LOCUS       NM_010342               3692 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neuropeptides B/W receptor 1 (Npbwr1), mRNA.
ACCESSION   NM_010342 XM_136404 XM_912251
VERSION     NM_010342.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3692)
  AUTHORS   Wang,R., Zheng,C., Jiang,W., Xie,X., Liao,R. and Zhou,G.
  TITLE     Neuropeptide W regulates proliferation and differentiation of
            ATDC5: Possible involvement of GPR7 activation, PKA and
            PKC-dependent signalling cascades
  JOURNAL   J Cell Mol Med 23 (3), 2093-2102 (2019)
   PUBMED   30609248
  REMARK    GeneRIF: The neuropeptide W (NPW) mRNA quickly elevated in the
            early differentiation (7-14 days) of ATDC5 cells, while NPW and
            neuropeptides B/W receptor 1 (GPR7) mRNA were reduced during the
            late stage (14-21 days) of differentiation.
REFERENCE   3  (bases 1 to 3692)
  AUTHORS   Nagata-Kuroiwa,R., Furutani,N., Hara,J., Hondo,M., Ishii,M.,
            Abe,T., Mieda,M., Tsujino,N., Motoike,T., Yanagawa,Y., Kuwaki,T.,
            Yamamoto,M., Yanagisawa,M. and Sakurai,T.
  TITLE     Critical role of neuropeptides B/W receptor 1 signaling in social
            behavior and fear memory
  JOURNAL   PLoS One 6 (2), e16972 (2011)
   PUBMED   21390312
  REMARK    GeneRIF: Important roles of NPBWR1 in regulating amygdala function
            during physical and social stress.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3692)
  AUTHORS   Uchio,N., Doi,M., Matsuo,M., Yamazaki,F., Mizoro,Y., Hondo,M.,
            Sakurai,T. and Okamura,H.
  TITLE     Circadian characteristics of mice depleted with GPR7
  JOURNAL   Biomed Res 30 (6), 357-364 (2009)
   PUBMED   20051645
  REMARK    GeneRIF: data demonstrate that GPR7 mRNA showed a significant
            circadian rhythm in the suprachiasmatic nucleus showing a peak at
            early subjective night in both light-dark and constant dark
REFERENCE   5  (bases 1 to 3692)
  AUTHORS   Ishii,M., Fei,H. and Friedman,J.M.
  TITLE     Targeted disruption of GPR7, the endogenous receptor for
            neuropeptides B and W, leads to metabolic defects and adult-onset
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10540-10545 (2003)
   PUBMED   12925742
  REMARK    GeneRIF: role for GPR7 and its endogenous ligands, neuropeptide B
            and neuropeptide W, in regulating energy homeostasis.
REFERENCE   6  (bases 1 to 3692)
  AUTHORS   O'Dowd,B.F., Scheideler,M.A., Nguyen,T., Cheng,R., Rasmussen,J.S.,
            Marchese,A., Zastawny,R., Heng,H.H., Tsui,L.C., Shi,X. et al.
  TITLE     The cloning and chromosomal mapping of two novel human
            opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed
            in discrete areas of the brain
  JOURNAL   Genomics 28 (1), 84-91 (1995)
   PUBMED   7590751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157993.7.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_912251.2, XM_136404.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK138357.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3692              AC157993.7         21155-24846         c
FEATURES             Location/Qualifiers
     source          1..3692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.89 cM"
     gene            1..3692
                     /gene="Npbwr1"
                     /gene_synonym="Gpr7; Nbpwr1"
                     /note="neuropeptides B/W receptor 1"
                     /db_xref="GeneID:226304"
                     /db_xref="MGI:MGI:891989"
     exon            1..3692
                     /gene="Npbwr1"
                     /gene_synonym="Gpr7; Nbpwr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1095
                     /gene="Npbwr1"
                     /gene_synonym="Gpr7; Nbpwr1"
                     /note="G protein-coupled receptor 7"
                     /codon_start=1
                     /product="neuropeptides B/W receptor type 1"
                     /protein_id="NP_034472.1"
                     /db_xref="CCDS:CCDS48214.1"
                     /db_xref="GeneID:226304"
                     /db_xref="MGI:MGI:891989"
                     /translation="MHNLTLFESGGDNVSCGGSSLGCPNGSSLAPLPLPQPLAVAVPV
                     VYGVICAVGLAGNSAVLYVLLRTPRMKTVTNVFILNLAIADELFTLVLPINIADFLLR
                     RWPFGEVMCKLIVAVDQYNTFSSLYFLAVMSADRYLVVLATAESRRVSGRTYGAARAV
                     SLAVWALVTLVVLPFAVFARLDEEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPV
                     TTICALYTTLLCRLRAIQLDSHAKALDRAKKRVTLLVAAILAVCLLCWTPYHLSTIVA
                     LTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRRSLRQLVSCRSA"
     regulatory      3667..3672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npbwr1"
                     /gene_synonym="Gpr7; Nbpwr1"
                     /note="hexamer: AATAAA"
     polyA_site      3692
                     /gene="Npbwr1"
                     /gene_synonym="Gpr7; Nbpwr1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcctggg tgcagatccc tgtaaacgtg ggcgcataaa cctcgagttt cgcggggctg
       61 ctgagtggaa tcctggtggt cgcctgctct ccagccctct ccaagatgca taacttaacg
      121 cttttcgagt ctggagggga caacgtgtct tgcggcggct catctttggg ctgtcccaac
      181 gggtccagcc tggctcctct gccgctgccg cagccactgg cggtagcagt gcctgtcgtc
      241 tacggggtaa tttgcgccgt gggactggct ggcaactctg cggtgctgta cgtactgctg
      301 cgcacgccgc gcatgaagac tgtcaccaac gtgttcatcc tcaacctggc tatcgccgat
      361 gagctcttca ccctcgtgct gcccatcaac atcgcggact tcctgctgag gcgctggccc
      421 ttcggggagg tcatgtgcaa gctcattgta gccgtcgacc agtacaacac tttctctagc
      481 ctctacttcc tcgccgtcat gagcgccgac cgatacctgg tggttctggc cacagcagag
      541 tcgcgccggg tgtccgggcg cacttacggt gcagcgcgtg ctgtcagtct ggcggtgtgg
      601 gcgctggtga cgctggtcgt gctgcccttt gcggtattcg ctcggctgga cgaggagcag
      661 ggtcggcgcc agtgcgtgct ggtcttcccg cagcccgagg ccttctggtg gcgtgccagc
      721 cgtctctaca cactagtatt gggctttgcc atcccggtga ccaccatctg tgctctctat
      781 accactctgc tctgccgact gcgtgctatc cagctagata gccacgccaa ggccctggat
      841 cgtgccaaga agcgcgtgac cttgttggtg gcggcgattc tggctgtgtg cctcctctgc
      901 tggacgcctt atcacctgag taccatagtg gccctcacca ccgacctccc gcaaacgccg
      961 ctggtcatcg gcatctctta cttcatcacc agcctgagct atgctaacag ctgcctcaac
     1021 cctttcctct atgccttcct ggacgacagc ttccgcagaa gcctccggca attggtgtca
     1081 tgccgttcag cctgatgccc tttccacctc tttccaccgc aggcagcact gccagctggg
     1141 ttcaggagaa ttccgggact gtggttccca agtgcagccc gaaatcctga ggcccattcc
     1201 aggcattcag taccacaggc cctacccagg actgatacca caggccctaa ccaggactga
     1261 tccgggattt gcccggcctt gaggtgaggc tggtgtgtag catgcctgag gacagcttgg
     1321 gccagggcac cttactattt tgtccccaca gctgagggca gggcttgaca cctgaacgta
     1381 gggtaaatgg tggggcagtg ttgttggaac gtgattttaa ttctctctct atttcactgt
     1441 gagtaggctc ctaggatgtc ccaggcatct cttcctcagc gttaagtctg tgtattttgt
     1501 ttctttgctt tccaccacgg atgacctccc tggtaaacag cctggcctga tgcttcttag
     1561 gaacactcta actgcctggc cacgcctcac tggagatgtg tgtgtgtgtg tgtgtgtgtg
     1621 tgtgtgtgtg ttagagtgga ggtgtggtgg tgtggaggtg tggtggtgtg gtggtgtggt
     1681 ggtgtggtgg tatggtggtg tggtggtgtg gtggtggtgg tgaagggggc tagaacctag
     1741 ctgtgactga caagaataga gataatcacc tgctcagtat gccccacctt tcttcgtttt
     1801 accgaagccg atctatatgg ccctaaaaag actttaaccg aggctgcaaa agccaagagt
     1861 acagagaaat caccggagag tgaggttcca gctccctcta gaggagtcag gtgtacagaa
     1921 cgtttctgag ctgcttttgc acagggtggt gcaccagcca acagctcttt aaatctttgg
     1981 tcctttgtag cttctgtaaa gtagtccaaa atttccttcc tgcctcatag ccttcacagg
     2041 cttcccatac aacttagacc atttccttgt aactatgtac agtttttctg gaccaagaac
     2101 tttgtaaata atacatatat cttactctca cagtcttctt aacttagagg aatatgagaa
     2161 ataaaagatg agacctgttc caactatggt tccccttccc tgagtattct tccaggacct
     2221 cccttcagtg agatccaggt acgggaaccg ccttgcatcc ctagcttttt cttgtctgga
     2281 cacttaccta accacaagga acatctaaat tttgtccaat tctaaagtcc cggggaacat
     2341 ctgcttctga ttacccacag ggaacagtca acacctactt tcctctcttt agtctctact
     2401 tatggaagac aagctccagg cctcctcctc gaggcctgga gtaaccagac tcatcagtga
     2461 tagcgtcttt taaacgatat gtttaggatg atccccagga agaaatgata tgattttcaa
     2521 gtatcatttt tcctatggga aagtttggtt atatgtggaa ccaagactct tgccagcaga
     2581 ctttgtttac aaagtttggc atgaaagtca attatttctc agttatttgt attcaatgtt
     2641 cccttcaaaa atatgcagaa gggaaatact ctctcttgca agaggaaggc taaatttccc
     2701 tctgattttg gtgtatgaga attgattggt tcctacggtg tcagagttgt gggaagattg
     2761 gggtaatttt caagtacaaa ctgagaaaac taatttagag gctgtgtgtc ttgggtgcaa
     2821 ataacagtaa attgtctaaa agttgtccat cagtcatgca cttgaaccat ggtcatcatg
     2881 gcctcagaac gggcctctgc tgtggccttc agaagtgtct ggaatgtgtt cataagcttc
     2941 agacttctgg gaagcactcc acagatattt cttttaaaac ttaaattttg tatgattttc
     3001 tgtaattttt ccaaattagg attttaaaat tgagcaacct gtagctcatc cagggtgata
     3061 ataaaggatg cagtggagct ttggacacag atacagccaa gtactgtcac attaattgga
     3121 aacccagtct ccatacatgc agcagcaaca tagataagaa ggaggtcctg gtagttttct
     3181 gtctgtcatg ccattgctgc tagagatagg tttatgtctg tcttgcagtc tctggatgct
     3241 gccggaaaaa cacaagagag atataactgt acccatcaca gctcagtaca gactggaagt
     3301 ctagtttgca tcaagaggat tcaatatcag tgtcacactg gctttctaaa gcccctcgtg
     3361 atcacttcac ctttctgtga gcatttgggc agttatatat aaataaatat ataaatataa
     3421 ggcatctata tttaaccttt tatctcttaa gtaaaacata gaataaataa acaagtcaca
     3481 tagtaggaaa atttgtaatt ccatagttct tacagccttg gtgtaaacta tgttgtttta
     3541 acgcttctaa tatctaaaag tgtgaatttg gttttactta ttttagtata attgtataaa
     3601 gtgggtttaa tgctttctca agaaatgcag caatttgcta attgattgca gaagatccaa
     3661 gtctaaaata aaaggtgaaa cattctgtgt ga
//
