LOCUS       NM_153288                549 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus neuropeptide B (Npb), transcript variant 1, mRNA.
ACCESSION   NM_153288 XM_994596
VERSION     NM_153288.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 549)
  AUTHORS   Kelly,M.A., Beuckmann,C.T., Williams,S.C., Sinton,C.M., Motoike,T.,
            Richardson,J.A., Hammer,R.E., Garry,M.G. and Yanagisawa,M.
  TITLE     Neuropeptide B-deficient mice demonstrate hyperalgesia in response
            to inflammatory pain
  JOURNAL   Proc Natl Acad Sci U S A 102 (28), 9942-9947 (2005)
   PUBMED   15983370
  REMARK    GeneRIF: NPB is a factor in the modulation of responses to
            inflammatory pain and body weight homeostasis.
REFERENCE   2  (bases 1 to 549)
  AUTHORS   Ishii,M., Fei,H. and Friedman,J.M.
  TITLE     Targeted disruption of GPR7, the endogenous receptor for
            neuropeptides B and W, leads to metabolic defects and adult-onset
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10540-10545 (2003)
   PUBMED   12925742
  REMARK    GeneRIF: role for GPR7 and its endogenous ligands, neuropeptide B
            and neuropeptide W, in regulating energy homeostasis.
REFERENCE   3  (bases 1 to 549)
  AUTHORS   Tanaka,H., Yoshida,T., Miyamoto,N., Motoike,T., Kurosu,H.,
            Shibata,K., Yamanaka,A., Williams,S.C., Richardson,J.A.,
            Tsujino,N., Garry,M.G., Lerner,M.R., King,D.S., O'Dowd,B.F.,
            Sakurai,T. and Yanagisawa,M.
  TITLE     Characterization of a family of endogenous neuropeptide ligands for
            the G protein-coupled receptors GPR7 and GPR8
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6251-6256 (2003)
   PUBMED   12719537
REFERENCE   4  (bases 1 to 549)
  AUTHORS   Fujii,R., Yoshida,H., Fukusumi,S., Habata,Y., Hosoya,M.,
            Kawamata,Y., Yano,T., Hinuma,S., Kitada,C., Asami,T., Mori,M.,
            Fujisawa,Y. and Fujino,M.
  TITLE     Identification of a neuropeptide modified with bromine as an
            endogenous ligand for GPR7
  JOURNAL   J Biol Chem 277 (37), 34010-34016 (2002)
   PUBMED   12118011
  REMARK    GeneRIF: identified a neuropeptide modified with bromine; an
            endogenous ligand for GPR7
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141698.1.
            
            On Apr 6, 2007 this sequence version replaced NM_153288.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141698.1, BB442010.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               AK141698.1         2-550
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.33 cM"
     gene            1..549
                     /gene="Npb"
                     /gene_synonym="mPPL7; PPL7"
                     /note="neuropeptide B"
                     /db_xref="GeneID:208990"
                     /db_xref="MGI:MGI:2387153"
     exon            1..263
                     /gene="Npb"
                     /gene_synonym="mPPL7; PPL7"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..392
                     /gene="Npb"
                     /gene_synonym="mPPL7; PPL7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; preproprotein L7; preproneuropeptide B"
                     /codon_start=1
                     /product="neuropeptide B isoform 1 precursor"
                     /protein_id="NP_695020.1"
                     /db_xref="CCDS:CCDS25746.1"
                     /db_xref="GeneID:208990"
                     /db_xref="MGI:MGI:2387153"
                     /translation="MARCRTLVAAALALLLPPALAWYKPAAGPHHYSVGRASGLLSSF
                     HRFPSTRRSESPALRVGTGPLRNLEMRPSVRSLALCVKDVTPNLQSCQRQLNSRGTFQ
                     CKADVFLSLHETDCQST"
     exon            264..549
                     /gene="Npb"
                     /gene_synonym="mPPL7; PPL7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      549
                     /gene="Npb"
                     /gene_synonym="mPPL7; PPL7"
                     /note="putative"
ORIGIN      
        1 cgctacattc tgcctgcccc tgtcacagct ccatggcccg gtgtaggacg ctggtggccg
       61 ctgccctggc gctgctcctg ccgccagccc tcgcgtggta caagcccgcg gcgggacccc
      121 accactactc ggtgggccgc gcctcggggc tactgtcgag tttccacagg ttcccgtcca
      181 cgcgacgctc cgagtctcca gcactccggg tgggaaccgg acctctgcgc aatttagaga
      241 tgcgccccag cgtaaggagc cttgccctgt gtgtcaaaga tgtgaccccg aacctgcaga
      301 gctgccagcg gcaactcaac agccgaggga ctttccagtg taaagcggac gtcttcttgt
      361 cgctgcacga gactgattgc cagagcacct gagccctgaa ccccaaccct gcggccggtg
      421 actctcccca acccccatat gcccagtctt gcttgaagta gcacagaccc tgtgtgggtt
      481 tggcccctag ctcccaccat gctccatagc aaatggctaa attaataaag aagcaaaact
      541 gtctctgct
//
