LOCUS       NM_008719               4180 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neuronal PAS domain protein 2 (Npas2), mRNA.
ACCESSION   NM_008719
VERSION     NM_008719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   He,Y., Cen,H., Guo,L., Zhang,T., Yang,Y., Dong,D. and Wu,B.
  TITLE     Circadian oscillator NPAS2 regulates diurnal expression and
            activity of CYP1A2 in mouse liver
  JOURNAL   Biochem Pharmacol 206, 115345 (2022)
   PUBMED   36379250
  REMARK    GeneRIF: Circadian oscillator NPAS2 regulates diurnal expression
            and activity of CYP1A2 in mouse liver.
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Gamble,M.C., Chuan,B., Gallego-Martin,T., Shelton,M.A., Puig,S.,
            O'Donnell,C.P. and Logan,R.W.
  TITLE     A role for the circadian transcription factor NPAS2 in the
            progressive loss of non-rapid eye movement sleep and increased
            arousal during fentanyl withdrawal in male mice
  JOURNAL   Psychopharmacology (Berl) 239 (10), 3185-3200 (2022)
   PUBMED   35915264
  REMARK    GeneRIF: A role for the circadian transcription factor NPAS2 in the
            progressive loss of non-rapid eye movement sleep and increased
            arousal during fentanyl withdrawal in male mice.
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Shibuya,Y., Hokugo,A., Okawa,H., Kondo,T., Khalil,D., Wang,L.,
            Roca,Y., Clements,A., Sasaki,H., Berry,E., Nishimura,I. and
            Jarrahy,R.
  TITLE     Therapeutic downregulation of neuronal PAS domain 2 (Npas2)
            promotes surgical skin wound healing
  JOURNAL   Elife 11, e71074 (2022)
   PUBMED   35040776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4180)
  AUTHORS   Yoshioka,H., Tominaga,S., Suzui,M., Shinohara,Y., Maeda,T. and
            Miura,N.
  TITLE     Involvement of Npas2 and Per2 modifications in zinc-induced acute
            diurnal toxicity in mice
  JOURNAL   J Toxicol Sci 47 (12), 547-553 (2022)
   PUBMED   36450499
  REMARK    GeneRIF: Involvement of Npas2 and Per2 modifications in
            zinc-induced acute diurnal toxicity in mice.
REFERENCE   6  (bases 1 to 4180)
  AUTHORS   Curtis,A.M., Seo,S.B., Westgate,E.J., Rudic,R.D., Smyth,E.M.,
            Chakravarti,D., FitzGerald,G.A. and McNamara,P.
  TITLE     Histone acetyltransferase-dependent chromatin remodeling and the
            vascular clock
  JOURNAL   J Biol Chem 279 (8), 7091-7097 (2004)
   PUBMED   14645221
REFERENCE   7  (bases 1 to 4180)
  AUTHORS   Dudley,C.A., Erbel-Sieler,C., Estill,S.J., Reick,M., Franken,P.,
            Pitts,S. and McKnight,S.L.
  TITLE     Altered patterns of sleep and behavioral adaptability in
            NPAS2-deficient mice
  JOURNAL   Science 301 (5631), 379-383 (2003)
   PUBMED   12843397
  REMARK    GeneRIF: results indicate that NPAS2 plays a substantive role in
            maintaining circadian behaviors in normal light:dark cycle and
            feeding conditions and that NPAS2 is critical for adaptability to
            food restriction
REFERENCE   8  (bases 1 to 4180)
  AUTHORS   Garcia,J.A., Zhang,D., Estill,S.J., Michnoff,C., Rutter,J.,
            Reick,M., Scott,K., Diaz-Arrastia,R. and McKnight,S.L.
  TITLE     Impaired cued and contextual memory in NPAS2-deficient mice
  JOURNAL   Science 288 (5474), 2226-2230 (2000)
   PUBMED   10864874
REFERENCE   9  (bases 1 to 4180)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   10 (bases 1 to 4180)
  AUTHORS   Zhou,Y.D., Barnard,M., Tian,H., Li,X., Ring,H.Z., Francke,U.,
            Shelton,J., Richardson,J., Russell,D.W. and McKnight,S.L.
  TITLE     Molecular characterization of two mammalian bHLH-PAS domain
            proteins selectively expressed in the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 713-718 (1997)
   PUBMED   9012850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC109166.2, U77969.1, BB524729.2 and BG070037.2.
            
            On Dec 4, 2007 this sequence version replaced NM_008719.1.
            
            Summary: The protein encoded by this gene is a member of the basic
            helix-loop-helix (bHLH)-PAS family of transcription factors. The
            encoded protein may play a regulatory role in the acquisition of
            specific types of memory. It also may function as a part of a
            molecular clock operative in the mammalian forebrain. [provided by
            RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109166.2, U77969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1857              BC109166.2         1-1857
            1858-3126           U77969.1           1932-3200
            3127-3538           BB524729.2         289-700
            3539-3933           BG070037.2         249-643             c
            3934-4180           BG070037.2         1-247               c
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 17.98 cM"
     gene            1..4180
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /note="neuronal PAS domain protein 2"
                     /db_xref="GeneID:18143"
                     /db_xref="MGI:MGI:109232"
     exon            1..471
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            472..528
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            529..677
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            678..769
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            770..859
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            860..980
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1094
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1213
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1296
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1403
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1551
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1636
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1778
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1888
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1990
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2137
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2335
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2526
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2619
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2794
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..4180
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4156..4161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /note="hexamer: AATAAA"
     polyA_site      4178
                     /gene="Npas2"
                     /gene_synonym="bHLHe9; MOP4"
                     /note="major polyA site"
ORIGIN      
        1 gctgctcgcc aagagagagg actaggcacc ccaaacatcg ggattcgggg gtcctccgag
       61 ggtgctagag gggtactgcg tgcccggaca gaagctttca agattgcccg ctgcccttcc
      121 agagccccac cgcaggcatc ccgaagcgta gggagcccgg gacgcctgga gagtgtggtt
      181 gcctggccgg gcccttgtgt cactacgttc ctgggtctga cttggcttag ggctggactg
      241 aaagcccagt ctttgtgctt agacagctct gcgctcctgg gactccccgg gttggatgct
      301 acaacattgt tttagtggga ggtgtgcccc ctccccaagt agaggagggg tgcgaccttg
      361 acttttctaa aaagccactt agggtgggaa gcagggggca gggacaggta ccaagaggct
      421 caattcaaag ccagcctccc ccctctgccc gcctctcctt aactgcttaa gcaggcaaga
      481 ctgcatagaa actctaatgg acgaagatga gaaggataga gcaaagagag cctctcgaaa
      541 taagtctgag aagaagcgtc gggaccagtt caatgttctc atcaaagagc tcagctccat
      601 gctccctggt aacactcgga aaatggacaa aaccaccgtg ctggagaagg tcatcggatt
      661 cttgcagaaa cacaatgaag tctcagcaca aacagaaatc tgtgacatcc agcaggactg
      721 gaagccatca ttcctcagta acgaagaatt cacccagctg atgttggagg cattagatgg
      781 cttcgtcatc gtcgtgacaa cagacggcag catcatctat gtgtccgaca gtatcacacc
      841 tctccttgga catttaccgg cggatgtcat ggatcagaac ttgttaaatt tccttccaga
      901 gcaagaacat tccgaagttt ataaaatcct ttcttcccat atgcttgtga cggattcccc
      961 ctccccagaa ttcctaaaat ctgacaacga tttagagttt tattgccatc ttctcagagg
     1021 cagcttgaac ccaaaggaat ttccaactta cgaatatata aaatttgtag gaaattttcg
     1081 ctcttacaac aatgtgccta gcccctcctg taatggcttt gacaacaccc tttcaagacc
     1141 ctgccatgta cccctaggaa aggacgtctg cttcatcgcc accgtgcgcc tggcaacccc
     1201 gcagttctta aaggaaatgt gtgtagctga cgaaccttta gaggaattca cttcgaggca
     1261 tagcttggaa tggaaatttt tatttctgga tcacagagct cctccaatca taggatacct
     1321 gccctttgaa gtacttggca cctcaggcta cgactactac cacattgatg acctggagct
     1381 cctggccagg tgccaccagc atctgatgca gtttggcaaa gggaagtcgt gctgttaccg
     1441 gtttctaacc aaagggcagc agtggatttg gttgcaaacc cactactaca tcacctacca
     1501 ccaatggaac tccaagcctg agttcatcgt atgcacacac tcagtggtca gttacgcaga
     1561 tgttcgagtg gaaaggagac aggagctggc tctggaagac ccacccacag aggccatgca
     1621 cccctctgca gtgaaggaaa aggactcaag cctagagcct ccacagccct ttaatgcact
     1681 tgacatgggc gcctcaggtc ttcccagcag cccttctcca tcagcctcct caaggagttc
     1741 ccacaagtcc tcacacacag ccatgtcaga acccacctcc actccaacca agctgatggc
     1801 tgagaacagc accacagctt tgccaagacc ggccacccta ccccaggagt taccagtgca
     1861 ggggctcagc caggcagcca caatgccgac tgctctgcat tcctcagcct cctgcgacct
     1921 cacaaagcaa ctcctgctgc agagcctgcc tcagaccggc ttgcagagtc cacctgctcc
     1981 agtgacacag ttttcagcac aattcagcat gttccagacc attaaagacc aactggagca
     2041 gaggacacgg atcctgcagg ccaacattcg gtggcagcag gaagagcttc ataagatcca
     2101 ggaacaactc tgcctggtcc aggactccaa cgtccagatg tttctgcagc agccagctgt
     2161 gtccctgagc ttcagcagta cgcagcgacc agcagctcag cagcagctgc agcaaaggcc
     2221 cgccgcaccg tctcagcccc agcttgtggt caacactcca ctgcaggggc agatcacatc
     2281 cacccaagtc acaaaccagc acctgctccg agaatcgaat gtgatatccg cccagggtcc
     2341 aaagccaatg agaagttccc agctgctgcc tgccagcggc cgttcactga gcagcctgcc
     2401 atcccagttt agcagtacag cttccgtgct cccgcctggc ctgagcctca ccacgattgc
     2461 tcccacccct caggatgaca gccagtgcca gcccagccct gacttcggcc atgatcggca
     2521 gctcaggctg ttgctgagcc agcccatcca gcctatgatg cctgggtcct gcgatgccag
     2581 gcagccctca gaagtcagca gaactggacg gcaagtcaag tatgcacaga gccaagtgat
     2641 gtttccaagt ccagactcac accctaccaa cagcagcgca tccaccccgg tcctgctcat
     2701 ggggcaggca gtactccatc ccagcttccc tgcttcccgg ccatcgccac tgcagccagc
     2761 acaggcacag cagcagccac caccctattt gcaggcacca acatctctgc acagtgagca
     2821 gccggactcg ctccttctct ccaccttctc ccagcagccg ggaaccctgg gctatgcagc
     2881 cacacagtct acacctccgc aacccccacg cccctcccgc agggtcagcc ggctgtcaga
     2941 gtcctaaggt ctccagcagc catcagggta ataccctgac actggagtcc agacgcaacc
     3001 agctttaacc aatggaaaac ggggttggcc gtgggagatg ggatgaagcg tttacgtgat
     3061 tttggcgcac cctgtataca tttcagaact cctgatggta acgtgtctgg agtgtggcac
     3121 tggcagaatg gggaaagaac aggaatattg gccatgattc ttttgccctg ggcttcttgg
     3181 gcatccgcta cagccatacc agacaggaac caagtgtccc cgtgttggca ccgcttcctg
     3241 gtctatttgc agaggtggta cccctcgctg cctccaggag agagcgctcc aggtactcta
     3301 ccgactgaga caggtcccaa gccctaacag gccttcactc tcttgatagt ctttccttta
     3361 cagtcaagga ctacgttaaa ggtctctgga gagagtataa agagattatt tttcatcgtt
     3421 tttaaaaggt tttgttttaa tttgcacacc tgtgcacaag ggaaataact taggcacttt
     3481 cggagtttgt gtttgttttg ttttgtttaa taaggtccca tggcttcttt gggaatccac
     3541 gataagaaaa acaaccccac caatcagata gcggagcctg ttatttgaag ctgcagagcc
     3601 acacccttgg cctaacccct agcagactga ggctctccca tgcctaccag ggggtgtttt
     3661 ccttcctaaa cagaacactg gattcttcct gttaacttca ccgagagtag ctacaaaggt
     3721 ggacttagag ccaagcacaa tctcacaacg attccagaat tccctagaga cctcttgggg
     3781 ggcaacgggc aggctgcatc tcccaggaaa ccaggcaagg gcccgccatc ctagtgaggc
     3841 aggccaccgc acctttccac ttctcttccc catgattccg aagattggat tttccttttc
     3901 aggatgcact ttgctttttt tttttttttt tttgtatgtt ttgttatgtc gaggtatttc
     3961 taaagagaag attttatata attataagag gaagtgtagt gaattgtaca gctgttgtaa
     4021 taatgaccta tttctataaa aaaataaaat tgtacggatt atgtgtaaat tattttgtat
     4081 ctgagatacc agttccattc ccacatatga aagtataaag gtttccttgt gtttttctgt
     4141 gagtgaacat tttgtaataa attaacaagt ttgtacaatt
//
