LOCUS       NM_008718               2091 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus neuronal PAS domain protein 1 (Npas1), transcript
            variant 1, mRNA.
ACCESSION   NM_008718
VERSION     NM_008718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Morais-Silva,G., Campbell,R.R., Nam,H., Basu,M., Pagliusi,M.,
            Fox,M.E., Chan,C.S., Iniguez,S.D., Ament,S., Cramer,N., Marin,M.T.
            and Lobo,M.K.
  TITLE     Molecular, Circuit, and Stress Response Characterization of Ventral
            Pallidum Npas1-Neurons
  JOURNAL   J Neurosci 43 (3), 405-418 (2023)
   PUBMED   36443000
  REMARK    GeneRIF: Molecular, Circuit, and Stress Response Characterization
            of Ventral Pallidum Npas1-Neurons.
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Nunnelly,L.F., Campbell,M., Lee,D.I., Dummer,P., Gu,G., Menon,V.
            and Au,E.
  TITLE     St18 specifies globus pallidus projection neuron identity in MGE
            lineage
  JOURNAL   Nat Commun 13 (1), 7735 (2022)
   PUBMED   36517477
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Cui,Q., Du,X., Chang,I.Y.M., Pamukcu,A., Lilascharoen,V.,
            Berceau,B.L., Garcia,D., Hong,D., Chon,U., Narayanan,A., Kim,Y.,
            Lim,B.K. and Chan,C.S.
  TITLE     Striatal Direct Pathway Targets Npas1+ Pallidal Neurons
  JOURNAL   J Neurosci 41 (18), 3966-3987 (2021)
   PUBMED   33731445
  REMARK    GeneRIF: Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons.
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Erbel-Sieler,C., Dudley,C., Zhou,Y., Wu,X., Estill,S.J., Han,T.,
            Diaz-Arrastia,R., Brunskill,E.W., Potter,S.S. and McKnight,S.L.
  TITLE     Behavioral and regulatory abnormalities in mice deficient in the
            NPAS1 and NPAS3 transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13648-13653 (2004)
   PUBMED   15347806
  REMARK    GeneRIF: a regulatory program controlled in inhibitory interneurons
            by the NPAS1 and NPAS3 transcription factors may be either
            substantively or tangentially relevant to psychosis
REFERENCE   7  (bases 1 to 2091)
  AUTHORS   Kasahara,M., Watanabe,Y., Sumasu,M. and Nagata,T.
  TITLE     A family of MHC class I-like genes located in the vicinity of the
            mouse leukocyte receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13687-13692 (2002)
   PUBMED   12370446
REFERENCE   8  (bases 1 to 2091)
  AUTHORS   Chae,T.H., Allen,K.M., Davisson,M.T., Sweet,H.O. and Walsh,C.A.
  TITLE     Mapping of the mouse hyh gene to a YAC/BAC contig on proximal
            Chromosome 7
  JOURNAL   Mamm Genome 13 (5), 239-244 (2002)
   PUBMED   12016511
REFERENCE   9  (bases 1 to 2091)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   10 (bases 1 to 2091)
  AUTHORS   Zhou,Y.D., Barnard,M., Tian,H., Li,X., Ring,H.Z., Francke,U.,
            Shelton,J., Richardson,J., Russell,D.W. and McKnight,S.L.
  TITLE     Molecular characterization of two mammalian bHLH-PAS domain
            proteins selectively expressed in the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 713-718 (1997)
   PUBMED   9012850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164880.3, BY279348.1 and BC137863.1.
            
            On Jul 28, 2009 this sequence version replaced NM_008718.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.517715.1,
                                           SRR7345562.2905321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC164880.3         32967-32987
            22-165              BY279348.1         22-165
            166-2009            BC137863.1         1-1844
            2010-2091           AC164880.3         53945-54026
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.14 cM"
     gene            1..2091
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /note="neuronal PAS domain protein 1"
                     /db_xref="GeneID:18142"
                     /db_xref="MGI:MGI:109205"
     exon            1..136
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            137..314
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            315..550
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            551..624
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            625..714
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            715..883
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            884..999
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1157
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1264
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1412
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1507
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..2091
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2091
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /note="major polyA site"
ORIGIN      
        1 ggtctcaaag tctgcgaggc cgccgtgggc gccgagagcc gggctcccca gcccgcgcgc
       61 cccggggtct atggagcggc ccctccacgc cacccagtgg accccacgcc gcgccccgag
      121 cacgcccagc ggccagggaa ctgagcccca cctgcgactc cttcgcacct gaattcccga
      181 gtccccgtcg agatggcgac cccctatccc agaagcggtg gccgaggtga agtcaagtgc
      241 gggggcggcc gtggagccgg cgtcccctgg gatttcctgc ctgggctgat ggtcaaggcc
      301 ccgcccggac cctgcctgca ggcgcagcgc aaagagaagt cccgcaacgc tgcgcgctgg
      361 cgacgcggga aggaaaatct ggagttcttc gagctagcca agctgctccc tctgcccggt
      421 gccatctcca gccagctgga caaggcgtcc atcgtgcgtc ttagcgtcac ctacctccgc
      481 ctgcgtcgtt ttgccgcgct gggggcgccg ccctgggggt tgcgggccgt cgggcctccg
      541 gctggcctcg ccccaggccg ccgaggccct gtggctctgg tctctgaagt cttcgagcaa
      601 cacctaggtg gacacatcct acagtccttg gatggcttcg tgttcgcttt gaaccaggaa
      661 gggaaatttc tctacatctc agagacagtg tccatctacc tgggtctctc acaggtggag
      721 ctgacgggca gcagcgtctt cgactacatc catcctgggg accactcgga ggtcctagag
      781 caacttggat tgcgggctgc aagcatcggt ccccctacac caccttccgt gtcctcctct
      841 tcctcatcgt cttcctcctc gctggtggac acccctgaga ttgaagccag ccccaccgag
      901 gcatcgcctg ccttccgagc ccaagagcgg tccttctttg tccgcatgaa gtccaccctc
      961 accaagaggg gcctgaatgt caaagcctcg gggtacaagg tcattcatgt gacagggcgc
     1021 ctgagggccc gagccctggg tcttgtagcc cttggacaca cgctgccccc agccccactg
     1081 gctgagctgc ctttgcacgg acacatgatt gtcttccgcc tcagcctggg cctcaccatc
     1141 cttgcttgtg agagcagagt tagcgaccat atggacatgg ggccctcaga gcttgtggga
     1201 cgcagctgct accagtttgt tcatggacag gatgcaacca ggatccgcca aagccatctg
     1261 gacctgctgg acaaagggca ggtggtgact ggttactacc gttggctgca gcgtgcgggg
     1321 ggcttcgtgt ggctgcagtc tgtagccact gtggccggga acgggaagag cactggggag
     1381 catcacgtgc tgtgggtcag tcacgtgctc agcaatgctg aaggtagtca aacacccctg
     1441 gatgccttcc agcttccagc tattgtgtct caggaggagc catccaggcc aggcccagag
     1501 cccacagagg aagagcctcc agttgacggg aagcaggctg tgcctgcgga ccaggacaag
     1561 gacaaggacc ctcaggcccg aggcaaacgc atcaaagtgg aggccagccc gaaggaagct
     1621 agaggctcag aggacagtgg agaagaggag ctctcggatc caccggctcc acctcggcca
     1681 gaattcactt ctgtcatccg ggcgggagcc ctgaagcatg atccagtgct gccgtggggc
     1741 ttgacaactc ccggagaccc ctcacccgcc ctccttcatg caggcttcct gccacccgtt
     1801 gtgcggggcc tgtgcacccc aggcaccatc cgctatggcc ctgcggagtt gagcctgatg
     1861 tatccacatc tgcacaggct gggcgcaggc ccctcgcttc cagaggcctt ttaccctacg
     1921 ctgggcttgc cctatccggg gcccacaggt actagggtgc agcggaaggg agactgaaga
     1981 cagtgtaaca ccagagggcc aaacctgaga cacagatcaa gtcctggagt cattcttgag
     2041 aattaaacac catgccctaa ggggctccct ccccggggat gctgcctctc a
//
