LOCUS       NP_032744                594 aa            linear   ROD 11-DEC-2024
DEFINITION  neuronal PAS domain-containing protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_032744
VERSION     NP_032744.1
DBSOURCE    REFSEQ: accession NM_008718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 594)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   2  (residues 1 to 594)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   3  (residues 1 to 594)
  AUTHORS   Morais-Silva,G., Campbell,R.R., Nam,H., Basu,M., Pagliusi,M.,
            Fox,M.E., Chan,C.S., Iniguez,S.D., Ament,S., Cramer,N., Marin,M.T.
            and Lobo,M.K.
  TITLE     Molecular, Circuit, and Stress Response Characterization of Ventral
            Pallidum Npas1-Neurons
  JOURNAL   J Neurosci 43 (3), 405-418 (2023)
   PUBMED   36443000
  REMARK    GeneRIF: Molecular, Circuit, and Stress Response Characterization
            of Ventral Pallidum Npas1-Neurons.
REFERENCE   4  (residues 1 to 594)
  AUTHORS   Nunnelly,L.F., Campbell,M., Lee,D.I., Dummer,P., Gu,G., Menon,V.
            and Au,E.
  TITLE     St18 specifies globus pallidus projection neuron identity in MGE
            lineage
  JOURNAL   Nat Commun 13 (1), 7735 (2022)
   PUBMED   36517477
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 594)
  AUTHORS   Cui,Q., Du,X., Chang,I.Y.M., Pamukcu,A., Lilascharoen,V.,
            Berceau,B.L., Garcia,D., Hong,D., Chon,U., Narayanan,A., Kim,Y.,
            Lim,B.K. and Chan,C.S.
  TITLE     Striatal Direct Pathway Targets Npas1+ Pallidal Neurons
  JOURNAL   J Neurosci 41 (18), 3966-3987 (2021)
   PUBMED   33731445
  REMARK    GeneRIF: Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons.
REFERENCE   6  (residues 1 to 594)
  AUTHORS   Erbel-Sieler,C., Dudley,C., Zhou,Y., Wu,X., Estill,S.J., Han,T.,
            Diaz-Arrastia,R., Brunskill,E.W., Potter,S.S. and McKnight,S.L.
  TITLE     Behavioral and regulatory abnormalities in mice deficient in the
            NPAS1 and NPAS3 transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13648-13653 (2004)
   PUBMED   15347806
  REMARK    GeneRIF: a regulatory program controlled in inhibitory interneurons
            by the NPAS1 and NPAS3 transcription factors may be either
            substantively or tangentially relevant to psychosis
REFERENCE   7  (residues 1 to 594)
  AUTHORS   Kasahara,M., Watanabe,Y., Sumasu,M. and Nagata,T.
  TITLE     A family of MHC class I-like genes located in the vicinity of the
            mouse leukocyte receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13687-13692 (2002)
   PUBMED   12370446
REFERENCE   8  (residues 1 to 594)
  AUTHORS   Chae,T.H., Allen,K.M., Davisson,M.T., Sweet,H.O. and Walsh,C.A.
  TITLE     Mapping of the mouse hyh gene to a YAC/BAC contig on proximal
            Chromosome 7
  JOURNAL   Mamm Genome 13 (5), 239-244 (2002)
   PUBMED   12016511
REFERENCE   9  (residues 1 to 594)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   10 (residues 1 to 594)
  AUTHORS   Zhou,Y.D., Barnard,M., Tian,H., Li,X., Ring,H.Z., Francke,U.,
            Shelton,J., Richardson,J., Russell,D.W. and McKnight,S.L.
  TITLE     Molecular characterization of two mammalian bHLH-PAS domain
            proteins selectively expressed in the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 713-718 (1997)
   PUBMED   9012850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164880.3, BY279348.1 and BC137863.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.517715.1,
                                           SRR7345562.2905321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.14 cM"
     Protein         1..594
                     /product="neuronal PAS domain-containing protein 1 isoform
                     1"
                     /note="neuronal PAS domain-containing protein 1; neuronal
                     PAS1"
                     /calculated_mol_wt=63606
     Region          43..116
                     /region_name="bHLH-PAS_NPAS1_PASD5"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 1
                     (NPAS1) and similar proteins; cd19731"
                     /db_xref="CDD:381574"
     Site            order(48..51,53..58,61..62,83..84)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381574"
     Site            order(57,60..61,64..65,67..68,71,73..74,77,80..81,84..85,
                     88..89,92,94..98,106..109)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381574"
     Region          141..198
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          206..237
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97459.1)"
     Region          316..387
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(319,323,329,342..345,371,376)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(339,343,351,354..355,383,385)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          427..498
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97459.1)"
     CDS             1..594
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /coded_by="NM_008718.2:193..1977"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS20850.1"
                     /db_xref="GeneID:18142"
                     /db_xref="MGI:MGI:109205"
ORIGIN      
        1 matpyprsgg rgevkcgggr gagvpwdflp glmvkappgp clqaqrkeks rnaarwrrgk
       61 enleffelak llplpgaiss qldkasivrl svtylrlrrf aalgappwgl ravgppagla
      121 pgrrgpvalv sevfeqhlgg hilqsldgfv falnqegkfl yisetvsiyl glsqveltgs
      181 svfdyihpgd hsevleqlgl raasigpptp psvsssssss ssslvdtpei easpteaspa
      241 fraqersffv rmkstltkrg lnvkasgykv ihvtgrlrar alglvalght lppaplaelp
      301 lhghmivfrl slgltilace srvsdhmdmg pselvgrscy qfvhgqdatr irqshldlld
      361 kgqvvtgyyr wlqraggfvw lqsvatvagn gkstgehhvl wvshvlsnae gsqtpldafq
      421 lpaivsqeep srpgpeptee eppvdgkqav padqdkdkdp qargkrikve aspkeargse
      481 dsgeeelsdp papprpefts viragalkhd pvlpwglttp gdpspallha gflppvvrgl
      541 ctpgtirygp aelslmyphl hrlgagpslp eafyptlglp ypgptgtrvq rkgd
//
