LOCUS       NM_015760               3760 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus NADPH oxidase 4 (Nox4), transcript variant 1, mRNA.
ACCESSION   NM_015760
VERSION     NM_015760.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3760)
  AUTHORS   Kim,J.Y., Kang,W., Yang,S., Park,S.H., Ha,S.Y. and Paik,Y.H.
  TITLE     NADPH oxidase 4 deficiency promotes hepatocellular carcinoma
            arising from hepatic fibrosis by inducing M2-macrophages in the
            tumor microenvironment
  JOURNAL   Sci Rep 14 (1), 22358 (2024)
   PUBMED   39333166
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3760)
  AUTHORS   Wu,Z., Xi,Q., Zhao,Q. and Zhu,S.
  TITLE     GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR
            ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO
            INHIBIT FERROPTOSIS
  JOURNAL   Shock 62 (2), 245-254 (2024)
   PUBMED   38920138
  REMARK    GeneRIF: GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG
            MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4
            SIGNALING TO INHIBIT FERROPTOSIS.
REFERENCE   3  (bases 1 to 3760)
  AUTHORS   Ko,K., Choi,S., Jo,M., Kim,C., Boonpraman,N., Youm,J. and Yi,S.S.
  TITLE     NOX4 and its association with myeloperoxidase and osteopontin in
            regulating endochondral ossification
  JOURNAL   J Vet Sci 25 (4), e49 (2024)
   PUBMED   38910308
  REMARK    GeneRIF: NOX4 and its association with myeloperoxidase and
            osteopontin in regulating endochondral ossification.
REFERENCE   4  (bases 1 to 3760)
  AUTHORS   Jia,J., Tan,R., Xu,L., Wang,H., Li,J., Su,H., Zhong,X., Liu,P. and
            Wang,L.
  TITLE     Hederagenin improves renal fibrosis in diabetic nephropathy by
            regulating Smad3/NOX4/SLC7A11 signaling-mediated tubular cell
            ferroptosis
  JOURNAL   Int Immunopharmacol 135, 112303 (2024)
   PUBMED   38776855
  REMARK    GeneRIF: Hederagenin improves renal fibrosis in diabetic
            nephropathy by regulating Smad3/NOX4/SLC7A11 signaling-mediated
            tubular cell ferroptosis.
REFERENCE   5  (bases 1 to 3760)
  AUTHORS   Wang,J., Lai,D.A., Wang,J.J. and Zhang,S.X.
  TITLE     Effects of Nox4 upregulation on PECAM-1 expression in a mouse model
            of diabetic retinopathy
  JOURNAL   PLoS One 19 (5), e0303010 (2024)
   PUBMED   38748682
  REMARK    GeneRIF: Effects of Nox4 upregulation on PECAM-1 expression in a
            mouse model of diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3760)
  AUTHORS   Chamseddine,A.H. and Miller,F.J. Jr.
  TITLE     Gp91phox contributes to NADPH oxidase activity in aortic
            fibroblasts but not smooth muscle cells
  JOURNAL   Am J Physiol Heart Circ Physiol 285 (6), H2284-H2289 (2003)
   PUBMED   12855428
  REMARK    GeneRIF: neutrophil subunit gp91phox contributes to NADPH oxidase
            function in vascular fibroblasts, but not vascular smooth muscle
            cells.
REFERENCE   7  (bases 1 to 3760)
  AUTHORS   Yang,S., Madyastha,P., Bingel,S., Ries,W. and Key,L.
  TITLE     A new superoxide-generating oxidase in murine osteoclasts
  JOURNAL   J Biol Chem 276 (8), 5452-5458 (2001)
   PUBMED   11098048
REFERENCE   8  (bases 1 to 3760)
  AUTHORS   Shiose,A., Kuroda,J., Tsuruya,K., Hirai,M., Hirakata,H., Naito,S.,
            Hattori,M., Sakaki,Y. and Sumimoto,H.
  TITLE     A novel superoxide-producing NAD(P)H oxidase in kidney
  JOURNAL   J Biol Chem 276 (2), 1417-1423 (2001)
   PUBMED   11032835
REFERENCE   9  (bases 1 to 3760)
  AUTHORS   Lambeth,J.D., Cheng,G., Arnold,R.S. and Edens,W.A.
  TITLE     Novel homologs of gp91phox
  JOURNAL   Trends Biochem Sci 25 (10), 459-461 (2000)
   PUBMED   11050424
  REMARK    Review article
REFERENCE   10 (bases 1 to 3760)
  AUTHORS   Geiszt,M., Kopp,J.B., Varnai,P. and Leto,T.L.
  TITLE     Identification of renox, an NAD(P)H oxidase in kidney
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 8010-8014 (2000)
   PUBMED   10869423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY001994.1, AK050371.1, AK149455.1, AK149398.1 and CJ227847.1.
            
            On Oct 24, 2013 this sequence version replaced NM_015760.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042745.1, AF261944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               BY001994.1         2-147
            147-2331            AK050371.1         2-2186
            2332-3366           AK149455.1         2183-3217
            3367-3737           AK149398.1         3217-3587
            3738-3760           CJ227847.1         371-393
FEATURES             Location/Qualifiers
     source          1..3760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.96 cM"
     gene            1..3760
                     /gene="Nox4"
                     /note="NADPH oxidase 4"
                     /db_xref="GeneID:50490"
                     /db_xref="MGI:MGI:1354184"
     exon            1..254
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            255..350
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            351..461
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            462..546
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            547..644
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            645..672
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            673..745
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            746..826
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1043
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1208
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1271
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1332
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1414
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1534
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1643
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1712
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1813
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..3753
                     /gene="Nox4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2312..2317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nox4"
                     /note="hexamer: ATTAAA"
     polyA_site      2333
                     /gene="Nox4"
     regulatory      3628..3633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nox4"
                     /note="hexamer: AATAAA"
     polyA_site      3651
                     /gene="Nox4"
                     /note="major polyA site"
     regulatory      3734..3739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nox4"
                     /note="hexamer: AATAAA"
     polyA_site      3753
                     /gene="Nox4"
                     /note="major polyA site"
ORIGIN      
        1 gtggggaggc aagggagcag cgcggtggga gccgggtgga gacctccagc caggcctcca
       61 gactcagtac agcctttgac cctcgccccc acgccgctcc cctgcaggcg gcgcccctgg
      121 atctgctgcc ccggccactg atcgctcctt tcggtcctga gcaccgagca gggcgcagca
      181 ctccccgcgc cggcggcatg gcggtgtcct ggaggagctg gctggccaac gaaggggtta
      241 aacacctctg cctgctcatt tggctgtccc taaacgttct acttttctgg aaaaccttcc
      301 tgctgtacaa ccaagggcca gaatactact acattcacca aatgttgggc ctaggattgt
      361 gtttaagcag agcatctgca tctgtcctga acctcaactg cagcctcatc cttttaccta
      421 tgtgccggac agtcctggct tatcttcgag gatcacagaa ggtccctagc aggagaacaa
      481 gaagattgtt ggataaaagc aagactctac acatcacatg tggtgtaact atctgtattt
      541 tctcaggtgt gcatgtagcc gcccacttgg tgaatgccct caacttttca gtgaactaca
      601 gtgaagattt ccttgaactg aatgcagcaa gataccagaa tgaggatccc agaaagcttc
      661 tcttcacaac cattcctggt ctgacgggtg tctgcatggt ggtggtattg ttcctcatgg
      721 ttacagcttc tacctacgca ataagagttt ctaattatga tatcttctgg tatactcaca
      781 acctcttctt tgtcttctac atgctgctgc tgttgcatgt ttcaggtggt ttgttgaagt
      841 atcagacaaa tgtagacact caccctcctg gctgcattag tcttaaccag acatcatccc
      901 agaatatgtc cataccagac tacgtctcag aacattttca tggatctttg cctcgagggt
      961 tttcaaaatt agaagatcgt taccagaaaa cacttgtgaa gatttgcctg gaagaaccca
     1021 agttccaagc tcatttccca cagacctgga tttggatttc tggacctttg tgcctttatt
     1081 gtgcggagag actttaccga tgcatcagga gcaacaaacc tgtcaccatc atctcagtca
     1141 tcaatcatcc ctctgatgta atggaactcc gtatgatcaa agaaaacttt aaagcaagac
     1201 ctggccagta tattattctc cattgcccca gtgtatcagc attagaaaac cacccattta
     1261 ctctcacaat gtgtcctact gaaaccaaag caacatttgg tgtccacttt aaagtagtag
     1321 gagactggac agaacgattc cgggatttgc tactgcctcc atcaagtcaa gactctgaga
     1381 ttctgccctt cattcactct agaaattacc ctaagttata cattgatggt ccatttggaa
     1441 gcccatttga ggagtcactg aactatgaag ttagtctctg tgtggctgga ggcattggag
     1501 tcactccatt tgcatcgata ctaaacactc tactggatga ctggaaacca tacaagttaa
     1561 gaagactgta ctttatctgg gtgtgcagag acatccaatc attccagtgg tttgcagatt
     1621 tactctgtgt gttgcataac aagttttggc aagaaaacag acctgacttt gtgaacatcc
     1681 agctgtacct cagtcaaaca gatgggattc agaagataat tggagaaaaa tatcacacac
     1741 tgaattcgag acttttcatt gggcgtcctc ggtggaaact tttatttgat gaaatagcaa
     1801 aatgtaacag agggaaaaca gttggagttt tctgctgtgg acccagttct atttccaaga
     1861 ctcttcatag tttgagtaac cggaacaact catatgggac aaaatttgaa tacaataaag
     1921 aatccttcag ctgaaacctt aggagactac tggggacttt aaagaggaac aagtgcaatt
     1981 tctaagactt agaaactcag ctgaatcaaa cagctgtgct atgccaaaga ataccaaggg
     2041 tttgctattt atgattattt aaaatgagaa ttcagaaaat gtggcaaaat ggcatggtta
     2101 atctgcgagc caaaggggcc ctgaagaata tctgatgtgg tgattcacat tttgatgagc
     2161 aaattaaaag aatgccgtta gacgcacgct gttgattttt atgggaaatt caagaagtct
     2221 cttacaagga gctgaactca cttacactga agctgatagc tgcagccctc tttaaattgt
     2281 tttcggttga acacattcaa gattgaacaa aattaaaaat tcattgaaac tcagactcca
     2341 ttttctaggt tgtgcataag tggagtagct ttcatttgga taggctccag gcaaacactg
     2401 ggaggttgaa actgtagcac aaaactttgt atcgatacgg gtacttcata tctgctgctt
     2461 cactactgac tctcctgcct cgctgcagtg ttcctaatct atatgctcac aaagcttata
     2521 cccatgtgga tgtagtatct acttatgttt gcatcttatc ctccgtctag gaaaatctgc
     2581 tcccccttag ccaatcttgg acacaattat ttaatagaac tgtttgatca ccgatttgtt
     2641 caatttagtc ccatggctta gtaatgaaaa tgtgctttaa gcttatcctt aaaaaccaaa
     2701 gagctttgta tcttgcacca aacacagaag cacaagacct ctctcctttg actcactttg
     2761 atttcagata agagatgctg aattcatgga gtgataccct gctttgcttt ctacaaaagt
     2821 agaacttctt cagtatttat tcaaatttca gtttagaatc actaatatta tttttgcact
     2881 gtttgatatc acggtgagtt actagattta agtcccctgt tcatgtgatc caatcagttt
     2941 atcacctatt ttttaatatt caggaatcag aaggaaaatt tactacctta agaaagaaga
     3001 tattcataca gtttatcaac ttaatttggt atataattat taatgctatc aaataggaca
     3061 cattgctgaa attagtacct taacttatgc ttggtaatct tttgtatatc acatgattac
     3121 aataaatcct gttattattt ggatttcatg tgattcagta ctaacagaca agcatactaa
     3181 aacatttagc atcaaataac cacctgtata tttagttaca catatatttt ttttatcctt
     3241 ggaacacttt cctatccctc ctatgggcaa tgtgcaatgc tcatgtagac tgaactgtgg
     3301 agacataaac tatgacatca tagcaatgct gtctagatta caaagagttt tcacaaaaca
     3361 catactacaa aaataaaaat aaaaataaac ctcataaaaa aaaacttggg cttgtccagg
     3421 cttgatgtgc aatactgatt ccttaccaat cataacttat ttttatgcct atgtgaattc
     3481 atcacatttc aaaaattcag gtcaaactta caaaacaaga tgatatttca gacttgtgtg
     3541 ctatgttgag tgaacttcct tgcctaatct aaactccagt gcatgttcaa ggatctatat
     3601 gttaaacatg gtatattttt gaacaggaat aaattaaagc tttatcacac atatagaaga
     3661 cagcttcatt tctttttaga ttctatggtg gtggttactg ttgtataaat cttaaatcac
     3721 gaattttgat ggtaataaat attaaaatta aaaaaaaaaa
//
