LOCUS       NM_198958               1792 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus NADPH oxidase 3 (Nox3), mRNA.
ACCESSION   NM_198958 XM_139715
VERSION     NM_198958.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Mohri,H., Ninoyu,Y., Sakaguchi,H., Hirano,S., Saito,N. and
            Ueyama,T.
  TITLE     Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing
            Loss
  JOURNAL   J Neurosci 41 (21), 4716-4731 (2021)
   PUBMED   33849947
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Xu,Y., Yang,L., Zhao,X., Zhang,Y., Jones,T.A., Jones,S.M. and
            Lundberg,Y.W.
  TITLE     Functional cooperation between two otoconial proteins Oc90 and Nox3
  JOURNAL   J Vestib Res 31 (6), 441-449 (2021)
   PUBMED   33554930
  REMARK    GeneRIF: Functional cooperation between two otoconial proteins Oc90
            and Nox3.
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Celaya,A.M., Sanchez-Perez,I., Bermudez-Munoz,J.M., Rodriguez-de la
            Rosa,L., Pintado-Berninches,L., Perona,R., Murillo-Cuesta,S. and
            Varela-Nieto,I.
  TITLE     Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1)
            accelerates progressive hearing loss
  JOURNAL   Elife 8, e39159 (2019)
   PUBMED   30938680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Banfi,B., Malgrange,B., Knisz,J., Steger,K., Dubois-Dauphin,M. and
            Krause,K.H.
  TITLE     NOX3, a superoxide-generating NADPH oxidase of the inner ear
  JOURNAL   J Biol Chem 279 (44), 46065-46072 (2004)
   PUBMED   15326186
  REMARK    GeneRIF: NOX3 is a relevant source of ROS generation in the
            cochlear and vestibular systems and that NOX3-dependent ROS
            generation might contribute to hearing loss and balance problems in
            response to ototoxic drugs.
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Paffenholz,R., Bergstrom,R.A., Pasutto,F., Wabnitz,P., Munroe,R.J.,
            Jagla,W., Heinzmann,U., Marquardt,A., Bareiss,A., Laufs,J.,
            Russ,A., Stumm,G., Schimenti,J.C. and Bergstrom,D.E.
  TITLE     Vestibular defects in head-tilt mice result from mutations in Nox3,
            encoding an NADPH oxidase
  JOURNAL   Genes Dev 18 (5), 486-491 (2004)
   PUBMED   15014044
  REMARK    GeneRIF: an allelic series of mutations at the otoconia-deficient
            head tilt (het) locus, affecting the gene for NADPH oxidase 3
            (Nox3), identifies Nox3 as a protein with a clear enzymatic
            function indispensable for otoconia morphogenesis
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Fuller,P.M., Jones,T.A., Jones,S.M. and Fuller,C.A.
  TITLE     Neurovestibular modulation of circadian and homeostatic regulation:
            vestibulohypothalamic connection?
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15723-15728 (2002)
   PUBMED   12434016
REFERENCE   8  (bases 1 to 1792)
  AUTHORS   Lyon,M.F., Schimenti,J.C. and Evans,E.P.
  TITLE     Narrowing the critical regions for mouse t complex transmission
            ratio distortion factors by use of deletions
  JOURNAL   Genetics 155 (2), 793-801 (2000)
   PUBMED   10835400
REFERENCE   9  (bases 1 to 1792)
  AUTHORS   Jones,S.M., Erway,L.C., Bergstrom,R.A., Schimenti,J.C. and
            Jones,T.A.
  TITLE     Vestibular responses to linear acceleration are absent in
            otoconia-deficient C57BL/6JEi-het mice
  JOURNAL   Hear Res 135 (1-2), 56-60 (1999)
   PUBMED   10491954
REFERENCE   10 (bases 1 to 1792)
  AUTHORS   Bergstrom,R.A., You,Y., Erway,L.C., Lyon,M.F. and Schimenti,J.C.
  TITLE     Deletion mapping of the head tilt (het) gene in mice: a vestibular
            mutation causing specific absence of otoliths
  JOURNAL   Genetics 150 (2), 815-822 (1998)
   PUBMED   9755211
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098838.3 and AY573240.1.
            
            On Nov 17, 2006 this sequence version replaced NM_198958.1.
            
            Summary: This gene encodes a member of the NOX family of NADPH
            oxidases. These enzymes catalyze the transfer of electrons from
            NADPH to molecular oxygen to produce superoxide and other reactive
            oxygen species (ROS). The ROS generated by family members have been
            implicated in numerous biological functions including host defense,
            posttranlational processing of proteins, cellular signaling,
            regulation of gene expression, and cell differentiation. The
            protein encoded by this gene is expressed predominantly in the
            inner ear and is involved in the biogenesis of otoconia, which are
            crystalline structures of the inner ear involved in the perception
            of gravity and linear acceleration. In mouse mutations of this gene
            lead to the absence of otoconia and vestibular dysfunction.
            [provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106862.2, AY182377.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849384,
                                           SAMN00849385 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC098838.3         192731-192790       c
            61-540              AY573240.1         1-480
            541-541             AC098838.3         182398-182398       c
            542-1767            AY573240.1         482-1707
            1768-1792           AC098838.3         131769-131793       c
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 2.05 cM"
     gene            1..1792
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /note="NADPH oxidase 3"
                     /db_xref="GeneID:224480"
                     /db_xref="MGI:MGI:2681162"
     exon            1..108
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1767
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /note="head-tilt"
                     /codon_start=1
                     /product="NADPH oxidase 3"
                     /protein_id="NP_945196.2"
                     /db_xref="CCDS:CCDS28364.2"
                     /db_xref="GeneID:224480"
                     /db_xref="MGI:MGI:2681162"
                     /translation="MPVCWILNESGSFVVALLWLAVNAYLFIDTFFWYTEEEAFFYTR
                     VILGSALAWARASAVCLNFNCMLILLPVSRNFISLVRGTSVCCRGPWRRQLDKNLNFH
                     KLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGDAPNESYLNPVRTF
                     DMGTTTELLMTVSGITGLGISLALVFIMTSSTEFIRRSSYELFWYTHHIFVFFFISLA
                     IHGGGRIIRGQTPESLRLHNVTYCRDHYAEWQAAALCPVPQFSGKEPSAWKWALGPVV
                     LYACERIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSVSPLE
                     WHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFRVEGQAPSELCSMPRLAVDGPFGGS
                     LADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPELSKVYFYWICRDAGAFE
                     WFADLLLSLETRMSEQGKAHLLSYHIYLTGWDENQAIHIALHWDESLDVITGLKQKAF
                     YGRPNWNDEFKQIAYNHPSSSIGVFFCGSKAMSKTLQKMCRLYSSVDPRGVHFYYNKE
                     NF"
     exon            109..204
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            205..315
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            316..400
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            401..546
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            547..728
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            729..858
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            859..951
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1205
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1368
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1515
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1640
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1792
                     /gene="Nox3"
                     /gene_synonym="GP91-3; het; nmf250"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcaacgca caggctcaaa tggacggaaa ggaataacgt gttggagtaa gagaagtgtc
       61 atgccggtgt gctggattct gaacgagagt gggtccttcg tggttgctct cttatggctg
      121 gcagtaaacg cctatctgtt tattgacaca ttcttctggt atactgaaga ggaggctttc
      181 ttttatacac gagttattct gggttccgca ttggcatggg cccgggcatc tgccgtgtgc
      241 ctgaatttta actgcatgct aattctgtta cctgtcagtc ggaacttcat ttcactggtg
      301 agaggaacaa gtgtgtgctg tagaggacca tggagaagac aactagacaa aaacctcaac
      361 ttccacaaac tcgttgccta cgggatagct gtcaattcag ttatccacat tgtggcacac
      421 ttgttcaacc tggagcgtta tcacctgggt caggccaagg atgctgaagg gctgctggct
      481 gcactttcca aacttggcga tgccccaaat gagagctacc tcaatccagt ccgcaccttt
      541 gatatgggca caaccactga gctattgatg acagtgtcag gaattactgg cctgggtatc
      601 tctctggctc tggtcttcat catgacctct tcaaccgaat tcatcagaag gtcctcttat
      661 gagctcttct ggtacacaca ccatatcttt gtcttcttct tcatcagtct ggccatccac
      721 ggaggaggtc gcatcattcg aggccaaact ccagagagtc tccggctgca caatgtcacg
      781 tactgcagag accactatgc tgaatggcag gcagctgcct tatgccctgt acctcaattt
      841 tctggcaagg aaccttcggc ctggaaatgg gctttgggtc ctgtggtctt gtatgcgtgt
      901 gaaagaataa ttaggttctg gagatctcac caagaagttg tcattaccaa ggtggtgagt
      961 cacccatctg cagtcctgga acttcacatg aagaagcgag acttcaagat ggcacctgga
     1021 cagtacatct tcatccagtg cccatctgtc tcccccctgg agtggcaccc cttcactctc
     1081 acctccgctc cccaggagga cttcttcagt gtacacatca gagcctcagg agactggaca
     1141 gaggcgttat tgaaggcctt tagagtagag ggacaggctc ccagtgagct ctgtagcatg
     1201 ccgaggctag cagtggatgg gccctttgga ggctctctgg cagatgtatt tcactacccc
     1261 gtgagcgtgt gcattgcaac gggaattgga gtcactccct tcgcctctct tctgaagtct
     1321 gtgtggtata agtgttgtga atcacagagc ctgcctgagc tgagcaaggt gtacttctat
     1381 tggatctgcc gggatgccgg agcatttgag tggtttgctg atctgttact gtcactggaa
     1441 acacggatga gtgaacaagg gaaggctcat ttactgagct accatatata tctcactggc
     1501 tgggatgaaa accaggcaat tcacatagct ttacactggg atgaaagtct ggatgtgata
     1561 acaggcttaa agcagaaggc tttctatggg cgacccaact ggaacgacga attcaagcag
     1621 attgcctaca atcaccccag cagcagcatt ggcgtgttct tctgtggatc caaagccatg
     1681 tcaaagactc ttcaaaagat gtgtcgtttg tactcatctg tggatccgag gggcgttcat
     1741 ttctattaca acaaggaaaa cttctagatg ttgggggtac agtcaatgca ct
//
