agaactcacc acagaccctg
     1261 tggaactgtg gtcggcccct aaaagccaag cccggaaaga aaaggctttc catgacgagc
     1321 attttggccc cttcttccga accaaccaga tttttgtgac agctaagaac aggtccagct
     1381 acaagtacga ctccctgctg ctagggccca agaacttcag tgggatccta tccctggact
     1441 tgctgcagga gctgttggag ctacaggaga gacttcgaca cctgcaagtg tggtcccatg
     1501 aggcacagcg caacatctcc ctccaggaca tctgctatgc tcccctcaaa ccgcataaca
     1561 ccagcctcac tgactgctgt gtcaacagcc tccttcaata cttccagaac aaccacacac
     1621 tcctgctgct cacagccaac cagactctga atggccagac ctccctggtg gactggaagg
     1681 accatttcct ctactgtgcc aatgcccctc tcacgtacaa agatggcaca gccctggccc
     1741 tgagctgcat agctgactac ggggcacctg tcttcccctt ccttgctgtt gggggctacc
     1801 aagggacgga ctactcggag gcagaagccc tgatcataac cttctctatc aataactacc
     1861 ccgctgatga tccccgcatg gcccacgcca agctctggga ggaggctttc ttgaaggaaa
     1921 tgcaatcctt ccagagaagc acagctgaca agttccagat tgcgttctca gctgagcgtt
     1981 ctctggagga cgagatcaat cgcactacca tccaggacct gcctgtcttt gccatcagct
     2041 accttatcgt cttcctgtac atctccctgg ccctgggcag ctactccaga tggagccgag
     2101 ttgcggtgga ttccaaggct actctgggcc taggtggggt ggctgttgtg ctgggagcag
     2161 tcgtggctgc catgggcttc tactcctacc tgggtgtccc ctcctctctg gtcatcattc
     2221 aagtggtacc tttcctggtg ctggctgtgg gagctgacaa catcttcatc tttgttcttg
     2281 agtaccagag gctgcctagg atgcccgggg agcagcgaga ggctcacatt ggccgcaccc
     2341 tgggtagtgt ggcccccagc atgctgctgt gcagcctctc tgaggccatc tgcttctttc
     2401 taggggccct gacctccatg ccagctgtga ggacctttgc cttgacctct ggcttagcaa
     2461 tcatctttga cttcctgctc cagatgacag cctttgtggc cctgctctcc ctggatagca
     2521 agaggcagga ggcctctcgc cccgacgtcg tgtgctgctt ttcaagccga aatctgcccc
     2581 caccgaaaca aaaagaaggc ctcttacttt gcttcttccg caagatatac actcccttcc
     2641 tgctgcacag attcatccgc cctgttgtgc tgctgctctt tctggtcctg tttggagcaa
     2701 acctctactt aatgtgcaac atcagcgtgg ggctggacca ggatctggct ctgcccaagg
     2761 attcctacct gatagactac ttcctctttc tgaaccggta cttggaagtg gggcctccag
     2821 tgtactttga caccacctca ggctacaact tttccaccga ggcaggcatg aacgccattt
     2881 gctctagtgc aggctgtgag agcttctccc taacccagaa aatccagtat gccagtgaat
     2941 tccctaatca gtcttatgtg gctattgctg catcctcctg ggtagatgac ttcatcgact
     3001 ggctgacccc atcctcctcc tgctgccgca tttatacccg tggcccccat aaagatgagt
     3061 tctgtccctc aacggatact tccttcaact gtctcaaaaa ctgcatgaac cgcactctgg
     3121 gtcccgtgag acccacaaca gaacagtttc ataagtacct gccctggttc ctgaatgata
     3181 cgcccaacat cagatgtcct aaagggggcc tagcagcgta tagaacctct gtgaatttga
     3241 gctcagatgg ccagattata gcctcccagt tcatggccta ccacaagccc ttacggaact
     3301 cacaggactt tacagaagct ctccgggcat cccggttgct agcagccaac atcacagctg
     3361 aactacggaa ggtgcctggg acagatccca actttgaggt cttcccttac acgatctcca
     3421 atgtgttcta ccagcaatac ctgacggttc tccctgaggg aatcttcact cttgctctct
     3481 gcttcgtgcc cacctttgtg gtctgctacc tcctactggg cctggacata cgctcaggca
     3541 tcctcaacct gctctccatc attatgatcc tcgtggacac catcggcctc atggctgtgt
     3601 ggggtatcag ctacaatgct gtgtccctca tcaaccttgt cacggcagtg ggcatgtctg
     3661 tggagttcgt gtcccacatt acccggtcct ttgctgtaag caccaagcct acccggctgg
     3721 agagagccaa agatgctact atcttcatgg gcagtgcggt gtttgctgga gtggccatga
     3781 ccaacttccc gggcatcctc atcctgggct ttgctcaggc ccagcttatc cagattttct
     3841 tcttccgcct caacctcctg atcaccttgc tgggtctgct acacggcctg gtcttcctgc
     3901 ccgttgtcct cagctatctg gggccagatg ttaaccaagc tctggtactg gaggagaaac
     3961 tagccactga ggcagccatg gtctcagagc cttcttgccc acagtacccc ttcccggctg
     4021 atgcaaacac cagtgactat gttaactacg gctttaatcc agaatttatc cctgaaatta
     4081 atgctgctag cagctctctg cccaaaagtg accaaaagtt ctaatggagt aggagcttgt
     4141 ccaggctcca tggttcttgc tgataagggg ccacgagggt cttccctctg gttgtttcca
     4201 aggcctgggg aaagttgttc cagaaaaaaa ttgctggcat tcttgtcctg aggcagccag
     4261 cactggccac tttgttgtca taggtccccg aggccatgat cagattacct cctctgtaaa
     4321 gagaatatct tgagtattgt atgggatgta tcacatgtca attaaaaagg ccatggccta
     4381 tggcttaggc aggaaatagg gtgtggaaca tccaggagaa gaaaggattc tgggataaag
     4441 gacacttggg aacgtgtggc agtggtacct gagcacaggt aattagccat gtggcgaaat
     4501 gtagattaat ataaatgcat atctaagtta tgattctagt ctagctatat ggccaaggta
     4561 tttataaata t
//
