LOCUS       NM_001370962            6112 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus neuronal PAS domain protein 3 (Npas3), transcript
            variant 4, mRNA.
ACCESSION   NM_001370962
VERSION     NM_001370962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6112)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 6112)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6112)
  AUTHORS   Liu,J.W., Li,H. and Zhang,Y.
  TITLE     Npas3 regulates stemness maintenance of radial glial cells and
            neuronal migration in the developing mouse cerebral cortex
  JOURNAL   Front Cell Neurosci 16, 865681 (2022)
   PUBMED   36313621
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6112)
  AUTHORS   Li,Y., Fan,T., Li,X., Liu,L., Mao,F., Li,Y., Miao,Z., Zeng,C.,
            Song,W., Pan,J., Zhou,S., Wang,H., Wang,Y. and Sun,Z.S.
  TITLE     Npas3 deficiency impairs cortical astrogenesis and induces
            autistic-like behaviors
  JOURNAL   Cell Rep 40 (9), 111289 (2022)
   PUBMED   36044858
  REMARK    GeneRIF: Npas3 deficiency impairs cortical astrogenesis and induces
            autistic-like behaviors.
            Erratum:[Cell Rep. 2022 Nov 8;41(6):111551. doi:
            10.1016/j.celrep.2022.111551.. PMID: 36351396]
REFERENCE   5  (bases 1 to 6112)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   6  (bases 1 to 6112)
  AUTHORS   Pieper,A.A., Wu,X., Han,T.W., Estill,S.J., Dang,Q., Wu,L.C.,
            Reece-Fincanon,S., Dudley,C.A., Richardson,J.A., Brat,D.J. and
            McKnight,S.L.
  TITLE     The neuronal PAS domain protein 3 transcription factor controls
            FGF-mediated adult hippocampal neurogenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (39), 14052-14057 (2005)
   PUBMED   16172381
  REMARK    GeneRIF: Npas3-/- mice are deficient in expression of hippocampal
            FGF receptor subtype 1 mRNA.
REFERENCE   7  (bases 1 to 6112)
  AUTHORS   Brunskill,E.W., Ehrman,L.A., Williams,M.T., Klanke,J., Hammer,D.,
            Schaefer,T.L., Sah,R., Dorn,G.W. 2nd, Potter,S.S. and Vorhees,C.V.
  TITLE     Abnormal neurodevelopment, neurosignaling and behaviour in
            Npas3-deficient mice
  JOURNAL   Eur J Neurosci 22 (6), 1265-1276 (2005)
   PUBMED   16190882
  REMARK    GeneRIF: our observations indicate an important role for Npas3 in
            controlling normal brain development and neurosignaling pathways
REFERENCE   8  (bases 1 to 6112)
  AUTHORS   Erbel-Sieler,C., Dudley,C., Zhou,Y., Wu,X., Estill,S.J., Han,T.,
            Diaz-Arrastia,R., Brunskill,E.W., Potter,S.S. and McKnight,S.L.
  TITLE     Behavioral and regulatory abnormalities in mice deficient in the
            NPAS1 and NPAS3 transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13648-13653 (2004)
   PUBMED   15347806
  REMARK    GeneRIF: a regulatory program controlled in inhibitory interneurons
            by the NPAS1 and NPAS3 transcription factors may be either
            substantively or tangentially relevant to psychosis
REFERENCE   9  (bases 1 to 6112)
  AUTHORS   Brunskill,E.W., Witte,D.P., Shreiner,A.B. and Potter,S.S.
  TITLE     Characterization of npas3, a novel basic helix-loop-helix PAS gene
            expressed in the developing mouse nervous system
  JOURNAL   Mech Dev 88 (2), 237-241 (1999)
   PUBMED   10534623
REFERENCE   10 (bases 1 to 6112)
  AUTHORS   Cserjesi,P., Brown,D., Ligon,K.L., Lyons,G.E., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Olson,E.N.
  TITLE     Scleraxis: a basic helix-loop-helix protein that prefigures
            skeletal formation during mouse embryogenesis
  JOURNAL   Development 121 (4), 1099-1110 (1995)
   PUBMED   7743923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030137.13, AC159634.2, CR974571.9, AC120181.10, AC125451.7 and
            AC139934.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1068012.1,
                                           SRR7345562.984645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               CT030137.13        73917-74232         c
            317-406             AC159634.2         68659-68748         c
            407-651             CR974571.9         78428-78672         c
            652-728             AC120181.10        120196-120272       c
            729-818             AC125451.7         76384-76473         c
            819-993             AC139934.9         184055-184229
            994-1112            AC139934.9         240345-240463
            1113-1306           AC139934.9         281424-281617
            1307-1413           AC139934.9         285658-285764
            1414-1561           AC139934.9         298875-299022
            1562-1677           AC139934.9         302683-302798
            1678-6112           AC139934.9         304630-309064
FEATURES             Location/Qualifiers
     source          1..6112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 22.31 cM"
     gene            1..6112
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /note="neuronal PAS domain protein 3"
                     /db_xref="GeneID:27386"
                     /db_xref="MGI:MGI:1351610"
     exon            1..316
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..3014
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /note="isoform 4 is encoded by transcript variant 4;
                     neuronal PAS domain-containing protein 3; neuronal PAS3;
                     member of PAS protein 6; basic-helix-loop-helix-PAS
                     protein MOP6"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 3 isoform
                     4"
                     /protein_id="NP_001357891.1"
                     /db_xref="GeneID:27386"
                     /db_xref="MGI:MGI:1351610"
                     /translation="MIRIFPDFSVQVTAAAAGGAAAGVPAGAGMGRAGAAANGTPQNV
                     QGITSYQQRITAQHPLPNQSECRKIYRYDGIYCESTYQNLQALRKEKSRDAARSRRGK
                     ENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPN
                     TSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGL
                     SQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTTEDAASSASSSSQSETP
                     EPVETTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSH
                     GRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTP
                     VDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAI
                     NAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKASESSETSDSESDSKDTSED
                     NENSKSDEKGNQSENSEDPEPDRKKSGSACDNDMNCNDDGHSSSNPDSRDSDDSFEHS
                     DFEHPKAAEDGFGALGPMQIKVERYVESEADLRLQPCESLTSDSAKDSDSANEAGAQA
                     SSKHQKRKRRRKRQKGGSASRRRLSSASSPGLDAGLVEPPRLLSSPHSASVLKIKTEI
                     AEPINFDNDSSIWNYPPNREISRNESPYSMTKPPTSEHFPSPQGQGGSSGGGGALHVA
                     IPDSVLTPPGADGTAGRKTQFSGTAPVPSDPLSPPLSASPRDKHPGGGAGSGGGGPGA
                     SNSLLYTGDLEALQRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTL
                     AMQGNLLPNAHAVNFVDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQ
                     MPGGNVFTTAEGLFSTLPFPVYSNGIHAAQTLERKED"
     exon            317..406
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            407..651
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            652..728
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            729..818
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            819..993
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1112
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1306
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1413
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1561
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1677
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..6112
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6089..6094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /note="hexamer: AATAAA"
     polyA_site      6112
                     /gene="Npas3"
                     /gene_synonym="4930423H22Rik; bHLHe12"
                     /note="major polyA site"
ORIGIN      
        1 gcacagtggc cgcggctcac taatgggatt gcaggctggt gcctggctcc gctgctgccg
       61 ccgctcgcgc cgctgctgcc gccgccgccc gaacccgagc ccgagccccc gccagcccga
      121 gcccagagca gccgcgcctg gggctccaag ccgcggcgat gatccgaatc tttccggatt
      181 tcagcgtgca ggtgacggcc gcggcggccg gcggggcagc cgctggggta ccggccggtg
      241 cgggcatggg gagggccggc gccgcggcca acggcacccc gcagaacgtc cagggcatca
      301 cctcctacca gcagcgaata actgcccagc atcctctgcc caaccaatca gaatgtagga
      361 aaatctacag atatgacgga atctactgtg aatctaccta ccagaattta caagcactga
      421 gaaaggagaa atccagagat gctgctcgat cccgccgggg aaaagaaaat tttgagttct
      481 atgaattggc caagctgttg cctcttcctg ccgccatcac cagccagctc gacaaggcat
      541 ccatcatccg acttacaatt agttatctca agatgagaga ctttgccaac caaggggatc
      601 ctccatggaa cctgaggatg gaaggccctc caccaaacac ctcagtaaaa ggtgcacaac
      661 gaaggcggag ccccagcgca ctggccattg aagtatttga agcacatttg ggaagccaca
      721 ttttgcagtc cctggatggc ttcgtatttg cactaaatca agaaggaaaa tttttgtaca
      781 tttctgaaac cgtctctatc tacctaggcc tctcacaagt ggagctgaca ggtagcagcg
      841 tctttgacta tgtccaccct ggggaccacg tggagatggc agagcagctg ggcatgaagc
      901 tcccgcctgg gcggggtctc ctctcgcagg gcaccacaga ggacgcggcc agttcagcat
      961 cttcctcttc tcagtcagag acccctgagc cagtggagac gaccagccct agtctgctaa
     1021 ccacggacaa cacccttgaa cggtcctttt tcatccgaat gaagtctact ctgaccaaac
     1081 gtggagtcca catcaagtca tctgggtata aggtgattca cataacaggc cggcttcgcc
     1141 tcagagtgtc gctgtcccac gggaggaccg tccccagcca aatcatgggt ctggtggttg
     1201 tggctcacgc cttgcctccc cctacgatca atgaagtcag aattgactgc catatgttcg
     1261 tcactcgagt aaacatggat ctcaatatca tttactgtga aaataggatt agtgattaca
     1321 tggatctgac ccctgtagac atcgtaggga aaagatgcta ccacttcatc catgccgaag
     1381 atgtagaagg catcaggcac agtcacctgg acttgctgaa taagggtcag tgtgtgacca
     1441 agtactaccg ctggatgcag aagaatggag gctacatctg gatacagtct agtgccacca
     1501 tagctattaa tgcgaagaat gcaaatgaga agaacatcat ctgggtgaat tatcttctta
     1561 gtaatccgga gtacaaggac acacccatgg acattgcgca actcccgcat ttgccagaga
     1621 aagcgtcaga atcctcagag acatccgact ctgagtcaga ctctaaagac acctcagagg
     1681 acaatgagaa ctccaagtcc gacgagaagg gcaatcagtc cgagaatagc gaagatccgg
     1741 agcctgaccg caagaagtca ggcagcgcat gcgacaacga catgaactgc aacgacgatg
     1801 gccacagctc cagcaacccg gacagccgtg acagcgacga cagcttcgag cactcggact
     1861 ttgaacaccc caaggcggcc gaggatggct tcggcgcgct gggccctatg cagatcaaag
     1921 tggagcgcta cgtggagagc gaggcggacc tgcgactgca gccctgcgag tcgctcacgt
     1981 cggacagcgc caaggactca gacagcgcga acgaggcggg cgctcaggca tccagcaagc
     2041 accagaagcg caagcggcgg cggaaacggc agaagggcgg cagcgccagt cgccgacgcc
     2101 tgtccagcgc gtccagccca ggcctggacg ccggtctggt ggagcctccg cggctgctgt
     2161 catcgccgca cagcgcctct gtgctcaaga tcaagacaga gatcgccgag cccatcaact
     2221 tcgacaacga cagcagcatc tggaactacc cgcccaaccg ggagatctcc aggaacgaat
     2281 ccccgtacag catgaccaag ccccccacct ccgagcactt cccgtccccg cagggccagg
     2341 gaggcagcag cggtggcggg ggagcgctgc acgtggccat ccccgactcg gtcctcaccc
     2401 caccgggcgc cgatggcaca gctggccgca agactcagtt cagcggcaca gccccggtgc
     2461 cctctgatcc actgtcgccc ccgctctctg cgtccccgcg ggacaagcac cccgggggcg
     2521 gggcggggag tggcgggggt ggccctggtg catccaactc cttgctgtac actggggacc
     2581 tggaggccct gcagaggttg caagcgggca acgtcgtgct tccgctggtg caccgggtga
     2641 ccgggaccct ggcagccacc agcacagccg cacagagggt ctacaccacg ggcactatcc
     2701 gctacgcacc cgctgaggtg accctggcca tgcagggcaa cctgctaccc aacgcgcatg
     2761 ctgttaactt cgtggacgtt aacagcccag gctttggcct cgaccccaag acacccatgg
     2821 agatgctcta ccaccacgtg caccgactca acatgtcagg accatttggc ggcgccgtga
     2881 gcgcggccag cctcacacag atgccaggtg gcaacgtgtt caccacagcc gagggactct
     2941 tctccacgct gcccttccca gtctacagca acggtatcca cgcggcacag actctggagc
     3001 gcaaggagga ctgagcgggc cccactcagg aggcatcgtc gttttcgttt agacctttca
     3061 ttctagcact ttgaattcga gctggtcagc gtcttctcgc aacacggtgg ccccatccca
     3121 ccccctctct ttctttcatt agacttattc tttcttgtaa agacatgttt attttttgcc
     3181 ttcagagggt cagatgaccg gttgcctgcc attttgtctt ctaagatgtg tgttgggttg
     3241 tttgactttc ctttacatct ttattaagat gtctttaatg tgtatatgcc tctgccatag
     3301 aatactcagt cttgtggtca agagatttct caagtgacaa ccattgggtt ttcttcctaa
     3361 agatcttgat atgatcaaga tggaaagaga cacgcataaa cgattgtgcc ctgtttgact
     3421 aagtcaaatg aaatggggtg ggtgttttgt tttttgtttt tggttttttt ttttttttcc
     3481 tgttcctaat tcctttgaaa ataggggaat agtattttag aattttatgc agaatttaat
     3541 tctttttatg attaagattt taagattttt cttacttgca cacataaaaa taatttggtt
     3601 tcttaaactt aatttctggc ctgtgactag aatgtttgtt tttttgtttt ttttttaaaa
     3661 agtcggacta agtgttaatt actgaaacat taacttaatt tctaaaacca tggtgctatc
     3721 atttattaat ctataatgtc ttcatacaaa atgcagctcc tgggctggat tttggaagag
     3781 aaaatgtgtt ctgtcctggt ctggagtccc gttgctacag tcagtctcct tggttagtta
     3841 agacaaagcc ctcattaaca tttgctgcag gacttaaaaa ttttttacct cccaactaac
     3901 aaacatagcc tcactttcaa ttgaatgggt cagtaaagcc ctattaaaag gggacttttg
     3961 gacaactcgg actgatttga ggaacagttt aagtacatac tgccattttt gagattcttt
     4021 tgtccttagt cagtctaact gaggctggtt ttttgcaact tcagtaacac ttcagagtaa
     4081 aagaagaagg agaaatattt aacatgttct ttatttgggg tttttgtttg tttttatttc
     4141 ttgctaaaaa aaaataggtt tgtatggggg gtgctgattt gatagaattt atttcccttc
     4201 aattcttatt tgagttgaaa ccaacaagtt tttaaaacta aagaatgggt taataagctt
     4261 cagacagata actacaaccg aaaaccgcac attcaatgaa aaaaaaagag aaaaaaaaaa
     4321 gaaaaagaaa aagaaaaaag agcctatttt gtcttcgttg ccagaaatca gtgtggtgtc
     4381 aaacactcca aatgactgtc cagtgtagac tcttccccca cttcgttttt ggcagctgtt
     4441 tgttaaggca tctaatccca gatgtgaaaa ctgtaatgtg tgcaacgtgt agtgtccttg
     4501 gctgtgggtc ccattgcagt ttctgtgtgt ttctatatgc agtgtatgct aagctactgt
     4561 agtcgttttt tgtccccgtc ttctccgtgc tctgtctcta gtggagtggc acagttccat
     4621 tcctgcggtc ctagtgaatc ggtgactctt gggggttagt gggtttgtgt ggtggccttt
     4681 ccctgtgacg tcacccatat gcttctattg tctgtggatc ctgtcttact tttcgaaatc
     4741 cctgccgttg ctttgctgtt gtatactctc cctgcctccc ctgtctttcc ctgtctgccc
     4801 tttctctcct ctgcttcccc cttccctgat accccaaatc tgtatcattc tcagagataa
     4861 aaagaaaaaa gaaaaaaaaa gaaaaagaaa aaagactctt aactagctca aggttaatgg
     4921 agccatcttt cccacaacgg aattctggat gtgactttct ctgtggagta ctacacagag
     4981 ccctgaagaa taatgctcag atatattgaa taaattgacg ccatgcaacc tcagctgtta
     5041 acattcccag agtcccttgt gttctaccta taagcagtgg gtgcttttct ttgctttcct
     5101 ttcaggttgg ctgatggagc agtatataaa gcaattacca gttagacaga aaatgatttc
     5161 aaaggccaac caacattttt ttaaaaacaa aatgggaggg gttaatggaa tatagaattg
     5221 tcatatatat ttgtttattc gtgcaatgct aatatagtaa cttggctgtc ctttgaattg
     5281 tcactgtgct gagtggattt cctctagaac tctggattcc atgagttggg cccaggccgt
     5341 ggtagaataa taacagaaag aagataaatg ccacagatct tagcactggg cttccttgaa
     5401 ggacttaagt cagtttagaa gatgaaggaa gccgatggag aaatgtaaag attagctttg
     5461 gaagccgtcc tctagctatc gaacaatcaa gggaatgcac ctctcagcta caaagaacag
     5521 ccagacagct gggttttttt tttctttttc ttttataaat gtttctgtgt tgtgtcaaaa
     5581 tgatttctgg tgatttaaac taacagataa tcacagctgc tgtctaaatc catagtgttt
     5641 aaaaattaca aaatgaaaaa aaaaaaccac ttcattacct gtgaagactg tgtctgtgtt
     5701 tttaactatt tcttgtacaa atatatgaaa acttttatga ggagactggt gccacgtagc
     5761 tgaataatgg ggaaagggat ctttctgttc gtaaaaacct tagcagtgtt accaactcta
     5821 caatatatat atacaaataa ttaaagcgtt acaaagcgac agctatgcta catttgtttt
     5881 gtgtgaagct aaccggactt aacttcctga gtgcctggct tattttgaaa catttttttc
     5941 attgaccatt gataatgctg caaatcagaa atgtacatac ttcatttaca acagggttct
     6001 ttttatactt ttgtagattc tcatacatgt cacatacatg gttgtcttta tgtaacttaa
     6061 ttttttcatc cgcaggtgcc attttcataa taaacttctc ttggatttgt ta
//
