LOCUS       NM_172204               1673 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus NADPH oxidase activator 1 (Noxa1), transcript variant
            1, mRNA.
ACCESSION   NM_172204
VERSION     NM_172204.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1673)
  AUTHORS   Stevenson,M.D., Vendrov,A.E., Yang,X., Chen,Y., Navarro,H.A.,
            Moss,N., Runge,M.S., Arendshorst,W.J. and Madamanchi,N.R.
  TITLE     Reactivity of renal and mesenteric resistance vessels to
            angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling
  JOURNAL   Am J Physiol Renal Physiol 324 (4), F335-F352 (2023)
   PUBMED   36759130
  REMARK    GeneRIF: Reactivity of renal and mesenteric resistance vessels to
            angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling.
REFERENCE   2  (bases 1 to 1673)
  AUTHORS   Mironova,E., Archer,C.R., Vendrov,A.E., Runge,M.S.,
            Madamanchi,N.R., Arendshorst,W.J., Stockand,J.D. and Abd
            El-Aziz,T.M.
  TITLE     NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II
            activation of the epithelial sodium channel
  JOURNAL   Am J Physiol Renal Physiol 323 (6), F633-F641 (2022)
   PUBMED   36201326
  REMARK    GeneRIF: NOXA1-dependent NADPH oxidase 1 signaling mediates
            angiotensin II activation of the epithelial sodium channel.
REFERENCE   3  (bases 1 to 1673)
  AUTHORS   Vendrov,A.E., Stevenson,M.D., Lozhkin,A., Hayami,T., Holland,N.A.,
            Yang,X., Moss,N., Pan,H., Wickline,S.A., Stockand,J.D., Runge,M.S.,
            Madamanchi,N.R. and Arendshorst,W.J.
  TITLE     Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and
            Sodium Retention in Angiotensin II-induced Hypertension
  JOURNAL   Antioxid Redox Signal 36 (7-9), 550-566 (2022)
   PUBMED   34714114
  REMARK    GeneRIF: Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium
            Channel and Sodium Retention in Angiotensin II-induced
            Hypertension.
REFERENCE   4  (bases 1 to 1673)
  AUTHORS   Janus,P., Toma-Jonik,A., Vydra,N., Mrowiec,K., Korfanty,J.,
            Chadalski,M., Widlak,P., Dudek,K., Paszek,A., Rusin,M., Polanska,J.
            and Widlak,W.
  TITLE     Pro-death signaling of cytoprotective heat shock factor 1:
            upregulation of NOXA leading to apoptosis in heat-sensitive cells
  JOURNAL   Cell Death Differ 27 (7), 2280-2292 (2020)
   PUBMED   31996779
  REMARK    GeneRIF: Pro-death signaling of cytoprotective heat shock factor 1:
            upregulation of NOXA leading to apoptosis in heat-sensitive cells.
REFERENCE   5  (bases 1 to 1673)
  AUTHORS   Vendrov,A.E., Sumida,A., Canugovi,C., Lozhkin,A., Hayami,T.,
            Madamanchi,N.R. and Runge,M.S.
  TITLE     NOXA1-dependent NADPH oxidase regulates redox signaling and
            phenotype of vascular smooth muscle cell during atherogenesis
  JOURNAL   Redox Biol 21, 101063 (2019)
   PUBMED   30576919
  REMARK    GeneRIF: Our data support an important role for NOXA1-dependent
            NADPH oxidase activity in VSMC plasticity during restenosis and
            atherosclerosis, augmenting VSMC proliferation and migration and
            KLF4-mediated transition to macrophage-like cells, plaque
            inflammation, and expansion.
REFERENCE   6  (bases 1 to 1673)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 1673)
  AUTHORS   Valente,A.J., El Jamali,A., Epperson,T.K., Gamez,M.J., Pearson,D.W.
            and Clark,R.A.
  TITLE     NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain
  JOURNAL   Free Radic Biol Med 43 (3), 384-396 (2007)
   PUBMED   17602954
REFERENCE   8  (bases 1 to 1673)
  AUTHORS   Ambasta,R.K., Schreiber,J.G., Janiszewski,M., Busse,R. and
            Brandes,R.P.
  TITLE     Noxa1 is a central component of the smooth muscle NADPH oxidase in
            mice
  JOURNAL   Free Radic Biol Med 41 (2), 193-201 (2006)
   PUBMED   16814099
REFERENCE   9  (bases 1 to 1673)
  AUTHORS   Geiszt,M., Lekstrom,K., Witta,J. and Leto,T.L.
  TITLE     Proteins homologous to p47phox and p67phox support superoxide
            production by NAD(P)H oxidase 1 in colon epithelial cells
  JOURNAL   J Biol Chem 278 (22), 20006-20012 (2003)
   PUBMED   12657628
REFERENCE   10 (bases 1 to 1673)
  AUTHORS   Banfi,B., Clark,R.A., Steger,K. and Krause,K.H.
  TITLE     Two novel proteins activate superoxide generation by the NADPH
            oxidase NOX1
  JOURNAL   J Biol Chem 278 (6), 3510-3513 (2003)
   PUBMED   12473664
  REMARK    GeneRIF: role in activating superoxide generation by the NADPH
            oxidase NOX1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732585.8 and AK087263.1.
            
            On Jul 25, 2009 this sequence version replaced NM_172204.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF539798.1, AY255770.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AL732585.8         137655-137728       c
            75-987              AK087263.1         1-913
            988-1011            AL732585.8         129653-129676       c
            1012-1449           AK087263.1         914-1351
            1450-1485           AL732585.8         128496-128531       c
            1486-1673           AL732585.8         128190-128377       c
FEATURES             Location/Qualifiers
     source          1..1673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.97 cM"
     gene            1..1673
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /note="NADPH oxidase activator 1"
                     /db_xref="GeneID:241275"
                     /db_xref="MGI:MGI:2449980"
     exon            1..458
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1616
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="NADPH oxidase activator 1 isoform 1"
                     /protein_id="NP_757341.3"
                     /db_xref="CCDS:CCDS15749.1"
                     /db_xref="GeneID:241275"
                     /db_xref="MGI:MGI:2449980"
                     /translation="MSSLGDQIRDWHRGVLAVAREDWDSALCFFSDVREPLARMYFNR
                     GCVHLMAGDPEAALRAFDQAVTKDTCMAVGFLQRGVANFQLQRFQEAVSDFQLALAQL
                     RDNAVIDYTQLGLNFKLQAWEVLYNMASAQCQAGLWTKAANTLVEAISKWPEGAQDIL
                     DIAMDKVQKQVPLQLQQVPKGEVFQPPRRYLKHLEPMDFLGKAKVVASVIPDDHNAQP
                     QQRSQAEHAGHQPSSSMCKRVLSTTGGHTSPGLYDSLLASRRPGPGPSEVSSGSEGAA
                     TKDPESLVTVTVQCHFTVPLKVPRGTGLSSFQTLLAQALLHQTQTGQLSYKAPGEERS
                     WIPISTEESLQSIWRNVPVGPGGLQLQCQGVWGRPVLYQVVAQYNYRAQRPEDLDFHQ
                     GDTVDVLCEVDEAWLEGHRDGCVGIFPKCFVVPAGAYVEAMLVLGPQPGDQN"
     exon            459..541
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            542..650
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            651..785
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            786..893
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            894..941
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1011
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1100
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1255
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1370
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1485
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1673
                     /gene="Noxa1"
                     /gene_synonym="NY-CO-31; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctatgtga tcatagaccc tctcctcagt gctagggact tgtttaagta gttctaggcg
       61 gggcgtgaga gaggggccta agccttgggc catctactca gtttcaagga ccgactgtca
      121 caactccagt tgtcttgcta ccagctgctt ctcattgctg tcccggtccc cttggccctg
      181 gcctacggcc tcccagcttc tgtggggcac cctcctcctg tcccacgcgc tccagctaga
      241 atcgctaact tccttcgcct caaagcaggc gtccccgctc catgagctct ctaggggatc
      301 agatacggga ctggcaccgg ggtgtgctgg ccgtggcacg cgaagactgg gactctgcgc
      361 tgtgcttctt ctcagatgtc cgagagccgc tggctaggat gtactttaac aggggctgtg
      421 tgcatctgat ggcaggggat cccgaggctg cgctgcgggc atttgaccaa gcagtgacta
      481 aggacacctg catggctgtt ggcttcctcc agcggggagt ggccaatttc cagctgcaga
      541 ggttccagga ggctgtgtct gacttccagt tggccctggc acagctgagg gacaatgctg
      601 tcattgacta cacacaactg ggtctgaact tcaaattgca agcctgggag gtcctataca
      661 acatggcatc agcacagtgc caggcagggc tctggaccaa ggctgccaat actctagtgg
      721 aggcaatctc caaatggcca gagggggctc aagacatcct ggacattgcc atggacaaag
      781 tgcagaaaca ggtaccccta cagctacagc aagtgcccaa gggtgaggtc ttccagcctc
      841 ccaggcgata cctaaaacat ctggagccca tggatttcct tggcaaggct aaggtggtgg
      901 cttctgtcat tcctgatgac cacaacgccc agcctcagca gaggtcccag gcggagcatg
      961 ctggccacca gccatcctca tctatgtgta agagggtcct gagcactacg ggtggtcaca
     1021 cgagccctgg cctatatgat agtttgctgg catccagaag gcctggtcca ggcccctctg
     1081 aagtttcctc aggatctgag ggagcagcta caaaggaccc tgaatccttg gtgactgtca
     1141 ctgtgcagtg ccactttact gtgcccctga aggtcccaag aggaactggc ctgtccagtt
     1201 ttcagacact actagctcaa gccctccttc accagacgca gacagggcag ctcagttaca
     1261 aagccccagg agaggagaga tcctggattc ccatctccac ggaggagtcc ctgcagagta
     1321 tatggaggaa tgtgcccgtg ggcccaggag ggttgcagct ccagtgccag ggggtctggg
     1381 gccggccagt cctctaccaa gtagtagctc agtacaacta tcgtgcccaa agaccggagg
     1441 atttggactt ccaccaaggg gacacggtgg atgtcctgtg tgaagtggac gaagcatggc
     1501 tggagggaca ccgagatggc tgcgttggca ttttccctaa gtgctttgtg gtcccagctg
     1561 gcgcctatgt ggaagccatg cttgtactgg gaccccagcc aggagaccag aactagcaat
     1621 aaataccatg acaaaaccag ctttaattaa acaagcaaac aagcaaacaa aaa
//
