LOCUS       NM_153553               3278 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus neuronal PAS domain protein 4 (Npas4), mRNA.
ACCESSION   NM_153553
VERSION     NM_153553.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3278)
  AUTHORS   Wang,N., Zhao,Z., Wang,X., Chen,X., Jiang,F., Tan,Y., Chen,W. and
            Meng,Q.
  TITLE     Brain regions differences in amyloid-beta and gene expression in
            early APP/PS1 mice and identification ofNpas4 as a key molecule in
            Alzheimer's disease
  JOURNAL   Biomol Biomed 24 (6), 1816-1826 (2024)
   PUBMED   38958450
  REMARK    GeneRIF: Brain regions differences in amyloid-beta and gene
            expression in early APP/PS1 mice and identification of Npas4 as a
            key molecule in Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3278)
  AUTHORS   Kushinsky,D., Tsivourakis,E., Apelblat,D., Roethler,O.,
            Breger-Mikulincer,M., Cohen-Kashi Malina,K. and Spiegel,I.
  TITLE     Daily light-induced transcription in visual cortex neurons drives
            downward firing rate homeostasis and stabilizes sensory processing
  JOURNAL   Cell Rep 43 (9), 114701 (2024)
   PUBMED   39244753
REFERENCE   3  (bases 1 to 3278)
  AUTHORS   Wang,D.C., Santos-Valencia,F., Song,J.H., Franks,K.M. and Luo,L.
  TITLE     Embryonically active piriform cortex neurons promote intracortical
            recurrent connectivity during development
  JOURNAL   Neuron 112 (17), 2938-2954 (2024)
   PUBMED   38964330
REFERENCE   4  (bases 1 to 3278)
  AUTHORS   Ko,B., Yoo,J.Y., Yoo,T., Choi,W., Dogan,R., Sung,K., Um,D.,
            Lee,S.B., Kim,H.J., Lee,S., Beak,S.T., Park,S.K., Paik,S.B.,
            Kim,T.K. and Kim,J.H.
  TITLE     Npas4-mediated dopaminergic regulation of safety memory
            consolidation
  JOURNAL   Cell Rep 42 (7), 112678 (2023)
   PUBMED   37379214
REFERENCE   5  (bases 1 to 3278)
  AUTHORS   Jian,D., Qin,L., Gan,H., Zheng,S., Xiao,H., Duan,Y., Zhang,M.,
            Liang,P., Zhao,J. and Zhai,X.
  TITLE     NPAS4 Exacerbates Pyroptosis via Transcriptionally Regulating NLRP6
            in the Acute Phase of Intracerebral Hemorrhage in Mice
  JOURNAL   Int J Mol Sci 24 (9), 8320 (2023)
   PUBMED   37176030
  REMARK    GeneRIF: NPAS4 Exacerbates Pyroptosis via Transcriptionally
            Regulating NLRP6 in the Acute Phase of Intracerebral Hemorrhage in
            Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3278)
  AUTHORS   Stevens,J.D., Roalson,E.H. and Skinner,M.K.
  TITLE     Phylogenetic and expression analysis of the basic helix-loop-helix
            transcription factor gene family: genomic approach to cellular
            differentiation
  JOURNAL   Differentiation 76 (9), 1006-1022 (2008)
   PUBMED   18557763
REFERENCE   7  (bases 1 to 3278)
  AUTHORS   Lin,Y., Bloodgood,B.L., Hauser,J.L., Lapan,A.D., Koon,A.C.,
            Kim,T.K., Hu,L.S., Malik,A.N. and Greenberg,M.E.
  TITLE     Activity-dependent regulation of inhibitory synapse development by
            Npas4
  JOURNAL   Nature 455 (7217), 1198-1204 (2008)
   PUBMED   18815592
  REMARK    GeneRIF: identification of transcription factor Npas4, that plays a
            role in the development of inhibitory synapses by regulating the
            expression of activity-dependent genes, which in turn control the
            number of GABA-releasing synapses that form on excitatory neurons
REFERENCE   8  (bases 1 to 3278)
  AUTHORS   Flood,W.D., Moyer,R.W., Tsykin,A., Sutherland,G.R. and Koblar,S.A.
  TITLE     Nxf and Fbxo33: novel seizure-responsive genes in mice
  JOURNAL   Eur J Neurosci 20 (7), 1819-1826 (2004)
   PUBMED   15380003
  REMARK    GeneRIF: mRNA expression in the hippocampus 1 h following
            generalized convulsive seizure, in a pattern which is typical for
            other activity-dependant genes expressed in this structure.
REFERENCE   9  (bases 1 to 3278)
  AUTHORS   Moser,M., Knoth,R., Bode,C. and Patterson,C.
  TITLE     LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in
            limbic tissues and transactivates the CNS midline enhancer element
  JOURNAL   Brain Res Mol Brain Res 128 (2), 141-149 (2004)
   PUBMED   15363889
REFERENCE   10 (bases 1 to 3278)
  AUTHORS   Ooe,N., Saito,K., Mikami,N., Nakatuka,I. and Kaneko,H.
  TITLE     Identification of a novel basic helix-loop-helix-PAS factor, NXF,
            reveals a Sim2 competitive, positive regulatory role in
            dendritic-cytoskeleton modulator drebrin gene expression
  JOURNAL   Mol Cell Biol 24 (2), 608-616 (2004)
   PUBMED   14701734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124502.4.
            
            On Nov 30, 2016 this sequence version replaced NM_153553.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY730724.2, BC129861.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AC124502.4         133617-133946
            331-482             AC124502.4         134701-134852
            483-585             AC124502.4         135027-135129
            586-859             AC124502.4         135240-135513
            860-969             AC124502.4         135701-135810
            970-1105            AC124502.4         136138-136273
            1106-2535           AC124502.4         136404-137833
            2536-3278           AC124502.4         138492-139234
FEATURES             Location/Qualifiers
     source          1..3278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.2 cM"
     gene            1..3278
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /note="neuronal PAS domain protein 4"
                     /db_xref="GeneID:225872"
                     /db_xref="MGI:MGI:2664186"
     exon            1..330
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2564
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /note="bHLH-PAS type transcription factor NXF;
                     limbic-enhanced PAS protein; neuronal PAS4; HLH-PAS
                     transcription factor NXF"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 4"
                     /protein_id="NP_705781.1"
                     /db_xref="CCDS:CCDS29445.1"
                     /db_xref="GeneID:225872"
                     /db_xref="MGI:MGI:2664186"
                     /translation="MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMS
                     LACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVS
                     EHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQ
                     SSGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAM
                     FQSRHAKDLALLDVSESVLIYLGFERSELLCKSWYGLLHPEDLAQASSQHYRLLAESG
                     DIQAEMVVRLQAKHGGWTWIYCMLYSEGPEGPFTANNYPISDTEAWSLRQQLNSEDTQ
                     AAYVLGTPAVLPSFSENVFSQEQCSNPLFTPSLGTPRSASFPRAPELGVISTPEELPQ
                     PSKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPP
                     PSSSLQEQLTPSTVTFSEQLTPSSATFPDPLTSSLQGQLTESSARSFEDQLTPCTSSF
                     PDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLNSPSQTFPEQLSPNPTKTYFAQEG
                     CSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHY
                     TEKEQNEIDRLIQQISQLAQGVDRPFSAEAGTGGLEPLGGLEPLNPNLSLSGAGPPVL
                     SLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTPDPNGEWGSGDPEAEVPGGTL
                     SPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADELHQLQSQVQDSFHEDGSGG
                     EPTF"
     exon            331..482
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            483..585
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            586..859
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            860..969
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1105
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..2535
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..3278
                     /gene="Npas4"
                     /gene_synonym="LE-PAS; Nxf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcagcgc tgccgagcgg agcccaggag tggagcgaga gcgagcaaga gcctgagcga
       61 aaagaccggg aagcaaggaa gaggaagcct ccggtgcatc gggaaaggat cgcaggtgct
      121 cgggagccgg agctggagct ccacagccgg cagtcatgta ccgatccacc aagggcgcct
      181 ccaaggcgcg ccgcgaccag atcaacgccg agattcggaa cctcaaggag ctgctgccgt
      241 tggctgaagc ggacaaggtc cggctgtcct acctgcacat catgagtctt gcctgcatct
      301 acactcgcaa gggtgtcttc tttgctggag gcactccttt ggctggcccc accgggcttc
      361 tctctgctca agagcttgaa gacattgtgg cagcactacc tggatttctc cttgtattca
      421 cagctgaggg gaagttgcta tacctgtcgg agagtgtgag cgagcatctg ggccactcta
      481 tggtggacct ggttgcccag ggcgacagta tctacgatat cattgaccct gctgaccatc
      541 tcactgtgcg ccagcagctc accatgccct ctgctctgga tgctgatcgc cttttccgtt
      601 gtcgattcaa cacctccaag tccctccggc gccagagttc aggaaacaaa ctggtgctta
      661 ttcgaggtcg attccatgct cacccacctg gggcctactg ggcaggaaac cctgtgttca
      721 ccgctttctg cgccccactg gagccaagac cccgccctgg ccccggccct ggccctggcc
      781 ctggtcctgc ttctctcttc ctggccatgt tccagagccg gcatgctaag gacctagccc
      841 tactggacgt ttctgaaagt gtcctaatct acctgggctt tgagcgcagc gaactgctct
      901 gtaaatcatg gtatggactg ctacaccccg aggacctggc ccaagcttct tctcaacact
      961 accgcctgtt ggctgaaagt ggagatattc aggctgaaat ggtggtgaga cttcaagcca
     1021 agcatggagg ctggacatgg atttactgca tgctatactc agaaggtcca gaaggccctt
     1081 ttactgccaa taactaccct atcagtgaca cggaagcctg gagcctccgc cagcagctaa
     1141 actctgaaga cacccaggca gcctatgtcc taggaacccc agctgtgcta ccctcattct
     1201 ctgagaatgt cttctcccag gagcaatgct ctaatccact ctttacacca tccctgggga
     1261 ctcctagaag tgccagcttc cccagggctc ctgaactagg tgtgatctca acaccagaag
     1321 agcttcccca accctccaaa gagctggact tcagttacct gccattccct gctaggcctg
     1381 agccttccct ccaagcagac ctgagcaagg atttggtgtg tactccacct tacacacccc
     1441 accagccagg aggctgtgcc ttcctcttca gcctccatga acccttccag actcacttgc
     1501 cccctccgtc cagctctctc caagaacagc tgacaccaag tacagtgact ttctctgaac
     1561 agttgacacc cagcagtgct accttcccag acccactaac cagttcacta caaggacagt
     1621 tgacagaaag ctcagccaga agctttgaag accagttgac tccatgcacc tcttccttcc
     1681 ctgaccagct acttcccagc actgccacat tcccagagcc tctgggcagc cccgcccatg
     1741 agcagctgac tcctcccagc acagcattcc aggctcatct gaacagcccc agccaaacct
     1801 tcccagagca actgagcccc aatcctacca agacttactt cgcccaggag ggatgcagtt
     1861 ttctctatga gaagttgccc ccaagtccta gcagccctgg taatggggac tgtacactcc
     1921 tggccctagc tcagctccgg ggccccctct ctgtggatgt ccccctggtg cccgaaggcc
     1981 tgctcacacc tgaggcctct ccagtcaagc aaagtttctt ccactacaca gagaaagagc
     2041 aaaatgagat agatcgtctc attcagcaga tcagccagtt ggctcagggc gtggacaggc
     2101 ccttctcagc tgaggctggc actggggggc tggagccact tggagggctg gagcccctga
     2161 accctaacct gtccctgtca ggggctggac cccctgtgct tagcctggat cttaaaccct
     2221 ggaaatgcca ggagctggac ttcctggttg accctgataa tttattcctg gaagagacgc
     2281 cagtggaaga catcttcatg gatctttcta ctccagaccc caatggggaa tggggttcag
     2341 gggatcctga ggcagaggtc ccaggaggga ccctgtcacc ttgcaacaac ctgtccccag
     2401 aagatcacag cttcctggag gacttggcca cctatgaaac cgcctttgag acaggtgtct
     2461 caacattccc ctacgaaggg tttgctgatg agttgcatca actccagagc caagttcaag
     2521 acagcttcca tgaagatgga agtggagggg aaccaacgtt ttgaataagt ctgtgactta
     2581 acgtcttcaa gtatggcata ttgtcatcaa gacgtggagc cgctctccac ccccccggga
     2641 ctgttggggg gattctgggg gccagagggg gatatatctg attctccagg ccctgaagga
     2701 tttagggggg aggtgggagg gtaagggagg ggagcaactt tttaaaatca agagacttcg
     2761 agcgatccca gtttccattt caatctgtat tcactcgtag tgagtttcct tgaatggatt
     2821 tcaagcggag aatgggggag tctcacttcc tcaccgcgct gccccatggg cctgggccag
     2881 ttctccactc ctaggggcaa agccacccct gggctttggt gggggaaagg catggcccac
     2941 ctggggctag cctgtgcccc gaggggctct tgacacccac gtagaattct ctacaaacca
     3001 gtaacgggat ttcaattccg acggactctg ccgccctggc ggctcttcct gtgacttttg
     3061 cgccccgcgc ctggggtggg gggcgcgaag agacgctaca ttcctttccg atggaggaag
     3121 gcagatctgc cgtcacacgt gtgcttgcac gagtgcgtgt acctggtgcg ggactcaccc
     3181 ggccgccaga ccgcctaggc ttgcccaggt ggccacctcg tggtgctgcg gtgactttgt
     3241 agccaacttt ataataaagt ccagtttgcc tttttggt
//
