LOCUS       NM_001417027            2088 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus neuronal PAS domain protein 1 (Npas1), transcript
            variant 2, mRNA.
ACCESSION   NM_001417027 XM_006539614
VERSION     NM_001417027.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Morais-Silva,G., Campbell,R.R., Nam,H., Basu,M., Pagliusi,M.,
            Fox,M.E., Chan,C.S., Iniguez,S.D., Ament,S., Cramer,N., Marin,M.T.
            and Lobo,M.K.
  TITLE     Molecular, Circuit, and Stress Response Characterization of Ventral
            Pallidum Npas1-Neurons
  JOURNAL   J Neurosci 43 (3), 405-418 (2023)
   PUBMED   36443000
  REMARK    GeneRIF: Molecular, Circuit, and Stress Response Characterization
            of Ventral Pallidum Npas1-Neurons.
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Nunnelly,L.F., Campbell,M., Lee,D.I., Dummer,P., Gu,G., Menon,V.
            and Au,E.
  TITLE     St18 specifies globus pallidus projection neuron identity in MGE
            lineage
  JOURNAL   Nat Commun 13 (1), 7735 (2022)
   PUBMED   36517477
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Cui,Q., Du,X., Chang,I.Y.M., Pamukcu,A., Lilascharoen,V.,
            Berceau,B.L., Garcia,D., Hong,D., Chon,U., Narayanan,A., Kim,Y.,
            Lim,B.K. and Chan,C.S.
  TITLE     Striatal Direct Pathway Targets Npas1+ Pallidal Neurons
  JOURNAL   J Neurosci 41 (18), 3966-3987 (2021)
   PUBMED   33731445
  REMARK    GeneRIF: Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons.
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Erbel-Sieler,C., Dudley,C., Zhou,Y., Wu,X., Estill,S.J., Han,T.,
            Diaz-Arrastia,R., Brunskill,E.W., Potter,S.S. and McKnight,S.L.
  TITLE     Behavioral and regulatory abnormalities in mice deficient in the
            NPAS1 and NPAS3 transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 101 (37), 13648-13653 (2004)
   PUBMED   15347806
  REMARK    GeneRIF: a regulatory program controlled in inhibitory interneurons
            by the NPAS1 and NPAS3 transcription factors may be either
            substantively or tangentially relevant to psychosis
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Kasahara,M., Watanabe,Y., Sumasu,M. and Nagata,T.
  TITLE     A family of MHC class I-like genes located in the vicinity of the
            mouse leukocyte receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13687-13692 (2002)
   PUBMED   12370446
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Chae,T.H., Allen,K.M., Davisson,M.T., Sweet,H.O. and Walsh,C.A.
  TITLE     Mapping of the mouse hyh gene to a YAC/BAC contig on proximal
            Chromosome 7
  JOURNAL   Mamm Genome 13 (5), 239-244 (2002)
   PUBMED   12016511
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Zhou,Y.D., Barnard,M., Tian,H., Li,X., Ring,H.Z., Francke,U.,
            Shelton,J., Richardson,J., Russell,D.W. and McKnight,S.L.
  TITLE     Molecular characterization of two mammalian bHLH-PAS domain
            proteins selectively expressed in the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 713-718 (1997)
   PUBMED   9012850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164880.3.
            
            On Feb 23, 2023 this sequence version replaced XM_006539614.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3063142.1,
                                           SRR10662774.3627043.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC164880.3         32967-33102
            137-314             AC164880.3         34063-34240
            315-550             AC164880.3         34919-35154
            551-624             AC164880.3         44313-44386
            625-714             AC164880.3         44551-44640
            715-883             AC164880.3         46331-46499
            884-996             AC164880.3         47485-47597
            997-1154            AC164880.3         47809-47966
            1155-1261           AC164880.3         48311-48417
            1262-1409           AC164880.3         48794-48941
            1410-1504           AC164880.3         50467-50561
            1505-2088           AC164880.3         53443-54026
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.14 cM"
     gene            1..2088
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /note="neuronal PAS domain protein 1"
                     /db_xref="GeneID:18142"
                     /db_xref="MGI:MGI:109205"
     exon            1..136
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            137..314
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1974
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     neuronal PAS domain-containing protein 1; neuronal PAS1"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 1 isoform
                     2"
                     /protein_id="NP_001403956.1"
                     /db_xref="GeneID:18142"
                     /db_xref="MGI:MGI:109205"
                     /translation="MATPYPRSGGRGEVKCGGGRGAGVPWDFLPGLMVKAPPGPCLQA
                     QRKEKSRNAARWRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAA
                     LGAPPWGLRAVGPPAGLAPGRRGPVALVSEVFEQHLGGHILQSLDGFVFALNQEGKFL
                     YISETVSIYLGLSQVELTGSSVFDYIHPGDHSEVLEQLGLRAASIGPPTPPSVSSSSS
                     SSSSSLVDTPEIASPTEASPAFRAQERSFFVRMKSTLTKRGLNVKASGYKVIHVTGRL
                     RARALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDMGPSELV
                     GRSCYQFVHGQDATRIRQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKS
                     TGEHHVLWVSHVLSNAEGSQTPLDAFQLPAIVSQEEPSRPGPEPTEEEPPVDGKQAVP
                     ADQDKDKDPQARGKRIKVEASPKEARGSEDSGEEELSDPPAPPRPEFTSVIRAGALKH
                     DPVLPWGLTTPGDPSPALLHAGFLPPVVRGLCTPGTIRYGPAELSLMYPHLHRLGAGP
                     SLPEAFYPTLGLPYPGPTGTRVQRKGD"
     exon            315..550
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            551..624
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            625..714
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            715..883
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            884..996
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1154
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1261
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1409
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1504
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..2088
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2088
                     /gene="Npas1"
                     /gene_synonym="bHLHe11; MOP5"
                     /note="major polyA site"
ORIGIN      
        1 ggtctcaaag tctgcgaggc cgccgtgggc gccgagagcc gggctcccca gcccgcgcgc
       61 cccggggtct atggagcggc ccctccacgc cacccagtgg accccacgcc gcgccccgag
      121 cacgcccagc ggccagggaa ctgagcccca cctgcgactc cttcgcacct gaattcccga
      181 gtccccgtcg agatggcgac cccctatccc agaagcggtg gccgaggtga agtcaagtgc
      241 gggggcggcc gtggagccgg cgtcccctgg gatttcctgc ctgggctgat ggtcaaggcc
      301 ccgcccggac cctgcctgca ggcgcagcgc aaagagaagt cccgcaacgc tgcgcgctgg
      361 cgacgcggga aggaaaatct ggagttcttc gagctagcca agctgctccc tctgcccggt
      421 gccatctcca gccagctgga caaggcgtcc atcgtgcgtc ttagcgtcac ctacctccgc
      481 ctgcgtcgtt ttgccgcgct gggggcgccg ccctgggggt tgcgggccgt cgggcctccg
      541 gctggcctcg ccccaggccg ccgaggccct gtggctctgg tctctgaagt cttcgagcaa
      601 cacctaggtg gacacatcct acagtccttg gatggcttcg tgttcgcttt gaaccaggaa
      661 gggaaatttc tctacatctc agagacagtg tccatctacc tgggtctctc acaggtggag
      721 ctgacgggca gcagcgtctt cgactacatc catcctgggg accactcgga ggtcctagag
      781 caacttggat tgcgggctgc aagcatcggt ccccctacac caccttccgt gtcctcctct
      841 tcctcatcgt cttcctcctc gctggtggac acccctgaga ttgccagccc caccgaggca
      901 tcgcctgcct tccgagccca agagcggtcc ttctttgtcc gcatgaagtc caccctcacc
      961 aagaggggcc tgaatgtcaa agcctcgggg tacaaggtca ttcatgtgac agggcgcctg
     1021 agggcccgag ccctgggtct tgtagccctt ggacacacgc tgcccccagc cccactggct
     1081 gagctgcctt tgcacggaca catgattgtc ttccgcctca gcctgggcct caccatcctt
     1141 gcttgtgaga gcagagttag cgaccatatg gacatggggc cctcagagct tgtgggacgc
     1201 agctgctacc agtttgttca tggacaggat gcaaccagga tccgccaaag ccatctggac
     1261 ctgctggaca aagggcaggt ggtgactggt tactaccgtt ggctgcagcg tgcggggggc
     1321 ttcgtgtggc tgcagtctgt agccactgtg gccgggaacg ggaagagcac tggggagcat
     1381 cacgtgctgt gggtcagtca cgtgctcagc aatgctgaag gtagtcaaac acccctggat
     1441 gccttccagc ttccagctat tgtgtctcag gaggagccat ccaggccagg cccagagccc
     1501 acagaggaag agcctccagt tgacgggaag caggctgtgc ctgcggacca ggacaaggac
     1561 aaggaccctc aggcccgagg caaacgcatc aaagtggagg ccagcccgaa ggaagctaga
     1621 ggctcagagg acagtggaga agaggagctc tcggatccac cggctccacc tcggccagaa
     1681 ttcacttctg tcatccgggc gggagccctg aagcatgatc cagtgctgcc gtggggcttg
     1741 acaactcccg gagacccctc acccgccctc cttcatgcag gcttcctgcc acccgttgtg
     1801 cggggcctgt gcaccccagg caccatccgc tatggccctg cggagttgag cctgatgtat
     1861 ccacatctgc acaggctggg cgcaggcccc tcgcttccag aggcctttta ccctacgctg
     1921 ggcttgccct atccggggcc cacaggtact agggtgcagc ggaagggaga ctgaagacag
     1981 tgtaacacca gagggccaaa cctgagacac agatcaagtc ctggagtcat tcttgagaat
     2041 taaacaccat gccctaaggg gctccctccc cggggatgct gcctctca
//
