LOCUS       NM_027988               2239 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NADPH oxidase organizer 1 (Noxo1), transcript variant
            1, mRNA.
ACCESSION   NM_027988
VERSION     NM_027988.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2239)
  AUTHORS   Buchmann,G.K., Schurmann,C., Warwick,T., Schulz,M.H., Spaeth,M.,
            Muller,O.J., Schroder,K., Jo,H., Weissmann,N. and Brandes,R.P.
  TITLE     Deletion of NoxO1 limits atherosclerosis development in female mice
  JOURNAL   Redox Biol 37, 101713 (2020)
   PUBMED   32949971
  REMARK    GeneRIF: Deletion of NoxO1 limits atherosclerosis development in
            female mice.
REFERENCE   2  (bases 1 to 2239)
  AUTHORS   Seimetz,M., Sommer,N., Bednorz,M., Pak,O., Veith,C., Hadzic,S.,
            Gredic,M., Parajuli,N., Kojonazarov,B., Kraut,S., Wilhelm,J.,
            Knoepp,F., Henneke,I., Pichl,A., Kanbagli,Z.I., Scheibe,S.,
            Fysikopoulos,A., Wu,C.Y., Klepetko,W., Jaksch,P., Eichstaedt,C.,
            Grunig,E., Hinderhofer,K., Geiszt,M., Muller,N., Rezende,F.,
            Buchmann,G., Wittig,I., Hecker,M., Hecker,A., Padberg,W.,
            Dorfmuller,P., Gattenlohner,S., Vogelmeier,C.F., Gunther,A.,
            Karnati,S., Baumgart-Vogt,E., Schermuly,R.T., Ghofrani,H.A.,
            Seeger,W., Schroder,K., Grimminger,F., Brandes,R.P. and
            Weissmann,N.
  TITLE     NADPH oxidase subunit NOXO1 is a target for emphysema treatment in
            COPD
  JOURNAL   Nat Metab 2 (6), 532-546 (2020)
   PUBMED   32694733
  REMARK    Erratum:[Nat Metab. 2020 Jul;2(7):648. doi:
            10.1038/s42255-020-0248-z.. PMID: 32694792]
REFERENCE   3  (bases 1 to 2239)
  AUTHORS   Rezende,F., Moll,F., Walter,M., Helfinger,V., Hahner,F.,
            Janetzko,P., Ringel,C., Weigert,A., Fleming,I., Weissmann,N.,
            Kuenne,C., Looso,M., Rieger,M.A., Nawroth,P., Fleming,T.,
            Brandes,R.P. and Schroder,K.
  TITLE     The NADPH organizers NoxO1 and p47phox are both mediators of
            diabetes-induced vascular dysfunction in mice
  JOURNAL   Redox Biol 15, 12-21 (2018)
   PUBMED   29195137
  REMARK    GeneRIF: ROS production stimulated by NoxO1 and p47phox limit
            endothelium-dependent relaxation and maintain blood pressure in
            mice. However, NoxO1 and p47phox cannot substitute each other
            despite their similar effect on vascular function. Deletion of
            NoxO1 induced an anti-inflammatory phenotype, whereas p47phox
            deletion rather elicited a hyper-inflammatory response.
REFERENCE   4  (bases 1 to 2239)
  AUTHORS   Brandes,R.P., Harenkamp,S., Schurmann,C., Josipovic,I., Rashid,B.,
            Rezende,F., Lowe,O., Moll,F., Epah,J., Eresch,J., Nayak,A.,
            Kopaliani,I., Penski,C., Mittelbronn,M., Weissmann,N. and
            Schroder,K.
  TITLE     The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial
            Stalk Cell Phenotype
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (8), 1558-1565 (2016)
   PUBMED   27283741
  REMARK    GeneRIF: NoxO1 stimulates alpha-secretase activity probably through
            reactive oxygen species-mediated oxidation. Deletion of NoxO1
            attenuates Notch signaling and thereby promotes a tip-cell
            phenotype that results in increased angiogenesis.
REFERENCE   5  (bases 1 to 2239)
  AUTHORS   Street,V.A., Kujawa,S.G., Manichaikul,A., Broman,K.W.,
            Kallman,J.C., Shilling,D.J., Iwata,A.J., Robinson,L.C.,
            Robbins,C.A., Li,J., Liberman,M.C. and Tempel,B.L.
  TITLE     Resistance to noise-induced hearing loss in 129S6 and MOLF mice:
            identification of independent, overlapping, and interacting
            chromosomal regions
  JOURNAL   J Assoc Res Otolaryngol 15 (5), 721-738 (2014)
   PUBMED   24952082
REFERENCE   6  (bases 1 to 2239)
  AUTHORS   Dutta,S. and Rittinger,K.
  TITLE     Regulation of NOXO1 activity through reversible interactions with
            p22 and NOXA1
  JOURNAL   PLoS One 5 (5), e10478 (2010)
   PUBMED   20454568
  REMARK    GeneRIF: The first quantitative characterization of the
            interactions made between the cytosolic regulators NOXO1 and NOXA1
            and membrane-bound p22(phox), is presented.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2239)
  AUTHORS   Nakano,Y., Banfi,B., Jesaitis,A.J., Dinauer,M.C., Allen,L.A. and
            Nauseef,W.M.
  TITLE     Critical roles for p22phox in the structural maturation and
            subcellular targeting of Nox3
  JOURNAL   Biochem J 403 (1), 97-108 (2007)
   PUBMED   17140397
REFERENCE   8  (bases 1 to 2239)
  AUTHORS   Kiss,P.J., Knisz,J., Zhang,Y., Baltrusaitis,J., Sigmund,C.D.,
            Thalmann,R., Smith,R.J., Verpy,E. and Banfi,B.
  TITLE     Inactivation of NADPH oxidase organizer 1 results in severe
            imbalance
  JOURNAL   Curr Biol 16 (2), 208-213 (2006)
   PUBMED   16431374
REFERENCE   9  (bases 1 to 2239)
  AUTHORS   Cheng,G. and Lambeth,J.D.
  TITLE     Alternative mRNA splice forms of NOXO1: differential tissue
            expression and regulation of Nox1 and Nox3
  JOURNAL   Gene 356, 118-126 (2005)
   PUBMED   15949904
REFERENCE   10 (bases 1 to 2239)
  AUTHORS   Banfi,B., Clark,R.A., Steger,K. and Krause,K.H.
  TITLE     Two novel proteins activate superoxide generation by the NADPH
            oxidase NOX1
  JOURNAL   J Biol Chem 278 (6), 3510-3513 (2003)
   PUBMED   12473664
  REMARK    GeneRIF: role in activating superoxide generation by the NADPH
            oxidase NOX1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154566.2.
            
            On Jun 13, 2010 this sequence version replaced NM_027988.3.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157993.1, AK088226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-891               AC154566.2         65997-66887         c
            892-1080            AC154566.2         64713-64901         c
            1081-1161           AC154566.2         64523-64603         c
            1162-1237           AC154566.2         64260-64335         c
            1238-1415           AC154566.2         63999-64176         c
            1416-1597           AC154566.2         63671-63852         c
            1598-1711           AC154566.2         63464-63577         c
            1712-1829           AC154566.2         63106-63223         c
            1830-2239           AC154566.2         62591-63000         c
FEATURES             Location/Qualifiers
     source          1..2239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.49 cM"
     gene            1..2239
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /note="NADPH oxidase organizer 1"
                     /db_xref="GeneID:71893"
                     /db_xref="MGI:MGI:1919143"
     exon            1..891
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1080
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     CDS             1015..2064
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /note="nox organizer 1; sorting nexin-28"
                     /codon_start=1
                     /product="NADPH oxidase organizer 1"
                     /protein_id="NP_082264.2"
                     /db_xref="CCDS:CCDS50018.1"
                     /db_xref="GeneID:71893"
                     /db_xref="MGI:MGI:1919143"
                     /translation="MASPRHPVSAHAVALVQMDRLQTFAFSVCWSDNSDTFVRRSWDE
                     FRQLQKTLKKTFPVEAGLLRRSEQVLPKLPDAPLLTRRGHTGRGLVRLRLLDTYVQAL
                     LATSEHILRSSALHGFFVPKPLDLEPMLPPGSLVILPTPEEPLSQPRGSLDIHSLEAQ
                     SIPCVQPFHTLDIRDRPFHTKAQEILDILLRHPSGWWLVENKDQQVAWFPAPYLEEVA
                     TCQGQESGLALQGSGRQFCTTQAYEGSRSDELSVPSGARVHVLETSDRGWWLCRYNGR
                     TGLLPAMSLQPEGLGSLLGRPGFPDSAGADKVAEDRTIPPVVPTRPCMSAIQSRCCSI
                     TRRALGQEQGTRVPR"
     exon            1081..1161
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1237
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1415
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1597
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1711
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1829
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2239
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /note="hexamer: AATAAA"
     polyA_site      2239
                     /gene="Noxo1"
                     /gene_synonym="2310034C04Rik; hslt; P41NOX; P41NOXA;
                     P41NOXB; P41NOXC; Snx28"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggcgg cccgggtcgc ggaggcgtag gaggcctcgg ggcgggagga ggcggcgccg
       61 gaggcccagg ccgaggcggc actggcggct gcggctccgg ctctgcgggt actcttgcgc
      121 ctggtgaccc gccgcgagcc cggcgtgcgt ggtccatggt ggggttcagg cttcctccgg
      181 cagatgtgaa gtgtgtcgtg gaaggcgcgc tgcggctgtg ctgagatctt ggactgagat
      241 gagttccgag atgcttctcg catcaccccc atcgcttggc tcagacacct aagggcggca
      301 aaatttgggg tcttcctgcc ttacgacgtg cccacctaca cgcttctcgg tgccttagca
      361 acgcgcgacg gggcgtggcc tcacagagac cagacagtac ttattgccag aggctacctg
      421 tgccctagta actgtccccc actgcgcaac cttgagagag ggcgtgtcct catcctctag
      481 cttggataaa agattattat gcctatttta atagcagcct caggaatttc ttcctttttt
      541 tttttctttt ggagacaggg tctcatgtaa cttggactaa ctttgaactc tgtatgtagc
      601 tgagtgaaga tgatgttgaa ttcttgaatc tttttgccac cacaccacct cttcaagtgt
      661 ttgacttaaa cgcctgtgcc atcacaggaa gaattccttc cgctgcctcc atgtgttcat
      721 ttactctttc tgcaaatatt tgtagagtgg ctgctctctc caggtgctgt ttcctccact
      781 gagcagaaca aggaacaagc ctccctcttt agcctttaac cagtgatgca aatgcggaaa
      841 acccagtaca ccagaatcat atttacaaaa ctgatgaaag ctgtgcaggg gaaccaggaa
      901 actgaactct ttcctggatt gtgagtgctt cgaagggact ctacttaggg cagtgttggg
      961 gaattccact tcacttcttc cggatgctcg gagctccttc aagcatccat agtcatggca
     1021 agcccaagac acccagtatc agcccatgct gtagccttgg tgcaaatgga ccgactccag
     1081 acatttgcct tctccgtgtg ctggtcagac aacagtgaca catttgtgcg gaggagctgg
     1141 gatgagttca ggcagctcca gaagaccctt aagaaaacct tcccagtgga ggcaggcctg
     1201 ctacggagat ctgaacaagt tcttcccaag cttcctgatg ctccattgct gacacgtcgg
     1261 gggcatactg gtcgaggact ggtacgtttg cggctgctgg acacctatgt acaggcattg
     1321 ctggcaacct cagaacacat attgaggagt tcagcacttc acggcttctt tgtacccaaa
     1381 cctctggatc tggagcccat gctgcctcct ggcagcctgg tgatcctgcc tacaccagag
     1441 gagcccttat cccaacccag aggcagcctt gacattcata gcctggaggc tcagagcatt
     1501 ccctgtgtac agcctttcca cactcttgac ataagagaca gacctttcca caccaaggct
     1561 caagaaattc tggacatatt actacgacat ccttcaggct ggtggctggt ggagaacaag
     1621 gatcagcagg tagcctggtt tccagctccc tacctggagg aggtagcaac gtgccaaggc
     1681 caggagtcag gcctggcttt gcaaggaagt gggaggcagt tctgcactac tcaggcctac
     1741 gagggcagtc gctctgatga gctatccgtg ccctcagggg cacgtgtcca tgtgctggag
     1801 acctcagacc gaggctggtg gctgtgcagg tataatggcc ggacaggcct actccctgca
     1861 atgtcgctgc aacctgaagg gctgggctcg ctcctgggca ggccagggtt cccagacagt
     1921 gctggggcag acaaggtggc tgaggacagg accattcccc ctgtagtacc aactcgtccc
     1981 tgtatgagtg ccatccagag tcgatgctgc tccattaccc gcagggcact gggacaggaa
     2041 caagggactc gggttccccg ttgaggattg tattgctgct ctgcagagag gttgtactgt
     2101 caaagccaac ctcaggcaaa gcagggatct agacctcacc aagaaagcag gattaagagt
     2161 ggggctctat ggctggcagg gccacgggcc agctaacttt ctatttcctc taaataaaac
     2221 tggaatgact tcacccaaa
//
