LOCUS       NM_001081152            7287 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus nuclear protein in the AT region (Npat), transcript
            variant 1, mRNA.
ACCESSION   NM_001081152 XM_146900
VERSION     NM_001081152.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7287)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7287)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7287)
  AUTHORS   Cui,Z., Zhao,F., Chen,X., Li,J., Jin,X., Han,Y., Wang,L., Zhou,Y.
            and Lu,L.
  TITLE     NPAT Supports CD8+ Immature Single-Positive Thymocyte Proliferation
            and Thymic Development
  JOURNAL   J Immunol 209 (5), 916-925 (2022)
   PUBMED   35922064
  REMARK    GeneRIF: NPAT Supports CD8(+) Immature Single-Positive Thymocyte
            Proliferation and Thymic Development.
REFERENCE   4  (bases 1 to 7287)
  AUTHORS   Chen,C., Gallagher,J.R., Tarlton,J., van Aalten,L., Bray,S.E.,
            Ashford,M.L.J., McCrimmon,R.J., Pearson,E.R., McNeilly,A.D. and
            Sutherland,C.
  TITLE     The genetic association of the transcription factor NPAT with
            glycemic response to metformin involves regulation of fuel
            selection
  JOURNAL   PLoS One 16 (7), e0253533 (2021)
   PUBMED   34197485
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7287)
  AUTHORS   Jiang,X., Yin,S., Fan,S., Bao,J., Jiao,Y., Ali,A., Iqbal,F., Xu,J.,
            Zhang,Y. and Shi,Q.
  TITLE     Npat-dependent programmed Sertoli cell proliferation is
            indispensable for testis cord development and germ cell mitotic
            arrest
  JOURNAL   FASEB J 33 (8), 9075-9086 (2019)
   PUBMED   31084574
  REMARK    GeneRIF: Our data indicates that the function of Npat-dependent
            Sertoli cells is essential at multiple steps in testis development,
            and this study also identifies Sertoli cells as a major regulator
            of germ cell development, which are required to maintain a local
            growth niche to repress premature mitosis and meiosis of gonocytes.
REFERENCE   6  (bases 1 to 7287)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 7287)
  AUTHORS   Saito,T., Matsuda,Y., Ishii,H., Watanabe,F., Mori,M., Hayashi,A.,
            Araki,R., Fujimori,A., Fukumura,R., Morimyo,M., Tatsumi,K., Hori,T.
            and Abe,M.
  TITLE     Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head
            organization: an implication of co-evolution of ATM family members
            and cell cycle regulating genes
  JOURNAL   Mamm Genome 9 (9), 769-772 (1998)
   PUBMED   9716665
REFERENCE   8  (bases 1 to 7287)
  AUTHORS   Di Fruscio,M., Weiher,H., Vanderhyden,B.C., Imai,T., Shiomi,T.,
            Hori,T.A., Jaenisch,R. and Gray,D.A.
  TITLE     Proviral inactivation of the Npat gene of Mpv 20 mice results in
            early embryonic arrest
  JOURNAL   Mol Cell Biol 17 (7), 4080-4086 (1997)
   PUBMED   9199343
REFERENCE   9  (bases 1 to 7287)
  AUTHORS   Byrd,P.J., Cooper,P.R., Stankovic,T., Kullar,H.S., Watts,G.D.,
            Robinson,P.J. and Taylor,M.R.
  TITLE     A gene transcribed from the bidirectional ATM promoter coding for a
            serine rich protein: amino acid sequence, structure and expression
            studies
  JOURNAL   Hum Mol Genet 5 (11), 1785-1791 (1996)
   PUBMED   8923007
REFERENCE   10 (bases 1 to 7287)
  AUTHORS   Matsuda,Y., Imai,T., Shiomi,T., Saito,T., Yamauchi,M., Fukao,T.,
            Akao,Y., Seki,N., Ito,H. and Hori,T.A.
  TITLE     Comparative genome mapping of the ataxia-telangiectasia region in
            mouse, rat, and Syrian hamster
  JOURNAL   Genomics 34 (3), 347-352 (1996)
   PUBMED   8786135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156640.2.
            
            On Jul 25, 2022 this sequence version replaced NM_001081152.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080294.1, SRR10223971.9196.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC156640.2         73957-74098         c
            143-261             AC156640.2         65859-65977         c
            262-322             AC156640.2         62175-62235         c
            323-395             AC156640.2         61035-61107         c
            396-436             AC156640.2         59507-59547         c
            437-661             AC156640.2         58671-58895         c
            662-749             AC156640.2         57173-57260         c
            750-834             AC156640.2         56004-56088         c
            835-926             AC156640.2         54666-54757         c
            927-1014            AC156640.2         54490-54577         c
            1015-1111           AC156640.2         52924-53020         c
            1112-1237           AC156640.2         51938-52063         c
            1238-2872           AC156640.2         47469-49103         c
            2873-2988           AC156640.2         44313-44428         c
            2989-3097           AC156640.2         44121-44229         c
            3098-3158           AC156640.2         41198-41258         c
            3159-4290           AC156640.2         39967-41098         c
            4291-7287           AC156640.2         35578-38574         c
FEATURES             Location/Qualifiers
     source          1..7287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.12 cM"
     gene            1..7287
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="nuclear protein in the AT region"
                     /db_xref="GeneID:244879"
                     /db_xref="MGI:MGI:107605"
     exon            1..142
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..4368
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein NPAT"
                     /codon_start=1
                     /product="protein NPAT isoform 1"
                     /protein_id="NP_001074621.1"
                     /db_xref="CCDS:CCDS40637.1"
                     /db_xref="GeneID:244879"
                     /db_xref="MGI:MGI:107605"
                     /translation="MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDE
                     GFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMHSS
                     PGFAAHQRARTRNGIAEIKRQRWLASQAAPVSSELLVLPYASGQFTTSPLVATQAVKP
                     TGPISTPVRSNIVVVNQSQPQSTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQ
                     KKSLTSSGPHSSRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDS
                     SVAQVPKQTDSNPTEPETSIDELLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFD
                     YGKTKNNKNMPQISSQPMETNSNIVLPEETNLTIKSSFETEESDGQSGQPPFCTSYQN
                     EDVLLNDLKSGNSHDVLPQESQENFSQISSNIQKKTFKTAIPAEQKCALDITLESVSN
                     LSDFNQRGSSAECNEHCSELFASQIPTEAEVAVGEKNSLSADILSQSQYQPDQPSVPV
                     TSFVSLGGETNDKNLVLSGKNSQLLSQSTPLTTKPSKSQLCENSNNIIKVKTNPQASE
                     SADSSETANRKTETNTVSPAAAQPQADCQDNSPLQSKPPPGIGESLGVNVTEKIEIHL
                     EEPAPSDKQLSNDAASVDLNPTESKTEPLQSASAQEPEPPSVKDGDTIFLSLSEHNSC
                     EEVALVLGEGNPVKNNNSLSSESGGSVGVSPETQNTDGKTSNSTEVDASSIVSLKIII
                     SDDPFVSSDAELNSAVSSISGENLPTIILSSKSPAKNAEFVTCLSSEETASAVVSVEV
                     GDSGSMEQNLLVLKPEEPMVNNTQNEDGIAFSANVAPCVPKDGGYIQLMPTTSTAFGN
                     SSNILIATCMTDSTALGPTVSQSNVVVLPGSSAPMTAQPPQQQLQTPPKSNSAFAVSQ
                     AVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSTPPQQVLHMPLAAPVC
                     NRSIAQLPIPQKSQKAQGLRNKLITGKQVNNLTNLSSLSEACHTQRTEASDKNIATEL
                     GKKMEDTTISLSGERVAPPSKPFESHRRVLCFDSTVSSVANTQGSLYKMTSENKEKKE
                     ASFSHLDSPILSSTLKPPPNNAIKREREKTVPKILSKSETASSRHTTVKEVQSEKKVS
                     PTEVALESLHKATANKENELCGDGERPKNADTSKLPGGQQNGSLRNEKAIASLQELTK
                     KQATPSNNKNATSVGGTVKDQKQEQSKPASSLIGAEILQDVPIHSPANRSADTDLPVP
                     RTPGSGAGEKHKEEPSDSMKAPASRRCGEEGSMPRVMIPPVTADLPACSPASETGSEN
                     SVSMAAHTLMILSRAAIARTTATPLKDNTQQFRTSSRSTTKKRKIEELDECERNSRTS
                     GKNLANSSVPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE"
     exon            143..261
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            262..322
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            323..395
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            396..436
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            437..661
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            662..749
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            750..834
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            835..926
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1014
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1111
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1237
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..2872
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2988
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3097
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3158
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..4290
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..7287
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5671..5676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="hexamer: AATAAA"
     polyA_site      5703
                     /gene="Npat"
                     /gene_synonym="6820401K01"
     regulatory      5870..5875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="hexamer: AATAAA"
     polyA_site      5894
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="major polyA site"
     regulatory      6040..6045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="hexamer: TATAAA"
     polyA_site      6067
                     /gene="Npat"
                     /gene_synonym="6820401K01"
     regulatory      7143..7148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="hexamer: TATAAA"
     polyA_site      7172
                     /gene="Npat"
                     /gene_synonym="6820401K01"
     polyA_site      7249
                     /gene="Npat"
                     /gene_synonym="6820401K01"
     regulatory      7260..7265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npat"
                     /gene_synonym="6820401K01"
                     /note="hexamer: AATAAA"
     polyA_site      7287
                     /gene="Npat"
                     /gene_synonym="6820401K01"
ORIGIN      
        1 agcacctcca gtggaaccgg gagatgcggc ggcgccgggg ctgtcgccgt gtttgctttg
       61 agttgagtct cgtcccttca ggccgctccc tgtgcagctc ggatcatgct gttaccctcg
      121 gatgtagcca ggctggtatt gggttactta caacaagaaa accttacatc tacttgccag
      181 acttttattt tggaaagttc aaatttaaaa gaatatgcag aacactgtac tgatgaaggt
      241 tttattccag cctgcttact gtccttattt ggaaaaaact tgaccacaat tttgaatgag
      301 tatgtagcta tgaaagcaaa agaaacatca aatgatgtcc caacaataat gtcatctcta
      361 tggaagaagc tagaccacac actctctcag atcaggagca tgcacagttc tccagggttt
      421 gctgcccatc agagagctcg aacgagaaat ggaattgcag aaatcaagcg gcagcgatgg
      481 ctagcatctc aggcagctcc cgtcagttca gagttactgg ttttacctta tgcttcagga
      541 cagtttacca cttctccttt ggtagccaca caagctgtta agccaactgg cccaatttca
      601 actccagtga ggtcaaatat tgtggtggtc aaccagtcac agccacaaag tactgtaact
      661 aatacagctg gagagtcttt gaatatcatt cctggtcctc aggaaaggaa aactcaaacc
      721 agtttaatgt ctcctggtag acgtaaaagt gaatcacaaa agaagagtct cacatcatct
      781 ggaccgcatt catcaaggaa ttttcaggat ccaaatgcat ttgcagtaga aaaacaaatg
      841 gttattgaaa atgcaagaga gaaaatatta agcaacaaat ctcttcaaga aaaactagca
      901 gaaaacataa ataagttttt gactagtgat agtagtgttg ctcaagtacc taagcagaca
      961 gacagcaacc cgacagagcc agaaacgtca attgatgaac tgctaggcct tccgagtgaa
     1021 atccatatgt ctgaagaagc catacaagat attttggagc agacagaatc agaccccgcc
     1081 tttcaggcac tctttgatct ttttgactat ggtaaaacaa agaacaataa aaatatgcca
     1141 caaatctcta gtcaacctat ggagactaat tctaatatag tcttgcctga agaaactaat
     1201 ctaacaatta aaagttcttt tgaaactgaa gaatcagatg ggcagtctgg tcagcctcca
     1261 ttttgtacat cctatcaaaa tgaagatgta ttattaaatg atttgaagag tggcaacagc
     1321 catgatgttc ttccacagga atcccaggaa aacttctctc agataagctc taacattcaa
     1381 aaaaagacct ttaaaacagc catacctgct gaacagaagt gtgcccttga cattaccctt
     1441 gagtctgtgt ctaacttgag tgactttaac caaagaggaa gctctgctga atgtaatgaa
     1501 cattgttctg agttattcgc cagtcagata cccactgaag ctgaagtggc tgtgggtgag
     1561 aagaattctt tgtctgcaga tatactgagt caatctcagt atcagcctga tcagcccagt
     1621 gtgccagtga cttcatttgt gtctcttggt ggtgagacca atgacaaaaa cttagttctc
     1681 tctgggaaaa attcccagct tttgtcccaa agtactccac taactacaaa gccatcaaaa
     1741 agccaacttt gtgaaaattc taacaatata ataaaagtta aaactaatcc tcaggcttct
     1801 gagtcagcag actctagtga aactgcaaac aggaaaactg agactaacac tgtatcgcca
     1861 gctgctgcac agccacaagc agattgccaa gataactctc cactgcagag caaaccacct
     1921 cctgggattg gtgaaagttt gggtgtaaat gtgactgaga aaatagaaat tcatcttgaa
     1981 gaaccagccc cttcagataa acagctctct aatgatgcag cgtctgttga cttaaatcct
     2041 acggaaagca agacggagcc acttcagtct gccagtgctc aagagcccga gcccccttct
     2101 gtgaaagatg gagatactat ttttctctct ttgagtgaac ataacagctg tgaagaagtt
     2161 gcactggttc ttggagaagg taatcctgta aaaaataata attcgctttc ttcagaatct
     2221 ggtggttcag tgggagtctc tcctgagacc caaaatactg atggtaaaac tagcaactca
     2281 acagaggtag atgcatcaag tattgtctct ctcaaaatta tcattagtga tgatccattt
     2341 gtttcctcag atgcagagct taacagtgct gtgtctagta tcagtggaga aaacttacca
     2401 acgataattc tgtcttctaa atctcctgcc aaaaatgcag aatttgttac atgcctatct
     2461 tcagaagaaa ctgcaagtgc tgttgtatct gttgaagtag gggattccgg ctccatggag
     2521 cagaaccttt tagtgctcaa acctgaggag cccatggtaa acaacactca gaatgaagat
     2581 ggcattgctt tttcagccaa tgttgcacca tgtgttccta aggacggagg atacatacag
     2641 ttgatgccta ccacaagcac agcgtttggc aattcaagta acattctgat agctacctgt
     2701 atgactgatt caacagcctt gggaccaact gtcagtcagt ctaatgtagt ggtattgcct
     2761 gggagttctg cacctatgac tgcacagcct cctcaacagc agttacagac accacctaaa
     2821 tctaacagtg cgtttgctgt cagccaagct gtgtcgccaa acttttcaca aggatctgcc
     2881 atcataattg cttctccagt ccagcctgta cttcaaggaa tggtgggaat gatacctgtg
     2941 tctgtagttg gacagaatgg aaatacattc tctactcctc ctcagcaggt ccttcatatg
     3001 cctttagcag cacctgtttg taatagaagt atcgctcagc tccccattcc tcaaaaatcc
     3061 cagaaggctc agggactcag aaacaagctt attacaggaa aacaggtaaa taatttgaca
     3121 aacttgtcca gtctttcaga agcatgtcat acgcagagaa ctgaagcttc tgataagaat
     3181 atagccactg aacttgggaa aaaaatggaa gacaccacga tttccctctc aggagagagg
     3241 gtagctcctc ccagcaagcc atttgaaagt cataggcggg tgctttgttt cgatagtact
     3301 gtttcttctg ttgcaaatac acaggggtca ctgtataaga tgacctccga aaacaaagaa
     3361 aagaaggaag catccttttc tcatcttgac tcacccattc tgtcctctac cttaaaacca
     3421 cctcctaata acgccatcaa aagagagaga gagaaaaccg tgcccaagat tttatctaaa
     3481 tcagaaactg cctctagtcg acacaccact gtgaaagaag ttcagtctga aaagaaagtt
     3541 tcccccacag aagtggccct tgagtctctc cataaagcaa cagctaacaa ggagaatgaa
     3601 ttgtgcggtg atggggaaag gccgaagaat gcagacacct caaaactgcc tggtgggcag
     3661 cagaatggga gcttgaggaa cgaaaaagcc atagcctcgc tgcaggaatt gaccaaaaaa
     3721 caagccacac cctcaaacaa taaaaatgcc acttctgtag gtggaactgt gaaggatcaa
     3781 aaacaagagc agagtaaacc tgccagttct ttaattgggg cagaaatact gcaggatgtt
     3841 cccatccaca gcccagccaa taggagtgcc gatactgact tgccagtacc ccggacccct
     3901 ggctcaggag caggggaaaa gcataaagaa gagcctagtg acagtatgaa ggcccccgct
     3961 agtagacgct gtggtgaaga aggcagcatg ccaagagtaa tgatccctcc tgtcactgca
     4021 gacttgcctg cctgcagccc agccagtgaa acaggcagtg aaaacagtgt gagcatggct
     4081 gcccacacgc tcatgattct ctccagagca gcaattgcta ggactacagc aactcctcta
     4141 aaagataaca cgcagcagtt tagaacatct tcaaggagca ctacaaagaa acggaaaatt
     4201 gaggaattag atgagtgtga gagaaactcc cgcacgtctg gtaaaaatct tgctaattca
     4261 tcagtaccaa tgaaaaagaa gaaaatcaag aaaaagaagc tacctagttc atttccagca
     4321 ggaatggatg tggacaaatt cttgctctca ttgcattatg atgagtgaac gaacacccag
     4381 acacagagac cagtagctat ttaaaactag tgtccttcag atggcgagta ggaaacgggc
     4441 cagagacaga ctgcgaacat gacctgcact ttgactgtac tgaggtttca ctttatatct
     4501 aagtcatgct gtttctgaag cagcttccta gtttgtaaat agactctcat ggaatatttg
     4561 tattctaaaa gaacatacgc agaaatgtaa gtaaacccaa tctgcaaaac tgtacagctt
     4621 tgacactgta tattgtacat gtgtatattg tgtaaaaata gagcttaaat caacctaata
     4681 ttcccacact gtcttgattg acttcgcccg aggcttattc ttctggagta ctttctcatc
     4741 tcctttggag gaagatgata attattctta caaattacct tcagccaata ttagataagc
     4801 cactaagtaa aaaataataa tgataaccac ctcaactggt tagtaaaata tctaatcagt
     4861 aaacaacagt tggatgatga tttcccccta gagtcaatat tttatcaccc ttcataaatt
     4921 tcagtaaaaa ctatatttct gaagttttat actttattct gatcatctat tctctttgtt
     4981 ttaaagagat ttttataaac catttattaa gtgttctgat atttcactta caactttttg
     5041 aaatctttta cagaacatta agtggttaga ctattgagcc ataaaaattt gagttatgta
     5101 gtagtcgaga tttcttgatt atatgtaaac tttccctaag cactggggat acaaagaatt
     5161 gcactaattc atagactttt tcacatacta gtgaccaatg cacatttaat ttaaatcttg
     5221 tatgtaaaag cttatatgga ggattgtctt ctggtgtctt tgaaagtcat atccatcata
     5281 agatgtaaaa atgcaaatca tagttatatt gtaatttagt ttaccctgaa atgggatgtg
     5341 taaataactg tgttcataca taacctatag aaccttgtgt tctttaaagt gttataaata
     5401 gttactctca aaaggtcctt aggggagtga gaggtgcctt ctctgtgttg gactgactca
     5461 taaacaacag tcaagttgaa aagctggcct aaactttaaa ggaatgacag aaattatcat
     5521 taatacttga ccgattgtgc ctagatattg aagtgttttc ttaagttctt actgtttaaa
     5581 tatcagcata ttaggatttt tttttctacg ggtgtatatt ttattaaaaa gtcactttct
     5641 tcaaccattt tttgtactgg gcctttaaga aataaatcca tcctactgta acaacaacaa
     5701 aaacgtcttc aagatgtaaa ttatgtcttt ttaattgcta gattttactg tacaaattta
     5761 tattttgaga aatgttctat gactgagctg ttctactcct aaggagctaa ctaagcatac
     5821 agttactgtt tgcataactc agtctgggtc tgtcctacag ttaggtttga ataaatatat
     5881 tttcattaac tttaccagtt tggatttata tttagaaatt ggttaaattt ctttgtagct
     5941 tagttaattc tctgtgtttt tcaggaattc atataatgca ggaaattaca gattttctcc
     6001 tgtaactcat atctatgtgc tgcataatga gaattcatat ataaactaac tcatgctctt
     6061 ttctatagct ctatgtgtgt ttttagtcag tgtctttcct gtaggccagg ctggctttga
     6121 actcattaca tagtccagtg actttgaagt cctggtcctc ctcatctacc tcctctaagt
     6181 gccaatattg caggcatgca ccatacacag agcttcagga ttcttgtcat tttgatttgt
     6241 ttcttgagat ggtagctatg tagttcttgt tgacctgtgt agacaagact aacgtcaaac
     6301 tcacagagat cctcctgcct ctgcctccca agtgctaggg gttaaaggtg tatattaccc
     6361 ctcctggcct tcaagattct tagtgaacta gcttgaaacc actagatagt ccaaagacag
     6421 ttagtgcaca cacacacaca aatatcaggt atttttatat ttctctgtca ttttccttta
     6481 ggaaaagggt tcttctgctg gctggccagc aagtcccagc tattctccta tgtttgtttg
     6541 ccatatctga agcaagggta aacacagcca ttcctggctt ttacatgggt ccctgaaatc
     6601 caaattcaga tcttcatctg ctgtcttcat gttgtgggtt tggttgtttg gggggttttg
     6661 ttttttcgct gttttggggt tttttttggt ttggtttggt ttttggtggt agtgctgggg
     6721 ttcttcagga tagggtttct atgtgtagcc ctggatgtcc taaaacagaa attcaccagc
     6781 ttcagcctcc ccagtactgg gcataaaagt atgtgctacc acacgtggct accacagttt
     6841 tttaaataaa ctttcctttc ccatgctcac atgctcctct tactgtgagt cacagtcttt
     6901 tacaattcta atgtccaaaa acttctgaca accaattctt tgttatccaa cttaacatta
     6961 aagctcattt catggcaaaa cattgttaaa gactgtgagg cccctcttac agtcctttat
     7021 ttcatttatc agaacattca taattcatta ttaaaatagt gtgcttaact tgtatgctat
     7081 tttgtgatat atgatacata tattacgtta ctttttagaa acccaaaatg ttctgaattg
     7141 tgtataaatt gtgttcattg gttgcatcat aactctagct gttattcgtg ttttttcaag
     7201 tatgcctgtt atacttccta attcagaatt aacactattt caaactaaac ttctattgaa
     7261 ataaattttt gaaatatgtt aaggtta
//
